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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 陳保中(Pau-Chung Chen) | |
| dc.contributor.author | Mei-Ju Chien | en |
| dc.contributor.author | 簡美茹 | zh_TW |
| dc.date.accessioned | 2022-11-24T03:22:53Z | - |
| dc.date.available | 2021-11-08 | |
| dc.date.available | 2022-11-24T03:22:53Z | - |
| dc.date.copyright | 2021-11-08 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-09-14 | |
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Mori, K., Yoshida, K., Hoshikawa, S., Ito, S., Yoshida, M., Satoh, M., Watanabe, C. (2006). Effects of perinatal exposure to low doses of cadmium or methylmercury on thyroid hormone metabolism in metallothionein-deficient mouse neonates. Toxicology, 228(1), 77-84. doi:https://doi.org/10.1016/j.tox.2006.08.017 Muñoz-Rocha, T. V., Tamayo, Y. O. M., Romero, M., Pantic, I., Schnaas, L., Bellinger, D., . . . Téllez-Rojo, M. M. (2018). Prenatal co-exposure to manganese and depression and 24-months neurodevelopment. Neurotoxicology, 64, 134-141. doi:10.1016/j.neuro.2017.07.007 Ng, S., Lin, C. C., Hwang, Y. H., Hsieh, W. S., Liao, H. F., Chen, P. C. (2013). Mercury, APOE, and children's neurodevelopment. Neurotoxicology, 37, 85-92. doi:10.1016/j.neuro.2013.03.012 Ng, S., Lin, C. C., Jeng, S. F., Hwang, Y. H., Hsieh, W. S., Chen, P. C. (2015). Mercury, APOE, and child behavior. Chemosphere, 120, 123-130. doi:10.1016/j.chemosphere.2014.06.003 Onnis, L., Truzzi, A., Ma, X. (2018). 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W., Weisgraber, K. H., Havel, R. J., . . . Blum, C. (1982). Proposed nomenclature of apoE isoproteins, apoE genotypes, and phenotypes. Journal of Lipid Research, 23(6), 911-914. doi:https://doi.org/10.1016/S0022-2275(20)38094-9 Zhang, Y.-M., Liu, X.-Z., Lu, H., Mei, L., Liu, Z.-P. (2009). Lipid Peroxidation and Ultrastructural Modifications in Brain after Perinatal Exposure to Lead and/or Cadmium in Rat Pups. Biomedical and Environmental Sciences, 22(5), 423-429. doi:https://doi.org/10.1016/S0895-3988(10)60021-9 Zivelin, A., Rosenberg, N., Peretz, H., Amit, Y., Kornbrot, N., Seligsohn, U. (1997). Improved Method for Genotyping Apolipoprotein E Polymorphisms by a PCR-Based Assay Simultaneously Utilizing Two Distinct Restriction Enzymes. Clinical Chemistry, 43(9), 1657-1659. doi:10.1093/clinchem/43.9.1657 | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/80941 | - |
| dc.description.abstract | "背景/目的 在當前的研究中，已知暴露於環境重金屬會對於出生後孩童的神經行為有相當的負面影響，並且，在文獻中提到，這些重金屬對於認知行為發展有著顯著的負相關性，語言溝通為認知發展的一種主要層面，然而目前並沒有針對母親孕程中環境重金屬暴露與孩童語言溝通發展之影響的相關研究。本研究目的即是希望透過問卷評估以及生物檢體，了解懷孕期間重金屬暴露對孩童語言發展的影響。 方法 本研究族群來自台灣出生世代追蹤研究，於2004至2005年間招募個案，在母親生產過後進行結構性問卷訪談，同時於生產時收取臍帶血作為生物檢體指標，以電感耦合電漿體質譜法分析砷、鎘、錳、汞及鉛等環境重金屬濃度。在孩童在兩至三歲期間的語言溝通發展情形，則以華語嬰幼兒溝通發展量表作為評估工具。 結果 在排除干擾因子及遺失資料篩選後，選取147組於北台灣出生之兒童及母親配對，在多變項線性迴歸模型當中，暴露於鎘金屬的幼兒在華語嬰幼兒溝通發展量表的總分(β=-29.95, p<0.05)及子項目字彙的產生(β=-28.37, p<0.05)分數顯著的負相關性。 在錳分成三組與語言發展分數分析後，雖無顯著的相關性但可在結果中觀察到中間的參考組比起其他兩組有正向相關的趨勢。而在不同的基因型組別分析後，尚無觀察到顯著的差異。 討論 本研究結果指出，在母親孕程中暴露環境重金屬與孩童早期語言發展的負面影響有關連性。然而在人們所存在的環境當中，重金屬持續地暴露，故在臍帶血中的重金屬濃度與孩童語言發展之間的因果關係及其機轉，則有待進一步的研究釐清。" | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-24T03:22:53Z (GMT). No. of bitstreams: 1 U0001-1309202113002500.pdf: 4880105 bytes, checksum: 3be195908d1ba5863645c6f19c50cd21 (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | CONTENTS 口試委員會審定書 I Thesis Verification Form II 誌謝 i 中文摘要 ii ABSTRACT iii CONTENTS v LIST OF TABLES vi LIST OF SUPPLEMENTARY TABLES vii LIST OF FIGURES viii Chapter 1 Introduction 1 Chapter 2 Materials and Methods 5 2.1 Study design and population 5 2.2 Measurement of heavy metals 7 2.3 APOE genotyping 8 2.4 The Mandarin-Chinese Communicative Developmental Inventory 9 2.5 The Home Observation for Measurement of the Environment inventory 11 2.6 Statistical analysis 12 Chapter 3 Results 13 Chapter 4 Discussion 15 Chapter 5 Conclusion 19 REFERENCE 20 APPENDIX 31 LIST OF TABLES TABLE 1. THE CHARACTERISTICS OF THE SUBJECTS. 25 TABLE 2. MEASUREMENTS OF LEVELS OF HEAVY METAL IN CORD BLOOD. 26 TABLE 3. CORRELATION MATRIX OF THE SUBJECTS' CORD BLOOD METAL LEVELS. 26 TABLE 4. THE DISTRIBUTION OF MCDI SCORE. 27 TABLE 5. MULTIPLE LINEAR REGRESSION MODEL OF MCDI SCORE AND HEAVY METALS. 28 TABLE 6. MULTIPLE LINEAR REGRESSION MODEL OF THE MCDI SCORE AND CATEGORIZE MANGANESE LEVELS. 29 TABLE 7. HEAVY METALS ON LANGUAGE DEVELOPMENT WITH DIFFERENT GENOTYPES OF APOE. 30 LIST OF SUPPLEMENTARY TABLES SUPPLEMENTARY TABLE 1. THE CHARACTERISTICS OF THE SUBJECTS. 31 SUPPLEMENTARY TABLE 2. THE DISTRIBUTION OF HEAVY METAL LEVELS BETWEEN TWO GROUPS. 32 SUPPLEMENTARY TABLE 3. MULTIPLE LINEAR REGRESSION MODEL OF MCDI SCORE AND HEAVY METALS. 33 SUPPLEMENTARY TABLE 4. MULTIPLE LINEAR REGRESSION MODEL OF THE MCDI SCORE AND CATEGORIZE MANGANESE LEVELS. 34 SUPPLEMENTARY TABLE 5. COMPARISON OF HEAVY METALS MEDIAN LEVELS IN DIFFERENT STUDIES. 35 LIST OF FIGURES FIGURE 1. THE FLOW CHART IN THIS STUDY. 24 FIGURE 2. COMPARISON OF ARSENIC MEDIAN LEVELS IN DIFFERENT STUDIES. 36 FIGURE 3. COMPARISON THE MEDIAN LEVELS OF CADMIUM IN DIFFERENT STUDIES. 37 FIGURE 4. COMPARISON THE MEDIAN LEVELS OF MANGANESE IN DIFFERENT STUDIES. 38 FIGURE 5. COMPARISON THE MEDIAN LEVELS OF MERCURY IN DIFFERENT STUDIES. 39 FIGURE 6. COMPARISON THE MEDIAN LEVELS OF LEAD IN DIFFERENT STUDIES. 40 | |
| dc.language.iso | en | |
| dc.subject | 語言發展 | zh_TW |
| dc.subject | 神經發展 | zh_TW |
| dc.subject | 幼童 | zh_TW |
| dc.subject | 重金屬 | zh_TW |
| dc.subject | lead | en |
| dc.subject | language | en |
| dc.subject | language development | en |
| dc.subject | child language | en |
| dc.subject | environmental metals | en |
| dc.subject | arsenic | en |
| dc.subject | cadmium | en |
| dc.subject | manganese | en |
| dc.subject | mercury | en |
| dc.subject | toddlers | en |
| dc.subject | young children | en |
| dc.title | 產前暴露環境重金屬與幼兒語言發展相關性 | zh_TW |
| dc.title | Prenatal exposure to environmental heavy metals and language development in toddlers | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 何文照(Hsin-Tsai Liu),陳美惠(Chih-Yang Tseng),楊曜旭 | |
| dc.subject.keyword | 重金屬,神經發展,語言發展,幼童, | zh_TW |
| dc.subject.keyword | language,language development,child language,environmental metals,arsenic,cadmium,manganese,mercury,lead,toddlers,young children, | en |
| dc.relation.page | 52 | |
| dc.identifier.doi | 10.6342/NTU202103142 | |
| dc.rights.note | 同意授權(限校園內公開) | |
| dc.date.accepted | 2021-09-14 | |
| dc.contributor.author-college | 公共衛生學院 | zh_TW |
| dc.contributor.author-dept | 環境與職業健康科學研究所 | zh_TW |
| 顯示於系所單位： | 環境與職業健康科學研究所 | |
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