可控制透水性聚吡咯奈米閥門陣列於微送藥系統之研究

Abstract

本論文利用多孔性電致動高分子聚吡咯(polypyrrole)做出可利用其材料本身之氧化還原來控制材料的透水性，利用此材料特性可以做出可重覆使用之奈米閥門陣列，聚吡咯可在內含鈉離子之溶液中驅動，包含人體體液。同時此奈米閥門陣列也提供了混合藥物的供應，此外該微送藥系統反應時間短(<1s)，並且具有極低功耗。 在本文章中，我們在氧化鋁薄膜(anodic aluminum oxide)上先鍍上一層金，接著再用電化學反應將聚吡咯聚合在金之上，最後再將鍍完聚吡咯後的薄膜合軟性電路板整合成微送藥系統。 此奈米閥門送藥系統可應用於植入式微送藥系統或生物感測晶片，因聚吡咯材料有相當高的重覆使用性，加上其應變量大，僅需極低的驅動能量(電壓<1 V，電流~10-5 A)，可在室溫下操作，易進行微製程，亦可在溶液中驅動。

The electro-active polymer polypyrrole has small power consumption in aqueous working media. Due to its stability, incorruptibility and micromachining compatibility, polypyrrole plays an important role in developing micro/nano-actuators for biological in vivo applications. This thesis presents a flexible and reusable polypyrrole nano-valve array for controllable drug delivery. This system works in aqueous media even in the body fluid. It also provides mixable drugs. The system has extremely low power consumption and short response time. The nano-valves are formed by depositing polypyrrole by a novel method on an anodic aluminum oxide (AAO) film which has uniform nano-holes. This method ensures the uniformlity of the polypyrrole and the integrity of the AAO film. After the deposition, the nano-valves are integrated with a flexible print circuit. The valves are actuated through the oxidation and reduction of the polypyrrole. The reduction state of the polypyrrole makes sodium ions entering the polypyrrole and hence swells the polypyrrole. During the swelling situation, the polypyrrole becomes permeable. Hence the valve is opened. Conversely, the polypyrrole is compressed and becomes impermeable in the oxidation state. By controlling the open/close time with constant voltage, the diffusive characteristics of the nano-valves can be easily changed.