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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 薛景中 | zh_TW |
| dc.contributor.advisor | Jing-Jong Shyue | en |
| dc.contributor.author | 鄭舒勻 | zh_TW |
| dc.contributor.author | Shu-Yun Cheng | en |
| dc.date.accessioned | 2025-08-21T16:08:28Z | - |
| dc.date.available | 2025-08-22 | - |
| dc.date.copyright | 2025-08-21 | - |
| dc.date.issued | 2025 | - |
| dc.date.submitted | 2025-07-31 | - |
| dc.identifier.citation | Deblase, C. R.; Dichtel, W. R. Moving Beyond Boron: The Emergence of New Linkage Chemistries in Covalent Organic Frameworks. Macromolecules 2016, 49 (15), 5297–5305. https://doi.org/10.1021/acs.macromol.6b00891.
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/99036 | - |
| dc.description.abstract | 共價有機框架（Covalent Organic Frameworks, COFs）為一種新型有機多孔材料，其有著結構清楚明確、可調性孔洞、比表面積大、穩定性高等特性，再加上碳、氧、氫、氮等輕元素之間具有穩固的強共價鍵，因而在能量儲存與轉換、光電元件、氣體分離、感應器、催化、藥物傳輸等領域有著廣泛的應用，在這些應用中，了解吸附和脫附的行為是COFs成功的關鍵。
本實驗採用界面聚合法將作為反應物的三甲醯間苯三酚（2,4,6-Triformylphloroglucinol, TFP）和三(4-胺基苯基)胺（Tris(4-aminophenyl)amine, TAPA）合成為β-酮烯胺（β-Ketoenamine-linked）連接的COF薄膜。利用掃描式電子顯微鏡（SEM）、原子力顯微鏡（AFM）、傅立葉轉換紅外線光譜儀（FTIR）、界面電位分析儀等方式對TAPA-TFP薄膜進行表徵，以了解其形貌、厚度、結構及界面電位。並利用能量消散型石英晶體微天平（QCM-D）的高質量靈敏度，連續記錄共振頻率和能量消散的變化，以研究小分子客體在不同pH值水溶液中的吸附與脫附行為。 將大約17.5 nm的獨立TAPA-TFP薄膜直接轉移到石英晶片上以形成穩定且均勻的塗層，選取磷酸鹽緩衝生理鹽水（Phosphate buffered saline, PBS）溶液作為本實驗的背景溶液，並分別通入酸性及鹼性的PBS溶液，得知TAPA-TFP薄膜在pH 6 – pH 3能有穩定結構，後續選擇咖啡因作為本次實驗的客體分子，將晶片暴露於含有咖啡因的緩衝溶液中，發現隨著pH值越小，QCM-D收取之資料變化顯示可逆的質量減少，結構會從通入藥物溶液後造成的鬆散再變得緻密，因而擠壓出咖啡因溶液。 | zh_TW |
| dc.description.abstract | Covalent organic frameworks (COFs) are a kind of emerging porous crystalline material, which have well-defined structure, tunable pore size, large specific surface area, high stability with robust covalent bonds between light elements of C, O, H, and N. As a result, they can be applied in energy storage and conversion, optoelectronics, gas separation, sensors, catalysis, drug delivery, etc. For these applications, the adsorption and desorption behaviors are key to their success.
In this work, the β-ketoenamine-linked COF synthesized from 2,4,6-triformylphloroglucinol (TFP) and tris(4-aminophenyl)amine (TAPA) film was prepared with interfacial polymerization. The TFP-TAPA film was characterized by SEM, AFM, FTIR, Zeta Potential Analyzer to identify its morphology, thickness, structure and zeta potential. For its high weight sensitivity, quartz-crystal microbalance with dissipation detection (QCM-D) was used for investigating the adsorption and desorption behaviors of small molecular guests in aqueous solution of different pHs. Approximate 17.5 nm thick standalone TFP-TAPA film was transferred to quartz crystal chip directly to form a stable and uniform coating. Using phosphate buffered saline (PBS) as the blank buffer, and the film was exposed to acidic and alkaline PBS solutions respectively. It was found that TAPA-TFP film can have a stable structure between pH 6 to 3. Subsequently, the chip was exposed to a buffer solution containing caffeine between pH 6 to 3. It was found that as the pH value decreased, the data collected by QCM-D showed a reversible mass reduction. The result reflected the structure would change from loose to dense, and some of the caffeine solution was lose from the film. | en |
| dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2025-08-21T16:08:28Z No. of bitstreams: 0 | en |
| dc.description.provenance | Made available in DSpace on 2025-08-21T16:08:28Z (GMT). No. of bitstreams: 0 | en |
| dc.description.tableofcontents | 誌謝 i
中文摘要 ii 英文摘要 iii 目次 v 圖次 viii 表次 xi 第一章 緒論 1 第二章 文獻回顧 3 2.1 共價有機框架簡介 3 2.1.1 共價有機框架（COFs）合成 5 2.1.1.1 溶劑熱法 Solvothermal Synthesis 6 2.1.1.2 微波輔助溶劑熱法 Microwave-assisted Solvothermal Synthesis 7 2.1.1.3 機械化學合成 Mechanochemical Synthesis 8 2.1.1.4 界面合成 Interfacial Synthesis 9 2.1.2 共價有機框架（COFs）結構與性質 11 2.1.2.1 含硼COFs 11 2.1.2.2 基於三嗪的COFs（Triazine‐based COFs） 11 2.1.2.3 亞胺鍵連接的COFs（Imine‐linked COFs） 12 2.1.2.4 醯亞胺鍵連接的COFs（Imide‐linked COFs） 14 2.1.2.5 β-酮烯胺連接的COFs（β-Ketoenamine-linked COFs） 14 2.1.3 共價有機框架（COFs）後修飾 16 2.1.4 TAPA-TFP簡介 19 2.2 石英晶體微天平於共價有機框架之研究 20 2.2.1 氣體感測 21 2.2.2 液相環境之QCM分析 23 2.2.3 以QCM監測COFs薄膜生長 24 第三章 實驗與儀器介紹 27 3.1 藥品與基材 27 3.2 實驗儀器與原理 28 3.2.1 掃描式電子顯微鏡（Scanning Electron Microscope, SEM） 28 3.2.2 原子力顯微鏡（Atomic Force Microscope, AFM） 29 3.2.3 傅立葉轉換紅外光譜儀（Fourier-transform infrared spectroscopy, FTIR） 30 3.2.4 界面電位分析儀（Zeta Potential Analyzer）55–58 31 3.2.5 能量消散型石英晶體微天平（Quartz Crystal Microbalance with Dissipation, QCM-D） 35 3.3 實驗流程 40 3.3.1 TAPA-TFP的合成 40 3.3.2 試片製備 41 3.3.3 SEM影像觀測 43 3.3.4 AFM量測 44 3.3.5 FT-IR量測 44 3.3.6 界面電位量測 44 3.3.7 QCM-D量測 45 第四章 實驗結果與討論 47 4.1 TAPA-TFP的合成 47 4.2 TAPA-TFP薄膜的厚度調整與鍍金矽基板的貼合 48 4.3 TAPA-TFP薄膜的FT-IR分析 51 4.4 TAPA-TFP薄膜的AFM分析 52 4.5 TAPA-TFP於不同環境pH值的界面電位 54 4.6 QCM-D分析 54 4.6.1 背景溶液的選擇 55 4.6.2 環境pH值 58 4.6.3 藥物吸附與脫附 64 4.6.3.1 阿斯匹靈 64 4.6.3.2 咖啡因 67 第五章 結論 72 第六章 參考文獻 74 | - |
| dc.language.iso | zh_TW | - |
| dc.subject | TAPA-TFP | zh_TW |
| dc.subject | 共價有機框架 | zh_TW |
| dc.subject | 脫附 | zh_TW |
| dc.subject | 吸附 | zh_TW |
| dc.subject | 能量消散型石英晶體微天平 | zh_TW |
| dc.subject | QCM-D | en |
| dc.subject | Absorption | en |
| dc.subject | Desorption | en |
| dc.subject | TAPA-TFP | en |
| dc.subject | Covalent organic frameworks (COFs) | en |
| dc.title | 能量消散型石英晶體微天平對於共價有機框架在水相環境中藥物客體吸脫附過程之研究 | zh_TW |
| dc.title | Quartz crystal microbalance with dissipation detection (QCM-D) studies of adsorption/desorption processes of guests in covalent organic frameworks (COFs) in aqueous environments | en |
| dc.type | Thesis | - |
| dc.date.schoolyear | 113-2 | - |
| dc.description.degree | 碩士 | - |
| dc.contributor.oralexamcommittee | 林煒淳;王榮輝 | zh_TW |
| dc.contributor.oralexamcommittee | Wei-Chun Lin;Jung-Hui Wang | en |
| dc.subject.keyword | 共價有機框架,TAPA-TFP,能量消散型石英晶體微天平,吸附,脫附, | zh_TW |
| dc.subject.keyword | Covalent organic frameworks (COFs),TAPA-TFP,QCM-D,Absorption,Desorption, | en |
| dc.relation.page | 84 | - |
| dc.identifier.doi | 10.6342/NTU202502775 | - |
| dc.rights.note | 同意授權(限校園內公開) | - |
| dc.date.accepted | 2025-08-05 | - |
| dc.contributor.author-college | 工學院 | - |
| dc.contributor.author-dept | 材料科學與工程學系 | - |
| dc.date.embargo-lift | 2030-07-30 | - |
| 顯示於系所單位： | 材料科學與工程學系 | |
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