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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 方俊民(Jim-Min Fang) | |
dc.contributor.author | Gang-Ting Fan | en |
dc.contributor.author | 范綱廷 | zh_TW |
dc.date.accessioned | 2021-06-13T17:28:27Z | - |
dc.date.available | 2004-10-19 | |
dc.date.copyright | 2004-10-19 | |
dc.date.issued | 2004 | |
dc.date.submitted | 2004-10-12 | |
dc.identifier.citation | 1.Stick, R. V., Carbohydrates: The sweet molecules of life. Academic Press, 2001.
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/39435 | - |
dc.description.abstract | 本論文中,以探討不同類型醣類化合物的合成為主。在近年來,醣類化學逐漸受到重視,除了發現此類分子是細胞間作用的媒介之外,在藥物的開發上,也佔有很重要的地位。但在傳統的醣類合成上,受到反應條件嚴苛及選擇性的問題影響,以致許多含醣分子的合成較為困難,本論文即分別針對以醣類為主的數種化合物進行合成的改進。
在選擇的幾種醣類化合物中,有生物體內天然的醣類配位基,如海膽卵子表面的2,5聚唾液酸,此為受精作用中不可或缺的媒介,合成此2,5聚唾液酸利用一完全 | zh_TW |
dc.description.abstract | In this thesis, new methods for the synthesis of several different types of glyco-conjugates were developed. The target including natural glyco-conjugated ligand, drug mimetic and derivatives.
2,5-neuraminic acid was chosen as the first target. This glycol-conjugate was a very important signal transductor during fertilization of the sea urchin. Here, an amide bond formation reaction was used to construct the 2,5-neuraminic acid dimer. By this method, glycosidic bond was formed through an exclusive | en |
dc.description.provenance | Made available in DSpace on 2021-06-13T17:28:27Z (GMT). No. of bitstreams: 1 ntu-93-D89223010-1.pdf: 1451311 bytes, checksum: b5b894781a870fc6037c693506eb9391 (MD5) Previous issue date: 2004 | en |
dc.description.tableofcontents | 目錄 i
圖目錄 iii 表目錄 iv 簡寫表 v 摘要 viii 第一章 2,5-聚唾液酸的合成 1 緒論 1 結果與討論 8 結論 14 第二章 利用Grubbs試劑合成C-Linked雙醣 15 緒論 15 結果與討論 21 結論 28 第三章 自然殺手T細胞活化劑及衍生物的合成 29 緒論 29 結果與討論 39 結論 62 論文總結論 63 實驗部份 64 參考文獻 125 | |
dc.language.iso | zh-TW | |
dc.title | 醣類化合物之合成
1、2,5雙唾液酸之合成 2、利用歧化反應合成醣類化合物 | zh_TW |
dc.title | Synthesis of Glyco-Conjugates
1. Synthesis of 2,5-Neuraminic acid dimer 2. Synthesis of Glyco-Conjugates via Olefin Metathesis | en |
dc.type | Thesis | |
dc.date.schoolyear | 93-1 | |
dc.description.degree | 博士 | |
dc.contributor.coadvisor | 林俊成(Chun-Cheng Lin) | |
dc.contributor.oralexamcommittee | 羅禮強(Lee-Chiang Lo),洪上程(Shang-Cheng Hung),林俊宏(Chun-Hung Lin),蔡蘊明(Yeun-Min Tsai) | |
dc.subject.keyword | 唾液酸,歧化反應,醣類, | zh_TW |
dc.subject.keyword | neuraminic acid,metathesis,c-linked,KRN7000,saccharide,ceramide,phytosphingosine, | en |
dc.relation.page | 134 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2004-10-13 | |
dc.contributor.author-college | 理學院 | zh_TW |
dc.contributor.author-dept | 化學研究所 | zh_TW |
顯示於系所單位: | 化學系 |
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