利用車輪烷結構穩定具高反應性的分子

Abstract

透過適當的設計，二胺與二醛分子所形成的亞胺大環可”夾鎖”到具有適當辨識系統的啞鈴型分子上，將其亞胺鍵還原並把所得之二級胺甲基化以後，便可分離得到穩定的車輪烷分子。利用車輪烷上內鎖大環在立體上所提供的保護，可使啞鈴型分子上具高反應性官能基得到穩定性的提升。

Through proper design, an imino macrocycle generated from a diamine and a dialdehyde can “clip” onto a dumbbell-shaped guest to generate the corresponding imino rotaxane, which can then be transformed to stable rotaxane via reduction and methylation. We hope to use the interlocked macrocycles of the rotaxane to provide the necessary steric protection for increasing the stability of the highly reactive functionalities on the dumbbell-shaped units.