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Title: | 製備MCP-1功能化之含鈀有機金屬框架(MCP-1-Pd@MIL-100)應用於單核球標靶與光熱治療潛力的材料 Synthesis of MCP-1 Functionalized Pd-embedded Metal-Organic Frameworks (MCP-1-Pd@MIL-100) for Monocytes-Targeting and Potential Photothermal Therapy |
Authors: | 蕭宏霖 Hung-Lin Hsiao |
Advisor: | 吳嘉文 |
Keyword: | 有機金屬框架,原位合成法 (de novo),鈀,光熱治療,單核球趨化蛋白-1 (MCP-1), MIL-100,de novo synthesis,palladium,photothermal therapy,monocyte chemoattractant protein-1 (MCP-1), |
Publication Year : | 2019 |
Degree: | 碩士 |
Abstract: | 光熱治療是一種癌症治療方式,相較於傳統的癌症治療,其對於正常組織的傷害較低。在眾多的光熱材料中,我們著重於有機金屬框架的材料合成(MIL-100)。 MIL-100是由有機配體(均苯三甲酸)與鐵團簇組成的孔洞材料,其具有高生物相容性、被生物降解性與高比表面積,於藥物釋放系統中,是種具有發展潛力的生醫材料。此外,為了將MIL-100應用於光熱治療,我們成功利用原位合成法將光熱材料-鈀包覆在MIL-100內。合成出的材料(Pd@MIL-100)具有粒徑大小、包覆鈀含量與光熱效果的可調性,且材料還擁有高生物相容性、促進免疫細胞THP-1的增殖與有效的光熱性質。接著,我們於嵌入鈀的MIL-100的表面修飾上單核球趨化蛋白-1 (MCP-1)後,使單核球能夠於短時間內增加材料的吞噬。在未來,具有MCP-1功能性且包覆鈀的MIL-100被認為是具有潛力將光熱治療應用於動物實驗。 Photothermal therapy, one of the cancer treatments, exhibits less harmful to normal tissues than other conventional treatments. Among different photothermal agents, we focus on synthesizing a metal-organic framework (MOF) based material (i.e. MIL-100) that consists of the organic ligand (i.e. trimesic acid) and iron clusters. The synthesized MIL material exhibits high biocompatibility, biodegradability and high specific surface area, which is a potential biomaterial for drug delivery system. In addition, to apply MIL-100 for photothermal therapy, we successfully synthesized palladium embedded MIL-100 through de novo method. The obtained material (i.e. Pd@MIL-100) demonstrates adjustable properties such as particle size, palladium content, and photothermal activity, etc. Furthermore, the Pd@MIL-100 material possesses high biocompatibility, enhanced cell proliferation, and efficient photothermal property. Subsequently, the Pd embedded MIL-100 is modified with monocyte chemoattractant protein-1 (MCP-1) in order to increase the cellular uptake of material in a short time. The synthesized MCP-1 functionalized, Pd-embedded MIL-100 material is expected to have great potential in photothermal therapy in vivo in the future. |
URI: | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/78780 |
DOI: | 10.6342/NTU201901374 |
Fulltext Rights: | 未授權 |
metadata.dc.date.embargo-lift: | 2024-07-19 |
Appears in Collections: | 化學工程學系 |
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ntu-107-2.pdf Restricted Access | 5.28 MB | Adobe PDF |
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