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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/77832完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 宋孔彬(Kung-Bin Sung) | |
| dc.contributor.author | Ting-Wen Yu | en |
| dc.contributor.author | 俞婷文 | zh_TW |
| dc.date.accessioned | 2021-07-11T14:35:40Z | - |
| dc.date.available | 2022-08-21 | |
| dc.date.copyright | 2017-08-31 | |
| dc.date.issued | 2017 | |
| dc.date.submitted | 2017-08-21 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/77832 | - |
| dc.description.abstract | 此研究致力於以非侵入性的方法由內頸靜脈（Internal Jugular Vein, IJV）定量中央靜脈血氧飽和濃度（Central Venous Oxygen Saturation, ScvO2）。我們以近紅外光譜學（Near-infrared Spectroscopy, NIRS）以及擴散式光學斷層掃描（Diffuse Optical Tomography, DOT）的理論為基礎建立此一方法。在研究的初期，我開發一項結合蒙地卡羅方法（Monte Carlo Method）與「MATLAB Optimization Toolbox」的模擬工具，用以探討「定量ScvO2」此一問題‧與團隊夥伴王巧懿一同訂定偵測架構後，我們以墨水和血液仿體實驗欲驗證此一偵測架構之可行性。仿體實驗結果顯示，此一架構具有偵測ScvO2變化量的能力。在模擬實驗結果則展現，此一方法能夠在我們設計之使用情境下以可以接受的誤差範圍內定量出ScvO2。 | zh_TW |
| dc.description.abstract | In this work, we are aiming to quantify central venous oxygen saturation (ScvO2) at the site of internal jugular vein (IJV). A noninvasive method based on Near-infrared Spectroscopy and the concept of Diffuse Optical Tomography have been formed. A briefly investigation on quantifying ScvO2 had been done by a self-developed simulation tool based on Monte Carlo method and MATLAB optimization toolbox. Afterwards, its feasibility were validated by ink- and blood-based phantom experiments. It is also the first time an overall optical study on tissue at IJV surroundings. Experimental result shows that it is possible to quantify ScvO2 by this proposed scheme. On the other hands, simulation tool is verified its robustness on this problem. Moreover, it had been proved that this tool is able to quantify ScvO2 within an acceptable error under the certain scenarios. | en |
| dc.description.provenance | Made available in DSpace on 2021-07-11T14:35:40Z (GMT). No. of bitstreams: 1 ntu-106-R04945034-1.pdf: 1919596 bytes, checksum: 7cfe85a3ba9893f8e83c25ca7aa6a3be (MD5) Previous issue date: 2017 | en |
| dc.description.tableofcontents | 誌謝 i
中文摘要 ii ABSTRACT iii CONTENTS iv LIST OF FIGURES vii LIST OF TABLES ix Chapter 1 Introduction 1 1.1 Background 1 1.2 Motivation 2 1.3 Challenge 2 1.4 Objective 2 1.5 Thesis Organization 3 Chapter 2 Preliminary 4 2.1 Near-infrared Spectroscopy 4 2.2 Diffuse Optical Tomography/ Topography 4 2.3 Monte Carlo Modeling of Light Transport in Tissue 4 Chapter 3 Overall Methodology 5 Chapter 4 Forward Problem 7 4.1 Forward Problem Formulation 7 4.1.1 Range of Operating Wavelength 7 4.1.2 Definition of Model Parameters 8 4.1.3 Standard Parameter Set 14 4.2 Forward Model 18 4.3 Result 19 4.3.1 Verification 19 4.3.2 Relation of ScvO2 to Diffuse Reflectance 20 4.4 Conclusion 25 Chapter 5 Experimental Verification 26 5.1 System 26 5.2 Phantom Design 27 5.2.1 Ink-based Phantom 27 5.2.2 Blood-based Phantom 31 5.3 Result 32 5.3.1 Comparison of Simulated and Experimental Results 32 5.4 Conclusion 39 Chapter 6 Inverse Problem 40 6.1 Inverse Problem Formulation 40 6.2 Inverse Method 41 6.2.1 Algorithm 41 6.2.2 Inverse Method Evaluation 43 6.3 Structural Parameters Quantification 43 6.3.1 Accuracy with Standard Parameter Set 44 6.3.2 Impact of Inaccurate Priors 46 6.4 ScvO2 Quantification 48 6.4.1 Impact of Inaccurate Priors 48 6.5 Demonstration 53 6.6 Conclusion 54 Chapter 7 Conclusion and Future Work 55 REFERENCE 56 | |
| dc.language.iso | en | |
| dc.subject | 中央靜脈血氧飽和濃度 | zh_TW |
| dc.subject | 內頸靜脈 | zh_TW |
| dc.subject | 近紅外光譜學 | zh_TW |
| dc.subject | 漫反射光譜學 | zh_TW |
| dc.subject | 擴散式光學斷層掃描 | zh_TW |
| dc.subject | Diffuse Reflectance Spectroscopy | en |
| dc.subject | Diffuse Optical Tomography | en |
| dc.subject | Internal Jugular Vein | en |
| dc.subject | Central Venous Oxygen Saturation | en |
| dc.subject | Near-infrared Spectroscopy | en |
| dc.title | 以空間暨頻譜解析漫反射光譜學技術定量中央靜脈血氧飽和濃度：模擬及仿體實驗研究 | zh_TW |
| dc.title | Quantifying Central Venous Oxygen Saturation by Spatially- and Spectrally- Resolved Diffuse Reflectance Spectroscopy:A Simulation and Phantom Experiment Study | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 105-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 江惠華(Hui-Hua Jiang),許富舜(Fu-Shun Hsu) | |
| dc.subject.keyword | 擴散式光學斷層掃描,漫反射光譜學,近紅外光譜學,中央靜脈血氧飽和濃度,內頸靜脈, | zh_TW |
| dc.subject.keyword | Diffuse Optical Tomography,Diffuse Reflectance Spectroscopy,Near-infrared Spectroscopy,Central Venous Oxygen Saturation,Internal Jugular Vein, | en |
| dc.relation.page | 59 | |
| dc.identifier.doi | 10.6342/NTU201704092 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2017-08-21 | |
| dc.contributor.author-college | 電機資訊學院 | zh_TW |
| dc.contributor.author-dept | 生醫電子與資訊學研究所 | zh_TW |
| 顯示於系所單位： | 生醫電子與資訊學研究所 | |
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