氣相多孔高分子材料中的多相分子運輸在生醫領域中的應用

Abstract

多孔材料的優越性能和廣泛應用前景，結合先進的製程技術及環保需求，使其具有極佳的發展潛力。本研究中探討了在生物醫學領域中，利用氣相製程製備的多孔聚合物的發展及應用，在這之中特別針對多相分子運輸進行深入了解。透過獨特的氣相昇華和沉積技術 (Chemical Vapor Deposition, CVD)，我們製造出了具有連通孔洞的宏孔材料Parylene C支架，並評估其在多重藥物釋放裝置以及過濾裝置應用上中的潛力。對於多重藥物釋放裝置，我們利用嵌入聚乳酸-甘醇酸(Poly(lactic-co-glycolic acid), PLGA) 微粒的Parylene C支架，並使用染料做為模擬的釋放分子，實現了多重藥物的控制和持續釋放。不僅如此，也透過Parylene C鍍膜技術搭載多孔Parylene C支架，實現了藥物的持續釋放。除此之外，我們還透過鎳鈦合金管搭載多孔Parylene C鍍膜，建構出一個過濾裝置，並評估其過濾懸浮液的過濾效率，以利後續進行生物體內的組織液蒐集應用。在本篇研究中指出，多孔Parylene C支架在多重藥物釋放系統以及生物醫學應用中的過濾程序中具有極佳的多功能性及有效性。

The superior performance and wide application prospects of porous materials make their development prospects very promising. This study explores the development and application of the vapor-fabricated interconnected macroporous material, Parylene C, in biomedical fields, focusing on multiphasic molecular transport. The material, which was fabricated by using the chemical vapor deposition (CVD) process, was evaluated for its potential in multiple drug release devices and filtration applications. The multiple drug release device was constructed using a Parylene C scaffold embedded with PLGA microparticles, enabling the controlled and sustained release of multiple drugs with dyes as simulated released molecules. Moreover, a sustained drug release device was fabricated with dense Parylene C film coating on the porous Parylene C scaffold. In addition, a filtration device that corresponds to porous Parylene C coating on the nitinol tube was also developed and tested for its efficiency in filtering suspension fluids. The research demonstrates the versatility and effectiveness of Parylene C in enhancing multiple drug release systems, sustained drug release systems, and filtration processes in biomedical applications.