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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/74846完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 盧彥文(Yen-Wen Lu) | |
| dc.contributor.author | Pei-Hsuan Wang | en |
| dc.contributor.author | 王姵璇 | zh_TW |
| dc.date.accessioned | 2021-06-17T09:08:44Z | - |
| dc.date.available | 2019-11-04 | |
| dc.date.copyright | 2019-11-04 | |
| dc.date.issued | 2019 | |
| dc.date.submitted | 2019-10-31 | |
| dc.identifier.citation | (2012). Fundamentals of biomechanics equilibrium, motion, and deformation / by Nihat Ozkaya... [et al.]. New York, NY, Springer New York.
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/74846 | - |
| dc.description.abstract | 理想的傷口癒合貼布需具備高生物相容性、高效之釋藥率且即使在潮濕的環境下亦能發揮良好之黏性。為了達到理想傷口癒合貼布之標準，本篇以仿生的概念製備仿壁虎腳掌微結構之貼布，藉由毛細作用力提升潮濕環境下之黏性。
微結構由阿拉伯膠和聚二甲基矽氧烷兩種材料所組成。聚二甲基矽氧烷可以提供良好的結構和黏性良好的結構和黏性，而阿拉伯膠藉由其高孔隙度抓住液體，增強貼布在潮濕環境下之黏性。 本研究以荷重元和原子力顯微鏡分別巨觀和微觀量測阿拉伯膠/聚二甲基矽氧烷貼布之黏性。結果顯示在巨觀和微觀下均可看見毛細作用力對黏性之貢獻。除此之外，結果亦顯示接觸分割效果和阿拉伯膠之孔隙度對黏性之貢獻。此外，於傷口癒合藥物釋放方面，為提升藥物釋放之效率，研究中藉阿拉伯膠之孔洞性達到提升釋放率之效。 總結，我們製備阿拉伯膠/聚二甲基矽氧烷之微結構貼布，以達到提升潮濕環境中之黏性。本篇中以常見之傷口癒合藥物：林可黴素研究藥物釋放率。阿拉伯膠/聚二甲基矽氧烷之微結構貼布不僅藉由毛細作用力在潮濕的環境中發揮良好的黏性，亦能控制高效率之藥物釋放。 | zh_TW |
| dc.description.abstract | Adhesives that possesses high biocompatibility, timely drug-release capability and excellent adhesion in wet environments, have been crucial in many medical applications. Inspired by nature, this thesis aims to developing an adhesive, which has an array of microscale pillars to mimic the sticky setae in gecko’ toes to enhance the compliance as well as to provide capillary forces for adhesion. The micropillars are made of two biopolymers: Polydimethylsiloxane (PDMS) and Gum-Arabic (GA): PDMS provides excellent structural and adhesion strength, while GA has highly-porous structures to hold liquid and to enhance the wet adhesion strength by capillary force. The adhesion strength of the GA/PDMS adhesives is macroscopically and microscopically evaluated by using the load cell and atomic force microscope (AFM). In addition, in the study, the impact of compliance, capillary force, and the porosity of GA, which influence the adhesion strength, are evaluated by normalization.
Moreover, the samples are tested to carry an antibiotic drug, lincomycin, for timely release in wound healing applications. It has been demonstrated that our proposed GA/PDMS micropillar adhesive not only allows better drug release control, but also carries the liquid for higher capillary forces for better wet adhesion performance. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-17T09:08:44Z (GMT). No. of bitstreams: 1 ntu-108-R06631039-1.pdf: 3165834 bytes, checksum: df3ef99cd3261c3fa2f598fc42490b11 (MD5) Previous issue date: 2019 | en |
| dc.description.tableofcontents | Table of contents
口試委員會審定書 i 誌謝 ii 中文摘要 iii Abstract iv Nomenclature v List of abbreviations vi Chapter 1 Introduction 1 1.1 Motivation 1 1.2 Overall Structure of Thesis 2 Chapter 2 Literature Review 3 2.1 Classification of Adhesives 3 2.2 Adhesion Mechanism for Gecko’s Toe 5 2.2.1 Contact Splitting Theory 5 2.2.2 Van der Waals Force 6 2.2.3 Capillary Force 7 2.3 Biologically-Inspired Adhesives 9 2.4 Adhesion Test 10 2.5 Drug Delivery Control in Adhesives 13 2.5.1 Materials for Biological-Inspired Adhesives 14 2.5.2 Adhesives for Drug Delivery 15 Chapter 3 Material and Methods 17 3.1 Mechanism for Wet Adhesion 17 3.1.1 Contact Mechanics 18 3.1.2 Capillary force 22 3.2 Relative Humidity 23 3.3 Design of The Adhesives 26 3.3.1 The Design of Material Synthesis 26 3.3.1.1 PDMS 27 3.3.1.2 Gum Arabic 27 3.3.1.3 PEG-da 29 3.3.2 The Design of Structured Adhesive 29 3.3.3 SEM Images of Submicron-structured Adhesive 30 3.4 Photolithography 31 Chapter 4 Adhesive Performance Evaluation on Adhesion Force and Drug Release 33 4.1. Load Cell 33 4.1.1 Force Curve 35 4.1.2 Preconditioning Test 36 4.2 Atomic Force Microscope (AFM) Spectroscopy 38 4.3 Drug Releasing Tests 40 Chapter 5 Results and Discussion 43 5.1 Macroscopic Adhesion Tests 43 5.1.1 Adhesion Force for Unstructured Samples 44 5.1.2 Contact Splitting Effect 45 5.1.3 Quantification of Capillary Force 50 5.1.4 Quantification of Capillary Force by The Porosity of GA 52 5.2 Microscopic Adhesive Tests 54 5.4 Comparison between Macroscopic and Microscopic Adhesion Strength Measurement 55 5.5 Drug Delivery Tests 58 Chapter 6 Conclusions and Prospective 61 6.1 Conclusion 61 6.2 Prospective 61 Appendix I: Two Photon Polymerization (TPP) 63 Appendix II: Protocols for Drug Delivery Test 80 References 82 | |
| dc.language.iso | en | |
| dc.title | 仿生阿拉伯膠/聚二甲基矽氧烷貼布-用以傳遞傷口癒合藥物 | zh_TW |
| dc.title | Biologically-Inspired Gum-Arabic/Polydimethylsiloxane Adhesive for Wound Healing Drug Delivery | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 108-1 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 李貫銘(Kuan-Ming Li),陳洵毅(Hsun-Yi Chen),林哲宇(Che-Yu Chen) | |
| dc.subject.keyword | 貼布,阿拉伯膠,傷口癒合,藥物釋放,林可黴素, | zh_TW |
| dc.subject.keyword | Adhesive,Gum-Arabic,wound healing,drug delivery,lincomycin, | en |
| dc.relation.page | 95 | |
| dc.identifier.doi | 10.6342/NTU201904250 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2019-11-01 | |
| dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
| dc.contributor.author-dept | 生物產業機電工程學研究所 | zh_TW |
| 顯示於系所單位： | 生物機電工程學系 | |
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