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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 顏家鈺 | zh_TW |
| dc.contributor.advisor | Jia-Yush Yen | en |
| dc.contributor.author | 王昱祥 | zh_TW |
| dc.contributor.author | Yu-Hsiang Wang | en |
| dc.date.accessioned | 2024-01-03T16:10:29Z | - |
| dc.date.available | 2024-01-04 | - |
| dc.date.copyright | 2024-01-03 | - |
| dc.date.issued | 2023 | - |
| dc.date.submitted | 2023-12-25 | - |
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Tandon, "Evaluation of Barrett universal II formula for intraocular lens power calculation in Asian Indian population," Indian journal of ophthalmology, vol. 68, no. 1, p. 59, 2020. [7] Y. Chen, L. Wei, W. He, Y. Lu, and X. Zhu, "Comparison of Kane, Hill-RBF 2.0, Barrett Universal II, and Emmetropia Verifying Optical formulas in eyes with extreme myopia," Journal of Refractive Surgery, vol. 37, no. 10, pp. 680-685, 2021. [8] A. Hillenmayer et al., "Evaluation of posterior capsule opacification of the Alcon Clareon IOL vs the Alcon Acrysof IOL using a human capsular bag model," BMC ophthalmology, vol. 20, no. 1, pp. 1-7, 2020. [9] H. N. Sen, A.-U. Sarikkola, R. J. Uusitalo, and L. Laatikainen, "Quality of vision after AMO Array multifocal intraocular lens implantation," Journal of Cataract & Refractive Surgery, vol. 30, no. 12, pp. 2483-2493, 2004. [10] J. A. Davison, "Clinical performance of Alcon SA30AL and SA60AT single-piece acrylic intraocular lenses," Journal of Cataract & Refractive Surgery, vol. 28, no. 7, pp. 1112-1123, 2002. [11] R. F. Steinert, B. L. Aker, D. J. Trentacost, P. J. Smith, and N. Tarantino, "A prospective comparative study of the AMO ARRAY zonal-progressive multifocal silicone intraocular lens and a monofocal intraocular lens," Ophthalmology, vol. 106, no. 7, pp. 1243-1255, 1999. [12] L. Zeng and F. Fang, "Advances and challenges of intraocular lens design," Applied optics, vol. 57, no. 25, pp. 7363-7376, 2018. [13] U. Ali, K. J. B. A. Karim, and N. A. Buang, "A review of the properties and applications of poly (methyl methacrylate)(PMMA)," Polymer Reviews, vol. 55, no. 4, pp. 678-705, 2015. [14] H. Cochrane and C. Lin, "The influence of fumed silica properties on the processing, curing, and reinforcement properties of silicone rubber," Rubber chemistry and technology, vol. 66, no. 1, pp. 48-60, 1993. [15] Y. Hu, X. Jiang, Y. Ding, H. Ge, Y. Yuan, and C. Yang, "Synthesis and characterization of chitosan–poly (acrylic acid) nanoparticles," Biomaterials, vol. 23, no. 15, pp. 3193-3201, 2002. [16] J. C. Javitt and R. F. Steinert, "Cataract extraction with multifocal intraocular lens implantation: a multinational clinical trial evaluating clinical, functional, and quality-of-life outcomes," Ophthalmology, vol. 107, no. 11, pp. 2040-2048, 2000. [17] M. N. I. Shiblee, K. Ahmed, A. Khosla, M. Kawakami, and H. Furukawa, "3D printing of shape memory hydrogels with tunable mechanical properties," Soft matter, vol. 14, no. 38, pp. 7809-7817, 2018. [18] 王丹琦, 袁群, 殷长俊, 高志山, and 李新华, "基于我国人眼数据的人工晶体模型及其三维打印技术研究," Laser & Optoelectronics Progress, vol. 57, no. 21, pp. 213301--1, 2020. [19] S. Hatefi and K. Abou-El-Hossein, "Review of single-point diamond turning process in terms of ultra-precision optical surface roughness," The International Journal of Advanced Manufacturing Technology, vol. 106, pp. 2167-2187, 2020. [20] Z. Chen, Z. Wang, M. Ren, X. Zhang, L. Zhu, and X. Jiang, "Development of an on-machine measurement system for ultra-precision machine tools using a chromatic confocal sensor," Precision engineering, vol. 74, pp. 232-241, 2022. [21] F. Vega, M. Valentino, F. Rigato, and M. S. Millán, "Optical design and performance of a trifocal sinusoidal diffractive intraocular lens," Biomedical Optics Express, vol. 12, no. 6, pp. 3338-3351, 2021. [22] J.-P. Montheard, M. Chatzopoulos, and D. Chappard, "2-hydroxyethyl methacrylate (HEMA): chemical properties and applications in biomedical fields," Journal of Macromolecular Science, Part C: Polymer Reviews, vol. 32, no. 1, pp. 1-34, 1992. [23] Y.-C. Chung, J. E. Park, J. W. Choi, and B. C. Chun, "The graft-polymerization of poly (ethylene glycol) phenyl ether acrylate onto polyurethane and its impact on the mechanical properties and chain packing," Fibers and Polymers, vol. 21, pp. 290-299, 2020. [24] F.-Y. Lee, X.-J. Wang, W.-H. Su, and T.-C. Hsu, "A Facile Fabrication Route of Poly (Ethylene Glycol Phenyl Ether Acrylate) Photopolymers with Efficient Optical Response for Holographic Storage," Crystals, vol. 10, no. 10, p. 935, 2020. [25] S. S. Chen and U. b. Staff, "Styrene," Kirk‐Othmer Encyclopedia of Chemical Technology, 2000. [26] X.-R. Li, X.-L. Wang, and H. Koseki, "Study on thermal decomposition characteristics of AIBN," Journal of hazardous materials, vol. 159, no. 1, pp. 13-18, 2008. [27] F. C. Galeazzo, R. Y. Miura, J. A. Gut, and C. C. Tadini, "Experimental and numerical heat transfer in a plate heat exchanger," Chemical Engineering Science, vol. 61, no. 21, pp. 7133-7138, 2006. [28] G. Hou, J. Wang, and A. Layton, "Numerical methods for fluid-structure interaction—a review," Communications in Computational Physics, vol. 12, no. 2, pp. 337-377, 2012. | - |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/91339 | - |
| dc.description.abstract | 人眼的水晶體為透明且可讓光線自由通過之構造，然而隨著年齡增長、眼部受外力受傷、眼睛病變、高度近視等原因，對水晶體功能或結構產生影響，導致水晶體混濁而造成白內障。白內障最常見處理方式為超音波乳化手術進行水晶體置換，原有水晶體會先被取下並由人工水晶體代替。
本論文旨在透過設計符合生物相容性的光學透明材料製成之人工水晶體，配合材料以及光學幾何設計製造模具，並藉由臺大之單點鑽石切削設備來製作，完成人工水晶體製程，並建立模擬和實驗環境，優化製造技術。此模型涵蓋了使用有限元素法(FEM)建立之人工水晶體本體與應用計算熱傳學於液體固化情形，並於其表面考慮流固耦合的交互現象，透過給定的溫度變化曲線來達到模擬人工水晶體熱固化的結果。 本文首先了解此人工水晶體的相關發展，並了解其材料與固化方式，並將市售之水晶體數位模型化，再以設計的材料進行製作，透過其數位模型模擬以及實體成型進行驗證，分析其相關熱固化情形。 | zh_TW |
| dc.description.abstract | The lens of the human eye is a transparent structure that allows light to pass through freely.However,with age,external injury to the eye, eye disease, high myopia, etc., it will affect the function or structure of the lens, resulting in turbidity of the lens and cause cataracts. The most common treatment for cataracts is phacoemulsification surgery for lens replacement, in which the original lens is first removed and replaced by an intraocular lens.
The purpose of this thesis is to design an intraocular lens made of biocompatible optically transparent materials, and manufacture a mold with matching materials and optical geometric design. Build simulation and experimental environments to optimize manufacturing techniques. This model covers the intraocular lens body established by the finite element method (FEM) and the application of computational heat transfer in the case of liquid solidification, and considers the interaction phenomenon of fluid-structure interaction on its surface, through a given temperature change curve to simulate artificial The result of thermal curing of intraocular lens. This paper firstly understands the related development of this intraocular lens, and understands its material and curing method. The commercially available lens is digitally modeled, and then made with the designed material. It is verified through its digital model simulation and solid molding, and its related heat curing condition. | en |
| dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2024-01-03T16:10:29Z No. of bitstreams: 0 | en |
| dc.description.provenance | Made available in DSpace on 2024-01-03T16:10:29Z (GMT). No. of bitstreams: 0 | en |
| dc.description.tableofcontents | 口試委員審定書…………………………………………………………………… i
誌謝………………………………………………………………………………… ii 中文摘要………………………………………………………………………… iii Abstract…………………………………………………………………………… iv 目錄……………………………………………………………………………… v 圖目錄……………………………………………………………………… viii 表目錄…………………………………………………………………………… xi 第一章 緒論 ……………………………………………………………………… 1 1.1 研究動機 ……………………………………………………………… 1 1.1.1 人工水晶體之歷史沿革………………………………………… 1 1.1.2 研究動機與目的………………………………………………… 3 1.1.3 整合型計畫研究團隊…………………………………………… 4 1.2 文獻回顧………………………………………………………………… 5 1.3 論文架構………………………………………………………………… 7 第二章 人工水晶體模具之製造過程………………………………………… 8 2.1 人工水晶體製造技術………………………………………………… 8 2.1.1 積層製造技術………………………………………………… 8 2.1.2 鑽石單點切削技術……………………………………………. 12 2.2 人工水晶體模具設計………………………………………………… 13 2.2.1 模具製造之材料……………………………………………… 14 2.2.2 模具設計之規格……………………………………………… 14 2.3 人工水晶體模具製程………………………………………………… 15 2.3.1 模具製程使用機台…………………………………………… 16 2.3.2 模具排氣問題……………………………………………… 18 2.3.3 設計模具排氣孔切削製程…………………………………… 19 2.3.4 模具製造成果………………………………………………… 22 第三章 人工水晶體建模及架構……………………………………………… 26 3.1 人工水晶體數位模型………………………………………………… 26 3.1.1 水晶體模型幾何特徵………………………………………… 27 3.1.2 水晶體模型總覽……………………………………………… 29 3.2 數位模型使用的材料………………………………………………… 32 3.2.1 甲基丙烯酸 2-羥乙酯(HEMA)…………………………… 32 3.2.2 聚乙二醇苯醚丙烯酸酯(PEG-PEA)………………………… 34 3.2.3 苯乙烯(Styrene)……………………………………………… 35 3.2.4 偶氮二異丁腈(AIBN)……………………………… 36 3.3 數位模型模擬架構…………………………………………………… 37 3.3.1 流體與熱傳學………………………………………………… 37 3.3.2 溫度曲線設計………………………………………………… 39 3.3.3 邊界固定條件…………………………………………………… 41 3.3.4 材料參數設定………………………………………………… 42 3.3.5 流固耦合……………………………………………………… 43 第四章 模擬與模具實驗結果比較……………………………………………… 46 4.1 模具實驗與模擬結果………………………………………………… 46 4.1.1 實驗成品………………………………………………………… 46 4.1.2 固化模擬成果觀察……………………………………………… 48 4.1.3 沾黏及排氣問題………………………………………………… 49 4.2 其它實驗結果與模擬比較…………………………………………… 50 4.2.1 極端案例之模擬………………………………………………… 50 4.2.2 成品與模擬比較………………………………………………… 53 4.3 光學實驗成果…………………………………………………………… 55 第五章 結論與未來展望………………………………………………………… 58 5.1 結論…………………………………………………………………… 58 5.2 未來展望……………………………………………………………… 58 參考文獻………………………………………………………………………… 60 | - |
| dc.language.iso | zh_TW | - |
| dc.subject | 熱固化 | zh_TW |
| dc.subject | 鑽石單點切割 | zh_TW |
| dc.subject | 有限元素方法 | zh_TW |
| dc.subject | 人工水晶體製程 | zh_TW |
| dc.subject | 人工水晶體材料 | zh_TW |
| dc.subject | artificial crystal process | en |
| dc.subject | Finite element method | en |
| dc.subject | diamond single point cutting | en |
| dc.subject | artificial crystal material | en |
| dc.subject | thermal curing | en |
| dc.title | 配合生物相容性材料之人工水晶體製程研究 | zh_TW |
| dc.title | Research on the process of intraocular lens with biocompatible materials | en |
| dc.type | Thesis | - |
| dc.date.schoolyear | 112-1 | - |
| dc.description.degree | 碩士 | - |
| dc.contributor.oralexamcommittee | 王富正;戴子安 | zh_TW |
| dc.contributor.oralexamcommittee | Fu-Cheng Wang;Tzu-An Tai | en |
| dc.subject.keyword | 有限元素方法,鑽石單點切割,人工水晶體材料,熱固化,人工水晶體製程, | zh_TW |
| dc.subject.keyword | Finite element method,diamond single point cutting,artificial crystal material,thermal curing,artificial crystal process, | en |
| dc.relation.page | 62 | - |
| dc.identifier.doi | 10.6342/NTU202304561 | - |
| dc.rights.note | 同意授權(全球公開) | - |
| dc.date.accepted | 2023-12-26 | - |
| dc.contributor.author-college | 工學院 | - |
| dc.contributor.author-dept | 機械工程學系 | - |
| 顯示於系所單位： | 機械工程學系 | |
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