人工眼角膜之光學模擬分析與架設Shack-Hartmann 波前量測儀器

Abstract

近年來，許多人因角膜受損而導致失明，是全球性的議題，對於那些病人而言，角膜的數量不足一直是個問題，因此用人工角膜替代受損角膜成為一種很好的取代方案。而具交聯網絡結構(interpenetrating polymer network, IPN)的水凝膠材料作為一種具生物相容性、親水性且有一定機械性質之材料，被認為是很好製作人工眼角膜的材料，配合3D列印可客製化等特性，提供病人除角膜移植外另一種更好的選擇。 本論文中我們建構模擬眼模型來分析用於製造人造角膜的兩種IPN水凝膠材料，P-407-DA(Poloxamer 407 diacrylate)+PAA(Polyacrylic acid)與P-407-DA+PHEMA(Poly(2-hydroxyethyl methacrylate))的光學性質。我們模擬三種不同的人工角膜表面類型，並使用Zernike多項式來分析它們的波前像差。結果表明，雙錐面是這三種表面的最佳面型。此外，我們發現增加人造角膜表面的非球面度對於模擬真實角膜也是非常重要的。本論文最後，我們也架構了一套Shack-Hartmann波前量測儀器用於量測光學元件之波前像差。

In recent years, lots of people are blindness due to the corneal problem, which is a global issue. Due to the problem of the shortage of donor corneas, for those patients, artificial cornea is another way to solve their problem. IPN hydrogel is a good artificial corneal material due to its good biocompatibility, hydrophilicity and mechanical properties. In conjunction with 3D printing customizable features, it gives patients another choice to replace the damage cornea from transplant surgery to artificial cornea. In this thesis, we simulate an eye model to analyze the optical quality of two different IPN hydrogel, P-407-DA+PAA and P407DA+PHEMA, which is with biocompatibility property for manufacturing artificial cornea. We simulate three difference surface types and use the Zernike polynomials to check their wavefront aberrations. The results show that biconic surface is the best surface type of these three surfaces in this work. Also, we found that increasing the asphericity in the surface of artificial cornea is important to approach the real cornea in our simulations. At last, we construct the Shack-Hartmann wavefront sensor to measure the optical element’s wavefront aberration.