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Title: | 神經在Aeolosoma viriew頭部再生中所扮演的角色 The role of nerve on anterior regeneration in Aeolosoma viride |
Authors: | Yi-Tse Wu 吳易澤 |
Advisor: | 陳俊宏 |
Keyword: | 神經,再生,環節動物, nevre,regeneration,annelid,aeolosoma,retinoic acid, |
Publication Year : | 2011 |
Degree: | 碩士 |
Abstract: | Several kinds of animal models, such as planarian, hydra, and salamander have been used to study on regeneration, which is the way of animals to repair their lost tissues. Compared with highly differentiated and much complicated animals such as salamander, the body plan of planarian and hydra with no coelom and body segmentation is much simpler than that of salamander. There is a large evolutionary gap among them. Based on the well-accepted phylogenic relationship, annelids with true coelom and body segmentation have the evolutional position between them. Aeolosoma viride, an annelid living in fresh water possesses great regeneration ability: four days to regenerate its head and three days to regenerate its tail. Cell proliferation and blastema formation near the wounded site in A. viride could be observed by BrdU staining. In salamander, the blastema formation and regeneration will fail in its legs when the wounded nerve is further destroyed. In planarian, the body axial was lost after the nerve was removed. In this study, A. viride treated with AG879, the inhibitor of the nerve growth factor receptor, was obviously delayed regeneration, but still alive. The cell proliferation and blastema formation during regeneration were also inhibited under AG879 treatment. This result suggested that nerves also govern regeneration in A. viride. Together, A. viride reproduces asexually and is easily maintained in lab, I believe it can be a good animal model for regeneration study in the future. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/37340 |
Fulltext Rights: | 有償授權 |
Appears in Collections: | 動物學研究所 |
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ntu-100-1.pdf Restricted Access | 1.11 MB | Adobe PDF |
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