仿生阿拉伯膠/聚二甲基矽氧烷貼布-用以傳遞傷口癒合藥物

Abstract

理想的傷口癒合貼布需具備高生物相容性、高效之釋藥率且即使在潮濕的環境下亦能發揮良好之黏性。為了達到理想傷口癒合貼布之標準，本篇以仿生的概念製備仿壁虎腳掌微結構之貼布，藉由毛細作用力提升潮濕環境下之黏性。 微結構由阿拉伯膠和聚二甲基矽氧烷兩種材料所組成。聚二甲基矽氧烷可以提供良好的結構和黏性良好的結構和黏性，而阿拉伯膠藉由其高孔隙度抓住液體，增強貼布在潮濕環境下之黏性。 本研究以荷重元和原子力顯微鏡分別巨觀和微觀量測阿拉伯膠/聚二甲基矽氧烷貼布之黏性。結果顯示在巨觀和微觀下均可看見毛細作用力對黏性之貢獻。除此之外，結果亦顯示接觸分割效果和阿拉伯膠之孔隙度對黏性之貢獻。此外，於傷口癒合藥物釋放方面，為提升藥物釋放之效率，研究中藉阿拉伯膠之孔洞性達到提升釋放率之效。 總結，我們製備阿拉伯膠/聚二甲基矽氧烷之微結構貼布，以達到提升潮濕環境中之黏性。本篇中以常見之傷口癒合藥物：林可黴素研究藥物釋放率。阿拉伯膠/聚二甲基矽氧烷之微結構貼布不僅藉由毛細作用力在潮濕的環境中發揮良好的黏性，亦能控制高效率之藥物釋放。

Adhesives that possesses high biocompatibility, timely drug-release capability and excellent adhesion in wet environments, have been crucial in many medical applications. Inspired by nature, this thesis aims to developing an adhesive, which has an array of microscale pillars to mimic the sticky setae in gecko’ toes to enhance the compliance as well as to provide capillary forces for adhesion. The micropillars are made of two biopolymers: Polydimethylsiloxane (PDMS) and Gum-Arabic (GA): PDMS provides excellent structural and adhesion strength, while GA has highly-porous structures to hold liquid and to enhance the wet adhesion strength by capillary force. The adhesion strength of the GA/PDMS adhesives is macroscopically and microscopically evaluated by using the load cell and atomic force microscope (AFM). In addition, in the study, the impact of compliance, capillary force, and the porosity of GA, which influence the adhesion strength, are evaluated by normalization. Moreover, the samples are tested to carry an antibiotic drug, lincomycin, for timely release in wound healing applications. It has been demonstrated that our proposed GA/PDMS micropillar adhesive not only allows better drug release control, but also carries the liquid for higher capillary forces for better wet adhesion performance.