配合生物相容性材料之人工水晶體製程研究

Abstract

人眼的水晶體為透明且可讓光線自由通過之構造，然而隨著年齡增長、眼部受外力受傷、眼睛病變、高度近視等原因，對水晶體功能或結構產生影響，導致水晶體混濁而造成白內障。白內障最常見處理方式為超音波乳化手術進行水晶體置換，原有水晶體會先被取下並由人工水晶體代替。 本論文旨在透過設計符合生物相容性的光學透明材料製成之人工水晶體，配合材料以及光學幾何設計製造模具，並藉由臺大之單點鑽石切削設備來製作，完成人工水晶體製程，並建立模擬和實驗環境，優化製造技術。此模型涵蓋了使用有限元素法(FEM)建立之人工水晶體本體與應用計算熱傳學於液體固化情形，並於其表面考慮流固耦合的交互現象，透過給定的溫度變化曲線來達到模擬人工水晶體熱固化的結果。 本文首先了解此人工水晶體的相關發展，並了解其材料與固化方式，並將市售之水晶體數位模型化，再以設計的材料進行製作，透過其數位模型模擬以及實體成型進行驗證，分析其相關熱固化情形。

The lens of the human eye is a transparent structure that allows light to pass through freely.However,with age,external injury to the eye, eye disease, high myopia, etc., it will affect the function or structure of the lens, resulting in turbidity of the lens and cause cataracts. The most common treatment for cataracts is phacoemulsification surgery for lens replacement, in which the original lens is first removed and replaced by an intraocular lens. The purpose of this thesis is to design an intraocular lens made of biocompatible optically transparent materials, and manufacture a mold with matching materials and optical geometric design. Build simulation and experimental environments to optimize manufacturing techniques. This model covers the intraocular lens body established by the finite element method (FEM) and the application of computational heat transfer in the case of liquid solidification, and considers the interaction phenomenon of fluid-structure interaction on its surface, through a given temperature change curve to simulate artificial The result of thermal curing of intraocular lens. This paper firstly understands the related development of this intraocular lens, and understands its material and curing method. The commercially available lens is digitally modeled, and then made with the designed material. It is verified through its digital model simulation and solid molding, and its related heat curing condition.