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Title: | 生醫脈衝磁場刺激儀製作測試 Design and fabrication of pulsed magnetic field stimulation device for biomedical applications |
Authors: | Chain-An Chen 陳建安 |
Advisor: | 傅昭銘(Chao-Ming Fu) |
Keyword: | 跨顱磁刺激,線圈設計,荷姆霍茲形線圈,脈衝磁場製作,磁場模擬,磁刺激神經, Transcranial magnetic stimulation,Coil design,Pulsed magnetic field fabrication,Magnetic field simulation,Nerve magnetic stimulation, |
Publication Year : | 2012 |
Degree: | 碩士 |
Abstract: | 脈衝磁場在生物醫學領域有許多的應用,其中一個重要的應用為跨顱磁刺激
(transcranial magnetic stimulation, TMS),是利用瞬間電流產生脈衝磁場,而磁場在 腦部、神經與肌肉等特定部位產生感應電場刺激,是一項非侵入式刺激技術,可 應用於認知心理學、神經科學以及精神疾病的治療研究。目前已有許多研究與治 療方式持續發展,然而目前常使用的TMS 刺激的深度大約為1.5~3 公分,大腦有 許多部位無法刺激到,為了刺激更深的部位,設計刺激距離更長的跨顱磁刺激是 一個重要的課題。 本研究利用電腦模擬不同形狀參數的荷姆霍茲形線圈的磁場與感應電場分 布,找出適合的線圈形狀,本研究亦實際製作線圈與脈衝磁場產生裝置並量測磁 場分布與感應電場分布。本研究製作的脈衝磁場裝置,感應電場隨刺激距離衰減 率約為傳統八字形線圈的30%,因此可以將刺激距離提高到7cm 以上。本研究亦 利用自製裝置實際應用在刺激牛蛙坐骨神經,使之產生肌肉抽動與量測到神經訊 號。本研究未來可應用在大腦深刺激的研究。 Transcranial magnetic stimulation (TMS) is an application of Pulsed magnetic field in the biomedical field. TMS is using the pulse magnetic field induce a electric field in the specific parts of the brain, nerve and muscle. Induced electric field stimulation is a non-invasive stimulation techniques can be applied to the study of cognitive psychology, neuroscience and mental illness treatment. At present, many research and treatment of sustainable development, however, the depth of to stimulate of currently TMS Equipment is about 1.5 to 3 cm. Designed a longer distances stimulate in order to stimulate the deeper parts is an important issue. This study use the computer to simulate the magnetic field and the induced electric field distribution of different shape parameters of helmholtz coil, and fabricate a pulse magnetic field generate device and measured the magnetic field distribution and the induced electric field distribution of the home-made pulsed magnetic field devices. The induced electric field decay rate vary with the stimulus distance is less than the typical 8-figur coil, and the stimulation distance is more 7 cm. This study use the home-made device to stimulate the bullfrog sciatic nerve, then observe a muscle twitch and measure the nerve signals. This study can be applied to the study of the deep brain stimulation. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/15922 |
Fulltext Rights: | 未授權 |
Appears in Collections: | 物理學系 |
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File | Size | Format | |
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ntu-101-1.pdf Restricted Access | 16.2 MB | Adobe PDF |
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