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Title: | 水膠開發及其藥物釋放應用 Synthesis and Characterization of Hydrogels for Uses in Controlled-Release Application |
Authors: | Xue-Yu Liu 劉學昱 |
Advisor: | 戴子安(Chi-An Dai) |
Keyword: | poloxamer 407,可注射水膠,藥物釋放,超音波, poloxamer 407,injectable hydrogel,drug delivery,ultrasonic, |
Publication Year : | 2017 |
Degree: | 碩士 |
Abstract: | 本研究目的為開發一個可注射型之具有包覆藥物的水膠載體,並將其應用於藥物釋放系統上,利用注射式方式,注入含藥傷口修復膠,可避免開刀所產生之問題,經由數月之藥物釋放,肌腱之修復,與水膠之後續逐步降解,可成為完全不需手術之新式治療方法。
本實驗使用P407水膠作為可注射水膠之原型,P407為一種分別為親水-親油-親水三種鏈段的高分子,因此高分子水溶液會在低溫時與水均勻混合,而在高溫時達到LCST形成高分子水膠,但此水膠沒有緊密的機械強度,容易散掉,因此需要改變末端形成雙鍵以此化學交聯,形成高機械強度之高分子水膠。首先先將末端官能基清基(hydroxyl groups)經丙烯醯氯反應而形成具有丙烯酸官能基高分子,且經由核磁共振(NMR)確認丙烯酸有無接上。調整不同組成之P407DA與交聯劑EGDMA來改變水膠的孔洞結構,或是加入不同比例的acrylic acid來改變水膠與藥物之間的作用力,藉由改變這兩種因素進而影響藥物釋放的速率,由掃描釋電子顯微鏡(SEM)觀察孔洞大小的改變,並以動態熱機械分析儀(DMA)測量水膠之楊氏係數,輔以佐證孔洞大小的正確性,本實驗利用AA改變水膠對藥物的作用力,進而影響超音波對藥物釋放的作用速率,並且加入EGDMA改變水膠的porosity降低緩釋時的藥物釋放量以此達到類似週期性打針的目的。 In this study, we designed an injectable and biodegradable hydrogel in drug delivery system. The drug can be injected with the hydrogel to make the drug keep at that place and avoid the problem of surgery. Through a few months of drug delivery, the hydrogel would degradable slowly becoming a new treatment without surgery Hydrogels based on Poloxamer 407 marcromers are prepared by thermal-curing. Poloxamer 407 is triblock copolymers with PEO-PPO-PEO. So the Poloxamer will have the sol-gel transition. But the mechanical property of P407 is too low to maintain drug, we should make the P407 have double bound to form a chemical curing hydrogel. The terminal hydroxyl groups of marcromers are modified to acrylated functional groups, and further characterized by NMR to confirm acrylation. Different concentration of P407DA and crosslinker (EGDMA) change the porosity of hydrogel, and adding the acrylic acid will change the interaction of drug with hydrogel. By SEM, we can measurement the porosity of the hydrogel. Using DMA measurement the young’s modulus can double check the morphology of SEM. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/77738 |
DOI: | 10.6342/NTU201702690 |
Fulltext Rights: | 未授權 |
Appears in Collections: | 化學工程學系 |
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ntu-106-R04524073-1.pdf Restricted Access | 2.06 MB | Adobe PDF |
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