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Title: | 醣類化合物之合成
1、2,5雙唾液酸之合成 2、利用歧化反應合成醣類化合物 Synthesis of Glyco-Conjugates 1. Synthesis of 2,5-Neuraminic acid dimer 2. Synthesis of Glyco-Conjugates via Olefin Metathesis |
Authors: | Gang-Ting Fan 范綱廷 |
Advisor: | 方俊民(Jim-Min Fang) |
Keyword: | 唾液酸,歧化反應,醣類, neuraminic acid,metathesis,c-linked,KRN7000,saccharide,ceramide,phytosphingosine, |
Publication Year : | 2004 |
Degree: | 博士 |
Abstract: | 本論文中,以探討不同類型醣類化合物的合成為主。在近年來,醣類化學逐漸受到重視,除了發現此類分子是細胞間作用的媒介之外,在藥物的開發上,也佔有很重要的地位。但在傳統的醣類合成上,受到反應條件嚴苛及選擇性的問題影響,以致許多含醣分子的合成較為困難,本論文即分別針對以醣類為主的數種化合物進行合成的改進。
在選擇的幾種醣類化合物中,有生物體內天然的醣類配位基,如海膽卵子表面的2,5聚唾液酸,此為受精作用中不可或缺的媒介,合成此2,5聚唾液酸利用一完全 In this thesis, new methods for the synthesis of several different types of glyco-conjugates were developed. The target including natural glyco-conjugated ligand, drug mimetic and derivatives. 2,5-neuraminic acid was chosen as the first target. This glycol-conjugate was a very important signal transductor during fertilization of the sea urchin. Here, an amide bond formation reaction was used to construct the 2,5-neuraminic acid dimer. By this method, glycosidic bond was formed through an exclusive |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/39435 |
Fulltext Rights: | 有償授權 |
Appears in Collections: | 化學系 |
Files in This Item:
File | Size | Format | |
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ntu-93-1.pdf Restricted Access | 1.42 MB | Adobe PDF |
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