利用超音波震盪法包覆超順磁氧化鐵奈米粒子與疏水性藥物於水性生物可降解聚胺酯奈米粒子之製備與性質分析

Abstract

Superparamagnetic iron oxide nanoparticles (SPIO NPs) have a wide range of biomedical applications such as in magnetic resonance imaging (MRI), targeting, and hyperthermia therapy. Aggregation of SPIO NPs can occur because of the hydrophobic surface and high surface energy of SPIO NPs. Here, we developed a facile method to encapsulate SPIO NPs in amphiphilic biodegradable polymer. Anionic biodegradable polyurethane nanoparticles (PU NPs) with ~40 nm size and different chemistry were prepared by waterborne processes. SPIO NPs were synthesized from chemical co-precipitation. SPIO NPs were then added in the aqueous dispersion of PU NPs, followed with high frequency (~20 kHz) ultrasonic vibration for 3 min. This method rendered SPIO-PU hybrid NPs (size ~110 nm) suspended in water. SPIO-PU hybrid NPs contained about 50-60 wt% SPIO and retained the superparamagnetic property (evaluated by a magnetometer) as well as high contrast in MRI. Using the same method, hydrophobic drug (Vitamin K3, VK3) or (9-(methylaminomethyl)anthracene, MAMA) could also be encapsulated in PU NPs. The VK3-PU or MAMA-PU hybrid NPs had ~40 nm size and different release profiles for PU with different chemistry. The encapsulation efficiency for VK3 and MAMA was high (~95%) without burst release. The encapsulation mechanism may be attributed to the low Tg and good compliance of PU NPs. The new encapsulation method by waterborne biodegradable PU NPs is simple, rapid, and effective to produce multimodular NP carriers