光聚合3D列印幹細胞傷口貼布

Abstract

間質幹細胞擁有高度的免疫調節以及再生能力，也因此近幾年來間質幹細胞一直都是細胞治療的主力人選，至今也已有眾多臨床試驗證實間質幹細胞在傷口癒合的過程中有良好的表現。然而間質幹細胞促進傷口的癒合的機制以及怎樣給予細胞才能達到最好的效果還尚未有一個完整的解釋。這份研究中我們提出多種細胞治療傷口貼布好讓細胞可以在治療期間停留在傷口處，這些以明膠為基底的傷口貼布透過3D列印技術可以客製化的製作出各種形狀，以配合各種不同的臨床需求。細胞在這樣的貼布裡面能夠維持活性超過12小時，這樣的保存條件也讓細胞貼布在未來有機會變成一個令人期待的新興產品。

Mesenchymal stem cells (MSCs) have been shown to be potential candidates to cell therapy due to their immunomodulation and regeneration abilities. Lots of clinical trials have reached successful results that MSCs could enhance the wound healing process. However, the mechanism how MSCs affect the process and what is the most efficient way to apply cells to the wound still need to be investigated. Some novel cell-embedded patches are introduced in this study to keep the cells at the wound site. The GelMA-based wound healing patch can be fabricated on customization to any shape to meet the clinical needs through 3D printing technique. Most of the cells could survive for more than 12hrs under proper condition, which made the patch a promising product for clinical use in the near future.