以空間暨頻譜解析漫反射光譜學技術定量中央靜脈血氧飽和濃度：模擬及仿體實驗研究

Abstract

此研究致力於以非侵入性的方法由內頸靜脈（Internal Jugular Vein, IJV）定量中央靜脈血氧飽和濃度（Central Venous Oxygen Saturation, ScvO2）。我們以近紅外光譜學（Near-infrared Spectroscopy, NIRS）以及擴散式光學斷層掃描（Diffuse Optical Tomography, DOT）的理論為基礎建立此一方法。在研究的初期，我開發一項結合蒙地卡羅方法（Monte Carlo Method）與「MATLAB Optimization Toolbox」的模擬工具，用以探討「定量ScvO2」此一問題‧與團隊夥伴王巧懿一同訂定偵測架構後，我們以墨水和血液仿體實驗欲驗證此一偵測架構之可行性。仿體實驗結果顯示，此一架構具有偵測ScvO2變化量的能力。在模擬實驗結果則展現，此一方法能夠在我們設計之使用情境下以可以接受的誤差範圍內定量出ScvO2。

In this work, we are aiming to quantify central venous oxygen saturation (ScvO2) at the site of internal jugular vein (IJV). A noninvasive method based on Near-infrared Spectroscopy and the concept of Diffuse Optical Tomography have been formed. A briefly investigation on quantifying ScvO2 had been done by a self-developed simulation tool based on Monte Carlo method and MATLAB optimization toolbox. Afterwards, its feasibility were validated by ink- and blood-based phantom experiments. It is also the first time an overall optical study on tissue at IJV surroundings. Experimental result shows that it is possible to quantify ScvO2 by this proposed scheme. On the other hands, simulation tool is verified its robustness on this problem. Moreover, it had been proved that this tool is able to quantify ScvO2 within an acceptable error under the certain scenarios.