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DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 邵耀華 | zh_TW |
dc.contributor.advisor | Yio-Wha Shau | en |
dc.contributor.author | 蕭聖洋 | zh_TW |
dc.contributor.author | Sheng-Yang Xiao | en |
dc.date.accessioned | 2023-08-15T16:24:04Z | - |
dc.date.available | 2023-11-09 | - |
dc.date.copyright | 2023-08-15 | - |
dc.date.issued | 2023 | - |
dc.date.submitted | 2023-08-01 | - |
dc.identifier.citation | 衛服部統計處,111年國人死因統計結果,2023.06, https://www.mohw.gov.tw/cp-16-74869-1.html
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/88459 | - |
dc.description.abstract | 本研究主要分為離心清洗系統與量測系統兩大部分。量測系統使用雷射作為光源,並使用光敏電阻作為光接收器,利用稜鏡分光特性和光學原理的應用,透過Snell’s law與Beer’s law的轉換,將電訊號同時轉換為具有物理意義的濃度與密度量測值,提供非接觸式量測動態管流的功能。同時,使用自製的逆流離心系統,將培養基替代品之8%鹽水與細胞替代品PS聚苯乙烯塑膠微粒混合,模擬細胞收穫流程進行分離與清洗。最後將兩者結合,使用量測系統來動態監測鹽水稀釋濃度。研究結果顯示本系統的動態濃度量測結果最大誤差為15%,但在稀釋過程中會逐漸減小。當稀釋濃度降為目標濃度時,誤差為3.1%。使用圓管量測折射率時,根據入射角的不同產生的光學現象,折射率最大誤差為13.5%。但最終本系統量測動態鹽水稀釋密度的最大誤差僅為1.9%。
以上結果驗證了本研究之量測系統在細胞收穫系統中的可行性,提供了一種可以應用在細胞收穫程序的非接觸式量測管流濃度與密度的系統。 | zh_TW |
dc.description.abstract | The present study is divided into two main parts: the centrifugal cleaning system and the measurement system. The measurement system utilizes a laser as the light source and employs a photoresistor as the light receiver. By applying the principles of prism dispersion and optical theory, and through the transformation based on Snell's law and Beer's law, the electrical signals are converted into physically meaningful concentration and density measurements. This system provides a non-contact method for dynamically measuring fluid flow in tubes. Additionally, a self-made counterflow centrifugation system is utilized to separate and clean a mixture of 8% saline solution (as a substitute for culture medium) and PS polystyrene plastic particles (as a substitute for cells), simulating the cell harvesting process. Finally, both systems are combined, and the measurement system is used to dynamically monitor the dilution concentration of the saline solution. The research results showed that the maximum error in the dynamic concentration measurement of this system is 15%. However, it gradually decreases during the dilution process. When the dilution concentration reaches the target concentration, the error is reduced to 3.1%. When measuring the refractive index using a cylindrical tube, the maximum error due to different incident angles and resulting optical phenomena is 13.5%. However, in the end, the maximum error in measuring the dynamic saline dilution density with this system is only 1.9%.
These results verify the feasibility of the measurement system in the context of cell harvesting systems, providing a non-contact measurement system for monitoring flow concentration and density that can be applied in cell harvesting procedures. | en |
dc.description.provenance | Submitted by admin ntu (admin@lib.ntu.edu.tw) on 2023-08-15T16:24:04Z No. of bitstreams: 0 | en |
dc.description.provenance | Made available in DSpace on 2023-08-15T16:24:04Z (GMT). No. of bitstreams: 0 | en |
dc.description.tableofcontents | 誌謝 i
摘要 ii Abstract iii 符號表 v 表目次 ix 圖目次 x 第一章 緒論 - 1 - 第一節、 研究背景 - 1 - 第二節、 研究動機與目的 - 2 - 第三節、 研究架構 - 3 - 第二章 文獻回顧 - 4 - 第一節、 細胞收穫系統之介紹 - 4 - 第二節、 細胞規格之介紹 - 8 - 第三節、 量測系統之介紹 - 9 - 第三章 研究方法 - 24 - 第一節、 實驗設計 - 24 - 1-1 實驗設備 - 24 - 1-2 待量測之物理參數 - 26 - 第二節、 量測系統的設計 - 26 - 第三節、 數據量測與收集的方法 - 29 - 3-1 量測理論與數學式 - 29 - 3-2 靜態量測 - 30 - 3-3 動態量測 - 32 - 3-4 名詞定義 - 33 - 第四節、 離心清洗系統的設計 - 34 - 4-1 離心清洗系統示意圖 - 34 - 4-2 細胞與培養基替代品的選擇 - 35 - 4-3 稀釋方法與流程介紹 - 36 - 第五節、 系統整合與實驗流程 - 38 - 第四章 研究結果與討論 - 40 - 第一節、 探討圓管量測折射率與Snell’s law之關係 - 40 - 第二節、 將水與甘油混合量測折射率 - 45 - 第三節、 不同濃度鹽水之吸光度與透射電壓之關係 - 46 - 第四節、 不同濃度的鹽水之折射率與折射電壓之關係 - 48 - 第五節、 不同濃度的鹽水之吸光度與透射電壓之關係 - 49 - 第六節、 鹽水之濃度與吸光度之關係 - 49 - 第七節、 動態量測之濃度與密度理論值與量測值對照圖 - 50 - 7-1 鹽水濃度理論值與量測值之對照圖 - 51 - 7-2 鹽水密度理論值與量測值之對照圖 - 52 - 第八節、 動態量測8%鹽水稀釋與顆粒清洗之成果 - 54 - 第九節、 實驗限制 - 56 - 第五章 結論 - 59 - 參考文獻 - 61 - | - |
dc.language.iso | zh_TW | - |
dc.title | 非接觸式密度與濃度測量裝置的設計 | zh_TW |
dc.title | Design of non-contact density and concentration measuring device | en |
dc.type | Thesis | - |
dc.date.schoolyear | 111-2 | - |
dc.description.degree | 碩士 | - |
dc.contributor.oralexamcommittee | 林哲宇;趙聖德;李皇德 | zh_TW |
dc.contributor.oralexamcommittee | Che-Yu Lin;Sheng-Der Chao;Huang-Te Li | en |
dc.subject.keyword | 折射率量測,管流量測,動態量測,逆流離心淘析,細胞收穫系統, | zh_TW |
dc.subject.keyword | Refractive index measurement,tube flow measurement,dynamic measurement,counterflow centrifugal elutriation,cell harvesting system, | en |
dc.relation.page | 64 | - |
dc.identifier.doi | 10.6342/NTU202302345 | - |
dc.rights.note | 同意授權(限校園內公開) | - |
dc.date.accepted | 2023-08-03 | - |
dc.contributor.author-college | 工學院 | - |
dc.contributor.author-dept | 應用力學研究所 | - |
顯示於系所單位: | 應用力學研究所 |
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