以脂筏啟發之分子異質性實現具功能性與結構複雜度之Frank-Kasper相

Abstract

在超分子化學中，有序軟物質具更高的結構複雜度時可賦予其新興之功能。為了構築具備結構複雜性與功能性的 Frank–Kasper（FK）相，本研究導入類似脂筏（lipid raft）概念的異質性，將剛性芳香族樹枝狀分子（Ar2）與柔性脂肪族樹枝狀分子（D2）進行摻合。此策略可保持 FK σ 相晶格之長程週期性，並同時產生具表面凹陷結構的膠束。這些凹陷區域猶如酵素的活性口袋，能容納客體分子並促進其進行光二聚化反應。結構分析證實，該設計能提升階層性架構的複雜度，並展現可調控的催化表現。此研究提供一項多功能策略，用以設計兼具分子辨識、超分子精準組裝與催化功能的 FK 相有序材料。

In supramolecular chemistry, higher structural complexity enables emergent functions in ordered soft matter. To construct structurally complex and functional Frank–Kasper (FK) phases, lipid raft–inspired heterogeneity is introduced by blending rigid aromatic dendrons (Ar2) with flexible aliphatic dendrons (D2). This approach creates micelles with surface concavities while preserving long-range periodicity of the FK σ lattice. The concave domains serve as enzyme-like pockets that accommodate guest molecules and facilitate photo-dimerization reactions. Structural analyses confirm that these features enhance complexity in hierarchical architecture and enable tunable catalytic performance. This work presents a versatile strategy for designing FK phases that integrate molecular recognition, supramolecular precision, and catalytic function within an ordered framework.