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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 傅昭銘(Chao-Ming Fu) | |
dc.contributor.author | Chain-An Chen | en |
dc.contributor.author | 陳建安 | zh_TW |
dc.date.accessioned | 2021-06-07T17:55:30Z | - |
dc.date.copyright | 2012-08-17 | |
dc.date.issued | 2012 | |
dc.date.submitted | 2012-08-15 | |
dc.identifier.citation | [1] Thompson, S. P. (1910). A Physiological Effect of an Alternating Magnetic Field. Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character, 82(557), 396-398.
[2] Kolin, A., Brill, N. Q., Broberg, P. J. (1959). Stimulation of Irritable Tissues by Means of an Alternating Magnetic Field. Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 102(1), 251-253. [3] Polson, M., Barker, A., Freeston, I. (1982). Stimulation of nerve trunks with time-varying magnetic fields. Medical and Biological Engineering and Computing, 20(2), 243-244. [4] AT, B. (1985). Non-invasive magnetic stimulation of the human motor cortex. Lancet, 1, 1106-1107. [5] Ueno, S., Tashiro, T., Harada, K. (1988). Localized stimulation of neural tissues in the brain by means of a paired configuration of time-varying magnetic fields. Journal of Applied Physics, 64(10), 5862-5864. [6] Epstein, C. M., Sekino, M., Yamaguchi, K., Kamiya, S., Ueno, S. (2002). Asymmetries of prefrontal cortex in human episodic memory: effects of transcranial magnetic stimulation on learning abstract patterns. Neuroscience Letters, 320(1–2), 5-8. [7] Ilmoniemi, R. J., Ruohonen, J., Karhu, J. (1999). Transcranial magnetic stimulation--a new tool for functional imaging of the brain. Critical reviews in biomedical engineering, 27(3-5), 241-284. [8] Iramina, K., Maeno, T., Ueno, S. (2004). Topography of EEG responses evoked by transcranial magnetic stimulation to the cerebellum. Magnetics, IEEE Transactions on, 40(4), 2982-2984. [9] Iwahashi, M., Koyama, Y., Hyodo, A., Hayami, T., Ueno, S., Iramina, K. (2009). Measurements of evoked electroencephalograph by transcranial magnetic stimulation applied to motor cortex and posterior parietal cortex. Journal of Applied Physics, 105(7), 07B321-307B321-323. [10] O’Reardon, J. P., Solvason, H. B., Janicak, P. G., Sampson, S., Isenberg, K. E., Nahas, Z., Sackeim, H. A. (2007). Efficacy and Safety of Transcranial Magnetic Stimulation in the Acute Treatment of Major Depression: A Multisite Randomized Controlled Trial. Biological Psychiatry, 62(11), 1208-1216. [11] Elahi, B., Elahi, B., Chen, R. (2009). Effect of transcranial magnetic stimulation on Parkinson motor function—Systematic review of controlled clinical trials. Movement Disorders, 24(3), 357-363. [12] Ogiue-Ikeda, M., Kawato, S., Ueno, S. (2003). The effect of repetitive transcranial magnetic stimulation on long-term potentiation in rat hippocampus depends on stimulus intensity. Brain Research, 993(1–2), 222-226. [13] Ogiue-Ikeda, M., Kawato, S., Ueno, S. (2005). Acquisition of ischemic tolerance by repetitive transcranial magnetic stimulation in the rat hippocampus. Brain Research, 1037(1–2), 7-11. [14] Ueno, S. (2012). Studies on magnetism and bioelectromagnetics for 45 years: From magnetic analog memory to human brain stimulation and imaging. Bioelectromagnetics, 33(1), 3-22. [15] Yamaguchi, S., Ogiue-Ikeda, M., Sekino, M., Ueno, S. (2004). The effect of repetitive magnetic stimulation on the tumor development. Magnetics, IEEE Transactions on, 40(4), 3021-3023. [16] Yamaguchi, S., Ogiue-Ikeda, M., Sekino, M., Ueno, S. (2005). Effects of magnetic stimulation on tumors and immune functions. Magnetics, IEEE Transactions on, 41(10), 4182-4184. [17] Yamaguchi, S., Ogiue-Ikeda, M., Sekino, M., Ueno, S. (2006). Effects of pulsed magnetic stimulation on tumor development and immune functions in mice. Bioelectromagnetics, 27(1), 64-72. [18] Ogiue-Ikeda, M., Sato, Y., Ueno, S. (2003). A new method to destruct targeted cells using magnetizable beads and pulsed magnetic force. NanoBioscience, IEEE Transactions on, 2(4), 262-265. [19] Fujishiro, T., Enomoto, H., Ugawa, Y., Takahashi, S., Ueno, S., Kitamura, T. (2000). Magnetic stimulation on the sacral roots for the treatment of stress incontinence: An investigational study and placebo controlled trial. The Journal of Urology, 164(4), 1277-1279. [20] Fujishiro, T., Takahashi, S., Enomoto, H., Ugawa, Y., Ueno, S., Kitamura, T. (2002). Magnetic Stimulation of the Sacral Roots for the Treatment of Urinary Frequency and Urge Incontinence: An Investigational Study and Placebo Controlled Trial. The Journal of Urology, 168(3), 1036-1039. [21] Hong, B., Kuwaki, T., Ju, K., Kumada, M., Akai, M., Ueno, S. (2002). Changes in blood pressure and heart rate by repetitive transcranial magnetic stimulation in rats. Neuroscience Letters, 329(1), 57-60. [22] Thielscher, A., Kammer, T. (2004). Electric field properties of two commercial figure-8 coils in TMS: calculation of focality and efficiency. Clinical Neurophysiology, 115(7), 1697-1708. [23] Peterchev, A. V., Jalinous, R., Lisanby, S. H. (2008). A Transcranial Magnetic Stimulator Inducing Near-Rectangular Pulses With Controllable Pulse Width (cTMS). Biomedical Engineering, IEEE Transactions on, 55(1), 257-266. [24] Salinas, F. S., Lancaster, J. L., Fox, P. T. (2007). Detailed 3D models of the induced electric field of transcranial magnetic stimulation coils. Physics in Medicine and Biology, 52(10), 2879. [25] Luquet, S., Barra, V., Lemaire, J. J. (2005, 17-18 Jan. 2006). Transcranial Magnetic Stimulation : Magnetic Field Computation in empty free space. Paper presented at the Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference of the. [26] Guizhi, X., Yong, C., Shuo, Y., Mingshi, W., Weili, Y. (2005, 17-18 Jan. 2006). The Optimal Design of Magnetic Coil in Transcranial Magnetic Stimulation. Paper presented at the Engineering in Medicine and Biology Society, 2005. IEEE-EMBS 2005. 27th Annual International Conference. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/15922 | - |
dc.description.abstract | 脈衝磁場在生物醫學領域有許多的應用,其中一個重要的應用為跨顱磁刺激
(transcranial magnetic stimulation, TMS),是利用瞬間電流產生脈衝磁場,而磁場在 腦部、神經與肌肉等特定部位產生感應電場刺激,是一項非侵入式刺激技術,可 應用於認知心理學、神經科學以及精神疾病的治療研究。目前已有許多研究與治 療方式持續發展,然而目前常使用的TMS 刺激的深度大約為1.5~3 公分,大腦有 許多部位無法刺激到,為了刺激更深的部位,設計刺激距離更長的跨顱磁刺激是 一個重要的課題。 本研究利用電腦模擬不同形狀參數的荷姆霍茲形線圈的磁場與感應電場分 布,找出適合的線圈形狀,本研究亦實際製作線圈與脈衝磁場產生裝置並量測磁 場分布與感應電場分布。本研究製作的脈衝磁場裝置,感應電場隨刺激距離衰減 率約為傳統八字形線圈的30%,因此可以將刺激距離提高到7cm 以上。本研究亦 利用自製裝置實際應用在刺激牛蛙坐骨神經,使之產生肌肉抽動與量測到神經訊 號。本研究未來可應用在大腦深刺激的研究。 | zh_TW |
dc.description.abstract | Transcranial magnetic stimulation (TMS) is an application of Pulsed magnetic field in the biomedical field. TMS is using the pulse magnetic field induce a electric field in the specific parts of the brain, nerve and muscle. Induced electric field stimulation is a non-invasive stimulation techniques can be applied to the study of cognitive psychology, neuroscience and mental illness treatment. At present, many research and treatment of sustainable development, however, the depth of to stimulate of currently TMS Equipment is about 1.5 to 3 cm. Designed a longer distances stimulate in order to stimulate the deeper parts is an important issue.
This study use the computer to simulate the magnetic field and the induced electric field distribution of different shape parameters of helmholtz coil, and fabricate a pulse magnetic field generate device and measured the magnetic field distribution and the induced electric field distribution of the home-made pulsed magnetic field devices. The induced electric field decay rate vary with the stimulus distance is less than the typical 8-figur coil, and the stimulation distance is more 7 cm. This study use the home-made device to stimulate the bullfrog sciatic nerve, then observe a muscle twitch and measure the nerve signals. This study can be applied to the study of the deep brain stimulation. | en |
dc.description.provenance | Made available in DSpace on 2021-06-07T17:55:30Z (GMT). No. of bitstreams: 1 ntu-101-R98222078-1.pdf: 16587250 bytes, checksum: c545fcead42086d0ec4d9747bba41a48 (MD5) Previous issue date: 2012 | en |
dc.description.tableofcontents | 口試委員會審定書 #
誌謝 i 中文摘要 ii ABSTRACT iii CONTENTS iv LIST OF FIGURES vii Chapter 1 前言 1 1.1 脈衝磁場在生醫領域的應用 1 1.1.1 刺激神經相關研究……….. 1 1.1.2 非刺激神經的研究 3 1.1.3 目前常用TMS的規格 4 1.2 研究動機與目的 6 1.2.1 研究動機 6 1.2.2 研究目的 8 Chapter 2 基本原理 9 2.1 充放電電路分析 10 2.1.1 充電階段 10 2.1.2 放電階段 11 2.2 磁場與感應電場 17 2.3 動作電位 18 2.3.1 靜止膜電位 20 2.3.2 細胞膜等效電路 21 2.4 差動放大器 21 Chapter 3 電腦模擬與裝置製作 24 3.1 以電腦模擬最佳線圈形狀 24 3.1.1 參數介紹 24 3.1.2 形狀參數與表現參數的關係 27 3.2 電路部份 30 3.2.1 變壓器 31 3.2.2 橋式整流器 32 3.2.3 電容 33 3.2.4 開關 34 3.2.5 阻尼電阻與二極體 36 3.2.6 電壓測量 37 3.3 線圈部份 38 3.4 神經訊號擷取裝置 40 3.4.1 載台支架 41 3.4.2 載台與屏蔽裝置 42 3.4.3 差動放大電路 47 3.4.4 訊號紀錄 49 Chapter 4 結果與討論 50 4.1 電路狀態 50 4.2 磁場與感應電場分佈 50 4.3 神經訊號 53 Chapter 5 結論 56 5.1 結論 56 5.2 未來展望 56 REFERENCE 58 | |
dc.language.iso | zh-TW | |
dc.title | 生醫脈衝磁場刺激儀製作測試 | zh_TW |
dc.title | Design and fabrication of pulsed magnetic field stimulation device for biomedical applications | en |
dc.type | Thesis | |
dc.date.schoolyear | 100-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 張富雄(Fu-Hsiung Chang),符文美(Wen-Mei Fu) | |
dc.subject.keyword | 跨顱磁刺激,線圈設計,荷姆霍茲形線圈,脈衝磁場製作,磁場模擬,磁刺激神經, | zh_TW |
dc.subject.keyword | Transcranial magnetic stimulation,Coil design,Pulsed magnetic field fabrication,Magnetic field simulation,Nerve magnetic stimulation, | en |
dc.relation.page | 61 | |
dc.rights.note | 未授權 | |
dc.date.accepted | 2012-08-16 | |
dc.contributor.author-college | 理學院 | zh_TW |
dc.contributor.author-dept | 物理研究所 | zh_TW |
顯示於系所單位: | 物理學系 |
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