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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
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dc.contributor.advisor | 廖尉斯(Wei-Ssu Liao) | |
dc.contributor.author | Hsiao-Yuan Chu | en |
dc.contributor.author | 朱孝媛 | zh_TW |
dc.date.accessioned | 2021-07-11T14:37:46Z | - |
dc.date.available | 2022-08-30 | |
dc.date.copyright | 2017-08-30 | |
dc.date.issued | 2017 | |
dc.date.submitted | 2017-08-04 | |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/77935 | - |
dc.description.abstract | 微液珠陣列是一具有可大面積製作高密度多功能性平台的技術,此平台上之數千滴獨立微小型液珠可被使用於多樣的應用,例如:快速藥物篩選、微型反應器與生物檢測。由於微液珠的形成藉由表面之潤濕性質決定,而自組裝單分子層之圖案化是一項利用自組裝分子之末端官能基來有效控制表面性質之技術,因此本篇論文以化學拔除法製作出具備自組裝單分子層圖案的平台,利用活化的聚二甲基矽氧烷印章選擇性地將修飾於金上的羥基硫醇分子移除,並於此化學拔除區域回填入與羥基硫醇分子性質相異之硫醇分子,以形成高解析度之自組裝單分子層圖案。將化學拔除法與不連續去濕技術結合,我們可成功設計出一具有高輸出、高效率且低成本的多功能性微液珠陣列平台。本項研究中除藉由改變聚二甲基矽氧印章圖案的尺寸、大小、形狀來有效控制自組裝單分子層從毫米至微米或奈米等級的分布情形,也可將自組裝單分子層圖案化平台拓展應用於控制具高或低表面張力之液體如水溶液或乙醇,並能藉由自組裝分子的選擇來增加圖案化平台的多樣性,同時準確地調控表面分子環境以形成良好之微液珠陣列。 | zh_TW |
dc.description.abstract | Microdroplet arrays are attractive platforms due to their wide applications, such as high-throughput screening, microreactor, and biological sensing. The formation of microdroplet is governed by surface wettability, which is controlled by surface chemical properties and molecular environments. Self-assembled monolayer (SAM) patterning is a useful approach to modulate surface morphology through their terminal functional groups. Herein, a facile and simple strategy to manufacture microdroplet arrays via chemical lift-off lithography (CLL) is demonstrated. In CLL, hydroxyl-terminated SAMs on the gold substrate can be selectively lifted off by activated polydimethylsiloxane (PDMS) stamps. The remaining hydroxyl terminated alkanethiols and post-lift off region backfilled hydrophobic molecules provide distinguishable hydrophobicity areas to assist liquids in dewetting process for microdroplets formation. With the change of PDMS stamp size and shape, an effective and simple approach to control self-assembled monolayer patterning is achieved. This platform is suitable for confining not only aqueous but also low surface-tension liquid droplets. This strategy enables convenient and precise control of surface molecular environments to create microdroplets for applications such as biosensing, drug screening, and clinical diagnosis. | en |
dc.description.provenance | Made available in DSpace on 2021-07-11T14:37:46Z (GMT). No. of bitstreams: 1 ntu-106-R04223102-1.pdf: 3609507 bytes, checksum: cd4f90e9128b899926975b9cdd19c108 (MD5) Previous issue date: 2017 | en |
dc.description.tableofcontents | 誌謝 i
摘要 ii Abstract iii 目錄 iv 圖目錄 vii 表目錄 x 第一章 緒論 1 1.1 微液珠陣列平台簡介 1 1.1.1 疏水-親水圖案化製作方法 1 1.1.2 微液珠陣列之應用 3 1.2 自組裝單分子層 4 1.2.1 矽烷單分子層 4 1.2.2 脂肪酸單分子層 5 1.2.3 有機硫單分子層 6 1.3 單分子層圖形化之技術 7 1.3.1 光微影技術 8 1.3.2 電子束微影技術 11 1.3.3 浸筆奈米微影技術 13 1.3.4 軟微影技術 15 1.3.5 化學拔除法 18 1.4 化學拔除法 19 1.5 接觸角 22 1.5.1 接觸角定義 22 1.5.2 接觸角量測方法 23 1.6 不連續去濕技術 24 第二章 實驗方法與步驟 26 2.1 實驗藥品 26 2.2 實驗材料 27 2.3 實驗儀器 27 2.4 實驗步驟 29 2.4.1 模具之製作 29 2.4.2 模具翻製 35 2.4.3 金基材之製備 35 2.4.4 微液珠陣列平台之設計 36 2.4.5 微液珠陣列平台之表面結構鑑定 39 2.4.6 探討不同溶液對微液珠生成之影響 41 第三章 結果與討論 42 3.1 水接觸角(WCA)數值θ之探討 43 3.1.1 修飾不同硫醇自組裝單分子層的金對WCA之影響 43 3.1.2 PDMS印章接觸時間(stamp seal time)對於WCA之影響 44 3.1.3 浸泡PFDT溶液時間(PFDT treatment time)對於WCA之影響 46 3.1.4 探討不同碳鏈數目之羥基硫醇分子對WCA之影響 49 3.2 XPS鑑定表面結構 51 3.3 原子力顯微鏡鑑定表面結構 53 3.4 微液珠陣列 54 第四章 結論 58 第五章 參考文獻 59 | |
dc.language.iso | zh-TW | |
dc.title | 以化學拔除法製備微液珠陣列平台 | zh_TW |
dc.title | Microdroplet Array Fabrication via Chemical Lift-Off Lithography | en |
dc.type | Thesis | |
dc.date.schoolyear | 105-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 呂家榮(Chia-Jung Lu),李介仁(Jie-Ren Li),王宗興(Tsung-Shing Wang),陳浩銘(Hao Ming Chen) | |
dc.subject.keyword | 化學拔除法,微液珠陣列,自組裝單分子層, | zh_TW |
dc.subject.keyword | chemical lift-off lithography,microdroplet arrays,self-assembled monolayers, | en |
dc.relation.page | 68 | |
dc.identifier.doi | 10.6342/NTU201702590 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2017-08-04 | |
dc.contributor.author-college | 理學院 | zh_TW |
dc.contributor.author-dept | 化學研究所 | zh_TW |
顯示於系所單位: | 化學系 |
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