探索帶電之官能化聚(3,4-乙烯基二氧噻吩)共聚物及兩性離子高分子刷在抗生物沾黏上之應用

Abstract

隨著醫療技術的進步，生物醫學應用相關的研究也大幅增加。在不同的材料中，聚(3,4-乙二氧基噻吩)（PEDOT）被認為是一種有潛力的導電材料，可用於生物電子傳感器。為了研究PEDOT表面電荷對蛋白質結合行為的影響，我們開發了一種新的帶正電荷的官能化EDOT單體，即EDOT-N+。我們使用電化學方法將帶有負電荷的羧酸官能化EDOT單體（EDOT-COOH）與EDOT-N+進行共聚，並調整了不同的單體比例。結果表明，在 [EDOT-N+] : [EDOT-COOH] = 8:2的比例下，實際鍍上去的高分子共聚物的比例會是1:1，此poly(EDOT-N+-co-EDOT-COOH)共聚物表現出良好的抗污染性能。因此，我們提出了一種由等密度正負官能基團組成的共聚物產生類似兩性離子高分子的抗污染性能。

除了在生物醫學領域的應用外，兩性離子高分子的特殊抗污染性能使其在許多不同的領域中同樣成為受歡迎的材料。隨著水資源短缺的問題日益嚴重，新型淨水技術的研發變得刻不容緩。太陽能水純化被認為是一種有前景的方法，因為地球表面有71%的面積被水覆蓋，其中蘊藏量最大的就是海水，再加上隨處可得源源不絕的太陽能可供利用，這將會是一種環境友善且永續的淨水方式。我們設計了一個雙層結構的太陽能水純化平台，利用吸水性良好的醋酸纖維膜作為基材，配合金屬有機框架作為絕緣層，同時利用其多孔結構進行水傳輸。碳黑和聚多巴胺則是作為吸光材，將吸收的光轉化為熱能。而為了延長太陽能水純化平台的使用壽命，我們特別在平台底部設計了一層兩性離子高分子刷旨在實現抗污染功能，使水中的污染物不會沾附在平台上，以防止平台的多孔結構被堵塞而導致水純化效率下降甚至是失去功能。

With the advancement of medical technology, research in biomedical applications also essentially increases. Among different materials, poly(3,4-ethylenedioxythiophene) (PEDOT) has been regarded as a promising conductive material for bioelectronics. To investigate the surface charge effect on protein binding behavior on PEDOT, we developed a new positively charged functionalized EDOT monomer, EDOT-N+. We used an electrochemical method to copolymerize EDOT-N+ with negatively charged carboxylic acid-functionalized EDOT monomer, EDOT-COOH, with different feed ratios. The results show that at [EDOT- N+] : [EDOT-COOH] = 8:2, where an actual 1:1 ratio of the copolymer was determined, the poly(EDOT-N+-co-EDOT-COOH) presented good antifouling performance. Therefore, we propose a zwitterion-like antifouling property from the poly(EDOT-N+-co-EDOT-COOH) with an equal density of both positive and negative functional groups.

Despite applications in the biomedical field, the special antifouling property of zwitterionic polymer makes it a popular material in many different professions. As the water scarcity issue becomes more serious, there must come out with some solutions to produce clean water. Solar desalination has been regarded as a promising method since there is inexhaustible seawater on earth and ubiquitous solar energy readily available. This would be an environmental-friendly and sustainable method to produce clean water. We designed a double-layer structure for the desalination platform with a highly water-sorbent cellulose acetate membrane as the substrate and metal-organic framework working as the insulating layer while also serving as water absorbing layer crediting to the porous structure to allow water transport. Carbon black and polydopamine are solar-absorbing materials that convert absorbed light into heat. To extend the service life of the platform, we especially designed a layer of zwitterionic polymer brush at the bottom of the desalination platform aiming to provide an antifouling function so that the pollutants in the water would be repelled from the platform, preventing the porous structure of the platform being obstructed and make the platform fail.