請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/80656完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 呂廷璋(Ting-Jang Lu) | |
| dc.contributor.author | Zhi-Yue Wang | en |
| dc.contributor.author | 王之玥 | zh_TW |
| dc.date.accessioned | 2022-11-24T03:11:57Z | - |
| dc.date.available | 2021-11-03 | |
| dc.date.available | 2022-11-24T03:11:57Z | - |
| dc.date.copyright | 2021-11-03 | |
| dc.date.issued | 2021 | |
| dc.date.submitted | 2021-10-22 | |
| dc.identifier.citation | 斐鑒；丁志遵，中國植物誌1985,54-119。 汪晶晶；劉亦迅；劉迪等，「盾葉薯蕷中甾體皂苷及其體外血小板活性研究」中國中藥雜志，2014,39(19):3787。 劉景仁；張建國；劉大智，最新科學抗癌藥用植物圖鑑2016,175-178。 楊登傑。「台灣產薯蕷的類固醇皂素及皂配基分析與加工處理對皂素之影響」。博士論文，國立臺灣大學食品科技研究所，2003。https://hdl.handle.net/11296/ufmcee。 張玉君；孫燕；葛斐林等，「山藥資源調查及形態鑒定」北京中醫藥2018,37卷第五期。 National Center for Biotechnology Information. PubChem Compound Summary for CID 9898279, Ginsenoside rb1. https://pubchem.ncbi.nlm.nih.gov/compound/Ginsenoside-rb1. Accessed June 16, 2021. Liu, S.Y.; Lin, G.E.; Lu, S.H., Production and recipe for dioscorea 1998(Technical Report TARI-75), Taiwan Agricultural Research Institute, Taiwan (1998). Liu, T. S. and Huang, T. C. 1962. On the Taiwan species of dioscorea. Bot. Bull. Acad. Sin. 3: 133-149 Agrawal, P. K.; Jain, D. C.; Gupta, R. K.; Thakur, R. S., Carbon-13 NMR spectroscopy of steroidal sapogenins and steroidal saponins. Phytochemistry 1985, 24, 2479-2496. Amir, M.; Ahmad, A.; Siddique, N.; Mujeeb, M.; Ahmad, S.; Siddique, W., Development and Validation of HPTLC Method for the Estimation of Diosgenin in In Vitro Culture and Rhizome of Dioscorea deltoidea. Acta Chromatographica 2012, 24, 111-121. Araghiniknam, M.; Chung, S.; Nelson-White, T.; Eskelson, C.; R. Watson, R., Antioxidant activity of dioscorea and dehydroepiandrosterone (DHEA) in older humans. Life Sciences 1996, 59, PL147-PL157. Atsukwei, D.; Daniel, E.; Adams, M.; Tende, J.; Tope, O.; Danmallam, L., Contraceptive effect of ethanolic extract of Dioscorea villosa tuber on reproductive hormones of female Wistar rats. Int. J. Biochem. Res. Rev. 2015, 5, 135-144. Avula, B.; Wang, Y.-H.; Wang, M.; Ali, Z.; Smillie, T. J.; Zweigenbaum, J.; Khan, I. A., Characterization of steroidal saponins from Dioscorea villosa and D. cayenensis using ultrahigh performance liquid chromatography/electrospray ionization quadrupole time-of-flight mass spectrometry. Planta medica 2014a, 80, 321. Avula, B.; Wang, Y. H.; Wang, M.; Ali, Z.; Smillie, T. J.; Zweigenbaum, J.; Khan, I. A., Characterization of steroidal saponins from Dioscorea villosa and D. cayenensis using ultrahigh performance liquid chromatography/electrospray ionization quadrupole time-of-flight mass spectrometry. Planta medica 2014b, 80, 321-9. Baah, F.; Maziya-Dixon, B.; Asiedu, R.; Oduro, I.; Ellis, W. O., Nutritional and biochemical composition of D. alata (Dioscorea spp.) tubers. 2009. Bai, B.; Li, M.-J.; Wang, Y.; Liu, X.-H., Studies on chemical constituents of Dioscorea opposita. Zhongguo Zhong yao za zhi= Zhongguo zhongyao zazhi= China journal of Chinese materia medica 2008, 33, 1272-1274. Barile, E.; Bonanomi, G.; Antignani, V.; Zolfaghari, B.; Sajjadi, S. E.; Scala, F.; Lanzotti, V., Saponins from Allium minutiflorum with antifungal activity. Phytochemistry 2007, 68, 596-603. Bruneton, J., Pharmacognosy, phytochemistry, medicinal plants. Lavoisier publishing: 1995. Byeon, S.; Oh, J.; Lim, J. S.; Lee, J. S.; Kim, J.-S., Protective effects of Dioscorea batatas flesh and peel extracts against ethanol-induced gastric ulcer in mice. Nutrients 2018, 10, 1680. Cai, J.; Liu, M.; Wang, Z.; Ju, Y., Apoptosis induced by dioscin in Hela cells. Biological and Pharmaceutical Bulletin 2002, 25, 193-196. Choi, E. M.; Koo, S. J.; Hwang, J.-K., Immune cell stimulating activity of mucopolysaccharide isolated from yam (Dioscorea batatas). Journal of Ethnopharmacology 2004, 91, 1-6. Chwalek, M.; Lalun, N.; Bobichon, H.; Plé, K.; Voutquenne-Nazabadioko, L., Structure-activity relationships of some hederagenin diglycosides: haemolysis, cytotoxicity and apoptosis induction. Biochimica et biophysica acta 2006, 1760, 1418-27. Cui, M.; Song, F.; Zhou, Y.; Liu, Z.; Liu, S., Rapid identification of saponins in plant extracts by electrospray ionization multi‐stage tandem mass spectrometry and liquid chromatography/tandem mass spectrometry. Rapid Communications in Mass Spectrometry 2000, 14, 1280-1286. Darbour, N.; Bayet, C.; Doreau, A.; Raad, I.; Phung, B. H.; Dumontet, C.; Di Pietro, A.; Dijoux-Franca, M.-G.; Guilet, D., Selective modulation of P-glycoprotein activity by steroidal saponines from Paris polyphylla. Fitoterapia 2009, 80, 39-42. De Combarieu, E.; Falzoni, M.; Fuzzati, N.; Gattesco, F.; Giori, A.; Lovati, M.; Pace, R., Identification of Ruscus steroidal saponins by HPLC-MS analysis. Fitoterapia 2002, 73, 583-596. Dinan, L.; Harmatha, J.; Lafont, R., Chromatographic procedures for the isolation of plant steroids. Journal of Chromatography A 2001, 935, 105-123. Domon, B.; Costello, C. E., A systematic nomenclature for carbohydrate fragmentations in FAB-MS/MS spectra of glycoconjugates. Glycoconjugate Journal 1988, 5, 397-409. Eddy, C. R.; Wall, M. E.; Scott, M. K., Catalog of infrared absorption spectra of steroidal sapogenin acetates. Analytical Chemistry 1953, 25, 266-271. Elekofehinti, O. O.; Omotuyi, I. O.; Kamdem, J. P.; Ejelonu, O. C.; Alves, G. V.; Adanlawo, I. G.; Rocha, J. B. T., Saponin as regulator of biofuel: implication for ethnobotanical management of diabetes. Journal of physiology and biochemistry 2014, 70, 555-567. Fedorova, G.; Randak, T.; Lindberg, R. H.; Grabic, R., Comparison of the quantitative performance of a Q-Exactive high-resolution mass spectrometer with that of a triple quadrupole tandem mass spectrometer for the analysis of illicit drugs in wastewater. Rapid Communications in Mass Spectrometry 2013, 27, 1751-1762. Feng, B.; Kang, L.-p.; Ma, B.-p.; Quan, B.; Zhou, W.-b.; Wang, Y.-z.; Zhao, Y.; Liu, Y.-x.; Wang, S.-q., The substrate specificity of a glucoamylase with steroidal saponin-rhamnosidase activity from Curvularia lunata. Tetrahedron 2007, 63, 6796-6812. Feng, B.; Huang, H.-z.; Zhou, W.-b.; Kang, L.-p.; Zou, P.; Liu, Y.-x.; Yu, H.-s.; Han, B.-q.; Li, Y.-y.; Zhang, L.-l.; Zhang, T.; Ma, B.-p., Substrate specificity, purification and identification of a novel pectinase with the specificity of hydrolyzing the α-1,4-glycosyl residue in steroidal saponin. Process Biochemistry 2010, 45, 1383-1392. Fu, Y. L.; Yu, Z. Y.; Tang, X. M.; Zhao, Y.; Yuan, X. L.; Wang, S.; Ma, B. P.; Cong, Y. W., Pennogenin glycosides with a spirostanol structure are strong platelet agonists: structural requirement for activity and mode of platelet agonist synergism. Journal of Thrombosis and Haemostasis 2008, 6, 524-533. Gao, H.; Kuroyanagi, M.; Wu, L.; Kawahara, N.; Yasuno, T.; Nakamura, Y., Antitumor-promoting constituents from Dioscorea bulbifera L. in JB6 mouse epidermal cells. Biological and Pharmaceutical Bulletin 2002, 25, 1241-1243. Gao, H.; Shui, A.; Chen, Y.; Zhang, X.; Wu, L., The chemical compositions of Dioscorea bulbifera L. J. Shenyang Pharm. Univ 2003, 20, 178-180. Gao, X.; Sun, W.; Fu, Q.; Niu, X., Rapid Identification of Steroidal Saponins in Trillium Tschonoskii Maxim by Ultraperformance Liquid Chromatography Coupled to Electrospray Ionisation Quadrupole Time-of-Flight Tandem Mass Spectrometry. Phytochemical Analysis 2015, 26, 269-278. Gong, G.; Qin, Y.; Huang, W.; Zhou, S.; Wu, X.; Yang, X.; Zhao, Y.; Li, D., Protective effects of diosgenin in the hyperlipidemic rat model and in human vascular endothelial cells against hydrogen peroxide-induced apoptosis. Chemico-biological interactions 2010, 184, 366-375. Guo, L.; Su, J.; Deng, B. W.; Yu, Z. Y.; Kang, L. P.; Zhao, Z. H.; Shan, Y. J.; Chen, J. P.; Ma, B. P.; Cong, Y. W., Active pharmaceutical ingredients and mechanisms underlying phasic myometrial contractions stimulated with the saponin extract from Paris polyphylla Sm. var. yunnanensis used for abnormal uterine bleeding. Human Reproduction 2008, 23, 964-971. Gupta, R. K.; Jain, D. C.; Thakur, R. S., Furostanol glycosides from Trigonella foenum-graecum seeds. Phytochemistry 1984, 23, 2605-2607. Gupta, R. K.; Jain, D. C.; Thakur, R. S., Two furostanol saponins from Trigonella foenum-graecum. Phytochemistry 1986, 25, 2205-2207. Hou, W.-C.; Chen, H.-J.; Lin, Y.-H., Dioscorins, the major tuber storage proteins of yam (Dioscorea batatas Decne), with dehydroascorbate reductase and monodehydroascorbate reductase activities. Plant Science 1999, 149, 151-156. Hsu, K.-M.; Tsai, J.-L.; Chen, M.-Y.; Ku, H.-M.; Liu, S.-C., Molecular phylogeny of dioscorea (Dioscoreaceae) in east and southeast asia. Blumea-Biodiversity, Evolution and Biogeography of Plants 2013, 58, 21-27. Hu, K.; Dong, A.; Yao, X.; Kobayashi, H.; Iwasaki, S., Antineoplastic agents II: four furostanol glycosides from rhizomes of Dioscorea collettii var. hypoglauca. Planta medica 1997, 63, 161-165. Hu, K.; Yao, X., Methyl protogracillin (NSC-698792): the spectrum of cytotoxicity against 60 human cancer cell lines in the National Cancer Institute's anticancer drug screen panel. Anti-cancer drugs 2001, 12, 541-7. Huang, H.; Jiang, Q.; Chen, Y.; Li, X.; Mao, X.; Chen, X.; Huang, L.; Gao, W., Preparation, physico–chemical characterization and biological activities of two modified starches from yam (Dioscorea Opposita Thunb.). Food Hydrocolloids 2016, 55, 244-253. Ji, H.; Ding, X.; Tao, G., Screening of steroidal saponins from the bulbs of Lilium brownii var. colchesteri by combination of high performance liquid chromatography-electrospray ionization mass spectrometry and electron impact mass spectrometry. Se pu= Chinese journal of chromatography 2001, 19, 403-406. Jing, S.-S.; Wang, Y.; Li, X.-J.; Li, X.; Zhao, W.-S.; Zhou, B.; Zhao, C.-C.; Huang, L.-Q.; Gao, W.-Y., Phytochemical and chemotaxonomic studies on Dioscorea collettii. Biochemical Systematics and Ecology 2017, 71, 10-15. Jing, Y.; Zhao, Y., Progress in studies on chemical constituents and pharmacological effect of Trigonella foenum-graecum. Chinese Traditional and Herbal Drugs 1994. Jones, R. N.; Katzenellenbogen, E.; Dobriner, K., The infrared absorption spectra of the steroid sapogenins. Journal of the American Chemical Society 1953, 75, 158-166. Kang, L.-p.; Zhao, Y.; Pang, X.; Yu, H.-s.; Xiong, C.-q.; Zhang, J.; Gao, Y.; Yu, K.; Liu, C.; Ma, B.-p., Characterization and identification of steroidal saponins from the seeds of Trigonella foenum-graecum by ultra high-performance liquid chromatography and hybrid time-of-flight mass spectrometry. Journal of Pharmaceutical and Biomedical Analysis 2013, 74, 257-267. Kanmoto, T.; Mimaki, Y.; Sashida, Y.; Nikaido, T.; Koike, K.; Ohmoto, T., Steroidal constituents from the underground parts of Reineckea carnea and their inhibitory activity on cAMP phosphodiesterase. Chem Pharm Bull (Tokyo) 1994, 42, 926-31. Kim, N.; Kim, S. H.; Kim, Y. J.; Kim, J. K.; Nam, M. K.; Rhim, H.; Yoon, S. K.; Choi, S. Z.; Son, M.; Kim, S. Y.; Kuh, H. J., Neurotrophic activity of DA-9801, a mixture extract of Dioscorea japonica Thunb. and Dioscorea nipponica Makino, in vitro. J Ethnopharmacol 2011, 137, 312-9. Komori, T., Glycosides from Dioscorea bulbifera. Toxicon 1997, 35, 1531-1535. Król-Kogus, B.; Głód, D.; Krauze-Baranowska, M., Qualitative and quantitative HPLC-ELSD-ESI-MS analysis of steroidal saponins in fenugreek seed. Acta pharmaceutica (Zagreb, Croatia) 2020, 70, 89-99. Li, H.; Huang, W.; Wen, Y.; Gong, G.; Zhao, Q.; Yu, G., Anti-thrombotic activity and chemical characterization of steroidal saponins from Dioscorea zingiberensis C.H. Wright. Fitoterapia 2010a, 81, 1147-1156. Li, H.; Huang, W.; Wen, Y.; Gong, G.; Zhao, Q.; Yu, G., Anti-thrombotic activity and chemical characterization of steroidal saponins from Dioscorea zingiberensis CH Wright. Fitoterapia 2010b, 81, 1147-1156. Li, L.; Tsao, R.; Dou, J.; Song, F.; Liu, Z.; Liu, S., Detection of saponins in extract of Panax notoginseng by liquid chromatography–electrospray ionisation-mass spectrometry. Analytica chimica acta 2005, 536, 21-28. Li, R.; Zhou, Y.; Wu, Z.; Ding, L., ESI-QqTOF-MS/MS and APCI-IT-MS/MS analysis of steroid saponins from the rhizomes of Dioscorea panthaica. Journal of Mass Spectrometry 2006a, 41, 1-22. Li, R.; Zhou, Y.; Wu, Z. J.; Ding, L. S., ESI-QqTOF-MS/MS and APCI-IT-MS/MS analysis of steroid saponins from the rhizomes of Dioscorea panthaica. Journal Of Mass Spectrometry 2006b, 41, 1-22. Li, X.; Jing, S.; Man, S.; Li, X.; Zhao, C.; Wang, Y.; Gao, W., A new acetylated spirostanol saponin and other constituents from the rhizomes of Dioscorea althaeoides R. Knuth (Dioscoreaceae). Biochemical Systematics and Ecology 2016, 65, 17-22. Zhao.; Wang, Y.; Sun, J.; Li, X.; Zhao, C.; Zhao, P.; Man, S.; Gao, W., Chemotaxonomic studies of 12 Dioscorea species from China by UHPLC-QTOF-MS/MS analysis. Phytochemical Analysis 2020, 31, 164-182. Liu, M.-J.; Wang, Z.; Ju, Y.; Wong, R. N.-S.; Wu, Q.-Y., Diosgenin induces cell cycle arrest and apoptosis in human leukemia K562 cells with the disruption of Ca2+ homeostasis. Cancer Chemotherapy and Pharmacology 2005, 55, 79-90. Liu, S.-C.; Lin, J.-T.; Hu, C.-C.; Yang, D.-J., Functional properties and effective phytochemicals of yam (Dioscorea spp.). 中山醫學雜誌 2015a, 26, 1-7. Liu, X.; Yu, J.; Liu, M.; Shu, J.; Huang, H., Research progress of bioactivity of steroidal saponins in recent ten years. Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica 2015b, 40, 2518-2523. Man, S.; Gao, W.; Zhang, Y.; Huang, L.; Liu, C., Chemical study and medical application of saponins as anti-cancer agents. Fitoterapia 2010, 81, 703-714. Milgate, J.; Roberts, D. C. K., The nutritional biological significance of saponins. Nutrition Research 1995, 15, 1223-1249. Mimaki, Y.; Kuroda, M.; Kameyama, A.; Sashida, Y.; Hirano, T.; Oka, K.; Maekawa, R.; Wada, T.; Sugita, K.; Beutler, J. A., Cholestane glycosides with potent cytostatic activities on various tumor cells from Ornithogalum saundersiae bulbs. Bioorganic Medicinal Chemistry Letters 1997, 7, 633-636. Mimaki, Y.; Yokosuka, A.; Kuroda, M.; SASHIDA, Y., Cytotoxic activities and structure-cytotoxic relationships of steroidal saponins. Biological and Pharmaceutical Bulletin 2001, 24, 1286-1289. Murakami, T.; Kishi, A.; Matsuda, H.; Yoshikawa, M., Medicianal Foodstuffs. XVII. Fenugreek Seed. (3) : Structures of New Furostanol-Type Steroid Saponins, Trigoneosides Xa, Xb, XIb, XIIa, XIIb, and XIIIa, from the Seeds of Egyptian Trigonella foenum-graecum L. CHEMICAL PHARMACEUTICAL BULLETIN 2000, 48, 994-1000. Oda, K.; Matsuda, H.; Murakami, T.; Katayama, S.; Ohgitani, T.; Yoshikawa, M., Adjuvant and haemolytic activities of 47 saponins derived from medicinal and food plants. Biological Chemistry 2000, 381, 67-74. Omonigho, S.; Ikenebomeh, M., Effects of different preservative treatments on the chemical changes of pounded white yam (Dioscorea rotundata) in storage at 28±2 C. Food Chemistry 2000, 68, 201-209. Pang, X.; Cong, Y.; Yu, H. S.; Kang, L. P.; Feng, B.; Han, B. X.; Zhao, Y.; Xiong, C. Q.; Tan, D. W.; Song, W.; Liu, B.; Cong, Y. W.; Ma, B. P., Spirostanol Saponins Derivated from the Seeds of Trigonella foenum-graecum by beta-Glucosidase Hydrolysis and Their Inhibitory Effects on Rat Platelet Aggregation. Planta medica 2012, 78, 276-285. Potter, J. D.; Topping, D. L.; Oakenfull, D., Soya, saponins, and plasma-cholesterol. Lancet (London, England) 1979, 1, 223. Qi, H.; Feng, F.; Zhai, J.; Chen, F.; Liu, T.; Zhang, F.; Zhang, F., Development of an analytical method for twelve dioscorea saponins using liquid chromatography coupled to Q-Exactive high resolution mass spectrometry. Talanta 2019, 191, 11-20. Salehi, B.; Sener, B.; Kilic, M.; Sharifi-Rad, J.; Naz, R.; Yousaf, Z.; Nixwell Mudau, F.; Valere Tsouh Fokou, P.; M. Ezzat, S.; H. El Bishbishy, M.; Taheri, Y.; Lucariello, G.; Durazzo, A.; Lucarini, M.; Suleria, H. A. R.; Santini, A., Dioscorea Plants: A Genus Rich in Vital Nutrapharmaceuticals- A Review. Iranian Journal of Pharmaceutical Research 2019, 18, 68-89. Sautour, M.; Mitaine-Offer, A.-C.; Miyamoto, T.; Wagner, H.; Lacaille-Dubois, M.-A., A new phenanthrene glycoside and other constituents from Dioscorea opposita. Chemical and pharmaceutical bulletin 2004, 52, 1235-1237. Sautour, M.; Mitaine-Offer, A.-C.; Lacaille-Dubois, M.-A., The Dioscorea genus: a review of bioactive steroid saponins. Journal of Natural Medicines 2007, 61, 91-101. Sauvaire, Y.; Baissac, Y.; Leconte, O.; Petit, P.; Ribes, G., Steroid Saponins from Fenugreek and some of their Biological Properties. In Saponins Used in Food and Agriculture, Waller, G. R.; Yamasaki, K., Eds. Springer US: Boston, MA, 1996; pp 37-46. Shan, N.; Wang, P.-t.; Zhu, Q.-l.; Sun, J.-y.; Zhang, H.-y.; Liu, X.-y.; Cao, T.-x.; Chen, X.; Huang, Y.-j.; Zhou, Q.-h., Comprehensive characterization of yam tuber nutrition and medicinal quality of Dioscorea opposita and D. alata from different geographic groups in China. Journal of Integrative Agriculture 2020, 19, 2839-2848. Shen, Z.; Zhang, W.; Zhao, W.; Huang, W., Simultaneous determination of four major steroidal saponins in seven species of Dioscorea L. by HPLC-ELSD. Chinese Herbal Medicines 2011, 3, 70-74. Solliec, M.; Roy-Lachapelle, A.; Sauvé, S., Quantitative performance of liquid chromatography coupled to Q-Exactive high resolution mass spectrometry (HRMS) for the analysis of tetracyclines in a complex matrix. Analytica Chimica Acta 2015, 853, 415-424. Song, F.; Cui, M.; Liu, Z.; Yu, B.; Liu, S., Multiple-stage tandem mass spectrometry for differentiation of isomeric saponins. Rapid Communications in Mass Spectrometry 2004, 18, 2241-2248. Sparg, S. G.; Light, M. E.; van Staden, J., Biological activities and distribution of plant saponins. Journal of Ethnopharmacology 2004, 94, 219-243. Tang, W.; Eisenbrand, G., Chinese drugs of plant origin: chemistry, pharmacology, and use in traditional and modern medicine. Springer Science Business Media: 2013. Teponno, R. B.; Tapondjou, A. L.; Gatsing, D.; Djoukeng, J. D.; Abou-Mansour, E.; Tabacchi, R.; Tane, P.; Stoekli-Evans, H.; Lontsi, D., Bafoudiosbulbins A, and B, two anti-salmonellal clerodane diterpenoids from Dioscorea bulbifera L. var sativa. Phytochemistry 2006, 67, 1957-1963. Teponno, R. B.; Tapondjou, A. L.; Abou-Mansour, E.; Stoeckli-Evans, H.; Tane, P.; Barboni, L., Bafoudiosbulbins F and G, further clerodane diterpenoids from Dioscorea bulbifera L. var sativa and revised structure of Bafoudiosbulbin B. Phytochemistry 2008, 69, 2374-2379. Tong, Q. Y.; Qing, Y.; Shu, D.; He, Y.; Zhao, Y. L.; Li, Y.; Wang, Z. L.; Zhang, S. Y.; Xing, Z. h.; Xu, C.; Wei, Y. Q.; Huang, W.; Wu, X. H., Deltonin, a Steroidal Saponin, Inhibits Colon Cancer Cell Growth <i>in Vitro</i> and Tumor Growth <i>in Vivo</i> via Induction of Apoptosis and Antiangiogenesis. Cellular Physiology and Biochemistry 2011, 27, 233-242. Wang, G.-X.; Han, J.; Zhao, L.-W.; Jiang, D.-X.; Liu, Y.-T.; Liu, X.-L., Anthelmintic activity of steroidal saponins from Paris polyphylla. Phytomedicine 2010, 17, 1102-1105. Wang, G.; Liu, J.-S.; Lin, B.-B.; Wang, G.-K.; Liu, J.-K., Two new furanoid norditerpenes from Dioscorea bulbifera. Chemical and Pharmaceutical Bulletin 2009, 57, 625-627. Wang, L.; Wang, X.; Yuan, X.; Zhao, B., Simultaneous analysis of diosgenin and sarsasapogenin in Asparagus officinalis byproduct by thin-layer chromatography. Phytochemical Analysis 2011, 22, 14-17. Wang, T.; Liu, Z.; Li, J.; Zhong, M.; Li, J.; Chen, X.; Bi, K., Determination of protodioscin in rat plasma by liquid chromatography–tandem mass spectrometry. Journal of Chromatography B 2007a, 848, 363-368. Wang, W.; Zhao, Y.; Rayburn, E. R.; Hill, D. L.; Wang, H.; Zhang, R., In vitro anti-cancer activity and structure-activity relationships of natural products isolated from fruits of Panax ginseng. Cancer Chemother Pharmacol 2007b, 59, 589-601. Wang, W.; Zhao, Y.; Jing, W.; Zhang, J.; Xiao, H.; Zha, Q.; Liu, A., Ultrahigh-performance liquid chromatography-ion trap mass spectrometry characterization of the steroidal saponins of Dioscorea panthaica Prain et Burkill and its application for accelerating the isolation and structural elucidation of steroidal saponins. Steroids 2015, 95, 51-65. Wang, Y.; Liu, H.; Bao, J.; Hong, Y.; Yang, Z.; Zhang, C., The saccharification–membrane retrieval–hydrolysis (SMRH) process: a novel approach for cleaner production of diosgenin derived from Dioscorea zingiberensis. Journal of cleaner production 2008, 16, 1133-1137. Wolfender, J. L.; Rodriguez, S.; Hostettmann, K., Liquid chromatography coupled to mass spectrometry and nuclear magnetic resonance spectroscopy for the screening of plant constituents. Journal of Chromatography A 1998, 794, 299-316. Woo, K. W.; Kwon, O. W.; Kim, S. Y.; Choi, S. Z.; Son, M. W.; Kim, K. H.; Lee, K. R., Phenolic derivatives from the rhizomes of Dioscorea nipponica and their anti-neuroinflammatory and neuroprotective activities. Journal of ethnopharmacology 2014, 155, 1164-1170. Wu, J.; Lin, L.; Chau, F.-t., Ultrasound-assisted extraction of ginseng saponins from ginseng roots and cultured ginseng cells. Ultrasonics Sonochemistry 2001, 8, 347-352. Xing, G.; Yu-Ping, Z.; Bao-Cheng, W.; Ya-Mei, Z.; Jian-Qun, C.; Yue-Yu, H., Phylogeny of Dioscorea sect. Stenophora based on chloroplast matK, rbcL and trnL-F sequences. Journal of Systematics and Evolution 2008, 46, 315-321. Yang, D.-J.; Lu, T.-J.; Hwang, L. S., Isolation and Identification of Steroidal Saponins in Taiwanese Yam Cultivar (Dioscorea pseudojaponica Yamamoto). Journal of Agricultural and Food Chemistry 2003, 51, 6438-6444. Yang, H.; Yin, H.; Shen, Y.; Xia, G.; Zhang, B.; Wu, X.; Cai, B.; Tam, J. P., A more ecological and efficient approach for producing diosgenin from Dioscorea zingiberensis tubers via pressurized biphase acid hydrolysis. Journal of Cleaner Production 2016, 131, 10-19. Yang, M. H.; Yoon, K. D.; Chin, Y.-W.; Park, J. H.; Kim, S. H.; Kim, Y. C.; Kim, J., Neuroprotective effects of Dioscorea opposita on scopolamine-induced memory impairment in in vivo behavioral tests and in vitro assays. Journal of Ethnopharmacology 2009, 121, 130-134. Yi, T.; Chen, H.-B.; Zhao, Z.-Z.; Jiang, Z.-H.; Cai, S.-Q.; Wang, T.-M., Comparative Analysis of the Major Constituents in the Traditional Tibetan Medicinal Plants Saussurea laniceps and S. medusa by LC–DAD–MS. Chromatographia 2009, 70, 957-962. Yi, T.; Tang, Y.; Zhang, J.; Zhao, Z.; Yang, Z.; Chen, H., Characterization and determination of six flavonoids in the ethnomedicine “Dragon’s Blood” by UPLC-PAD-MS. Chemistry Central journal 2012, 6, 1-7. Yi, T.; Chen, Q.; He, X.; So, S.; Lo, Y.; Fan, L.; Xu, J.; Tang, Y.; Zhang, J.; Zhao, Z.; Chen, H., Chemical quantification and antioxidant assay of four active components in Ficus hirta root using UPLC-PAD-MS fingerprinting combined with cluster analysis. Chemistry Central journal 2013, 7, 115. Yin, J.; Kouda, K.; Tezuka, Y.; Tran, Q. L.; Miyahara, T.; Chen, Y.; Kadota, S., Steroidal glycosides from the rhizomes of Dioscorea spongiosa. Journal of natural products 2003, 66, 646-650. Yongming, G.; Lihong, Y.; Wenqian, L.; Pingkai, O., Determination of diosgenin in Dioscoreo zingiberensis cell by RP-HPLC. Natural Product Research and Development 2004, 16, 331-333. Yoshikawa, M.; Murakami, T.; Komatsu, H.; Murakami, N.; Yamahara, J.; Matsuda, H., Medicinal Foodstuffs. IV. Fenugreek Seed. (1) : Structures of Trigoneosides Ia, Ib, IIa, IIb, IIIa, and IIIb, New Furostanol Saponins from the Seeds of Indian Trigonella foenum-graecum L. CHEMICAL PHARMACEUTICAL BULLETIN 1997, 45, 81-87. Yoshikawa, M.; Xu, F.; Morikawa, T.; Pongpiriyadacha, Y.; Nakamura, S.; Asao, Y.; Kumahara, A.; Matsuda, H., Medicinal Flowers. XII.<sup>1)</sup> New Spirostane-Type Steroid Saponins with Antidiabetogenic Activity from <i>Borassus flabellifer</i>. Chemical and Pharmaceutical Bulletin 2007, 55, 308-316. Yu, Y.; Hu, S.; Li, G.; Xue, J.; Li, Z.; Liu, X.; Yang, X.; Dong, B.; Wang, D.; Wang, X.; Liu, S.; Liu, J.; Chen, B.; Wang, L.; Liu, S.; Chen, Q.; Shen, C.; Wang, Z.; Wang, Y., Comparative effectiveness of Di'ao Xin Xue Kang capsule and Compound Danshen tablet in patients with symptomatic chronic stable angina. Sci Rep 2014, 4, 7058-7058. Yun, H.; Lijian, C.; Wenhong, Z.; Yuhong, D.; Yongli, W.; Qiang, W.; Ding, Z., Separation and identification of steroidal compounds with cytotoxic activity against human gastric cancer cell lines in vitro from the rhizomes of Paris polyphylla var. chinensis. Chemistry of Natural Compounds 2007, 43, 672-677. ZAN, L.-x.; ZHONG, X.-l.; SUN, W.-j., HPLC and spectrophotometry determination of saponins in Dioscorea zingiberensis CH Wright. Chinese Journal of Pharmaceutical Analysis 2008, 28, 111-114. Zhang, L.; Qiu, H.; Yuan, S.; Guo, M.; Guo, Z.; Yu, L., Revelation of mechanism for aqueous saponins content decrease during storage of Dioscorea zingiberensis C. H. Wright tubers: An essential prerequisite to ensure clean production of diosgenin. Industrial Crops and Products 2018, 125, 178-185. Zhang, R.; Huang, B.; Du, D.; Guo, X.; Xin, G.; Xing, Z.; Liang, Y.; Chen, Y.; Chen, Q.; He, Y.; Huang, W., Anti-thrombosis effect of diosgenyl saponins in vitro and in vivo. Steroids 2013, 78, 1064-1070. Zhang, Y.; Li, H.-Z.; Zhang, Y.-J.; Jacob, M. R.; Khan, S. I.; Li, X.-C.; Yang, C.-R., Atropurosides A–G, new steroidal saponins from Smilacina atropurpurea. Steroids 2006, 71, 712-719. Zhang, Y.; Yu, H. Y.; Chao, L. P.; Qu, L.; Ruan, J. Y.; Liu, Y. X.; Dong, Y. Z.; Han, L. F.; Wang, T., Anti-inflammatory steroids from the rhizomes of Dioscorea septemloba Thunb. Steroids 2016, 112, 95-102. Zhang, Z.; Gao, W.; Wang, R.; Huang, L., Changes in main nutrients and medicinal composition of Chinese yam (Dioscorea opposita) tubers during storage. Journal of food science and technology 2014, 51, 2535-2543. Zhao, Y.; Kang, L.; Yu, H.; Zhang, J.; Xiong, C.; Pang, X.; Gao, Y.; Liu, C.; Ma, B., Structure characterization and identification of steroidal saponins from the rhizomes of Anemarrhena asphodeloides by ultra performance liquid chromatography and hybrid quadrupole time-of-flight mass spectrometry. International Journal of Mass Spectrometry 2013, 341-342, 7-17. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/80656 | - |
| dc.description.abstract | "薯蕷(Dioscorea spp.)與葫蘆巴(Trigonella foenum-graecum.)是中國傳統食藥材料，其生理活性差異來自於其中主要活性物質——固醇類皂苷(steroidal saponins)的多元結構，因此需要鑑別其組成的分析平臺。本研究使用超高效能液相層析串聯高解析質譜法(UHPLC-HRMS)建立鑑別47種固醇類皂苷之方法。高解析質譜分析平台藉由化合物層析性質、精確分子量、同位素分佈與分子斷裂模式可以鑑別出35種furostanol型皂苷與12種spirostanol型皂苷，其中包含10對同分異構物，有39種採用定量或半定量分析。食用薯蕷中皂苷含量遠低於藥用薯蕷與葫蘆巴，所有樣品中普遍存在的皂苷為protodioscin。葫蘆巴和薯蕷中只有43.6%的皂苷是相同的。葫蘆巴豆芽(HLB_Bu)具有29種固醇類皂苷，主要成分為furostanol型皂苷，其含量佔了總皂苷含量的95%以上。diosgenin、trillin、deltonin、protodeltonin僅存在於特定樣品中。zingiberenoside B為盾葉薯蕷中獨有的成分。三種萆薢中，只有粉萆薢中含有trigoneoside XIIIb與zingiberensis New Saponin。trigoneoside XVIIa、trigoneoside XVIIb、FU5、trigoneoside IIa與trigoneoside IIb是區分葫蘆巴豆與葫蘆巴豆芽的指標化合物。薯蕷中皂苷含量最高的是皮，其次是肉，最少的是葉子和梗。基隆山藥皮中的皂苷含量為梗中的9.39倍。由於雙葡萄醣皂苷(diosgenin diglucoside)、單醣皂苷和皂苷元等spirostanol型皂苷在天然植物中的含量低，因此需要使用三氟乙酸(trifluoroacetic acid, TFA)水解上述萃取物來增加。薯蕷中固醇皂苷不會受光照與熱加工的影響，但容易受到微生物群落(microbial community)與酵素的作用而產生結構的變化。本研究利用UHPLC-HRMS所建立的分析平台，可以有效篩選鑑別薯蕷與葫蘆巴中的固醇類皂苷，通過定量與半定量的方式靈敏地檢測出不同品種、部位以及加工方式樣品中的皂苷差異與含量，可協助薯蕷育種篩選與製程品質管控需求之應用。" | zh_TW |
| dc.description.provenance | Made available in DSpace on 2022-11-24T03:11:57Z (GMT). No. of bitstreams: 1 U0001-2010202112534500.pdf: 13669417 bytes, checksum: 55e7e9dc11c4d65b16d7a33b0699dfe1 (MD5) Previous issue date: 2021 | en |
| dc.description.tableofcontents | 目錄 摘要 i Abstract ii 目錄 iv 圖目錄 viii 表目錄 xv 壹、 前言 1 貳、文獻回顧 2 第一章、薯蕷與葫蘆巴 2 1.1 薯蕷 2 1.2 薯蕷的種類 3 1.3 薯蕷的生理活性 7 1.4 葫蘆巴 8 第二章、C-27固醇類皂苷 9 2.1 皂苷 9 2.2 薯蕷與葫蘆巴中C-27固醇類皂苷 10 第三章、固醇類皂苷的生理活性 14 3.1 抗腫瘤活性 14 3.2 抗炎、抗真菌活性 14 3.3 降低血醣血脂 15 3.4 溶血作用 15 3.5 體外血小板活性 15 3.6 驅蟲劑 16 3.7 皂苷生理活性與結構的關係 17 第四章、分析固醇類皂苷的方法 18 4.1 紅外線光譜法 18 4.2 紫外線光譜法 18 4.3 酸水解 18 4.4 酵素水解 18 4.5 核磁共振光谱分析 19 4.5.1 使用核磁共振氫譜判斷Aglycon和寡醣側鏈的結構 20 4.5.2 使用核磁共振碳譜判斷Aglycon和寡醣側鏈的結構 20 4.6 液相層析串聯質譜 21 4.7 固醇皂苷系統命名方法 24 叁、研究目的及架構 25 肆、材料與方法 26 第一章、實驗材料 26 1.1 薯蕷與葫蘆巴樣品列表 26 1.2 代表性基質 30 第二章、實驗藥品 31 2.1 標準品 31 2.2 化學藥品 31 第三章、實驗儀器及數據處理軟體 31 3.1 前處理儀器設備 31 3.2 高效液相層析串聯質譜儀 32 3.3 數據處理軟體 32 第四章、實驗方法 33 4.1 樣品前處理 33 4.1.1 氣炸鍋處理山藥樣品 33 4.1.2 熱風乾燥處理山藥樣品 33 4.1.3 水煮處理山藥樣品 33 4.1.4 水蒸處理山藥樣品 33 4.1.5 酸水解樣品 33 4.1.6 内部標準品的選擇、濃度選擇以及添加方式 34 4.1.7 品管樣品的製備 34 4.2 層析移動相配置 35 4.2.1 乙腈分析系統 35 4.2.2 甲醇分析系統 35 4.3 層析儀相關參數設定 35 4.4 質譜儀參數設定 37 4.5 固醇皂苷絕對定量與相對定量分析 39 伍、結果與討論 40 第一章、超高效液相層析儀分析條件評估 40 1.1 固醇皂苷的萃取 40 1.2 移動相的選擇 40 1.3 管柱的選擇 42 第二章、固醇皂苷以超高效液相層析串聯高解析質譜法分析 46 2.1 固醇皂苷以超高效液相層析儀分離 46 2.2 固醇皂苷以高解析質譜偵測 53 2.3 固醇類皂苷於高解析質譜儀上正負電模式的選擇與前驅離子的種類 53 2.3.1 F-I、F-II、F-III、F-IV、F-VI、F-VII、S型皂苷正負電模式的選擇與前驅離子的種類 53 2.3.2 F-V型皂苷正負電模式的選擇與前驅離子的種類 54 2.4 固醇類皂苷碎片離子與結構的關係 55 2.5 固醇類皂苷之代表性基質選擇以及效應評估 67 2.6 基質匹配檢量缐 69 2.7 方法定量極限 70 2.8 方法回收率 70 第三章、薯蕷與葫蘆巴中固醇皂苷的分佈情形 71 3.1 薯蕷及葫蘆巴樣品所含固醇類皂苷種數比較 71 3.2 薯蕷及葫蘆巴樣品所含固醇類皂苷總量比較 73 3.3 薯蕷及葫蘆巴樣品中固醇類皂苷比較 75 3.4 薯蕷及葫蘆巴樣品主成分分析結果 103 3.5 薯蕷中不同部位的皂苷含量和種類比較 106 3.6 加工處理後薯蕷中固醇類皂苷含量變化 107 柒、參考文獻 111 捌、附錄 123 第一章、薯蕷與葫蘆巴樣品之固醇皂苷含量玫瑰圖 123 第二章、品管樣品中固醇皂苷滯留時間與含量之品質管制 134 第三章、品管樣品固醇皂苷之含量品管圖 137 第四章、品管樣品固醇皂苷之時間品管圖 151 第五章、固醇類皂苷定性圖譜 166 第六章、Chromolith 管柱附加信息 215 | |
| dc.language.iso | zh-TW | |
| dc.subject | 超高效能液相層析串聯高解析質譜法 | zh_TW |
| dc.subject | 薯蕷 | zh_TW |
| dc.subject | 葫蘆巴 | zh_TW |
| dc.subject | 固醇類皂苷 | zh_TW |
| dc.subject | Dioscorea | en |
| dc.subject | UHPLC-HRMS | en |
| dc.subject | steroidal saponins | en |
| dc.subject | fenugreek | en |
| dc.title | 利用超高效能液相層析串聯高解析質譜法建立薯蕷與葫蘆巴中的固醇類皂苷分析平臺 | zh_TW |
| dc.title | Establishment of analytical platform for steroidal saponins in Dioscorea spp. and Trigonella foenum-graecum. by UHPLC-MS | en |
| dc.date.schoolyear | 109-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 陳宏彰(Hsin-Tsai Liu),張永和(Chih-Yang Tseng),王惠珠,楊登傑 | |
| dc.subject.keyword | 薯蕷,葫蘆巴,固醇類皂苷,超高效能液相層析串聯高解析質譜法, | zh_TW |
| dc.subject.keyword | Dioscorea,fenugreek,steroidal saponins,UHPLC-HRMS, | en |
| dc.relation.page | 276 | |
| dc.identifier.doi | 10.6342/NTU202103921 | |
| dc.rights.note | 同意授權(限校園內公開) | |
| dc.date.accepted | 2021-10-25 | |
| dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
| dc.contributor.author-dept | 食品科技研究所 | zh_TW |
| 顯示於系所單位： | 食品科技研究所 | |
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