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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 呂廷璋 | zh_TW |
| dc.contributor.advisor | Ting-Jang Lu | en |
| dc.contributor.author | 劉昀諠 | zh_TW |
| dc.contributor.author | Yun-Hsuan Liu | en |
| dc.date.accessioned | 2025-02-27T16:39:55Z | - |
| dc.date.available | 2025-02-28 | - |
| dc.date.copyright | 2025-02-27 | - |
| dc.date.issued | 2024 | - |
| dc.date.submitted | 2024-08-14 | - |
| dc.identifier.citation | 呂雅珍，以液相層析串聯質譜法分析臺灣婦女泌乳期間母乳寡醣與三酸甘油酯之變化。國立臺灣大學。臺北市，2022。
柯鈞銓，以超高效液相層析串聯質譜法分析油脂中三酸甘油酯及固醇化合物特徵。國立臺灣大學。臺北市，2016。 Al-Tamer, Y. Y.; Mahmood, A. A., The influence of Iraqi mothers' socioeconomic status on their milk-lipid content. Eur. J. Clin. Nutr. 2006, 60, 1400-1405. Aly, M. R. E.; Ibrahim, E. S. I.; El Ashry, E. S. H.; Schmidt, R. R., Synthesis of lacto-N-neotetraose and lacto-N-tetraose using the dimethylmaleoyl group as amino protective group. Carbohydr. Res. 1999, 316, 121-132. Andreas, N. J.; Kampmann, B.; Mehring Le-Doare, K., Human breast milk: A review on its composition and bioactivity. Early Hum. Dev. 2015, 91, 629-635. Arab-Tehrany, E.; Jacquot, M.; Gaiani, C.; Imran, M.; Desobry, S.; Linder, M., Beneficial effects and oxidative stability of omega-3 long-chain polyunsaturated fatty acids. Trends Food Sci. 2012, 25, 24-33. 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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/97204 | - |
| dc.description.abstract | 母乳是嬰兒理想的營養來源，母乳寡醣與脂質是母乳中第三及第二豐富的成分。本研究使用液相層析串聯質譜法解析母乳中21種母乳寡醣以及三酸甘油酯中奇數鏈脂肪酸、EPA和DHA脂肪酸之分布。樣品來自成大醫院與臺大醫院招募118位母親所提供的319個母乳，其分別在出生後第 1、2.5、4、5、8、16、24和52週進行收集。本研究以不同的特徵結構對母乳寡醣進行分類並討論泌乳期間其在母乳中的分布情情況，並藉由母乳寡醣上的結構特徵碎片辨別抗原表位以推測母親之基因型。臺灣母親Se+Le+型的比例高達9成，且觀察到Se−Le+基因型的臺灣母親其母乳中唾液酸化母乳寡醣的占比較全球平均結果低。最後則透過相關性分析探討相同分泌狀態下母嬰特徵與母親食用之營養補充品對母乳寡醣分布的影響。另一方面，本研究於臺灣婦女的母乳中鑑別出86個三酸甘油酯，包含4種含有奇數鏈脂肪酸之三酸甘油酯β-PPeO、β-PeOO、β-MaPO和β-OMaO，以及4種含有含有EPA或DHA之三酸甘油酯β-PODh、β-OPDh、β-OEpO和β-OOEp。其中在甘油骨幹的sn-2位置上具有Pentadecylic acid (C15:0)、Margaric acid (C17:0) 和Eicosapentaenoic acid (EPA, 20:5 n-3) 的酯化。此外觀察到母親的飲食習慣與基因可能不會影響母乳中含有EPA或DHA之三酸甘油酯。 | zh_TW |
| dc.description.abstract | Human milk (HM) provides newborns with ideal natural nutrition. Human milk oligosaccharides (HMOs) and lipids are the third and second most abundant components in breast milk. Liquid chromatography-tandem mass spectrometry was used to identify 21 HMOs and odd-chain fatty acids, EPA, and DHA in triglycerides (TG) of HM. A total of 237 human milk samples were obtained from 89 women who delivered healthy full-term infants by NCKUH and NTUH recruited. The milk sample were collected on postnatal week 1, 2.5, 4, 5, 8,16, 24 and 52. We classified HMOs based on different characteristic fragments to discuss their profile in HM during lactation. Antigenic epitopes on the HMOs were also identified, which inferred the Se+Le+ type was up to 90% of Taiwanese mothers. Additionally, the fraction of sialylated HMOs in HM of Taiwanese mothers with Se−Le+ genotype is lower than the global average. Finally, correlation analysis was conducted to explore the effects of maternal-infant characteristics and dietary supplements consumed by mothers on the profile of HMOs in the same mike group. On the other hand, this study identified 86 TGs in HM of Taiwanese women, including 4 TGs containing odd-chain fatty acids, β-PPeO, β-PeOO, β-MaPO, and β-OMaO, and 4 TG s containing Eicosapentaenoic acid (EPA, 20:5 n-3) or Docosahexaenoic acid (DHA, 22:6 n-3), which are β-PODh, β-OPDh, β-OEpO and β-OOEp. Among these TGs, only Pentadecylic acid (C15:0), Margaric acid (C17:0) and EPA esterified at the sn-2 position of the glycerol backbone. In addition, it was observed that the mother's dietary patterns and genetic background may not affect the level of the TGs with EPA or DHA in HM. | en |
| dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2025-02-27T16:39:55Z No. of bitstreams: 0 | en |
| dc.description.provenance | Made available in DSpace on 2025-02-27T16:39:55Z (GMT). No. of bitstreams: 0 | en |
| dc.description.tableofcontents | 摘要 i
Abstract ii 目次 iii 圖次 ix 表次 xi 附圖目次 xiii 附表目次 xv 第一章、前言 1 第二章、文獻回顧 2 第一節、母乳 (human milk) 2 第二節、母乳寡醣 (human milk oligosaccharides, HMOs) 5 一、母乳寡醣的結構組成 8 二、母乳寡醣的合成 17 1. 乳糖的合成 17 2. 母乳寡醣的合成 17 三、母乳寡醣的生理功能 25 1. 岩藻糖基化母乳寡醣 26 2. 唾液酸化母乳寡醣 28 3. 無岩藻糖基化中性母乳寡醣 29 4. 母乳寡醣對母親的生理影響 30 四、母乳中母乳寡醣的組成輪廓與主要影響因子 31 1. 母乳寡醣於母乳中的分布 31 2. 影響母乳中母乳寡醣含量的主要因子 31 五、母乳寡醣結構解析 34 第三節、母乳中的三酸甘油酯 40 一、母乳中三酸甘油酯的結構組成 41 1. 母乳中的脂肪酸 41 2. 母乳三酸甘油酯中脂肪酸獨特的位置分布 44 二、母乳中三酸甘油酯的生理功能 45 1. sn-2 palmitate於新生兒脂質吸收的重要性 45 2. 母乳中的微生物群和脂肪酸 47 三、母乳中三酸甘油酯的組成輪廓 48 四、影響母乳中脂肪酸分布之因子 49 1. 母體基因於母乳中脂肪酸分布之影響 49 2. 母親飲食於母乳中脂肪酸分布之影響 50 五、透過飲食來源攝取之脂肪酸 51 1. 母乳中的奇數鏈脂肪酸 (odd chain fatty acids, OCFA) 51 2. 母乳中的EPA和DHA 52 第四節、當前研究限制 55 第三章、研究目的與實驗架構 56 第四章、材料與方法 57 第一節、實驗材料 57 一、母乳樣品 57 二、油脂樣品 59 第二節、藥品與試劑 59 一、標準品 59 二、化學藥品 60 第三節、儀器設備 61 一、裝置及標準品 61 三、器具 62 四、軟體 63 第四節、實驗方法 64 一、母乳寡醣樣品前處理 64 1. 母乳樣品前處理 64 2. 去脂肪與去蛋白質 64 3. 還原反應 64 二、母乳寡醣試劑空白樣品前處理 64 三、母乳寡醣檢量線製作 65 1. 配置流程 65 2. 處理流程 66 四、母乳寡醣查核樣品之製備 66 五、母乳寡醣樣品標準添加法 66 1. 處理流程 67 六、以液相層析串聯質譜法分析母乳寡醣 67 1. 液相層析儀分析條件 67 2. 液相層析系統與質譜系統之間的六向閥切換 67 3. 質譜儀條件設定 67 七、母乳寡醣絕對定量與相對定量分析 69 八、母乳三酸甘油酯樣品前處理 69 九、母乳三酸甘油酯樣品空白前處理 70 十、母乳三酸甘油酯基質匹配檢量線之製作 70 十一、母乳三酸甘油酯與系統查核樣品之製備 71 1. 母乳三酸甘油酯查核樣品 (quality control samples for human milk triglycerides, HMTGQC) 71 2. 系統查核樣品 (quality control samples for TG method, TG Method QC) 71 十二、母乳三酸甘油酯標準添加法之製備 72 十三、以液相層析串聯質譜法分析母乳三酸甘油酯 72 1. 管柱後添加系統 (post column addition) 72 2. 液相層析儀分析條件 72 3. 質譜儀條件設定 73 十四、母乳三酸甘油酯之絕對定量與相對定量分析 74 十五、統計試驗 74 1. 母乳寡醣組別差異 74 2. 分泌者與非分泌者個別母乳寡醣之組別差異 74 3. 母嬰特徵、母親孕期及哺乳期營養補充品之攝取與母乳寡醣分布之相關性分析 74 第五章、結果與討論 76 第一節、泌乳期前52週母乳中母乳寡醣之含量 76 一、母乳中主要的寡醣成分 76 二、不同母親母乳之母乳寡醣濃度變異性 78 三、母乳寡醣於不同泌乳週期之變化 80 四、個別母乳寡醣在不同週期之變化 83 五、帶有血型抗原特徵之母乳寡醣於泌乳期間含量變化 87 六、以母乳寡醣組成對母親之基因表型進行分類 91 1. 參考Austin等人 (2019) 之分組方法 (Austin et al., 2019) 92 2. 參考Wang 等人 (2020) 之分組方法 (Wang et al., 2020b) 92 3. 臺灣母親與其他地區人群母乳中母乳寡醣輪廓組成之比較 93 4. 臺灣母親不同母乳組別中母乳寡醣的分布 100 第二節、母親食用營養補充品及基本資料與母乳寡醣分布 107 一、母嬰特徵與母乳寡醣分布 107 1. 母親血型與母乳寡醣相關性 107 2. 嬰兒胎次與母乳寡醣相關性 108 3. 妊娠週數與母乳寡醣相關性 108 4. 分娩方式與母乳寡醣相關性 109 5. 母親居住城市與母乳寡醣相關性 109 二、母親孕期食用營養補充品與母乳寡醣分布 110 1. 孕期食用營養補充品與母乳寡醣相關性 110 2. 孕期食用綜合維他命與母乳寡醣相關性 110 3. 孕期食用葉酸與母乳寡醣相關性 111 4. 孕期食用綜合維他命及葉酸與母乳寡醣相關性 111 5. 孕期食用益生菌與母乳寡醣相關性 111 三、母親哺乳期食用營養補充品與母乳寡醣分布 112 1. 哺乳期食用營養補充品與母乳寡醣相關性 112 2. 哺乳期食用綜合維他命與母乳寡醣相關性 112 3. 哺乳期食用葉酸與母乳寡醣相關性 112 4. 哺乳期食用卵磷脂與母乳寡醣相關性 113 5. 哺乳期食用綜合維他命及卵磷脂與母乳寡醣相關性 113 6. 哺乳期食用鈣與母乳寡醣相關性 113 7. 哺乳期食用益生菌與母乳寡醣相關性 113 第三節、三酸甘油酯之分析方法擴增與母乳中三酸甘油酯之分布 126 一、LXQ母乳三酸甘油酯分析平台之化合物清單擴建 126 1. 魚油樣品中三酸甘油酯之分布 126 二、母乳查核樣品中奇數鏈脂肪酸之分布 138 三、母乳中含有EPA或DHA之三酸甘油酯 145 第六章、結論 153 第七章、參考文獻 155 第八章、附錄 177 第一節、母乳寡醣結構解析 177 一、母乳寡醣以高效能液相層析中分離 177 二、母乳寡醣於高效能液相層析串聯質譜儀之檢測模式 186 1. 加成離子的選擇 186 2. 前驅離子之質量精確度 (mass accuracy) 189 3. 利用產物離子定性與定量母乳寡醣 189 三、方法確效 196 1. 母乳寡醣之檢量線 196 2. 母乳寡醣之方法定量極限 196 3. 母乳寡醣之回收率 196 第二節、母乳三酸甘油酯結構解析 204 一、母乳三酸甘油酯以高效能液相層析中分離 204 二、母乳中三酸甘油酯於高效能液相層析串聯質譜儀之檢測模式 210 1. 以特徵碎片離子辨別母乳中三酸甘油酯組成 210 2. 判別三酸甘油酯 (AAB型及ABA型) 之情形 211 3. 三酸甘油酯命名規則與化合物清單排序 216 三、方法確效 219 1. 母乳三酸甘油酯前處理稀釋倍數對於基質效應之影響 219 2. 內標基質效應評估 220 3. 母乳三酸甘油酯之基質匹配檢量線 222 4. 母乳三酸甘油酯之方法定量極限及回收率 223 5. 母乳三酸甘油酯之回收率 223 第三節、個別母乳寡醣在不同週期之變化圖 226 第四節、不同地區研究中母親母乳寡醣組成之數據 228 第五節、母乳捐贈者之背景資料與飲食習慣調查 235 一、成大醫院90位捐贈者之背景資料與飲食習慣 235 二、臺大醫院28位捐贈者之背景資料與飲食習慣 237 第六節、母乳寡醣分析數據品管 247 第七節、同意人體研究證明書 257 | - |
| dc.language.iso | zh_TW | - |
| dc.subject | 泌乳期 | zh_TW |
| dc.subject | 分泌狀態 | zh_TW |
| dc.subject | 母乳三酸甘油酯 | zh_TW |
| dc.subject | 母乳寡醣 | zh_TW |
| dc.subject | 母乳 | zh_TW |
| dc.subject | Secretor status | en |
| dc.subject | human milk | en |
| dc.subject | human milk oligosaccharides | en |
| dc.subject | human milk triacylglycerols | en |
| dc.subject | lactation period | en |
| dc.title | 臺灣母親母乳中寡醣和三酸甘油酯的輪廓分析 | zh_TW |
| dc.title | Profiling analysis of oligosaccharides and triacylglycerols in human milk from Taiwanese mothers | en |
| dc.type | Thesis | - |
| dc.date.schoolyear | 113-1 | - |
| dc.description.degree | 碩士 | - |
| dc.contributor.oralexamcommittee | 張永和;王惠珠;謝淑貞;陳宏彰 | zh_TW |
| dc.contributor.oralexamcommittee | Yung-Ho Chang;Huei-ju Wang;Shu-Chen Hsieh;Hong-Jhang Chen | en |
| dc.subject.keyword | 母乳,母乳寡醣,母乳三酸甘油酯,泌乳期,分泌狀態, | zh_TW |
| dc.subject.keyword | human milk,human milk oligosaccharides,human milk triacylglycerols,lactation period,Secretor status, | en |
| dc.relation.page | 268 | - |
| dc.identifier.doi | 10.6342/NTU202404307 | - |
| dc.rights.note | 同意授權(限校園內公開) | - |
| dc.date.accepted | 2024-08-14 | - |
| dc.contributor.author-college | 生物資源暨農學院 | - |
| dc.contributor.author-dept | 食品科技研究所 | - |
| dc.date.embargo-lift | 2025-02-28 | - |
| 顯示於系所單位： | 食品科技研究所 | |
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