血液在表面張力驅動微流道內之分析

Abstract

在微小尺度下，表面張力的影響將逐漸增大，因此利用材料的親疏水特性製作的流道，使流體在流道內僅依靠表面張力前進，是近年來微流道領域內被廣為討論的方法，而本研究即血液在表面張力驅動的微流道中進行分析，期望能夠在生醫檢測領域得到較為實際的應用，在本文中，由於血液可以分成血漿及血球，而血液的流動機制，是由於血漿受到表面張力的驅動而帶動血球前進，因此將探討血液在流道內的表現並作出分析。在實驗中，發現由於血球比重大於血漿比重，改變流動的傾斜角度，可以發現流動速度亦隨著流動角度改變而變化，因此亦提出了進一步的分析，證明改變角度即改變系統中之黏滯項，確實影響了流體流動之結果。

In this article, surface tension driven blood flow in a microchannel with red blood cells (RBCs) aggregation resulting in the different viscosity by handling sloping condition has been studied. According to the non-homogeneous and non-Newtonian characteristics, the heavier RBCs are driven by surrounding lighter plasma with the effect of blood aggregation which is influenced by the ratio of gravity, viscosity and capillary force in a surface tension driven blood flow system. However, the capillary force and viscosity have been decided in fabrication process. By changing the slope, we found the gravity made a great impact on hematocrit ( volume percentage of cells), thus, the viscosity was changed.