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  1. NTU Theses and Dissertations Repository
  2. 工學院
  3. 高分子科學與工程學研究所
請用此 Handle URI 來引用此文件: http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/19785
標題: 利用超音波震盪法包覆超順磁氧化鐵奈米粒子與疏水性藥物於水性生物可降解聚胺酯奈米粒子之製備與性質分析
A facile method to prepare superparamagnetic iron oxide and hydrophobic drug encapsulated biodegradable polyurethane nanoparticles
作者: Kuo-Wei Cheng
程國瑋
指導教授: 徐善慧
關鍵字: 超順磁奈米氧化鐵粒子;生物可降解聚胺酯奈米粒子;藥物釋放;混成奈米粒子,
superparamagnetic iron oxide (SPIO); polyurethane;drug release;hybrid nanoparticles,
出版年 : 2015
學位: 碩士
摘要: Superparamagnetic iron oxide nanoparticles (SPIO NPs) have a wide range of biomedical applications such as in magnetic resonance imaging (MRI), targeting, and hyperthermia therapy. Aggregation of SPIO NPs can occur because of the hydrophobic surface and high surface energy of SPIO NPs. Here, we developed a facile method to encapsulate SPIO NPs in amphiphilic biodegradable polymer. Anionic biodegradable polyurethane nanoparticles (PU NPs) with ~40 nm size and different chemistry were prepared by waterborne processes. SPIO NPs were synthesized from chemical co-precipitation. SPIO NPs were then added in the aqueous dispersion of PU NPs, followed with high frequency (~20 kHz) ultrasonic vibration for 3 min. This method rendered SPIO-PU hybrid NPs (size ~110 nm) suspended in water. SPIO-PU hybrid NPs contained about 50-60 wt% SPIO and retained the superparamagnetic property (evaluated by a magnetometer) as well as high contrast in MRI. Using the same method, hydrophobic drug (Vitamin K3, VK3) or (9-(methylaminomethyl)anthracene, MAMA) could also be encapsulated in PU NPs. The VK3-PU or MAMA-PU hybrid NPs had ~40 nm size and different release profiles for PU with different chemistry. The encapsulation efficiency for VK3 and MAMA was high (~95%) without burst release. The encapsulation mechanism may be attributed to the low Tg and good compliance of PU NPs. The new encapsulation method by waterborne biodegradable PU NPs is simple, rapid, and effective to produce multimodular NP carriers
URI: http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/19785
全文授權: 未授權
顯示於系所單位:高分子科學與工程學研究所

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