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標題: | 功能性聚丙二醇-二腺嘌呤奈米顆粒性質研究 Functional nanoparticles of Poly(propylene glycol)-bis-Adenine |
作者: | Shun-Chieh Lee 李舜傑 |
指導教授: | 李篤中(Duu-Jong Lee) |
關鍵字: | 超分子,奈米顆粒,溫度感應,藥物輸送,聚丙二醇, supramolecular,nanoparticles,temperature-responsive,drug delivery,poly(propylene glycol), |
出版年 : | 2015 |
學位: | 碩士 |
摘要: | 本研究合成並純化有機高分子材料「聚丙二醇-二腺嘌呤」,並以核磁共振、質譜儀與凝膠滲透層析法確立其結構。掃描式與穿透式電子顯微鏡,以及動態雷射光散射技術顯示聚丙二醇-二腺嘌呤溶於水中會形成奈米顆粒,其平均粒徑約為100奈米。聚丙二醇-二腺嘌呤的臨界微胞濃度(CMC)以芘(pyrene)的螢光光譜決定,其結果為8×10^(-2) mg/mL。最低臨界溶解溫度(LCST)係以紫外光�可見光光譜儀測定,結果發現聚丙二醇-二腺嘌呤的最低臨界溶解溫度會隨其在水中濃度變化,且其在濃度越高時變化幅度越小。此材料最低臨界溶解溫度範圍涵蓋人體體溫。初步的藥物載入與釋放實驗顯示,此材料有很好的藥物包覆率與最低臨界溶解溫度附近快速的藥物釋放表現,有潛力作為標靶藥物傳輸之載體。 The polymer PPG-bis-adenine was synthesized and purified, and the chemical structure was characterized by NMR, mass spectroscopy, and chromatography. Scanning electron microscopy, transmission electron microscopy and dynamic light scattering showed the existence of nanoparticles formed by PPG-bis-adenine, and the mean diameter of nanoparticles was determined to be about 100 nm in aqueous solution. The critical aggregation concentration was determined using pyrene fluorescent emission and was determined to be around 8×10^(-2) mg/mL. The LCST behavior is studied using UV/Visible spectrophotometer. It is found that the LCST is concentration-dependent, and the variation of LCST is less significant at higher concentrations. The LCST range covers human body temperature. Preliminary drug loading and release experiments revealed good entrapment efficiency and instant release of drug at LCST phase change, showing potential of PPG-bis-adenine as a targeted drug carrier. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/4453 |
全文授權: | 同意授權(全球公開) |
顯示於系所單位: | 化學工程學系 |
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