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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 呂廷璋(Ting-Jang Lu) | |
| dc.contributor.author | Wei-Yuan Wu | en |
| dc.contributor.author | 吳瑋元 | zh_TW |
| dc.date.accessioned | 2021-05-20T00:50:00Z | - |
| dc.date.available | 2025-12-31 | |
| dc.date.available | 2021-05-20T00:50:00Z | - |
| dc.date.copyright | 2021-03-03 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-02-08 | |
| dc.identifier.citation | 劉忬函。（2019）。加工肉產品之活性雙羰基物質及糖化終產物分析。國立臺灣大學食品科技研究所碩士論文。 Ahmad, S.; Khan, H.; Siddiqui, Z.; Khan, M. Y.; Rehman, S.; Shahab, U.; Godovikova, T.; Silnikov, V.; Moinuddin, AGEs, RAGEs and s-RAGE; friend or foe for cancer. Semin. Cancer Biol. 2018, 49, 44-55. Allaman, I.; Bélanger, M.; Magistretti, P. J. J. F. i. n., Methylglyoxal, the dark side of glycolysis. 2015, 9, 23. Arena, E.; Ballistreri, G.; Tomaselli, F.; Fallico, B., Survey of 1,2-dicarbonyl compounds in commercial honey of different floral origin. J. Food Sci. 2011, 76, C1203-C1210. Atrott, J.; Haberlau, S.; Henle, T., Studies on the formation of methylglyoxal from dihydroxyacetone in Manuka (Leptospermum scoparium) honey. Carbohydr. Res. 2012, 361, 7-11. Ball, D. W., The chemical composition of maple syrup. Journal of Chemical Education 2007, 84, 1647. Bao, J. M.; He, M. Y.; Liu, Y. W.; Lu, Y. J.; Hong, Y. Q.; Luo, H. H.; Ren, Z. L.; Zhao, S. 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H., Major carbohydrate, polyol, and oligosaccharide profiles of agave syrup. Application of this data to authenticity analysis. J. Agric. Food Chem. 2012, 60, 8745-8754. Yan, S.; Sun, M. H.; Zhao, L. L.; Wang, K.; Fang, X. M.; Wu, L. M.; Xue, X. F., Comparison of differences of alpha-dicarbonyl compounds between naturally matured and artificially heated acacia honey: their application to determine honey quality. J. Agric. Food Chem. 2019, 67, 12885-12894. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/8200 | - |
| dc.description.abstract | 活性雙羰基物質(reactive dicarbonyl species, RDS)為醣類降解物，容易在焦糖化反應及梅納反應中生成，被認為是造成代謝相關疾病的原因之一。市售糖漿在製作過程中使用的熱處理可能產生大量的RDS。為了瞭解市售糖漿中RDS的含量及分布，本研究利用o-phenylenediamine將RDS衍生成quinoxaline類化合物，搭配液相層析串聯質譜法同步分析市售糖漿中16種RDS，其中包含glyoxal及methylglyoxal。除此之外亦針對分析方法進行最適化，包含空白樣品、衍生劑品牌、衍生條件、淨化試劑、RDS衍生物穩定度及分析管柱的選擇。RDS總含量在高果糖糖漿(754.5-1318 μg/g)及龍舌蘭糖漿(大於1024 μg/g)中較高；葡萄糖糖漿(0.625-78.99 μg/g)、麥芽糖糖漿(8.413-10.30 μg/g)及楓糖漿(2.511-17.81 μg/g)則較低；葡萄糖、果糖及蔗糖中亦可偵測到RDS (trace-177.6 μg/g)。本分析方法未來可用於分析市售糖漿在製作及儲藏過程中RDS的分布及變化，並對市售產品進行品質控管。 | zh_TW |
| dc.description.abstract | Reactive dicarbonyl species (RDS), the degradation products of saccharides in caramelization and Maillard reactions, are considered to be related to the diabetic complications and chronic diseases. It can be expected that abundant RDS emerge in the commercial syrups due to the thermal processing. In order to monitor RDS in commercial syrups, RDS are derivatized with o-phenylenediamine to quinoxaline derivatives. There are 16 RDS analyzed simultaneously by LC-MS/MS, including glyoxal and methylglyoxal. In addition, this analytical method is optimized, including blank, the brand of derivatization reagent, derivatization conditions, clean-up solvents, stability of quinoxaline derivative, and analytical column. Contents of total RDS are higher in high-fructose syrups (754.5-1318 μg/g) and agave syrups (beyond 1024 μg/g) than that in glucose syrups (0.625-78.99 μg/g), maltose syrups (8.413-10.30 μg/g), and maple syrups (2.511-17.81 μg/g). RDS are also detected in glucose, fructose and sucrose (trace-177.6 μg/g). This analytical method can be applied to understand the distribution and change of contents of RDS in the commercia syrups during the production process and storage, and further monitor the quality of syrups. | en |
| dc.description.provenance | Made available in DSpace on 2021-05-20T00:50:00Z (GMT). No. of bitstreams: 1 U0001-0802202111191300.pdf: 7560025 bytes, checksum: 1aa31f603e80edd018063bf6cb27e894 (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | 摘要 I Abstract III 圖目錄 VII 表目錄 X 壹、前言 1 貳、文獻回顧 2 第一節、活性雙羰基物質 2 一、結構與活性 2 二、來源與清除 7 三、分析方法 16 第二節、糖化終產物 23 一、結構與活性 23 二、來源與清除 25 第三節、活性雙羰基物質清除劑 27 一、黃酮類化合物 27 第四節、市售糖漿 29 一、高果糖糖漿 29 二、龍舌蘭糖漿 33 參、研究目的與實驗架構 34 肆、材料與方法 35 第一節、實驗材料 35 第二節、藥劑與試劑 36 第三節、儀器設備與軟體 38 第四節、實驗方法 40 伍、結果與討論 46 第一節、活性雙羰基物質之建議分析方法 46 第二節、活性雙羰基物質分析平台的最佳化 48 一、衍生劑品牌的選擇 48 二、空白樣品的選擇 48 三、衍生條件的選擇 50 四、淨化試劑的選擇 54 五、活性雙羰基物質衍生物的穩定性評估 57 六、分析管柱的選擇 60 第三節、活性雙羰基物質定性分析 66 一、活性雙羰基物質衍生物於液相層析串聯質譜儀之檢測模式 66 第四節、方法確效 71 一、活性雙羰基物質之基質匹配檢量線、方法定量極限及回收率 71 第五節、市售糖漿中活性雙羰基物質含量 75 陸、結論 84 柒、參考文獻 85 捌、附錄 92 第一節、活性雙羰基物質衍生物之一次離子及二次離子萃取離子層析圖 92 第二節、活性雙羰基物質衍生物之結構解析 94 第三節、參考文獻中活性雙羰基物質衍生物之二次離子 109 第四節、活性雙羰基物質之可能生成機制 112 第五節、活性雙羰基物質之品質管制系統 116 第六節、其他 126 | |
| dc.language.iso | zh-TW | |
| dc.title | 以液相層析串聯質譜法分析糖漿產品中活性雙羰基化合物 | zh_TW |
| dc.title | Analysis of reactive dicarbonyl species in syrup products by LC-MS/MS | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 109-1 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 謝淑貞(Shu-Chen Hsieh),陳宏彰(Hung-Jang Chen),張永和(Yung-Ho Chang),魏國晉(Guor-Jien Wei) | |
| dc.subject.keyword | 活性雙羰基物質,液相層析串聯質譜法,glyoxal,methylglyoxal,高果糖糖漿, | zh_TW |
| dc.subject.keyword | reactive dicarbonyl species,LC-MS/MS,glyoxal,methylglyoxal,high fructose syrups, | en |
| dc.relation.page | 129 | |
| dc.identifier.doi | 10.6342/NTU202100669 | |
| dc.rights.note | 同意授權(全球公開) | |
| dc.date.accepted | 2021-02-09 | |
| dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
| dc.contributor.author-dept | 食品科技研究所 | zh_TW |
| dc.date.embargo-lift | 2025-12-31 | - |
| 顯示於系所單位： | 食品科技研究所 | |
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