請用此 Handle URI 來引用此文件：
http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/78467完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 沈立言 | zh_TW |
| dc.contributor.advisor | Lee-Yan Sheen | en |
| dc.contributor.author | 黃韻如 | zh_TW |
| dc.contributor.author | Yun-Ju Huang | en |
| dc.date.accessioned | 2021-07-11T14:58:36Z | - |
| dc.date.available | 2024-12-31 | - |
| dc.date.copyright | 2020-01-21 | - |
| dc.date.issued | 2020 | - |
| dc.date.submitted | 2002-01-01 | - |
| dc.identifier.citation | 中文部分
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/78467 | - |
| dc.description.abstract | 根據世界衛生組織 (WHO) 於 2008 年以失能調整生命年 (DALY) 指標預測憂鬱症至 2030 年成為全球疾病負擔的第二名。研究指出自 1990 至 2010 台灣憂鬱焦慮患者比例倍增。因此，若能從天然食物中找尋具有對抗憂鬱效能或潛力之成分，以此開發機能性食品，特別是針對亞健康族群可做為預防或延緩憂鬱症的發生，並以此降低社會、經濟的損失及醫療成本的支出。近年來，大蒜於學術上的研究廣泛，主要的研究為抗菌、抗發炎、抗氧化、抗血栓、抗癌抗腫瘤、調節血脂及護肝之作用，但對於抗憂鬱相關研究則較為有限。本研究目的為探討大蒜精油 (garlic essential oil, GEO) 及其活性成分二丙烯基二硫化物 (diallyl disulfide, DADS) 對於強迫游泳試驗 (forced swimming test, FST) 和不可預期性的慢性溫和壓力試驗 (unpredictable chronic mild stress, UCMS) 誘導之類憂鬱大鼠是否具抗憂鬱效果。實驗其間給予每公斤體重 25 和 50 毫克之大蒜精油和每公斤體重 10 和 20 毫克之大蒜精油中主要活性成分 DADS，其結果顯示在強迫游試驗中 GEO 夠顯著降低不活動時間及增加游泳的時間，且 GEO 能夠有效改善蔗糖偏好程度下降及增加開放空間 試 驗 中 的 總 移 動 距 離 。 以 高 效 能 液 相 層 析 (high performance liquid chromatography, HPLC) 檢測腦部單胺類物質含量並計算其代謝轉換比率，發現GEO 及其活性成分 DADS 能夠顯著降低因壓力引致代謝速率升高的情形及增加多巴胺和血清素含量。在蛋白質表現方面，大蒜精油能顯著增加海馬迴腦源性神經滋養因子 (brain-derived neurotrophic factor, BDNF) 和 PDS-95 蛋白質表現量及提升海馬迴環化單磷酸腺苷反應元件結合蛋白 (cAMP response element binding protein, CREB) 與蛋白質激酶 B (protein kinase B, AKT) 磷酸化型態之表現。綜合上述結果，GEO 可藉由增加單胺類物質合成及降低代謝轉換比率，透過多巴胺及血清素系統共同之影響來調節神經傳導物質。此外，亦能同時提升額葉皮質及海馬迴中腦源性神經滋養因子相關路徑表現而達到抗憂鬱之功效。 | zh_TW |
| dc.description.abstract | Depression is one of the most prevalent chronic neuropsychiatric disorders that expected to increase over the next 10 years. Due to the limitation of efficacy and undesirable adverse effects of antidepressant, the chronic and recurrent depression is still present at high rates. Accordingly, it is important to develop efficient and safe drugs as alternative therapeutics for mental illness. Forced swimming test (FST) is a very effective and well-established platform to predict the antidepressant efficacy in rodent. Garlic is a dietary supplement derived from the bulb of Allium sativum and widely used as a flavoring agent for food and a medicinal agent for the treatment of a variety of diseases. The antidepressant property of garlic essential oil (GEO) has not been reported scientifically. The present study investigated the possible antidepressant-like effects of repeated (28
days) administration of GEO, which dosage are 25 and 50 mg/kg bw by gavage to rats exposed to a forced swimming test (FST). In addition, GEO has been reported to contain more than 30 organosulfur compounds (OSCs), and DAS, DADS, and DATS have been identified as the three major components. The result showed that GEO decreased the immobility time in the FST without accompanying changes in general activity in the open field test (OFT) during treatment, suggesting an antidepressant-like effect. In addition, unpredictable chronic mild stress (UCMS) employs exposure to inescapable or uncontrollable stress and can reliably detect antidepressant drug response. Treatment GEO significantly reversed the sucrose preference and restored the higher turnover ratio of serotonin (5-HT) and dopamine (DA) in prefrontal cortex and hippocampus in unpredictable chronic mild stress. Furthermore, GEO not only increased brain-derived neurotrophic factor (BDNF) expression, but also promoted phosphorylation of cAMP response element binding protein (CREB) and protein kinase B (AKT) in prefrontal cortex and hippocampus. | en |
| dc.description.provenance | Made available in DSpace on 2021-07-11T14:58:36Z (GMT). No. of bitstreams: 1 ntu-109-D04641004-1.pdf: 6529380 bytes, checksum: ddb12dd0cc14123c3fa9ee9ddd11748b (MD5) Previous issue date: 2020 | en |
| dc.description.tableofcontents | 誌謝 ................................................................ i
中文摘要 ........................................................... ii Abstract .......................................................... iii 目錄 ............................................................... iv 圖目錄 ............................................................. vi 表目錄 ............................................................. ix 縮寫表 .............................................................. x 第一章、前言 ........................................................ 1 第二章、文獻回顧 .................................................... 3 第一節、憂鬱症 .................................................. 3 一、定義 .................................................... 3 二、分類及診斷 .............................................. 3 三、流行病學 ................................................ 4 四、自殺與憂鬱症 ............................................ 6 五、成因 .................................................... 7 六、治療方式 ............................................... 14 七、常見的動物評估模式 ..................................... 19 第二節、大蒜精油 ............................................... 24 一、大蒜 ................................................... 24 二、大蒜精油與成分之生理活性 ............................... 24 三、大蒜之神經保護功效 ..................................... 26 第三章、研究目的 ................................................... 30 第一節、研究假說 ............................................... 30 第二節、研究目的 ............................................... 30 第四章、實驗架構 ................................................... 32 第一節、大蒜精油成分分析 ....................................... 32 第二節、強迫游泳試驗與開放空間試驗 ............................. 33 第三節、不可預期性的慢性溫和壓力試驗與開放空間試驗 ............. 34 第五章、材料與方法 35 第一節、實驗材料 35 第二節、實驗方法 41 第六章、實驗結果 51 第一節、大蒜精油成分分析 51 第二節、強迫游泳試驗中大鼠體重、攝食與水攝取量 53 第三節、強迫游泳試驗與開放空間試驗 57 第四節、不可預期性的慢性溫和壓力試驗之大鼠體重 61 第五節、不可預期性的慢性溫和壓力試驗與開放空間試驗 63 第六節、組織切片之檢測 67 第七節、腦部單胺類物質之檢測 69 第八節、血清皮質固醇濃度檢測 85 第九節、腦部蛋白質分析 88 第七章、討論 104 第一節、大蒜精油成分討論 104 第二節、強迫游泳試驗與開放空間試驗 106 第三節、不可預期性的慢性溫和壓力試驗與開放空間試驗 108 第四節、血清皮質固醇濃度檢測 110 第五節、腦部單胺類物質之檢測 111 第六節、腦部蛋白質之分析 118 第八章、結論 124 參考文獻 126 第一節、中文部分 126 第二節、英文部分 126 | - |
| dc.language.iso | zh_TW | - |
| dc.subject | 腦源性神經滋養因子 | zh_TW |
| dc.subject | 不可預期性的慢性溫和壓力試驗 | zh_TW |
| dc.subject | 強迫游泳試驗 | zh_TW |
| dc.subject | 憂鬱症 | zh_TW |
| dc.subject | 大蒜精油 | zh_TW |
| dc.subject | forced swimming test | en |
| dc.subject | depression | en |
| dc.subject | garlic essential oil | en |
| dc.subject | unpredictable chronic mild stress | en |
| dc.subject | BDNF | en |
| dc.title | 大蒜精油及其活性成分之抗憂鬱作用機制研究 | zh_TW |
| dc.title | Investigation the mechanism of antidepressant-like effects of garlic essential oil and its bioactive compound | en |
| dc.type | Thesis | - |
| dc.date.schoolyear | 108-1 | - |
| dc.description.degree | 博士 | - |
| dc.contributor.oralexamcommittee | 謝慶良;朱永麟;胡宗明;黃翠琴 | zh_TW |
| dc.contributor.oralexamcommittee | Ching-Liang Hsieh;Yung-Lin Chu;Tsung-Ming Hu;Tsui-Chin Huang | en |
| dc.subject.keyword | 憂鬱症,大蒜精油,強迫游泳試驗,不可預期性的慢性溫和壓力試驗,腦源性神經滋養因子, | zh_TW |
| dc.subject.keyword | depression,forced swimming test,garlic essential oil,unpredictable chronic mild stress,BDNF, | en |
| dc.relation.page | 161 | - |
| dc.identifier.doi | 10.6342/NTU202000136 | - |
| dc.rights.note | 未授權 | - |
| dc.date.accepted | 2020-01-16 | - |
| dc.contributor.author-college | 生物資源暨農學院 | - |
| dc.contributor.author-dept | 食品科技研究所 | - |
| dc.date.embargo-lift | 2025-01-21 | - |
| 顯示於系所單位： | 食品科技研究所 | |
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