請用此 Handle URI 來引用此文件:
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/90552
完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 潘敏雄 | zh_TW |
dc.contributor.advisor | Min-Hsiung Pan | en |
dc.contributor.author | 林品萱 | zh_TW |
dc.contributor.author | Pin-Xuan Lin | en |
dc.date.accessioned | 2023-10-03T16:36:02Z | - |
dc.date.available | 2023-11-09 | - |
dc.date.copyright | 2023-10-03 | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2023-08-02 | - |
dc.identifier.citation | 任珮君、張嫻君、陳盟松、蘇致柔(2019)。紅龍果果粉熱風乾燥技術之開發與粉圓產品之應用。臺中區農業改良場研究彙報,63-75。
行政院農業委員會(2023a)。農產品批發市場交易行情站-產品行情比較。取自:https://amis.afa.gov.tw/fruit/FruitChartProdTransPriceVolumeTrend.aspx 行政院農業委員會(2023b)。農業統計資料查詢。取自: https://agrstat.coa.gov.tw/sdweb/public/inquiry/InquireAdvance.aspx 行政院農業委員會(2018)。紅龍果綜合栽培管理技術。行政院農業委員會臺中區農業改良場技術專刊,198。 財政部關務署(2023)。海關進出口統計。取自:https://portal.sw.nat.gov.tw/APGA/GA30 陳盟松(2017)。臺灣紅龍果產期調節技術發展。臺中區農業改良場特刊,91-100。 劉玹君、張峻齊(2022)。讓產銷失衡的「X」線消失!-紅龍果多元加值應用趨勢分析。豐年雜誌,72,74-79。 衛生福利部國民健康署(2006)。量腰圍 測三高 中老年病不上身。取自:https://www.hpa.gov.tw/pages/list.aspx?nodeid=221 衛生福利部國民健康署(2016)。代謝症候群。取自:https://www.hpa.gov.tw/pages/list.aspx?nodeid=221 衛生福利部國民健康署(2018)。臺灣肥胖防治策略。取自:https://www.hpa.gov.tw/File/Attach/10299/File_11744.pdf 衛生福利部國民健康署(2020)。國民營養健康狀況變遷調查 (106-109年) 成果報告。取自:https://www.hpa.gov.tw/Pages/List.aspx?nodeid=3998 衛生福利部國民健康署(2023)。成人肥胖防治實證指引。取自:https://www.hpa.gov.tw/File/Attach/10042/File_20342.pdf 鍾宜姍(2015)。火龍果皮萃取物對於以飲食誘發肥胖大鼠脂質代謝及發炎反應的影響。臺北醫學大學保健營養學研究所。 World health organization (WHO) (2000). Obesity: preventing and managing the global epidemic. World health organization (WHO) (2022). WHO European regional obesity report 2022. World Health Organization. Regional Office for Europe. World obesity federation (2023). World Obesity Atlas 2023. Abedimanesh, N., Asghari, S., Mohammadnejad, K., Daneshvar, Z., Rahmani, S., Shokoohi, S., Farzaneh, A. H., Hosseini, S. H., Jafari Anarkooli, I., & Noubarani, M. (2021). The anti-diabetic effects of betanin in streptozotocin-induced diabetic rats through modulating AMPK/SIRT1/NF-κB signaling pathway. Nutrition & Metabolism, 18, 1-13. Adhi, N. G. M. A. D., Suastuti, N. W. B., & Putra, A. A. B. (2018). Activity of Hylocereus Costarioensis’s extract as antiobesity and hypolipidemic of obese rats. International Journal of Pharmaceutical Research and Allied Sciences, 7(1), 201-208. Akhiruddin, M. A. S. (2013). Nutritional composition, antioxidant properties of Hylocereus Polyrhizus powder and their effects on plasma glucose level and lipid profiles in diabetic rats andpre-diabetic subjects Universiti Putra Malaysia. Arivalagan, M., Karunakaran, G., Roy, T. K., Dinsha, M., Sindhu, B. C., Shilpashree, V. M., Satisha, G. C., & Shivashankara, K. S. (2021). Biochemical and nutritional characterization of dragon fruit (Hylocereus species). Food Chemistry, 353, 129426. Armougom, F., Henry, M., Vialettes, B., Raccah, D., & Raoult, D. (2009). Monitoring bacterial community of human gut microbiota reveals an increase in Lactobacillus in obese patients and Methanogens in anorexic patients. PloS one, 4(9), e7125. Arora, T., Sharma, R., & Frost, G. (2011). Propionate. Anti-obesity and satiety enhancing factor? Appetite, 56(2), 511-515. Artemniak-Wojtowicz, D., Kucharska, A., & Pyrżak, B. (2020). Obesity and chronic inflammation crosslinking. Central European Journal of Immunology, 45(4), 461-468. Barter, P., Gotto, A. M., LaRosa, J. C., Maroni, J., Szarek, M., Grundy, S. M., Kastelein, J. J., Bittner, V., & Fruchart, J.-C. (2007). HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events. New England Journal of Medicine, 357(13), 1301-1310. Bates, S. T., Clemente, J. C., Flores, G. E., Walters, W. A., Parfrey, L. W., Knight, R., & Fierer, N. (2013). Global biogeography of highly diverse protistan communities in soil. The ISME Journal, 7(3), 652-659. Bell, J. A., Kivimaki, M., & Hamer, M. (2014). Metabolically healthy obesity and risk of incident type 2 diabetes: a meta‐analysis of prospective cohort studies. Obesity Reviews, 15(6), 504-515. Berger, J.-M., & Moon, Y.-A. (2021). Increased hepatic lipogenesis elevates liver cholesterol content. Molecules and Cells, 44(2), 116. Bäckhed, F., Ding, H., Wang, T., Hooper, L. V., Koh, G. Y., Nagy, A., Semenkovich, C. F., & Gordon, J. I. (2004). The gut microbiota as an environmental factor that regulates fat storage. Proceedings of the National Academy of Sciences, 101(44), 15718-15723. Bradford, M. M. (1976). A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Analytical Biochemistry, 72(1), 248-254. Bray, G. A., Frühbeck, G., Ryan, D. H., & Wilding, J. P. H. (2016). Management of obesity. The Lancet, 387(10031), 1947-1956. Brown, A. J., Goldsworthy, S. M., Barnes, A. A., Eilert, M. M., Tcheang, L., Daniels, D., Muir, A. I., Wigglesworth, M. J., Kinghorn, I., & Fraser, N. J. (2003). The Orphan G protein-coupled receptors GPR41 and GPR43 are activated by propionate and other short chain carboxylic acids. Journal of Biological Chemistry, 278(13), 11312-11319. Carter, J. K., Bhattacharya, D., Borgerding, J. N., Fiel, M. I., Faith, J. J., & Friedman, S. L. (2021). Modeling dysbiosis of human NASH in mice: Loss of gut microbiome diversity and overgrowth of Erysipelotrichales. PloS one, 16(1), e0244763. Chai, X., Wen, L., Song, Y., He, X., Yue, J., Wu, J., Chen, X., Cai, Z., & Qi, Z. (2023). DEHP exposure elevated cardiovascular risk in obese mice by disturbing the arachidonic acid metabolism of gut microbiota. Science of the Total Environment, 875, 162615. Chang, P. V., Hao, L., Offermanns, S., & Medzhitov, R. (2014). The microbial metabolite butyrate regulates intestinal macrophage function via histone deacetylase inhibition. Proceedings of the National Academy of Sciences, 111(6), 2247-2252. Chen, C., Zeng, Y., Xu, J., Zheng, H., Liu, J., Fan, R., Zhu, W., Yuan, L., Qin, Y., Chen, S., Zhou, Y., Wu, Y., Wan, J., Mi, M., & Wang, J. (2016). Therapeutic effects of soluble dietary fiber consumption on type 2 diabetes mellitus. Experimental and Therapeutic Medicine, 12(2), 1232-1242. Choi, S. S., & Diehl, A. M. (2008). Hepatic triglyceride synthesis and nonalcoholic fatty liver disease. Current Opinion in Lipidology, 19(3), 295-300. Clement, J. S., Mabry, T. J., Wyler, H., & Dreiding, A. S. (1994). Chemical review and evolutionary significance of the betalains. Caryophyllales: Evolution and Systematics, 247-261. Dai, F. J., & Chau, C. F. (2017). Classification and regulatory perspectives of dietary fiber. Journal of Food and Drug Analysis, 25(1), 37-42. Daly, K., & Shirazi-Beechey, S. P. (2006). Microarray analysis of butyrate regulated genes in colonic epithelial cells. DNA and Cell Biology, 25(1), 49-62. Daneschvar, H. L., Aronson, M. D., & Smetana, G. W. (2016). FDA-approved anti-obesity drugs in the United States. The American Journal of Medicine, 129(8), 879.e1-879.e6. Davie, J. R. (2003). Inhibition of histone deacetylase activity by butyrate. The Journal of Nutrition, 133(7), 2485S-2493S. Davis, C. D. (2016). The gut microbiome and its role in obesity. Nutrition Today, 51(4), 167-174. Dhingra, D., Michael, M., Rajput, H., & Patil, R. T. (2012). Dietary fibre in foods: a review. Journal of Food Science and Technology, 49(3), 255-266. Ding, R. B., Bao, J., & Deng, C. X. (2017). Emerging roles of SIRT1 in fatty liver diseases. International Journal of Biological Sciences, 13(7), 852-867. Ding, S., Chi, M. M., Scull, B. P., Rigby, R., Schwerbrock, N. M., Magness, S., Jobin, C., & Lund, P. K. (2010). High-fat diet: bacteria interactions promote intestinal inflammation which precedes and correlates with obesity and insulin resistance in mouse. PloS one, 5(8), e12191. Do, M. H., Lee, E., Oh, M. J., Kim, Y., & Park, H. Y. (2018). High-glucose or-fructose diet cause changes of the gut microbiota and metabolic disorders in mice without body weight change. Nutrients, 10(6), 761. Eid, H. M., Wright, M. L., Anil Kumar, N., Qawasmeh, A., Hassan, S. T., Mocan, A., Nabavi, S. M., Rastrelli, L., Atanasov, A. G., & Haddad, P. S. (2017). Significance of microbiota in obesity and metabolic diseases and the modulatory potential by medicinal plant and food ingredients. Frontiers in Pharmacology, 8, 387. Fadlilah, S., Sucipto, A., Khasanah, F., Setiawan, D., & Rahil, N. H. (2020). Dragon fruit (Hylocereus polyrhizus) effectively reduces fasting blood sugar levels and blood pressure on excessive nutritional status. Pakistan Journal of Medical Sciences, 14, 1405-1412. Fang, C., Pan, J., Qu, N., Lei, Y., Han, J., Zhang, J., & Han, D. (2022). The AMPK pathway in fatty liver disease. Frontiers in Physiology, 13, 970292. Gandía-Herrero, F., Escribano, J., & García-Carmona, F. (2016). Biological activities of plant pigments betalains. Critical Reviews in Food Science and Nutrition, 56(6), 937-945. Gengatharan, A., Dykes, G. A., & Choo, W. S. (2015). Betalains: Natural plant pigments with potential application in functional foods. LWT - Food Science and Technology, 64(2), 645-649. Georgiev, V., Ilieva, M., Bley, T., & Pavlov, A. (2008). Betalain production in plant in vitro systems. Acta Physiologiae Plantarum, 30(5), 581-593. Gibson, G. R., Probert, H. M., Loo, J. V., Rastall, R. A., & Roberfroid, M. B. (2004). Dietary modulation of the human colonic microbiota: updating the concept of prebiotics. Nutrition Research Reviews, 17(2), 259-275. Griffin, B. A. (2013). Lipid metabolism. Surgery (Oxford), 31(6), 267-272. Grundy, S. M. (2016). Metabolic syndrome update. Trends in Cardiovascular Medicine, 26(4), 364-373. Hall, K. D. (2018). Did the food environment cause the obesity epidemic? Obesity, 26(1), 11-13. Hildebrandt, M. A., Hoffmann, C., Sherrill–Mix, S. A., Keilbaugh, S. A., Hamady, M., Chen, Y. Y., Knight, R., Ahima, R. S., Bushman, F., & Wu, G. D. (2009). High-fat diet determines the composition of the murine gut microbiome independently of obesity. Gastroenterology, 137(5), 1716-1724.e1712. Hill, D. A., & Artis, D. (2010). Intestinal bacteria and the regulation of immune cell homeostasis. Annual Review of Immunology, 28(1), 623-667. Holanda, M. O., Lira, S. M., Silva, J. Y. G. d., Marques, C. G., Coelho, L. C., Lima, C. L. S., Costa, J. T. G., Silva, G. S. d., Santos, G. B. M., Zocolo, G. J., Dionísio, A. P., & Guedes, M. I. F. (2021). Intake of pitaya (Hylocereus polyrhizus (F.A.C. Weber) Britton & Rose) beneficially affects the cholesterolemic profile of dyslipidemic C57BL/6 mice. Food Bioscience, 42, 101181. Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F., & Spiegelman, B. M. (1996). IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-α- and obesity-induced insulin resistance. Science, 271(5249), 665-670. Howard, B. V. (1999). Insulin resistance and lipid metabolism. The American Journal of Cardiology, 84(1, Supplement 1), 28-32. Ikonen, E. (2008). Cellular cholesterol trafficking and compartmentalization. Nature Reviews Molecular Cell Biology, 9(2), 125-138. Illumina, I. (2015). An introduction to next-generation sequencing technology. Illumina, Inc. Jacobs, D. R., Jr, Gross, M. D., & Tapsell, L. C. (2009). Food synergy: an operational concept for understanding nutrition. The American Journal of Clinical Nutrition, 89(5), 1543S-1548S. Janovská, A., Hatzinikolas, G., Staikopoulos, V., McInerney, J., Mano, M., & Wittert, G. A. (2008). AMPK and ACC phosphorylation: Effect of leptin, muscle fibre type and obesity. Molecular and Cellular Endocrinology, 284(1), 1-10. Jiang, X. T., Peng, X., Deng, G. H., Sheng, H. F., Wang, Y., Zhou, H. W., & Tam, N. F. Y. (2013). Illumina Sequencing of 16S rRNA Tag Revealed Spatial Variations of Bacterial Communities in a Mangrove Wetland. Microbial Ecology, 66(1), 96-104. Johnstone, R. W. (2002). Histone-deacetylase inhibitors: novel drugs for the treatment of cancer. Nature Reviews Drug Discovery, 1(4), 287-299. Kasprzak-Drozd, K., Oniszczuk, T., Stasiak, M., & Oniszczuk, A. (2021). Beneficial effects of phenolic compounds on gut microbiota and metabolic syndrome. International Journal of Molecular Sciences, 22(7), 3715. Kemper, J. K., Choi, S. E., & Kim, D. H. (2013). Sirtuin 1 deacetylase: a key regulator of hepatic lipid metabolism. Vitamins & Hormones, 91, 385-404. Kershaw, E. E., & Flier, J. S. (2004). Adipose tissue as an endocrine organ. The Journal of Clinical Endocrinology & Metabolism, 89(6), 2548-2556. Kim, C. H., Park, J., & Kim, M. (2014). Gut microbiota-derived short-chain fatty acids, T cells, and inflammation. Immune Network, 14(6), 277-288. Koh, A., De Vadder, F., Kovatcheva-Datchary, P., & Bäckhed, F. (2016). From dietary fiber to host physiology: short-chain fatty acids as key bacterial metabolites. Cell, 165(6), 1332-1345. Koh, Y. C., Lin, Y. C., Lee, P. S., Lu, T. J., Lin, K. Y., & Pan, M. H. (2020). A multi-targeting strategy to ameliorate high-fat-diet-and fructose-induced (western diet-induced) non-alcoholic fatty liver disease (NAFLD) with supplementation of a mixture of legume ethanol extracts. Food & Function, 11(9), 7545-7560. Komatsu, M., Takei, M., Ishii, H., & Sato, Y. (2013). Glucose‐stimulated insulin secretion: A newer perspective. Journal of Diabetes Investigation, 4(6), 511-516. Kompaniyets, L., Agathis, N. T., Nelson, J. M., Preston, L. E., Ko, J. Y., Belay, B., Pennington, A. F., Danielson, M. L., DeSisto, C. L., & Chevinsky, J. R. (2021). Underlying medical conditions associated with severe COVID-19 illness among children. JAMA network open, 4(6), e2111182. Kumar, H., & Salminen, S. (2016). Probiotics. In B. Caballero, P. M. Finglas, & F. Toldrá (Eds.), Encyclopedia of Food and Health (pp. 510-515). Academic Press. Kunutsor, S. K., Zaccardi, F., Karppi, J., Kurl, S., & Laukkanen, J. A. (2017). Is high serum LDL/HDL cholesterol ratio an emerging risk factor for sudden cardiac death? Findings from the KIHD study. Journal of Atherosclerosis and Thrombosis, 24(6), 600-608. Lavie, C. J., Deedwania, P., & Ortega, F. B. (2018). Obesity is rarely healthy. The lancet. Diabetes & Endocrinology, 6(9), 678-679. Le, N. L. (2022). Functional compounds in dragon fruit peels and their potential health benefits: a review. International Journal of Food Science & Technology, 57(5), 2571-2580. Le Poul, E., Loison, C., Struyf, S., Springael, J.-Y., Lannoy, V., Decobecq, M.-E., Brezillon, S., Dupriez, V., Vassart, G., & Van Damme, J. (2003). Functional characterization of human receptors for short chain fatty acids and their role in polymorphonuclear cell activation. Journal of Biological Chemistry, 278(28), 25481-25489. Lee, C. M. Y., Huxley, R. R., Wildman, R. P., & Woodward, M. (2008). Indices of abdominal obesity are better discriminators of cardiovascular risk factors than BMI: a meta-analysis. Journal of Clinical Epidemiology, 61(7), 646-653. Lee, M. H., Kim, J., Kim, G. H., Kim, M. S., & Yoon, S. S. (2023). Effects of Lactiplantibacillus plantarum FBT215 and prebiotics on the gut microbiota structure of mice. Food Science and Biotechnology, 32(4), 481-488. Lex, A., Gehlenborg, N., Strobelt, H., Vuillemot, R., & Pfister, H. (2014). UpSet: Visualization of Intersecting Sets. IEEE Transactions on Visualization and Computer Graphics, 20(12), 1983-1992. Liu, J., He, Z., Ma, N., & Chen, Z.-Y. (2020). Beneficial effects of dietary polyphenols on high-fat diet-induced obesity linking with modulation of gut microbiota. Journal of Agricultural and Food Chemistry, 68(1), 33-47, 1133167. Liu, T. H., Wang, J., Zhang, C. Y., Zhao, L., Sheng, Y. Y., Tao, G. S., & Xue, Y. Z. (2023). Gut microbial characteristical comparison reveals potential anti-aging function of Dubosiella newyorkensis in mice. Frontiers in Endocrinology, 14, 1133167. Liu, T. H., Zhao, L., Zhang, C. Y., Li, X. Y., Wu, T. L., Dai, Y. Y., Sheng, Y. Y., Ren, Y. L., & Xue, Y. Z. (2022). Gut microbial evidence chain in high-salt diet exacerbates intestinal aging process. Frontiers in Nutrition, 9, 1046833. Ljungh, A., & Wadstrom, T. (2006). Lactic acid bacteria as probiotics. Current Issues in Intestinal Microbiology, 7(2), 73-90. Lozupone, C. A., Hamady, M., Kelley, S. T., & Knight, R. (2007). Quantitative and qualitative β diversity measures lead to different insights into factors that structure microbial communities. Applied and Environmental Microbiology, 73(5), 1576-1585. Lunn, J., & Buttriss, J. L. (2007). Carbohydrates and dietary fibre. Nutrition Bulletin, 32(1), 21-64. Luo, J., Lin, X., Bordiga, M., Brennan, C., & Xu, B. (2021). Manipulating effects of fruits and vegetables on gut microbiota–a critical review. International Journal of Food Science & Technology, 56(5), 2055-2067. Luo, M., Mengos, A. E., Stubblefield, T. M., & Mandarino, L. J. (2012). High fat diet-induced changes in hepatic protein abundance in mice. Journal of Proteomics and Bioinformatics, 5(3), 60-66. Macia, L., Tan, J., Vieira, A. T., Leach, K., Stanley, D., Luong, S., Maruya, M., Ian McKenzie, C., Hijikata, A., Wong, C., Binge, L., Thorburn, A. N., Chevalier, N., Ang, C., Marino, E., Robert, R., Offermanns, S., Teixeira, M. M., Moore, R. J., . . . Mackay, C. R. (2015). Metabolite-sensing receptors GPR43 and GPR109A facilitate dietary fibre-induced gut homeostasis through regulation of the inflammasome. Nature Communications, 6(1), 6734. Magne, F., Gotteland, M., Gauthier, L., Zazueta, A., Pesoa, S., Navarrete, P., & Balamurugan, R. (2020). The Firmicutes/Bacteroidetes Ratio: A relevant marker of gut dysbiosis in obese patients? Nutrients, 12(5), 1474. Mardis, E. R. (2008). Next-generation DNA sequencing methods. The Annual Review of Genomics and Human Genetics, 9, 387-402. Martin-Gallausiaux, C., Marinelli, L., Blottière, H. M., Larraufie, P., & Lapaque, N. (2021). SCFA: Mechanisms and functional importance in the gut. Proceedings of the Nutrition Society, 80(1), 37-49. Martínez, I., Kim, J., Duffy, P. R., Schlegel, V. L., & Walter, J. (2010). Resistant starches types 2 and 4 have differential effects on the composition of the fecal microbiota in human subjects. PloS one, 5(11), e15046. Maruta, H., Yoshimura, Y., Araki, A., Kimoto, M., Takahashi, Y., & Yamashita, H. (2016). Activation of AMP-activated protein kinase and stimulation of energy metabolism by acetic acid in L6 myotube cells. PloS one, 11(6), e0158055. Matra, M., Totakul, P., & Wanapat, M. (2021). Utilization of dragon fruit waste by-products and non-protein nitrogen source: Effects on in vitro rumen fermentation, nutrients degradability and methane production. Livestock Science, 243, 104386. McKenzie, C. I., Mackay, C. R., & Macia, L. (2015). GPR43 – A prototypic metabolite sensor linking metabolic and inflammatory diseases. Trends in Endocrinology & Metabolism, 26(10), 511-512. Mebius, R. E., & Kraal, G. (2005). Structure and function of the spleen. Nature Reviews Immunology, 5(8), 606-616. Mortensen, P. B., Holtug, K., & Rasmussen, H. S. (1988). Short-chain fatty acid production from mono-and disaccharides in a fecal incubation system: implications for colonic fermentation of dietary fiber in humans. The Journal of Nutrition, 118(3), 321-325. Muir, L. A., Neeley, C. K., Meyer, K. A., Baker, N. A., Brosius, A. M., Washabaugh, A. R., Varban, O. A., Finks, J. F., Zamarron, B. F., & Flesher, C. G. (2016). Adipose tissue fibrosis, hypertrophy, and hyperplasia: Correlations with diabetes in human obesity. Obesity, 24(3), 597-605. Nakamura, S., Kuda, T., Midorikawa, Y., Takamiya, D., Takahashi, H., & Kimura, B. (2021). Detection and isolation of β-conglycinin-susceptible gut indigenous bacteria from ICR mice fed high-sucrose diet. Food Bioscience, 41, 100994. Neboh, E. E., Emeh, J. K., Aniebue, U. U., Ikekpeazu, E. J., Maduka, I. C., & Ezeugwu, F. O. (2012). Relationship between lipid and lipoprotein metabolism in trimesters of pregnancy in Nigerian women: Is pregnancy a risk factor? Journal of Natural Science, Biology, and Medicine, 3(1), 32. Nirogi, R., Goyal, V. K., Jana, S., Pandey, S. K., & Gothi, A. (2014). What suits best for organ weight analysis: review of relationship between organ weight and body/brain weight for rodent toxicity studies. International Journal of Pharmaceutical Sciences and Research, 5(4), 1525-1532. Omidizadeh, A., Yusof, R. M., Roohinejad, S., Ismail, A., Abu Bakar, M. Z., & El-Din A. Bekhit, A. (2014). Anti-diabetic activity of red pitaya (Hylocereus polyrhizus) fruit. RSC Advances, 4(108), 62978-62986. Oppert, J. M., Bellicha, A., van Baak, M. A., Battista, F., Beaulieu, K., Blundell, J. E., Carraça, E. V., Encantado, J., Ermolao, A., Pramono, A., Farpour-Lambert, N., Woodward, E., Dicker, D., & Busetto, L. (2021). Exercise training in the management of overweight and obesity in adults: Synthesis of the evidence and recommendations from the European Association for the study of Obesity Physical Activity Working Group. Obesity Reviews, 22(S4), e13273. Pan, W. H., & Yeh, W. T. (2008). How to define obesity? Evidence-based multiple action points for public awareness, screening, and treatment: an extension of Asian-Pacific recommendations. Asia Pacific Journal of Clinical Nutrition, 17(3), 370. Panche, A. N., Diwan, A. D., & Chandra, S. R. (2016). Flavonoids: an overview. Journal of Nutritional Science, 5, e47. Pansai, N., Chakree, K., Takahashi Yupanqui, C., Raungrut, P., Yanyiam, N., & Wichienchot, S. (2020). Gut microbiota modulation and immune boosting properties of prebiotic dragon fruit oligosaccharides. International Journal of Food Science & Technology, 55(1), 55-64. Paśko, P., Galanty, A., Zagrodzki, P., Luksirikul, P., Barasch, D., Nemirovski, A., & Gorinstein, S. (2021). Dragon fruits as a reservoir of natural polyphenolics with chemopreventive properties. Molecules, 26(8), 2158. Paul, B., Lewinska, M., & Andersen, J. B. (2022). Lipid alterations in chronic liver disease and liver cancer. JHEP Reports, 4(6), 100479. Plöger, S., Stumpff, F., Penner, G. B., Schulzke, J. D., Gäbel, G., Martens, H., Shen, Z., Günzel, D., & Aschenbach, J. R. (2012). Microbial butyrate and its role for barrier function in the gastrointestinal tract. Annals of the New York Academy of Sciences, 1258(1), 52-59. Popkin, B. M., Du, S., Green, W. D., Beck, M. A., Algaith, T., Herbst, C. H., Alsukait, R. F., Alluhidan, M., Alazemi, N., & Shekar, M. (2020). Individuals with obesity and COVID-19: A global perspective on the epidemiology and biological relationships. Obesity Reviews, 21(11), e13128. Pouliot, M. C., Després, J. P., Lemieux, S., Moorjani, S., Bouchard, C., Tremblay, A., Nadeau, A., & Lupien, P. J. (1994). Waist circumference and abdominal sagittal diameter: Best simple anthropometric indexes of abdominal visceral adipose tissue accumulation and related cardiovascular risk in men and women. The American Journal of Cardiology, 73(7), 460-468. Psichas, A., Sleeth, M. L., Murphy, K. G., Brooks, L., Bewick, G. A., Hanyaloglu, A. C., Ghatei, M. A., Bloom, S. R., & Frost, G. (2015). The short chain fatty acid propionate stimulates GLP-1 and PYY secretion via free fatty acid receptor 2 in rodents. International Journal of Obesity, 39(3), 424-429. Qiao, Y., Zhang, Z., Zhai, Y., Yan, X., Zhou, W., Liu, H., Guan, L., & Peng, L. (2022). Apigenin alleviates obesity-associated metabolic syndrome by regulating the composition of the gut microbiome. Frontiers in Microbiology, 12, 3854. Qu, H. Q., Li, Q., Rentfro, A. R., Fisher-Hoch, S. P., & McCormick, J. B. (2011). The definition of insulin resistance using HOMA-IR for Americans of Mexican descent using machine learning. PloS one, 6(6), e21041. Quina, F. H., & Bastos, E. L. (2018). Chemistry inspired by the colors of fruits, flowers and wine. Anais da Academia Brasileira de Ciências, 90, 681-695. Rahman, M. S., Hossain, K. S., Das, S., Kundu, S., Adegoke, E. O., Rahman, M. A., Hannan, M. A., Uddin, M. J., & Pang, M. G. (2021). Role of insulin in health and disease: An update. International Journal of Molecular Sciences, 22(12), 6403. Ramli, N. S., Brown, L., Ismail, P., & Rahmat, A. (2014). Effects of red pitaya juice supplementation on cardiovascular and hepatic changes in high-carbohydrate, high-fat diet-induced metabolic syndrome rats. BMC Complementary and Alternative Medicine, 14(1), 189. Rana, A., Samtiya, M., Dhewa, T., Mishra, V., & Aluko, R. E. (2022). Health benefits of polyphenols: A concise review. Journal of Food Biochemistry, 46(10), e14264. Reichardt, N., Duncan, S. H., Young, P., Belenguer, A., McWilliam Leitch, C., Scott, K. P., Flint, H. J., & Louis, P. (2014). Phylogenetic distribution of three pathways for propionate production within the human gut microbiota. The ISME Journal, 8(6), 1323-1335. Ribeiro, A. C., Poli, P., & Uehara, S. C. d. S. A. (2023). Increased risk of mortality from COVID-19 in people with obesity. Rev Rene (Online), e81453-e81453. Rico, D., Diana, A. B. M., Milton-Laskibar, I., Fernández-Quintela, A., Silván, J. M., Rai, D. K., Choudhary, A., Peñas, E., de Luis, D. A., & Martínez-Villaluenga, C. (2018). Characterization and in vitro evaluation of seaweed species as potential functional ingredients to ameliorate metabolic syndrome. Journal of Functional Foods, 46, 185-194. Rocha, V. Z., & Libby, P. (2009). Obesity, inflammation, and atherosclerosis. Nature Reviews Cardiology, 6(6), 399-409. Rohin, M. A. K., Abu Bakar, C. A., & Ali, A. M. (2014). Isolation and characterization of oligosaccharides composition in organically grown red pitaya, white pitaya and papaya. International Journal of Pharmacy and Pharmaceutical Sciences, 6(S2), 131-136. Ruel, I. L., Gaudet, D., Perron, P., Bergeron, J., Julien, P., & Lamarche, B. (2003). Effect of obesity on HDL and LDL particle sizes in carriers of the null P207L or defective D9N mutation in the lipoprotein lipase gene: the Québec LipD Study. International Journal of Obesity, 27(5), 631-637. Sakakibara, S., Yamauchi, T., Oshima, Y., Tsukamoto, Y., & Kadowaki, T. (2006). Acetic acid activates hepatic AMPK and reduces hyperglycemia in diabetic KK-A(y) mice. Biochemical and Biophysical Research Communications, 344(2), 597-604. Sanders, F. W., & Griffin, J. L. (2016). De novo lipogenesis in the liver in health and disease: more than just a shunting yard for glucose. Biological Reviews, 91(2), 452-468. Scott, K. P., Gratz, S. W., Sheridan, P. O., Flint, H. J., & Duncan, S. H. (2013). The influence of diet on the gut microbiota. Pharmacological Research, 69(1), 52-60. Seishima, M. (2003). Guideline for hyperlipidemia. Rinsho byori. The Japanese journal of clinical pathology, 51(6), 576-580. Selen, E. S., Choi, J., & Wolfgang, M. J. (2021). Discordant hepatic fatty acid oxidation and triglyceride hydrolysis leads to liver disease. JCI Insight, 6(2), e135626. Serra, D., Mera, P., Malandrino, M. I., Mir, J. F., & Herrero, L. (2013). Mitochondrial fatty acid oxidation in obesity. Antioxid Redox Signal, 19(3), 269-284. Setiawan, N., Shintawati, R., & Priyandoko, D. (2018). The role of red dragon fruit peel (Hylocereus polyrhizus) to improvement blood lipid levels of hyperlipidaemia male mice. Journal of Physics: Conference Series, 1013(1), 012167. Silvester, K. R., Bingham, S. A., Pollock, J. R., Cummings, J. H., & O'Neill, I. K. (1997). Effect of meat and resistant starch on fecal excretion of apparent N‐nitroso compounds and ammonia from the human large bowel. Nutrition and Cancer,29(1),13-23. Slavin, J. L., Martini, M. C., Jacobs, D. R., Jr, & Marquart, L. (1999). Plausible mechanisms for the protectiveness of whole grains. The American Journal of Clinical Nutrition, 70(3), 459s-463s. Smythe, P., & Efthimiou, G. (2022). In silico genomic and metabolic atlas of Limosilactobacillus reuteri DSM 20016: An insight into human health. Microorganisms, 10(7), 1341. Song, H., Chu, Q., Xu, D., Xu, Y., & Zheng, X. (2016a). Purified betacyanins from Hylocereus undatus peel ameliorate obesity and insulin resistance in high-fat-diet-fed mice. Journal of Agricultural and Food Chemistry, 64(1), 236-244. Song, H., Chu, Q., Yan, F., Yang, Y., Han, W., & Zheng, X. (2016b). Red pitaya betacyanins protects from diet-induced obesity, liver steatosis and insulin resistance in association with modulation of gut microbiota in mice. Journal of Gastroenterology and Hepatology, 31(8), 1462-1469. Song, H., Zheng, Z., Wu, J., Lai, J., Chu, Q., & Zheng, X. (2016). White pitaya (Hylocereus undatus) juice attenuates insulin resistance and hepatic steatosis in diet-induced obese mice. PloS one, 11(2), e0149670. Song, W., Song, C., Li, L., Wang, T., Hu, J., Zhu, L., & Yue, T. (2021). Lactobacillus alleviated obesity induced by high‐fat diet in mice. Journal of Food Science, 86(12), 5439-5451. Spor, A., Koren, O., & Ley, R. (2011). Unravelling the effects of the environment and host genotype on the gut microbiome. Nature Reviews Microbiology, 9(4), 279-290. Stecher, B., & Hardt, W. D. (2008). The role of microbiota in infectious disease. Trends in Microbiology, 16(3), 107-114. Surampudi, P., Enkhmaa, B., Anuurad, E., & Berglund, L. (2016). Lipid lowering with soluble dietary fiber. Current Atherosclerosis Reports, 18(12), 75. Sze, M. A., & Schloss, P. D. (2016). Looking for a signal in the noise: revisiting obesity and the microbiome. mBio, 7(4), e01018-01016. Talley, J. T., & Mohiuddin, S. S. (2022). Biochemistry, fatty acid oxidation. In StatPearls [Internet]. StatPearls Publishing. Taylor Jr, H. A., Coady, S. A., Levy, D., Walker, E. R., Vasan, R. S., Liu, J., Akylbekova, E. L., Garrison, R. J., & Fox, C. (2010). Relationships of BMI to cardiovascular risk factors differ by ethnicity. Obesity, 18(8), 1638-1645. Tian, L., Cao, W., Yue, R., Yuan, Y., Guo, X., Qin, D., Xing, J., & Wang, X. (2019). Pretreatment with Tilianin improves mitochondrial energy metabolism and oxidative stress in rats with myocardial ischemia/reperfusion injury via AMPK/SIRT1/PGC-1 alpha signaling pathway. Journal of Pharmacological Sciences, 139(4), 352-360. Timoneda, A., Feng, T., Sheehan, H., Walker‐Hale, N., Pucker, B., Lopez‐Nieves, S., Guo, R., & Brockington, S. (2019). The evolution of betalain biosynthesis in Caryophyllales. New Phytologist, 224(1), 71-85. Tseng, C. H., Chen, C. J., & Landolph, J. R. (2012). Diabetes and cancer: epidemiological, clinical, and experimental perspectives. Journal of Diabetes Research, 2012. Turnbaugh, P. J., Ridaura, V. K., Faith, J. J., Rey, F. E., Knight, R., & Gordon, J. I. (2009). The effect of diet on the human gut microbiome: A metagenomic analysis in humanized gnotobiotic mice. Science Translational Medicine, 1(6), 6ra14-6ra14. Tze, N. L., Han, C. P., Yusof, Y. A., Ling, C. N., Talib, R. A., Taip, F. S., & Aziz, M. G. (2012). Physicochemical and nutritional properties of spray-dried pitaya fruit powder as natural colorant. Food Science and Biotechnology, 21(3), 675-682. Wang, Z. Q., Yu, Y., Zhang, X. H., Floyd, Z. E., Boudreau, A., Lian, K., & Cefalu, W. T. (2012). Comparing the effects of nano-sized sugarcane fiber with cellulose and psyllium on hepatic cellular signaling in mice. International Journal of Nanomedicine, 2999-3012. Whittaker, R. H. (1972). Evolution and measurement of species diversity. Taxon, 21(2-3), 213-251. Wolska, A., & Remaley, A. T. (2021). Chapter 9 - Lipoproteins. In W. E. Winter, B. Holmquist, L. J. Sokoll, & R. L. Bertholf (Eds.), Handbook of diagnostic endocrinology (Third Edition) (pp. 287-308). Academic Press. Wright, S. M., & Aronne, L. J. (2012). Causes of obesity. Abdominal Radiology, 37(5), 730-732. Wu, W., Sun, M., Chen, F., Cao, A. T., Liu, H., Zhao, Y., Huang, X., Xiao, Y., Yao, S., Zhao, Q., Liu, Z., & Cong, Y. (2017). Microbiota metabolite short-chain fatty acid acetate promotes intestinal IgA response to microbiota which is mediated by GPR43. Mucosal Immunology, 10(4), 946-956. Wybraniec, S., & Mizrahi, Y. (2002). Fruit flesh betacyanin pigments in Hylocereus cacti. Journal of Agricultural and Food Chemistry, 50(21), 6086-6089. Xiong, Y., Miyamoto, N., Shibata, K., Valasek, M. A., Motoike, T., Kedzierski, R. M., & Yanagisawa, M. (2004). Short-chain fatty acids stimulate leptin production in adipocytes through the G protein-coupled receptor GPR41. Proceedings of the National Academy of Sciences, 101(4), 1045-1050. Xu, Y., Wang, N., Tan, H. Y., Li, S., Zhang, C., & Feng, Y. (2020). Function of Akkermansia muciniphila in obesity: Interactions with lipid metabolism, immune response and gut systems. Frontiers in Microbiology, 11, 219. Yamashita, H., Kaneyuki, T., & Tagawa, K. (2001). Production of acetate in the liver and its utilization in peripheral tissues. Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 1532(1), 79-87. Yin, R., Kuo, H. C., Hudlikar, R., Sargsyan, D., Li, S., Wang, L., Wu, R., & Kong, A. N. (2019). Gut microbiota, dietary phytochemicals and benefits to human health. Current Pharmacology Reports, 5, 332-344. Zhang, X., Li, X., Fang, H., Guo, F., Li, F., Chen, A., & Huang, S. (2019). Flavonoids as inducers of white adipose tissue browning and thermogenesis: signalling pathways and molecular triggers. Nutrition & Metabolism, 16(1), 47. Zhang, Y. J., Li, S., Gan, R. Y., Zhou, T., Xu, D. P., & Li, H. B. (2015). Impacts of gut bacteria on human health and diseases. International Journal of Molecular Sciences, 16(4), 7493-7519. | - |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/90552 | - |
dc.description.abstract | 截至2020年,台灣的成年人中有 39.3% 男性與 30.3% 女性為代謝症候群患者,由此可見代謝症候群為我國重要的公共衛生議題,而肥胖是顯著與其關連性極強的影響因子,因此預防肥胖為國人重要面臨的問題。紅龍果 (Dragon fruit, DF) 為台灣大量種植的水果之一,近年來由於農民大量栽種,導致其盛產而價格下跌,因此增加其利用管道以提升其產值為有潛力開發之途徑。過往研究說明紅龍果具有預防肥胖相關疾病之潛力,然而其以紅龍果皮、果肉或用有機溶劑萃取有效成分造成環境汙染及副產物浪費問題。本研究開發一種低浪費的加工方式,將整顆紅龍果分成不同部分,將紅肉紅龍果整顆進行均質並過濾,其中無法過濾的物質為果渣 PO (Pomace of red dragon fruit),過濾出的液體進行離心,取上清液 RS (Supernatant of red dragon fruit juice) 及沉澱物 RP (Precipitate of red dragon fruit juice),此外也取白肉紅龍果之上清液 WS (Supernatant of white dragon fruit juice) 作為 RS 之對照。液體經過冷凍乾燥後,以絕對乾燥重量4:6比例加入玉米澱粉作為賦形劑。樣品進行成分分析並投入高脂飲食誘導之 60 隻C57BL/6雄性小鼠中,進行為期 20 週試驗,評估紅龍果萃取物是否具有減緩肥胖與代謝失調之功效。樣品分析結果顯示,紅龍果萃取物含有酚類物質、類黃酮、甜菜素及膳食纖維。在動物實驗結果中,肥胖相關表徵方面顯示,四組樣品介入組在不影響攝食量與每日總熱量攝取之下,皆顯著減少小鼠的白色脂肪重量與體脂率並改善血脂表現,其中,RP 顯著降低高脂飲食造成的體重上升,減少肝臟及脾臟重量與肝損傷指標 AST 及 ALT。肝臟脂質代謝方面,四組樣品皆降低肝臟中的脂質蓄積及促炎性細胞因子 TNF-α、IL-6、IL-17,而RP顯著增加脂質代謝相關蛋白質 SIRT1、pAMPK及pACC,並有提高PGC-1α 及 CPT1A 表現的趨勢,以減少肝臟脂肪生合成並提高脂肪酸β氧化。血糖平衡方面,RP 顯著降低 OGTT 曲線下面積,而其與 RS 同時有降低空腹血糖、血清胰島素與 HOMA-IR 趨勢。腸道菌相及短鏈脂肪酸方面,四組樣品皆重改變了小鼠的腸道菌相組成,其中,RP、PO 及 WS 提高與預防肥胖或短鏈脂肪酸生成相關的 Lactobacilus johnsonii 及 Limosilactobacillus reuteri,且顯著提高小鼠盲腸中的乙酸鹽含量,此外,RP 顯著減少了與肥胖正相關的 Erysipelotrichia、Erysipelotrichales、Faecalibaculum 及 Faecalibaculum rodentium,且與 RS 皆提高與肥胖具負相關或短鏈脂肪酸的產生菌 Dubosiella 及 Dubosiella newyorkensis。PO 及 WS 組中則發現能代謝生成短鏈脂肪酸之Akkermansia muciniphila。綜上所述,四組樣品透過樣品中醣類、膳食纖維、甜菜紅、甜菜黃、酚類物質與類黃酮等有效成分共同作用,調控小鼠的脂質代謝、血糖穩態、腸道菌相組成與短鏈脂肪酸,而對調控代謝紊亂有一定程度的正面效果。其中,RP 對預防代謝症候群與肥胖具有最顯著的功效,而其主要生物活性成分可能為水溶性膳食纖維,因此具有最佳開發成預防代謝症候群之功能性食品之潛力。 | zh_TW |
dc.description.abstract | Until 2020, 39.3% of male and 30.3% of female Taiwanese adults were diagnosed with metabolic syndrome, highlighting it as a significant public health issue in our country. Obesity is a major contributing factor strongly associated with metabolic syndrome, making obesity prevention a crucial concern for the population. Dragon fruit (Bradford), one of the extensively cultivated fruits in Taiwan, has the potential to be developed further to increase its value due to the abundance resulting from large-scale farming, which has caused a decline in prices. Previous studies have suggested the potential of dragon fruit to prevent obesity-related diseases. However, extracting effective components from dragon fruit peel and pulp and using organic solvents have raised concerns about environmental pollution and byproduct waste. In this study, a low-waste processing method was developed to divide the whole fructification of DF into different sections. The red flesh of dragon fruit was homogenized and filtered, yielding the pomace of red dragon fruit (PO) as the residual material. The filtered liquid was centrifuged to obtain the supernatant of red DF juice (RS) and red DF juice (RP) precipitate. Additionally, the white DF juice (WS) supernatant was used as a control for RS. The liquid materials would be mixed with corn starch as an excipient in a 4:6 ratio before lyophilizing, and the active ingredient was subsequently analyzed to evaluate the potential of dragon fruit extracts in preventing obesity and metabolic disorders. Sixty male C57BL/6 mice were fed a high-fat diet with or without DF supplements for 20 weeks. The results demonstrated that the extracts contained bioactive constituents such as phenolics, flavonoids, betalains, and dietary fiber. In the animal experiments, four test groups significantly reduced white adipose tissue weight and body fat percentage and improved lipid profiles in mice without affecting food intake and daily calorie consumption. Specifically, RP significantly reduced body weight gain caused by a high-fat diet, decreased liver and spleen weights, and liver damage indicators, such as AST and ALT. In terms of liver lipid metabolism, all four supplementations reduced lipid accumulation in the liver and pro-inflammatory cytokines, TNF-α, IL-6, and IL-17. RP increased the expression of lipid metabolism-related proteins, such as SIRT1, pAMPK, and pACC. Also, PGC-1α and CPT1A of the liver in RP were slightly lower than those in HFD group, reducing liver fat synthesis and enhancing fatty acid β-oxidation. Regarding blood glucose balance, RP significantly decreased the area under the oral glucose tolerance test (OGTT) curve. Furthermore, RP and RS showed a decreasing trend in fasting blood glucose, serum insulin, and HOMA-IR. In terms of gut microbiota and short-chain fatty acids (SCFAs), all four sample groups modified the gut microbiota composition in mice. RP, PO, and WS increased the abundance of Lactobacillus johnsonii and Limosilactobacillus reuteri associated with obesity prevention and SCFA production. Moreover, RP significantly reduced obesity-associated bacteria, such as Erysipelotrichia, Erysipelotrichales, Faecalibaculum, and Faecalibaculum rodentium, while increased Dubosiella and Dubosiella newyorkensis, which are negatively correlated with obesity or involved in SCFA production, similar to RS. PO and WS groups revealed the presence of Akkermansia muciniphila, a bacteria capable of metabolizing and producing SCFAs. In conclusion, the four DF groups exerted positive effects on lipid metabolism, blood glucose homeostasis, gut microbiota composition, and SCFAs through the combined action of carbohydrates, dietary fiber, betacyanins, betaxanthins, phenolic compounds, and flavonoids present in the samples. Mainly, RP exhibited the most significant efficacy in preventing metabolic syndrome and obesity, possibly due to its soluble dietary fiber content. It is a promising candidate for developing functional foods targeting metabolic syndrome prevention. | en |
dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2023-10-03T16:36:02Z No. of bitstreams: 0 | en |
dc.description.provenance | Made available in DSpace on 2023-10-03T16:36:02Z (GMT). No. of bitstreams: 0 | en |
dc.description.tableofcontents | 中文摘要 II
Abstract IV 附圖目錄 X 附表目錄 XI 圖目錄 XII 表目錄 XIII 縮寫表 XIV 第一章、 文獻回顧 1 第一節、 代謝症候群 (Metabolic syndrome, MS) 1 第二節、 肥胖 (Obesity) 2 (一)、 定義 2 (二)、 成因及危害 3 (三)、 治療及預防 3 第三節、 肥胖與脂質代謝 5 (一)、 血液中的脂質代謝 5 (二)、 AMPK 及 SIRT1 共同調節肝臟脂質代謝 6 (三)、 肥胖對脂質代謝的影響 8 第四節、 肥胖與血糖調控 8 (一)、 胰島素的功能及作用機制 8 (二)、 肥胖與發炎反應及胰島素阻抗間的關係 9 第五節、 肥胖與腸道菌相 10 (一)、 腸道菌相與肥胖 10 (二)、 短鏈脂肪酸對肥胖的影響 10 第六節、 紅龍果 (Dragon fruit) 12 (一)、 紅龍果簡介 12 (二)、 台灣紅龍果面臨之問題 13 (三)、 紅龍果對肥胖之相關功效研究 15 第七節、 以紅龍果開發預防肥胖產品之潛力 16 第二章、 研究目的與實驗架構 17 第一節、 研究目的 17 第二節、 實驗架構 18 第三章、 材料與方法 20 第一節、 實驗材料 20 (一)、 樣品來源及製備 20 (二)、 儀器設備 21 (三)、 耗材及藥品試劑 22 (四)、 分析套組 23 (五)、 抗體 23 第二節、 樣品分析方法 24 (一)、 營養組成分析 24 (二)、 生物活性成分分析 26 第三節、 動物實驗 (in vivo) 方法 27 (一)、 動物品系與飼養環境 27 (二)、 動物實驗組別設計 28 (三)、 飼料配製 29 (四)、 口服葡萄糖耐受性試驗 (Oral Glucose Tolerance Test, OGTT) 30 (五)、 動物犧牲 30 (六)、 血液生化數值分析 (Serum biochemistry) 31 (七)、 組織切片染色 (H&E staining) 31 (八)、 肝臟三酸甘油酯 (Triglyceride, TG) 含量測定 34 (九)、 肝臟總膽固醇 (Total cholesterol, TC) 測定 35 (十)、 組織均質及蛋白質萃取 36 (十一)、 蛋白質定量 37 (十二)、 西方墨點法 (Western blotting) 38 (十三)、 細胞激素 (Cytokines) 測定 41 (十四)、 血清胰島素 (Insulin) 含量測定 43 (十五)、 微生物體全長 16S 擴增子定序分析 (Full-Length 16S Amplicon Sequencing) 44 (十六)、 短鏈脂肪酸 (Short-chain fatty acid, SCFA) 含量分析 45 第四節、 統計分析 46 第四章、 結果與討論 47 第一節、 樣品成分分析 47 (一)、 營養組成分析 47 (二)、 生物活性成分分析 48 第二節、 動物實驗 49 (一)、 紅龍果萃取物對餵食高脂飲食 C57BL/6 小鼠體重及外觀變化 49 (二)、 紅龍果萃取物對餵食高脂飲食 C57BL/6 小鼠攝食量之影響 50 (三)、 紅龍果萃取物對餵食高脂飲食 C57BL/6 小鼠血液生化值表現 51 (四)、 紅龍果萃取物對餵食高脂飲食 C57BL/6 小鼠臟器外觀及重量之影響 52 (五)、 紅龍果萃取物對餵食高脂飲食 C57BL/6 小鼠脂肪組織影響 54 (六)、 紅龍果萃取物對餵食高脂飲食 C57BL/6 小鼠肝臟脂質蓄積之影響 55 (七)、 紅龍果萃取物對餵食高脂飲食 C57BL/6 小鼠肝臟脂質代謝之蛋白質表現 57 (八)、 紅龍果萃取物對餵食高脂飲食 C57BL/6 小鼠發炎影響 58 (九)、 紅龍果萃取物對餵食高脂飲食 C57BL/6 小鼠葡萄糖耐量影響 58 (十)、 紅龍果萃取物對餵食高脂飲食 C57BL/6 小鼠空腹血糖及胰島素影響 59 (十一)、 紅龍果萃取物對餵食高脂飲食 C57BL/6 小鼠腸道菌相α多樣性 (Alpha diversity) 影響 60 (十二)、 紅龍果萃取物對餵食高脂飲食 C57BL/6 小鼠腸道菌相β多樣性 (Beta diversity) 影響 61 (十三)、 紅龍果萃取物對餵食高脂飲食 C57BL/6 小鼠腸道菌相組成影響 62 (十四)、 紅龍果萃取物對餵食高脂飲食 C57BL/6 小鼠腸道菌相組間差異物種影響 63 (十五)、 紅龍果萃取物對餵食高脂飲食 C57BL/6 小鼠糞便短鏈脂肪酸影響 64 第五章、 結論 67 第六章、 圖表 69 第七章、 附錄 106 | - |
dc.language.iso | zh_TW | - |
dc.title | 探討紅龍果全果實萃取物預防高脂飲食誘導小鼠代謝症候群之功效 | zh_TW |
dc.title | Exploring the effects of whole food-based dragon fruit extracts on metabolic disorders in high-fat diet-induced mice | en |
dc.type | Thesis | - |
dc.date.schoolyear | 111-2 | - |
dc.description.degree | 碩士 | - |
dc.contributor.oralexamcommittee | 何元順;郭靜娟;張嘉哲;黃步敏 | zh_TW |
dc.contributor.oralexamcommittee | Yuan-Soon Ho;Ching-Chuan Kuo;Chia-Che Chang;Bu-Miin Huang | en |
dc.subject.keyword | 代謝症候群,肥胖,紅龍果,脂質代謝,腸道菌相,水溶性膳食纖維, | zh_TW |
dc.subject.keyword | Metabolic syndrome,Obesity,Dragon fruit,Lipid metabolism,Gut microbiota,Soluble dietary fiber, | en |
dc.relation.page | 109 | - |
dc.identifier.doi | 10.6342/NTU202302725 | - |
dc.rights.note | 同意授權(限校園內公開) | - |
dc.date.accepted | 2023-08-07 | - |
dc.contributor.author-college | 生物資源暨農學院 | - |
dc.contributor.author-dept | 食品科技研究所 | - |
顯示於系所單位: | 食品科技研究所 |
文件中的檔案:
檔案 | 大小 | 格式 | |
---|---|---|---|
ntu-111-2.pdf 目前未授權公開取用 | 6.76 MB | Adobe PDF | 檢視/開啟 |
系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。