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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
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dc.contributor.advisor | 陳俊宏 | |
dc.contributor.author | Yi-Tse Wu | en |
dc.contributor.author | 吳易澤 | zh_TW |
dc.date.accessioned | 2021-06-13T15:24:55Z | - |
dc.date.available | 2014-09-14 | |
dc.date.copyright | 2011-09-14 | |
dc.date.issued | 2011 | |
dc.date.submitted | 2011-08-10 | |
dc.identifier.citation | Reference:
Agata, K., Saito, Y., and Nakajima, E. (2007). Unifying principles of regeneration I: Epimorphosis versus morphallaxis. Development, Growth & Differentiation 49, 73-78. Brockes, J.P., and Kumar, A. (2008). Comparative Aspects of Animal Regeneration. Annual Review of Cell and Developmental Biology 24, 525-549. Duester, G. (2008). Retinoic Acid Synthesis and Signaling during Early Organogenesis. Cell 134, 921-931. Egger, B., Gschwentner, R., Hess, M.W., Nimeth, K.T., Adamski, Z., Willems, M., Rieger, R., and Salvenmoser, W. (2009). The caudal regeneration blastema is an accumulation of rapidly proliferating stem cells in the flatworm Macrostomum lignano. BMC Developmental Biology 9, 41. Endo, T., Bryant, S.V., and Gardiner, D.M. (2004). A stepwise model system for limb regeneration. Developmental Biology 270, 135-145. Galliot, B., Quiquand, M., Ghila, L., de Rosa, R., Miljkovic-Licina, M., and Chera, S. (2009). Origins of neurogenesis, a cnidarian view. Developmental Biology 332, 2-24. Jaeger, J., Garza-Garcia, A., Harris, R., Esposito, D., Gates, P.B., and Driscoll, P.C. (2009). Solution Structure and Phylogenetics of Prod1, a Member of the Three-Finger Protein Superfamily Implicated in Salamander Limb Regeneration. PLoS ONE 4, e7123. Kragl, M., Knapp, D., Nacu, E., Khattak, S., Maden, M., Epperlein, H.H., and Tanaka, E.M. (2009). Cells keep a memory of their tissue origin during axolotl limb regeneration. Nature 460, 60-65. Kumar, A., Godwin, J.W., Gates, P.B., Garza-Garcia, A.A., and Brockes, J.P. (2007). Molecular Basis for the Nerve Dependence of Limb Regeneration in an Adult Vertebrate. Science 318, 772-777. Müller, M.C.M., Berenzen, A., and Westheide, W. (2003). Experiments on anterior regeneration in Eurythoe complanata ('Polychaeta', Amphinomidae): reconfiguration of the nervous system and its function for regeneration Zoomorphology 122, 95-103. 18 Miljkovic-Licina, M., Chera, S., Ghila, L., and Galliot, B. (2007). Head regeneration in wild-type hydra requires de novo neurogenesis. Development 134, 1191-1201. Muller, W.A. (1984). Retinoids and pattern formation in a hydroid. Journal of Embryology and Experimental Morphology 81, 253-271. Oviedo, N.J., Morokuma, J., Walentek, P., Kema, I.P., Gu, M.B., Ahn, J.-M., Hwang, J.S., Gojobori, T., and Levin, M. (2010). Long-range neural and gap junction protein-mediated cues control polarity during planarian regeneration. Developmental Biology 339, 188-199. Piirsoo, M., Kaljas, A., Tamm, K., and Timmusk, T. (2010). Expression of NGF and GDNF family members and their receptors during peripheral nerve development and differentiation of Schwann cells in vitro. Neuroscience Letters 469, 135-140. Romero, R., and Bueno, D. (2001). Disto-proximal regional determination and intercalary regeneration in planarians, revealed by retinoic acid induced disruption of regeneration. developemental biology 45, 669-673. Rossi, L., Salvetti, A., Batistoni, R., Deri, P., and Gremigni, V. (2007). Planarians, a tale of stem cells. Cellular and Molecular Life Sciences 65, 16-23. Satoh, A., Gardiner, D.M., Bryant, S.V., and Endo, T. (2007). Nerve-induced ectopic limb blastemas in the axolotl are equivalent to amputation-induced blastemas. Developmental Biology 312, 231-244. Silva, S.M.d., Gates, P.B., and Brockes, J.P. (2002). The Newt Ortholog of CD59 Is Implicated in Proximodistal Identity during Amphibian Limb Regeneration. Developemental Cell 3, 547-555. Sugio, M., Takeuchi, K., Kutsuna, J., Tadokoro, R., Takahashi, Y., Yoshida-Noro, C., and Tochinai, S. (2008). Exploration of embryonic origins of germline stem cells and neoblasts in Enchytraeus japonensis (Oligochaeta, Annelida). Gene Expression Patterns 8, 227-236. Wagner, D.E., Wang, I.E., and Reddien, P.W. (2011). Clonogenic Neoblasts Are Pluripotent Adult Stem Cells That Underlie Planarian Regeneration. Science 332, 19 811-816. Wenemoser, D., and Reddien, P.W. (2010). Planarian regeneration involves distinct stem cell responses to wounds and tissue absence. Developmental Biology 344, 979-991. Yazawa, S., Umesono, Y., Hayashi, T., Tarui, H., and Agata, K. (2009). Planarian Hedgehog/Patched establishes anterior-posterior polarity by regulating Wnt signaling. Proceedings of the National Academy of Sciences 106, 22329-22334. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/37340 | - |
dc.description.abstract | Several kinds of animal models, such as planarian, hydra, and salamander have been used to study on regeneration, which is the way of animals to repair their lost tissues. Compared with highly differentiated and much complicated animals such as salamander, the body plan of planarian and hydra with no coelom and body segmentation is much simpler than that of salamander. There is a large evolutionary gap among them. Based on the well-accepted phylogenic relationship, annelids with true coelom and body segmentation have the evolutional position between them. Aeolosoma viride, an annelid living in fresh water possesses great regeneration ability: four days to regenerate its head and three days to regenerate its tail. Cell proliferation and blastema formation near the wounded site in A. viride could be observed by BrdU staining. In salamander, the blastema formation and regeneration will fail in its legs when the wounded nerve is further destroyed. In planarian, the body axial was lost after the nerve was removed. In this study, A. viride treated with AG879, the inhibitor of the nerve growth factor receptor, was obviously delayed regeneration, but still alive. The cell proliferation and blastema formation during regeneration were also inhibited under AG879 treatment. This result suggested that nerves also govern regeneration in A. viride. Together, A. viride reproduces asexually and is easily maintained in lab, I believe it can be a good animal model for regeneration study in the future. | en |
dc.description.provenance | Made available in DSpace on 2021-06-13T15:24:55Z (GMT). No. of bitstreams: 1 ntu-100-R98b41017-1.pdf: 1136973 bytes, checksum: ed49dfb8abf5f716a93d5bb69cffaba3 (MD5) Previous issue date: 2011 | en |
dc.description.tableofcontents | Introduction……………………………………………………………… 1
The common process of regeneration ……………………………………………....1 Different kinds of regeneration ……………………………………………………1 Morphallaxis……………………………………………………………………...1 Epimorphosis……………………………………………………………………..2 The role of nerve in different experimental animals………………………………..2 In Hydra…………………………………………………………………………..2 In Planarian………………………………………………………………………. 3 In Salamander ………………………………………………………………………3 The effect of retinoic acid in regeneration ……………………………………………4 In Hydra……………………………………………………………………………..4 In Planarian………………………………………………………………………….4 In Salamander ………………………………………………………………………4 Aeolosoma viride……………………………………………………………………...5 The evolutionary gap between aforesaid animals……………………………………..5 Materials and Methods……………………………………………………...6 Animals………………………………………………………………………………..6 Amputation…………………………………………………………………………….6 Bromodeoxyuridine (BrdU) labeling………………………………………………….7 Immunohistochemistry………………………………………………………………..8 Analysis……………………………………………………………………………….8 BrdU intensity ……………………………………………………………………....8 The length of nerve regrowth ………………………………………………………8 Statistics……………………………………………………………………………….9 Results……………………………………………………………………..10 Cell proliferation to form blastema during head regeneration in A. viride…………..10 Neurogenesis during anterior regeneration in A. viride……………………………...11 A. viride regeneration was inhibited by nerve growth factor receptor inhibitor……..11 Retinoic acid can rescue the regeneration in of AG879 treated A. viride……………13 Discussion…………………………………………………………………14 Reference………………………………………………………………….17 Figures…………………20 | |
dc.language.iso | en | |
dc.title | 神經在Aeolosoma viriew頭部再生中所扮演的角色 | zh_TW |
dc.title | The role of nerve on anterior regeneration in Aeolosoma viride | en |
dc.type | Thesis | |
dc.date.schoolyear | 99-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 李心予,李宣書,管永恕 | |
dc.subject.keyword | 神經,再生,環節動物, | zh_TW |
dc.subject.keyword | nevre,regeneration,annelid,aeolosoma,retinoic acid, | en |
dc.relation.page | 29 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2011-08-11 | |
dc.contributor.author-college | 生命科學院 | zh_TW |
dc.contributor.author-dept | 動物學研究所 | zh_TW |
顯示於系所單位: | 動物學研究所 |
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