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標題: | 以化學拔除法製備微液珠陣列平台 Microdroplet Array Fabrication via Chemical Lift-Off Lithography |
作者: | Hsiao-Yuan Chu 朱孝媛 |
指導教授: | 廖尉斯(Wei-Ssu Liao) |
關鍵字: | 化學拔除法,微液珠陣列,自組裝單分子層, chemical lift-off lithography,microdroplet arrays,self-assembled monolayers, |
出版年 : | 2017 |
學位: | 碩士 |
摘要: | 微液珠陣列是一具有可大面積製作高密度多功能性平台的技術,此平台上之數千滴獨立微小型液珠可被使用於多樣的應用,例如:快速藥物篩選、微型反應器與生物檢測。由於微液珠的形成藉由表面之潤濕性質決定,而自組裝單分子層之圖案化是一項利用自組裝分子之末端官能基來有效控制表面性質之技術,因此本篇論文以化學拔除法製作出具備自組裝單分子層圖案的平台,利用活化的聚二甲基矽氧烷印章選擇性地將修飾於金上的羥基硫醇分子移除,並於此化學拔除區域回填入與羥基硫醇分子性質相異之硫醇分子,以形成高解析度之自組裝單分子層圖案。將化學拔除法與不連續去濕技術結合,我們可成功設計出一具有高輸出、高效率且低成本的多功能性微液珠陣列平台。本項研究中除藉由改變聚二甲基矽氧印章圖案的尺寸、大小、形狀來有效控制自組裝單分子層從毫米至微米或奈米等級的分布情形,也可將自組裝單分子層圖案化平台拓展應用於控制具高或低表面張力之液體如水溶液或乙醇,並能藉由自組裝分子的選擇來增加圖案化平台的多樣性,同時準確地調控表面分子環境以形成良好之微液珠陣列。 Microdroplet arrays are attractive platforms due to their wide applications, such as high-throughput screening, microreactor, and biological sensing. The formation of microdroplet is governed by surface wettability, which is controlled by surface chemical properties and molecular environments. Self-assembled monolayer (SAM) patterning is a useful approach to modulate surface morphology through their terminal functional groups. Herein, a facile and simple strategy to manufacture microdroplet arrays via chemical lift-off lithography (CLL) is demonstrated. In CLL, hydroxyl-terminated SAMs on the gold substrate can be selectively lifted off by activated polydimethylsiloxane (PDMS) stamps. The remaining hydroxyl terminated alkanethiols and post-lift off region backfilled hydrophobic molecules provide distinguishable hydrophobicity areas to assist liquids in dewetting process for microdroplets formation. With the change of PDMS stamp size and shape, an effective and simple approach to control self-assembled monolayer patterning is achieved. This platform is suitable for confining not only aqueous but also low surface-tension liquid droplets. This strategy enables convenient and precise control of surface molecular environments to create microdroplets for applications such as biosensing, drug screening, and clinical diagnosis. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/77935 |
DOI: | 10.6342/NTU201702590 |
全文授權: | 有償授權 |
顯示於系所單位: | 化學系 |
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ntu-106-R04223102-1.pdf 目前未授權公開取用 | 3.52 MB | Adobe PDF |
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