請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/95190完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 陳賢燁 | zh_TW |
| dc.contributor.advisor | Hsien-Yeh Chen | en |
| dc.contributor.author | 林奕維 | zh_TW |
| dc.contributor.author | Yi-Wei Lin | en |
| dc.date.accessioned | 2024-08-29T16:31:34Z | - |
| dc.date.available | 2024-08-30 | - |
| dc.date.copyright | 2024-08-29 | - |
| dc.date.issued | 2024 | - |
| dc.date.submitted | 2024-07-11 | - |
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Separation and Purification Technology, 2018. 207: p. 443-450. | - |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/95190 | - |
| dc.description.abstract | 多孔材料的優越性能和廣泛應用前景，結合先進的製程技術及環保需求，使其具有極佳的發展潛力。本研究中探討了在生物醫學領域中，利用氣相製程製備的多孔聚合物的發展及應用，在這之中特別針對多相分子運輸進行深入了解。透過獨特的氣相昇華和沉積技術 (Chemical Vapor Deposition, CVD)，我們製造出了具有連通孔洞的宏孔材料Parylene C支架，並評估其在多重藥物釋放裝置以及過濾裝置應用上中的潛力。對於多重藥物釋放裝置，我們利用嵌入聚乳酸-甘醇酸(Poly(lactic-co-glycolic acid), PLGA) 微粒的Parylene C支架，並使用染料做為模擬的釋放分子，實現了多重藥物的控制和持續釋放。不僅如此，也透過Parylene C鍍膜技術搭載多孔Parylene C支架，實現了藥物的持續釋放。除此之外，我們還透過鎳鈦合金管搭載多孔Parylene C鍍膜，建構出一個過濾裝置，並評估其過濾懸浮液的過濾效率，以利後續進行生物體內的組織液蒐集應用。在本篇研究中指出，多孔Parylene C支架在多重藥物釋放系統以及生物醫學應用中的過濾程序中具有極佳的多功能性及有效性。 | zh_TW |
| dc.description.abstract | The superior performance and wide application prospects of porous materials make their development prospects very promising. This study explores the development and application of the vapor-fabricated interconnected macroporous material, Parylene C, in biomedical fields, focusing on multiphasic molecular transport. The material, which was fabricated by using the chemical vapor deposition (CVD) process, was evaluated for its potential in multiple drug release devices and filtration applications. The multiple drug release device was constructed using a Parylene C scaffold embedded with PLGA microparticles, enabling the controlled and sustained release of multiple drugs with dyes as simulated released molecules. Moreover, a sustained drug release device was fabricated with dense Parylene C film coating on the porous Parylene C scaffold. In addition, a filtration device that corresponds to porous Parylene C coating on the nitinol tube was also developed and tested for its efficiency in filtering suspension fluids. The research demonstrates the versatility and effectiveness of Parylene C in enhancing multiple drug release systems, sustained drug release systems, and filtration processes in biomedical applications. | en |
| dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2024-08-29T16:31:34Z No. of bitstreams: 0 | en |
| dc.description.provenance | Made available in DSpace on 2024-08-29T16:31:34Z (GMT). No. of bitstreams: 0 | en |
| dc.description.tableofcontents | 口試委員會審定書 I
摘要 II Abstract III Contents IV List of Figures VI List of Tables VIII Chapter 1 Introduction 1 1.1 Macroporous Materials 1 1.2 Parylene 3 1.3 Multiple Drug Release Device 6 1.4 Interstitial Fluid Collection 8 Chapter 2 Material and Methods 12 2.1 Principles of Multiple Drug Release Device Fabrication 12 2.2 Principles of Sustained Drug Release Device Fabrication 13 2.3 Principles of Filtration Device Fabrication 14 Chapter 3 Experimental Section 16 3.1 Analytical Instruments and Material Characterizations 16 3.1.1 Optical Microscope 16 3.1.2 Fluorescence Microscope 16 3.1.3 Scanning Electron Microscope 16 3.1.4 Laser Scanning Confocal Microscope 17 3.1.5 UV-vis spectrophotometer 17 3.1.6 3D Laser Confocal Microscope 17 3.1.7 Mercury Intrusion Porosimeter 18 3.1.8 Particle Size Analyzer by Dynamic Light Scattering Method 18 3.1.9 Fourier Transform Infrared Spectroscopy (ATR) 18 3.1.10 Contact Angle Goniometer 19 3.2 Multiple Drug Release Device 19 3.2.1 Materials 19 3.2.2 Double Emulsion of PLGA Microparticles 20 3.2.3 Multiple Drug Release Device Fabrications 21 3.2.4 Multiple Drug Release Device for Fluorescence Observation 22 3.2.5 Drug Release Experiment 23 3.3 Sustained Drug Release Device 24 3.3.1 Materials 24 3.3.2 Sustained Drug Release Device Fabrications 24 3.3.3 Drug Release Experiments 25 3.4 Filtration Device 26 3.4.1 Materials 26 3.4.2 Porous Filtration Device Fabrication 26 3.4.3 In-vitro Filtration Efficiency Evaluation 28 3.4.4 Hydrophilic Modification of the Filtration Device 28 Chapter 4 Results and Discussion 30 4.1 Multiple Drug Release Device 30 4.1.1 Characteristics of the Multiple Drug Release Device 30 4.1.2 Release Profiles of the Multiple Drug Release Device 34 4.2 Sustained Drug Release Device 42 4.2.1 Characteristics of the Sustained Drug Release Device 42 4.2.2 Release Profiles of the Sustained Drug Release Device 43 4.3 Filtration Device 45 4.3.1 Filtration Efficiency of the Filtration Device 45 4.3.2 Hydrophilic Modification of the Filtration Device 54 Chapter 5 Conclusion 65 5.1 Recent Study Conclusion 65 5.2 Future Work 66 References 68 | - |
| dc.language.iso | en | - |
| dc.subject | 宏孔材料 | zh_TW |
| dc.subject | 聚一氯對二甲苯 | zh_TW |
| dc.subject | 化學氣相沉積 | zh_TW |
| dc.subject | 多重藥物釋放裝置 | zh_TW |
| dc.subject | 藥物緩釋裝置 | zh_TW |
| dc.subject | 過濾裝置 | zh_TW |
| dc.subject | sustained drug release device | en |
| dc.subject | macroporous material | en |
| dc.subject | Parylene C | en |
| dc.subject | multiple drug release device | en |
| dc.subject | filtration device | en |
| dc.subject | chemical vapor deposition (CVD) | en |
| dc.title | 氣相多孔高分子材料中的多相分子運輸在生醫領域中的應用 | zh_TW |
| dc.title | Multiphasic Molecular Transport in Vapor-Fabricated Porous Polymers for Biomedical Applications | en |
| dc.type | Thesis | - |
| dc.date.schoolyear | 112-2 | - |
| dc.description.degree | 碩士 | - |
| dc.contributor.oralexamcommittee | 吳俊吉;劉定宇 | zh_TW |
| dc.contributor.oralexamcommittee | Chen-Chi Wu;Ting-Yu Liu | en |
| dc.subject.keyword | 宏孔材料,聚一氯對二甲苯,化學氣相沉積,多重藥物釋放裝置,藥物緩釋裝置,過濾裝置, | zh_TW |
| dc.subject.keyword | macroporous material,Parylene C,chemical vapor deposition (CVD),multiple drug release device,sustained drug release device,filtration device, | en |
| dc.relation.page | 73 | - |
| dc.identifier.doi | 10.6342/NTU202401629 | - |
| dc.rights.note | 同意授權(全球公開) | - |
| dc.date.accepted | 2024-07-12 | - |
| dc.contributor.author-college | 工學院 | - |
| dc.contributor.author-dept | 化學工程學系 | - |
| 顯示於系所單位： | 化學工程學系 | |
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