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  1. NTU Theses and Dissertations Repository
  2. 電機資訊學院
  3. 生醫電子與資訊學研究所
請用此 Handle URI 來引用此文件: http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/7432
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dc.contributor.advisor李百祺(Pai-Chi Li)
dc.contributor.authorTeng-Yuan Yehen
dc.contributor.author葉騰遠zh_TW
dc.date.accessioned2021-05-19T17:43:29Z-
dc.date.available2023-08-21
dc.date.available2021-05-19T17:43:29Z-
dc.date.copyright2018-08-21
dc.date.issued2018
dc.date.submitted2018-08-18
dc.identifier.citation[1] 沈清良, '實用解剖學,' 4 ed: 華杏出版社股份有限公司, 2011.
[2] 許世昌, '新編解剖學,' 3 ed: 永大書局有限公司, 2013.
[3] 蔡秀鸞, '最新實用內外科護理學,' 5 ed: 永大書局有限公司, 2013.
[4] P. A. Tunick and I. Kronzon, 'Protruding atherosclerotic plaque in the aortic arch of patients with systemic embolization: a new finding seen by transesophageal echocardiography,' American heart journal, vol. 120, no. 3, pp. 658-660, 1990.
[5] E. G. Dimond, C. F. Kittle, and J. E. Crockett, 'Comparison of internal mammary artery ligation and sham operation for angina pectoris∗,' The American journal of cardiology, vol. 5, no. 4, pp. 483-486, 1960.
[6] F. Wackers, 'Exercise myocardial perfusion imaging,' Journal of nuclear medicine: official publication, Society of Nuclear Medicine, vol. 35, no. 4, pp. 726-729, 1994.
[7] N. R. Mollet et al., 'High-resolution spiral computed tomography coronary angiography in patients referred for diagnostic conventional coronary angiography,' Circulation, vol. 112, no. 15, pp. 2318-2323, 2005.
[8] J. Ge et al., 'Intravascular ultrasound imaging of angiographically normal coronary arteries: a prospective study in vivo,' Heart, vol. 71, no. 6, pp. 572-578, 1994.
[9] S. Okazaki et al., 'Early statin treatment in patients with acute coronary syndrome: demonstration of the beneficial effect on atherosclerotic lesions by serial volumetric intravascular ultrasound analysis during half a year after coronary event: the ESTABLISH Study,' Circulation, vol. 110, no. 9, pp. 1061-1068, 2004.
[10] F. G. S. Goar, F. J. Pinto, E. L. Alderman, P. J. Fitzgerald, M. L. Stadius, and R. L. Popp, 'Intravascular ultrasound imaging of angiographically normal coronary arteries: an in vivo comparison with quantitative angiography,' Journal of the American College of Cardiology, vol. 18, no. 4, pp. 952-958, 1991.
[11] I. De Scheerder et al., 'Intravascular ultrasound versus angiography for measurement of luminal diameters in normal and diseased coronary arteries,' American heart journal, vol. 127, no. 2, pp. 243-251, 1994.
[12] D. H. Turnbull et al., 'A 40–100 MHz B-scan ultrasound backscatter microscope for skin imaging,' Ultrasound in Medicine and Biology, vol. 21, no. 1, pp. 79-88, 1995.
[13] G. Lockwood, D. Turnball, D. Christopher, and F. S. Foster, 'Beyond 30 MHz [applications of high-frequency ultrasound imaging],' IEEE Engineering in Medicine and Biology Magazine, vol. 15, no. 6, pp. 60-71, 1996.
[14] W. G. Cady, Piezoelectricity: an introduction to the theory and applications of electromechanical phenomena in crystals. New York: McGraw-Hill, 1946.
[15] K. K. Shung, J. Cannata, and Q. Zhou, 'Piezoelectric materials for high frequency medical imaging applications: A review,' Journal of Electroceramics, vol. 19, no. 1, pp. 141-147, 2007.
[16] Q. Zhou, K. H. Lam, H. Zheng, W. Qiu, and K. K. Shung, 'Piezoelectric single crystal ultrasonic transducers for biomedical applications,' Progress in materials science, vol. 66, pp. 87-111, 2014.
[17] K. Nakamura, Ultrasonic transducers: Materials and design for sensors, actuators and medical applications. Elsevier, 2012.
[18] F. LEVASSORT, L. P. TRAN-HUU-HUE, D. CERTON, and M. LETHIECQ, 'PIEZOELECTRIC MATERIALS FOR ULTRASONIC TRANSDUCERS: REVIEW OF RECENT DEVELOPMENTS,' ed: Laboratoire d‟ Ultrasons, Signaux et Instrumentation, GIP Ultrasons, 2002.
[19] K. A. Snook et al., 'Design, fabrication, and evaluation of high frequency, single-element transducers incorporating different materials,' IEEE transactions on ultrasonics, ferroelectrics, and frequency control, vol. 49, no. 2, pp. 169-176, 2002.
[20] S. M. Ji, C. Y. Park, J. H. Sung, S. M. Kim, and J. S. Jeong, 'A Study of Backing Layer Structure for Intravascular Ultrasound Transducer,' Journal of Medical Devices, vol. 10, no. 3, p. 030933, 2016.
[21] H. Wang, T. Ritter, W. Cao, and K. K. Shung, 'High frequency properties of passive materials for ultrasonic transducers,' IEEE transactions on ultrasonics, ferroelectrics, and frequency control, vol. 48, no. 1, pp. 78-84, 2001.
[22] S. Thiagarajan, R. W. Martin, A. Proctor, I. Jayawadena, and F. Silverstein, 'Dual layer matching (20 MHz) piezoelectric transducers with glass and parylene,' IEEE transactions on ultrasonics, ferroelectrics, and frequency control, vol. 44, no. 5, pp. 1172-1174, 1997.
[23] R. Collin, 'Theory and design of wide-band multisection quarter-wave transformers,' Proceedings of the IRE, vol. 43, no. 2, pp. 179-185, 1955.
[24] P. Sun et al., 'High frequency PMN-PT 1-3 composite transducer for ultrasonic imaging application,' Ferroelectrics, vol. 408, no. 1, pp. 120-128, 2010.
dc.identifier.urihttp://tdr.lib.ntu.edu.tw/jspui/handle/123456789/7432-
dc.description.abstract血管內超音波系統(Intravascular Ultrasound)因能對血管內腔組織深層進行成像、提供血管硬化病灶長度資訊、且在即時成像等優勢,在臨床應用中有助於正確地評估病情。血管內超音波系統需透過高速旋轉超音波探頭與線性移動機構來實現血管影像,因此需要搭配超音波探頭微小化、旋轉與線性馬達、以及電路旋轉連接器等元件。本論文提出微小化超音波探頭的製程,並嘗試透過結合自製的旋轉移動機構來完成血管內超音波影像系統之原型。本研究使用聚偏二氟乙烯、鈮酸鋰、鈮鎂酸鉛-鈦酸鉛作為壓電材料,並將其固定於軟性電路板載板上。所製作出來的超音波探頭原型尺寸為0.5mm2。在自發自收量測以及頻譜分析中,三種材料的探頭其中心頻率分別落在50、45、34MHz、而相對應的頻寬分別為25、15、17MHz頻寬。最後我們整合超音波探頭、超音波系統與自製之旋轉移動機構,並實際對鎢線仿體進行成像。zh_TW
dc.description.abstractIntravascular ultrasound (IVUS) system, which can provide real-time information of vascular tissue, vascular sclerosis and lesion length, is a reliable image modality in clinical assessment. Generally, IVUS consists of a specified ultrasound transducer, rotational/linear motion motors, and the corresponding connector. We proposed a prototype of IVUS system which integrated a specified transducer fabrication for IVUS and a motor drive unit. Three materials, 1) Polyvinylidene Difluoride, 2) Lithium Niobate, and 3) Lead magnesium niobate-lead titanate, were used to fabricate the transducers. The size of the transducers are less than 0.5 mm2, and each transducer were mounted on a flexible printed circuit, and the final size of transducer. The central frequencies/bandwidths of our transducer are 50(25), 45(15), and 34(17)MHz respectively. Finally, the image of tungsten wire was successfully obtained by the prototype of our IVUS system.en
dc.description.provenanceMade available in DSpace on 2021-05-19T17:43:29Z (GMT). No. of bitstreams: 1
ntu-107-R01945035-1.pdf: 3623556 bytes, checksum: b94d86234bc93a7f5365118c44ec1e61 (MD5)
Previous issue date: 2018
en
dc.description.tableofcontents口試委員會審定書 #
誌謝 i
中文摘要 ii
ABSTRACT iii
目錄 iv
圖目錄 vii
表目錄 x
Chapter 1 緒論 1
1.1 動脈血管結構 2
1.2 動脈粥狀硬化 3
1.3 心血管疾病診斷檢查 5
1.4 血管內超音波 9
1.5 血管內超音波影像特性 10
1.6 研究動機與目的 11
1.7 論文架構 12
Chapter 2 超音波探頭設計理論 13
2.1 血管內超音波探頭架構 14
2.1.1 壓電材料 14
2.1.2 後方匹配層 16
2.1.3 前方匹配層 17
2.1.4 電極層 18
2.1.5 金屬外殼 18
2.2 超音波探頭效能評估 19
2.2.1 空間解析度 19
2.2.2 景深 20
2.2.3 頻寬 21
2.2.4 嵌入式損失 21
Chapter 3 血管內超音波探頭製作 22
3.1 血管內超音波探頭設計 22
3.1.1 制定探頭規格 22
3.2 血管內超音波探頭製作流程 24
3.2.1 壓電材料前處理與研磨 25
3.2.2 製作後方匹配層 27
3.2.3 晶體切割 28
3.2.4 軟性電路板連接 29
3.2.5 區域性絕緣阻隔與濺鍍電極層 30
3.2.6 製作前方匹配層與封裝 31
Chapter 4 血管內超音波探頭驗證與再設計 32
4.1 血管內超音波探頭量測 32
4.1.1 量測實驗環境架設 32
4.1.2 PVDF型血管內超音波探頭訊號分析 33
4.1.3 LN型血管內超音波探頭訊號分析 35
4.1.4 PMN-PT型血管內超音波探頭分析 37
4.2 血管內超音波探頭製程討論 38
4.3 血管內超音波探頭訊號討論 39
4.4 血管內超音波探頭再設計 40
4.4.1 金屬外殼封裝版本血管內超音波探頭製程流程 41
4.4.2 金屬外殼封裝版本血管內超音波探頭訊號分析 44
Chapter 5 血管內超音波影像系統應用 45
5.1 旋轉移動機構設計 45
5.1.1 經滑環訊號量測分析 47
5.2 鎢線仿體影像量測實驗結果 49
5.3 雜訊量測分析 53
5.4 血管仿體設計及製作 57
Chapter 6 結論與未來工作 58
6.1 結論 58
6.2 未來工作 59
參考文獻 63
dc.language.isozh-TW
dc.title血管內超音波探頭製程研究zh_TW
dc.titleFabrication Process Development of Intravascular Ultrasound (IVUS) Transduceren
dc.typeThesis
dc.date.schoolyear106-2
dc.description.degree碩士
dc.contributor.oralexamcommittee劉建宏(Jian-Hung Liu),謝寶育(Bao-Yu Hsieh),葉佳倫(Chia-Lun Yeh)
dc.subject.keyword血管內超音波,血管內超音波探頭,鈮鎂酸鉛-鈦酸鉛,聚偏二氟乙烯,鈮酸鋰,zh_TW
dc.subject.keywordintravascular ultrasound (IVUS),intravascular ultrasound transducer,lead magnesium niobate-lead titanate(PMN-PT),polyvinylidene difluoride(PVDF),lithium niobate,en
dc.relation.page66
dc.identifier.doi10.6342/NTU201803994
dc.rights.note同意授權(全球公開)
dc.date.accepted2018-08-18
dc.contributor.author-college電機資訊學院zh_TW
dc.contributor.author-dept生醫電子與資訊學研究所zh_TW
dc.date.embargo-lift2023-08-21-
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