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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 潘敏雄(Min-Hsiung Pan) | |
| dc.contributor.author | Yi - Wen Tsai | en |
| dc.contributor.author | 蔡亦雯 | zh_TW |
| dc.date.accessioned | 2021-06-17T06:00:10Z | - |
| dc.date.available | 2020-12-25 | |
| dc.date.copyright | 2020-12-25 | |
| dc.date.issued | 2020 | |
| dc.date.submitted | 2020-11-27 | |
| dc.identifier.citation | Abdelsalam, N. A., Ramadan, A. T., ElRakaiby, M. T., Aziz, R. K. (2020). Toxicomicrobiomics: The human microbiome vs. pharmaceutical, dietary, and environmental xenobiotics. Front Pharmacol, 11, 390. Aggarwal, B. B., Vijayalekshmi, R. V., Sung, B. (2009). Targeting inflammatory pathways for prevention and therapy of cancer: short-term friend, long-term foe. Clin Cancer Res, 15(2), 425-430. Andrés, N. C., Fermento, M. E., Gandini, N. A., Romero, A. L., Ferro, A., Donna, L. G., Facchinetti, M. M. (2014). Heme oxygenase-1 has antitumoral effects in colorectal cancer: involvement of p53. Experimental and molecular pathology, 97(3), 321-331. Antoniou, E., Margonis, G. A., Angelou, A., Zografos, G. C., Pikoulis, E. (2015). Cytokine networks in animal models of colitis-associated cancer. Anticancer Res, 35(1), 19-24. Bao, Y., Wang, W., Zhou, Z., Sun, C. (2014). Benefits and risks of the hormetic effects of dietary isothiocyanates on cancer prevention. PLoS One, 9(12), e114764. Barbosa, A. P., Silveira Gde, O., de Menezes, I. A., Rezende Neto, J. M., Bitencurt, J. L., Estavam Cdos, S., de Lima Ado, C., Thomazzi, S. M., Guimaraes, A. G., Quintans, L. J., Jr., dos Santos, M. R. (2013). Antidiabetic effect of the Chrysobalanus icaco L. aqueous extract in rats. J Med Food, 16(6), 538-543. Baxter, N. T., Zackular, J. P., Chen, G. Y., Schloss, P. D. (2014). Structure of the gut microbiome following colonization with human feces determines colonic tumor burden. Microbiome, 2(1), 1-11. Bhakta-Guha, D., Efferth, T. (2015). Hormesis: decoding two sides of the same coin. Pharmaceuticals (Basel), 8(4), 865-883. Bretin, L., Leger, D.-Y., Pinon, A., Bouramtane, S., Bregier, F., Sol, V., Chaleix, V., Liagre, B. (2019). Photodynamic therapy activity of new porphyrin-xylan-coated silica nanoparticles in a human colorectal cancer in vivo model. Paper presented at the 17th International Photodynamic Association World Congress, 11070, 110709A. Briede, I., Strumfa, I., Vanags, A., Gardovskis, J. (2020). The association between inflammation, epithelial mesenchymal transition and stemness in colorectal carcinoma. J Inflamm Res, 13, 15-34. Burns, M. B., Lynch, J., Starr, T. K., Knights, D., Blekhman, R. (2015). Virulence genes are a signature of the microbiome in the colorectal tumor microenvironment. Genome Med, 7(1), 1-12. Cagiola, M., Giulio, S., Miriam, M., Katia, F., Paola, P., Macri, A., Pasquali, P. (2006). In vitro down regulation of proinflammatory cytokines induced by LPS tolerance in pig CD14+ cells. Vet Immunol Immunopathol, 112(3-4), 316-320. Calabrese, E. J., Iavicoli, I., Calabrese, V. (2013). Hormesis: its impact on medicine and health. Hum Exp Toxicol, 32(2), 120-152. Cernat, L., Blaj, C., Jackstadt, R., Brandl, L., Engel, J., Hermeking, H., Jung, A., Kirchner, T., Horst, D. (2014). Colorectal cancers mimic structural organization of normal colonic crypts. PLoS One, 9(8), e104284. Chan, J. K. (2014). The wonderful colors of the hematoxylin-eosin stain in diagnostic surgical pathology. Int J Surg Pathol, 22(1), 12-32. Chau, L. Y. (2015). Heme oxygenase-1: emerging target of cancer therapy. J Biomed Sci, 22, 22. Chen, J., Pitmon, E., Wang, K. (2017). Microbiome, inflammation and colorectal cancer. Semin Immunol, 32, 43-53. Chun, K. S., Keum, Y. S., Han, S. S., Song, Y. S., Kim, S. H., Surh, Y. J. (2003). Curcumin inhibits phorbol ester-induced expression of cyclooxygenase-2 in mouse skin through suppression of extracellular signal-regulated kinase activity and NF-κB activation. Carcinogenesis, 24(9), 1515-1524. Clarke, G., Sandhu, K. V., Griffin, B. T., Dinan, T. G., Cryan, J. F., Hyland, N. P. (2019). Gut reactions: breaking down xenobiotic-microbiome interactions. Pharmacol Rev, 71(2), 198-224. Coleman, O. I., Nunes, T. (2016). Role of the microbiota in colorectal cancer: updates on microbial associations and therapeutic implications. Biores Open Access, 5(1), 279-288. Elatrech, I., Marzaioli, V., Boukemara, H., Bournier, O., Neut, C., Darfeuille-Michaud, A., Luis, J., Dubuquoy, L., El-Benna, J., Dang, P. M. C. (2015). Escherichia coli LF82 differentially regulates ROS production and mucin expression in intestinal epithelial T84 cells: implication of NOX1. Inflamm Bowel Dis, 21(5), 1018-1026. Erben, U., Loddenkemper, C., Doerfel, K., Spieckermann, S., Haller, D., Heimesaat, M. M., Siegmund, B., Kuhl, A. A. (2014). A guide to histomorphological evaluation of intestinal inflammation in mouse models. Int J Clin Exp Pathol, 7(8), 4557-4576. Esparza-López, J., Alvarado-Muñoz, J. F., Escobar-Arriaga, E., Ulloa-Aguirre, A., de Jesús Ibarra-Sánchez, M. (2019). Metformin reverses mesenchymal phenotype of primary breast cancer cells through STAT3/NF-κB pathways. BMC Cancer, 19(1), 728. Ferreira, C. M., Vieira, A. T., Vinolo, M. A. R., Oliveira, F. A., Curi, R., Martins, F. d. S. (2014). The central role of the gut microbiota in chronic inflammatory diseases. J Immunol Res, 2014. Ferrero-Miliani, L., Nielsen, O. H., Andersen, P. S., Girardin, S. E. (2007). Chronic inflammation: importance of NOD2 and NALP3 in interleukin-1beta generation. Clin Exp Immunol, 147(2), 227-235. Fischer, A. H., Jacobson, K. A., Rose, J., Zeller, R. (2008). Hematoxylin and eosin staining of tissue and cell sections. CSH Protoc, 2008, pdb prot4986. Furman, D., Campisi, J., Verdin, E., Carrera-Bastos, P., Targ, S., Franceschi, C., Ferrucci, L., Gilroy, D. W., Fasano, A., Miller, G. W., Miller, A. H., Mantovani, A., Weyand, C. M., Barzilai, N., Goronzy, J. J., Rando, T. A., Effros, R. B., Lucia, A., Kleinstreuer, N., Slavich, G. M. (2019). Chronic inflammation in the etiology of disease across the life span. Nat Med, 25(12), 1822-1832. Gao, Z., Guo, B., Gao, R., Zhu, Q., Qin, H. (2015). Microbiota disbiosis is associated with colorectal cancer. Front Microbiol, 6, 20. Godos, J., Biondi, A., Galvano, F., Basile, F., Sciacca, S., Giovannucci, E. L., Grosso, G. (2017). Markers of systemic inflammation and colorectal adenoma risk: Meta-analysis of observational studies. World J Gastroenterol, 23(10), 1909-1919. Grivennikov, S. I. (2013). Inflammation and colorectal cancer: colitis-associated neoplasia. Semin Immunopathol, 35(2), 229-244. Grivennikov, S. I., Wang, K., Mucida, D., Stewart, C. A., Schnabl, B., Jauch, D., Taniguchi, K., Yu, G. Y., Österreicher, C H., Hung, K. E. (2012). Adenoma-linked barrier defects and microbial products drive IL-23/IL-17-mediated tumour growth. Nature, 491(7423), 254-258. Guan, F., Wang, H., Shan, Y., Chen, Y., Wang, M., Wang, Q., Yin, M., Zhao, Y., Feng, X., Zhang, J. (2014). Inhibition of COX-2 and PGE2 in LPS-stimulated RAW264.7 cells by lonimacranthoide VI, a chlorogenic acid ester saponin. Biomed Rep, 2(5), 760-764. Guo, M., Li, Z. (2019). Polysaccharides isolated from Nostoc commune Vaucher inhibit colitis-associated colon tumorigenesis in mice and modulate gut microbiota. Food Funct, 10(10), 6873-6881. Guo, Y., Su, Z. Y., Zhang, C., Gaspar, J. M., Wang, R., Hart, R. P., Verzi, M. P., Kong, A. N. T. (2017). Mechanisms of colitis-accelerated colon carcinogenesis and its prevention with the combination of aspirin and curcumin: Transcriptomic analysis using RNA-seq. Biochem Pharmacol, 135, 22-34. Guo, Y., Wu, R., Gaspar, J. M., Sargsyan, D., Su, Z. Y., Zhang, C., Gaspar, J. M., Wang, R., Hart, R. P., Verzi, M. P., Kong, A-N. T. (2018). DNA methylome and transcriptome alterations and cancer prevention by curcumin in colitis-accelerated colon cancer in mice. Carcinogenesis, 39(5), 669-680. Han, S., Gao, H., Chen, S., Wang, Q., Li, X., Du, L. J., Li, J., Luo, Y. Y., Li, J. X., Zhao, L. C. (2019). Procyanidin A1 Alleviates Inflammatory Response induced by LPS through NF-κB, MAPK, and Nrf2/HO-1 Pathways in RAW264. 7 cells. Sci Rep-UK, 9(1), 1-13. Hendrickson, B. A., Gokhale, R., Cho, J. H. (2002). Clinical aspects and pathophysiology of inflammatory bowel disease. Clin Microbiol Rev, 15(1), 79-94. Herp, S., Brugiroux, S., Garzetti, D., Ring, D., Jochum, L. M., Beutler, M., Eberl, C., Hussain, S., Walter, S., Gerlach, R. G., Ruscheweyh, H. J., Huson, D., Sellin, M. E., Slack, E., Hanson, B., Loy, A., Baines, J. F., Rausch, P., Basic, M., Bleich, A., Berry, D., Stecher, B. (2019). Mucispirillum schaedleri Antagonizes Salmonella Virulence to Protect Mice against Colitis. Cell Host Microbe, 25(5), 681-694 e688. Hill, M. O., Gauch, H. G. (1980). Detrended correspondence analysis: an improved ordination technique. Vegetatio, 42, 47-58. Hnatyszyn, A., Hryhorowicz, S., Kaczmarek-Rys, M., Lis, E., Slomski, R., Scott, R. J., Plawski, A. (2019). Colorectal carcinoma in the course of inflammatory bowel diseases. Hered Cancer Clin Pract, 17, 18. Huynh, E., Penney, J., Caswell, J., Li, J. (2019). Protective effects of protegrin in dextran sodium sulfate-induced murine colitis. Front Pharmacol, 10, 156. Jami, E., Israel, A., Kotser, A., Mizrahi, I. (2013). Exploring the bovine rumen bacterial community from birth to adulthood. ISME J, 7(6), 1069-1079. Jandhyala, S. M., Talukdar, R., Subramanyam, C., Vuyyuru, H., Sasikala, M., Nageshwar Reddy, D. (2015). Role of the normal gut microbiota. World J Gastroenterol, 21(29), 8787-8803. Jiang, X. T., Peng, X., Deng, G. H., Sheng, H. F., Wang, Y., Zhou, H. W., Tam, N. F. (2013). Illumina sequencing of 16S rRNA tag revealed spatial variations of bacterial communities in a mangrove wetland. Microb Ecol, 66(1), 96-104. Johnson, C. H., Dejea, C. M., Edler, D., Hoang, L. T., Santidrian, A. F., Felding, B. H., Ivanisevic, J., Cho, K., Wick, E. C., Hechenbleikner, E. M. (2015). Metabolism links bacterial biofilms and colon carcinogenesis. Cell metabolism, 21(6), 891-897. Joo, T., Sowndhararajan, K., Hong, S., Lee, J., Park, S. Y., Kim, S., Jhoo, J. W. (2014). Inhibition of nitric oxide production in LPS-stimulated RAW 264.7 cells by stem bark of Ulmus pumila L. Saudi J Biol Sci, 21(5), 427-435. Jozkowicz, A., Was, H., Dulak, J. (2007). Heme oxygenase-1 in tumors: is it a false friend? Antioxid Redox Signal, 9(12), 2099-2117. Kanehara, K., Ohnuma, S., Kanazawa, Y., Sato, K., Kokubo, S., Suzuki, H., Karasawa, H., Suzuki, T., Suzuki, C., Naitoh, T., Unno, M., Abe, T. (2019). The indole compound MA-35 attenuates tumorigenesis in an inflammation-induced colon cancer model. Sci Rep, 9(1), 12739. Khan, Z., Siddiqui, N., Saif, M. W. (2018). Enterococcus faecalis infective endocarditis and colorectal carcinoma: case of new association gaining ground. Gastroenterology Res, 11(3), 238-240. Khodir, A. E., Said, E., Atif, H., ElKashef, H. A., Salem, H. A. (2019). Targeting Nrf2/HO-1 signaling by crocin: Role in attenuation of AA-induced ulcerative colitis in rats. Biomed Pharmacother, 110, 389-399. Klaunig, J. E., Kamendulis, L. M., Xu, Y. (2000). Epigenetic mechanisms of chemical carcinogenesis. Hum Exp Toxicol, 19(10), 543-555. Kocaadam, B., Sanlier, N. (2017). Curcumin, an active component of turmeric (Curcuma longa), and its effects on health. Crit Rev Food Sci Nutr, 57(13), 2889-2895. Kumar pandurangan, A., Divya, T., Kumar, K., Dineshbabu, V., Velavan, B., Sudhandiran, G. (2018). Colorectal carcinogenesis: Insights into the cell death and signal transduction pathways: A review. World J Gastrointest Oncol, 10(9), 244. Kuru, K. (2014). Optimization and enhancement of H E stained microscopical images by applying bilinear interpolation method on lab color mode. Theor Biol Med Model, 11, 9. Lai, C. S., Wu, J. C., Yu, S. F., Badmaev, V., Nagabhushanam, K., Ho, C. T., Pan, M. H. (2011). Tetrahydrocurcumin is more effective than curcumin in preventing azoxymethane‐induced colon carcinogenesis. Mol Nutr Food Res, 55(12), 1819-1828. Laparra, J. M., Sanz, Y. (2010). Interactions of gut microbiota with functional food components and nutraceuticals. Pharmacol Res, 61(3), 219-225. Lasry, A., Zinger, A., Ben-Neriah, Y. (2016). Inflammatory networks underlying colorectal cancer. Nat Immunol, 17(3), 230-240. Lee, W. H., Loo, C. Y., Bebawy, M., Luk, F., Mason, R. S., Rohanizadeh, R. (2013). Curcumin and its derivatives: their application in neuropharmacology and neuroscience in the 21st century. Curr Neuropharmacol, 11(4), 338-378. Li, B., Huang, C. (2017). Regulation of EMT by STAT3 in gastrointestinal cancer (Review). Int J Oncol, 50(3), 753-767. Lichtenstern, C. R., Ngu, R. K., Shalapour, S., Karin, M. (2020). Immunotherapy, Inflammation and Colorectal Cancer. Cells, 9(3), 618. Lin, X., Yi, Z., Diao, J., Shao, M., Zhao, L., Cai, H., Fan, Q., Yao, X., Sun, X. (2014). ShaoYao decoction ameliorates colitis-associated colorectal cancer by downregulating proinflammatory cytokines and promoting epithelial-mesenchymal transition. J Transl Med, 12, 105. Lintermans, L. L., Stegeman, C. A., Heeringa, P., Abdulahad, W. H. (2014). T cells in vascular inflammatory diseases. Front Immunol, 5, 504. Liu, C., Li, P., Qu, Z., Xiong, W., Liu, A., Zhang, S. (2019). Advances in the Antagonism of Epigallocatechin-3-gallate in the Treatment of Digestive Tract Tumors. Molecules, 24(9). Liu, W., Zhai, Y., Heng, X., Che, F. Y., Chen, W., Sun, D., Zhai, G. (2016). Oral bioavailability of curcumin: problems and advancements. J Drug Target, 24(8), 694-702. Liu, Y., Yin, T., Feng, Y., Cona, M. M., Huang, G., Liu, J., Song, S., Jiang, Y., Xia, Q., Swinnen, J. V., Bormans, G., Himmelreich, U., Oyen, R., Ni, Y. (2015). Mammalian models of chemically induced primary malignancies exploitable for imaging-based preclinical theragnostic research. Quant Imaging Med Surg, 5(5), 708-729. Long, A. G., Lundsmith, E. T., Hamilton, K. E. (2017). Inflammation and Colorectal Cancer. Curr Colorectal Cancer Rep, 13(4), 341-351. Louis, P., Hold, G. L., Flint, H. J. (2014). The gut microbiota, bacterial metabolites and colorectal cancer. Nature reviews microbiology, 12(10), 661-672. Lozupone, C., Lladser, M. E., Knights, D., Stombaugh, J., Knight, R. (2011). UniFrac: an effective distance metric for microbial community comparison. ISME J, 5(2), 169-172. Lu, R., Wu, S., Zhang, Y. G., Xia, Y., Zhou, Z., Kato, I., Dong, H., Bissonnette, M., Sun, J. (2016). Salmonella protein AvrA activates the STAT3 signaling pathway in colon cancer. Neoplasia, 18(5), 307-316. Lu, R., Wu, S., Zhang, Y., Xia, Y., Liu, X., Zheng, Y., Zheng, Y., Chen, H., Schaefer, KL., Zhou, Z., Bissonnette, M. (2014). Enteric bacterial protein AvrA promotes colonic tumorigenesis and activates colonic beta-catenin signaling pathway. Oncogenesis, 3(6), e105-e105. Mager, L. F., Wasmer, M. H., Rau, T. T., Krebs, P. (2016). Cytokine-Induced Modulation of Colorectal Cancer. Front Oncol, 6, 96. Mahal, A., Wu, P., Jiang, Z.-H., Wei, X. (2017). Synthesis and cytotoxic activity of novel tetrahydrocurcumin derivatives bearing pyrazole moiety. Nat prod bioprospect, 7(6), 461-469. Mangerich, A., Knutson, C. G., Parry, N. M., Muthupalani, S., Ye, W., Prestwich, E., Cui, L., McFaline, J. L., Mobley, M., Ge, Z. (2012). Infection-induced colitis in mice causes dynamic and tissue-specific changes in stress response and DNA damage leading to colon cancer. Proceedings of the National Academy of Sciences, 109(27), E1820-E1829. Mangifesta, M., Mancabelli, L., Milani, C., Gaiani, F., de'Angelis, N., de'Angelis, G. L., van Sinderen, D., Ventura, M., Turroni, F. (2018). Mucosal microbiota of intestinal polyps reveals putative biomarkers of colorectal cancer. Sci Rep, 8(1), 13974. Maxwell, J. R., Brown, W. A., Smith, C. L., Byrne, F. R., Viney, J. L. (2009). Methods of inducing inflammatory bowel disease in mice. Curr Protoc Pharmacol, Chapter 5, Unit5 58. Mbese, Z., Khwaza, V., Aderibigbe, B. A. (2019). Curcumin and its derivatives as potential therapeutic agents in prostate, colon and breast cancers. Molecules, 24(23), 4386. McFadden, R. M. T., Larmonier, C. B., Shehab, K. W., Midura-Kiela, M., Ramalingam, R., Harrison, C. A., Besselsen, D. G., Chase, J. H., Caporaso, J G., Jobin, C. (2015). The role of curcumin in modulating colonic microbiota during colitis and colon cancer prevention. Inflammatory bowel diseases, 21(11), 2483-2494. Medzhitov, R. (2010). Inflammation 2010: new adventures of an old flame. Cell, 140(6), 771-776. Ngabire, D., Seong, Y., Patil, M. P., Niyonizigiye, I., Seo, Y. B., Kim, G. D. (2018). Anti-Inflammatory Effects of Aster incisus through the Inhibition of NF-κB, MAPK, and Akt Pathways in LPS-Stimulated RAW 264.7 Macrophages. Mediators of Inflammation, 2018. Ohno, M., Nishida, A., Sugitani, Y., Nishino, K., Inatomi, O., Sugimoto, M., Kawahara, M., Andoh, A. (2017). Nanoparticle curcumin ameliorates experimental colitis via modulation of gut microbiota and induction of regulatory T cells. PLoS One, 12(10), e0185999. Oliveira, P. A., Colaco, A., Chaves, R., Guedes-Pinto, H., De-La-Cruz, P. L., Lopes, C. (2007). Chemical carcinogenesis. An Acad Bras Cienc, 79(4), 593-616. Orlando, F. A., Tan, D., Baltodano, J. D., Khoury, T., Gibbs, J. F., Hassid, V. J., . . . Alrawi, S. J. (2008). Aberrant crypt foci as precursors in colorectal cancer progression. J surg oncol, 98(3), 207-213. Parameswaran, N., Patial, S. (2010). Tumor necrosis factor-alpha signaling in macrophages. Crit Rev Eukaryot Gene Expr, 20(2), 87-103. Parang, B., Barrett, C. W., Williams, C. S. (2016). AOM/DSS Model of Colitis-Associated Cancer. Methods Mol Biol, 1422, 297-307. Paulson, J. N., Pop, M., Bravo, H. C. (2013). MetagenomeSeq: Statistical analysis for sparse high-throughput sequencing. Bioconductor package, 1(0), 191. Piwowarczyk, L., Stawny, M., Mlynarczyk, D. T., Muszalska-Kolos, I., Goslinski, T., Jelinska, A. (2020). Role of Curcumin and (-)-Epigallocatechin-3-O-Gallate in Bladder Cancer Treatment: A Review. Cancers, 12(7), 1801. Pompili, S., Sferra, R., Gaudio, E., Viscido, A., Frieri, G., Vetuschi, A., Latella, G. (2019). Can Nrf2 modulate the development of intestinal fibrosis and cancer in inflammatory bowel disease? International Journal of Molecular Sciences, 20(16), 4061. Prasad, S., Tyagi, A. K., Aggarwal, B. B. (2014). Recent developments in delivery, bioavailability, absorption and metabolism of curcumin: the golden pigment from golden spice. Cancer Res Treat, 46(1), 2-18. Rajitha, B., Nagaraju, G. P., Shaib, W. L., Alese, O. B., Snyder, J. P., Shoji, M., Pattnaik, S., Alam, A., El‐Rayes, B. F. (2017). Novel synthetic curcumin analogs as potent antiangiogenic agents in colorectal cancer. Molecular carcinogenesis, 56(1), 288-299. Ramasamy, T. S., Ayob, A. Z., Myint, H. H. L., Thiagarajah, S., Amini, F. (2015). Targeting colorectal cancer stem cells using curcumin and curcumin analogues: insights into the mechanism of the therapeutic efficacy. Cancer cell international, 15(1), 96. Raskov, H., Pommergaard, H. C., Burcharth, J., Rosenberg, J. (2014). Colorectal carcinogenesis-update and perspectives. World journal of gastroenterology: WJG, 20(48), 18151. Ren, J., Li, L., Wang, Y., Zhai, J., Chen, G., Hu, K. (2019). Gambogic acid induces heme oxygenase-1 through Nrf2 signaling pathway and inhibits NF-κB and MAPK activation to reduce inflammation in LPS-activated RAW264. 7 cells. Biomedicine Pharmacotherapy, 109, 555-562. Richmond, A., Su, Y. (2008). Mouse xenograft models vs GEM models for human cancer therapeutics. Dis Model Mech, 1(2-3), 78-82. Rosenberg, D. W., Giardina, C., Tanaka, T. (2009). Mouse models for the study of colon carcinogenesis. Carcinogenesis, 30(2), 183-196. Rossol, M., Heine, H., Meusch, U., Quandt, D., Klein, C., Sweet, M. J., Hauschildt, S. (2011). LPS-induced cytokine production in human monocytes and macrophages. Critical Reviews™ in Immunology, 31(5). Sarkar, S., Horn, G., Moulton, K., Oza, A., Byler, S., Kokolus, S., Longacre, M. (2013). Cancer development, progression, and therapy: an epigenetic overview. Int J Mol Sci, 14(10), 21087-21113. Sebastian, V., Salazar, G., Coronado-Arrazola, I., Schultz, B., Vallejos, O., Berkowitz, L. (2018). Heme Oxygenase-1 as a Modulator of Intestinal Inflammation Development and Progression. Front Immunol. 2018; 9: 1956. Sekirov, I., Russell, S. L., Antunes, L. C. M., Finlay, B. B. (2010). Gut microbiota in health and disease. Physiological reviews, 90(3), 859-904. Shehzad, A., Khan, S., Shehzad, O., Lee, Y. (2010). Curcumin therapeutic promises and bioavailability in colorectal cancer. Drugs Today, 46(7), 523. Shen, A., Liu, L., Chen, H., Qi, F., Huang, Y., Lin, J., Sferra, T. J., Sankararaman, S., Wei, L., Chu, J. Chen, Y., Peng, J. (2019). Cell division cycle associated 5 promotes colorectal cancer progression by activating the ERK signaling pathway. Oncogenesis, 8(3), 19. Skovierova, H., Okajcekova, T., Strnadel, J., Vidomanova, E., Halasova, E. (2018). Molecular regulation of epithelial-to-mesenchymal transition in tumorigenesis (Review). Int J Mol Med, 41(3), 1187-1200. Son, J. S., Khair, S., Pettet III, D. W., Ouyang, N., Tian, X., Zhang, Y., Zhu, W., Mackenzie, G. G., Robertson, C. E., Ir, D. (2015). Altered Interactions between the Gut Microbiome and Colonic Mucosa Precede Polyposis in APC Min/+ Mice. PLoS One, 10(6), e0127985. Song, G., Mao, Y. B., Cai, Q. F., Yao, L. M., Ouyang, G. L., Bao, S. D. (2005). Curcumin induces human HT-29 colon adenocarcinoma cell apoptosis by activating p53 and regulating apoptosis-related protein expression. Braz J Med Biol Res, 38(12), 1791-1798. Song, Y., Ye, M., Zhou, J., Wang, Z., Zhu, X. (2019). Targeting E-cadherin expression with small molecules for digestive cancer treatment. Am J Transl Res, 11(7), 3932-3944. Squarize, C. H., Castilho, R. M., Sriuranpong, V., Pinto Jr, D. S., Gutkind, J. S. (2006). Molecular cross-talk between the NFκB and STAT3 signaling pathways in head and neck squamous cell carcinoma. Neoplasia (New York, NY), 8(9), 733. Steinberg, G. R., Schertzer, J. D. (2014). AMPK promotes macrophage fatty acid oxidative metabolism to mitigate inflammation: implications for diabetes and cardiovascular disease. Immunol Cell Biol, 92(4), 340-345. Takayama, T., Katsuki, S., Takahashi, Y., Ohi, M., Nojiri, S., Sakamaki, S., Kato, J., Kogawa, K., Miyake, H., Niitsu, Y. (1998). Aberrant crypt foci of the colon as precursors of adenoma and cancer. New Engl J Med, 339(18), 1277-1284. Tamvakopoulos, C., Dimas, K., Sofianos, Z. D., Hatziantoniou, S., Han, Z., Liu, Z.-L., Wyche, J H., Pantazis, P. (2007). Metabolism and anticancer activity of the curcumin analogue, dimethoxycurcumin. Clin Cancer Res, 13(4), 1269-1277. Tanaka, T., Narazaki, M., Kishimoto, T. (2014). IL-6 in inflammation, immunity, and disease. Cold Spring Harb Perspect Biol, 6(10), a016295. Teymouri, M., Barati, N., Pirro, M., Sahebkar, A. (2018). Biological and pharmacological evaluation of dimethoxycurcumin: A metabolically stable curcumin analogue with a promising therapeutic potential. J Cell Physiol, 233(1), 124-140. Thorsen, J., Brejnrod, A., Mortensen, M., Rasmussen, M. A., Stokholm, J., Al-Soud, W. A., Sørensen, S., Bisgaard, H., Waage, J. (2016). Large-scale benchmarking reveals false discoveries and count transformation sensitivity in 16S rRNA gene amplicon data analysis methods used in microbiome studies. Microbiome, 4(1), 62. Tripathi, B. M., Edwards, D. P., Mendes, L. W., Kim, M., Dong, K., Kim, H., Adams, J. M. (2016). The impact of tropical forest logging and oil palm agriculture on the soil microbiome. Molecular Ecology, 25(10), 2244-2257. Valle, I., Tramalloni, D., Bragazzi, N. L. (2015). Cancer prevention: state of the art and future prospects. J Prev Med Hyg, 56(1), E21-27. Villegas, I., Sanchez-Fidalgo, S., de la Lastra, C. A. (2011). Chemopreventive effect of dietary curcumin on inflammation-induced colorectal carcinogenesis in mice. Mol Nutr Food Res, 55(2), 259-267. Vyas, A., Dandawate, P., Padhye, S., Ahmad, A., Sarkar, F. (2013). Perspectives on new synthetic curcumin analogs and their potential anticancer properties. Current pharmaceutical design, 19(11), 2047-2069. Walther, A., Johnstone, E., Swanton, C., Midgley, R., Tomlinson, I., Kerr, D. (2009). Genetic prognostic and predictive markers in colorectal cancer. Nat Rev Cancer, 9(7), 489-499. Wang, D., Dubois, R. N. (2010). The role of COX-2 in intestinal inflammation and colorectal cancer. Oncogene, 29(6), 781-788. Wang, J., Jiang, Y.-F. (2012). Natural compounds as anticancer agents: Experimental evidence. World J Exp Med, 2(3), 45. Wang, L., Chen, J., Xie, H., Ju, X., Liu, R. H. (2013). Phytochemical profiles and antioxidant activity of adlay varieties. J Agric Food Chem, 61(21), 5103-5113. Wang, X., Huycke, M. M. (2007). Extracellular superoxide production by Enterococcus faecalis promotes chromosomal instability in mammalian cells. Gastroenterology, 132(2), 551-561. Wong, K. E., Ngai, S. C., Chan, K. G., Lee, L. H., Goh, B. H., Chuah, L. H. (2019). Curcumin Nanoformulations for Colorectal Cancer: A Review. Front Pharmacol, 10, 152. Wong, M. C., Ding, H., Wang, J., Chan, P. S., Huang, J. (2019). Prevalence and risk factors of colorectal cancer in Asia. Intest Res, 17(3), 317. Wu, T. H., Li, Y. Y., Wu, T. L., Chang, J. W., Chou, W. C., Hsieh, L. L., Chen, J. R., Yeh, K. Y. (2014). Culture supernatants of different colon cancer cell lines induce specific phenotype switching and functional alteration of THP-1 cells. Cell Immunol, 290(1), 107-115. Xiang, L., Hu, Y. F., Wu, J. S., Wang, L., Huang, W. G., Xu, C. S., Meng, X. L., Wang, P. (2018). Semi-Mechanism-Based Pharmacodynamic Model for the Anti-Inflammatory Effect of Baicalein in LPS-Stimulated RAW264.7 Macrophages. Front Pharmacol, 9, 793. Xu, J., Lian, F., Zhao, L., Zhao, Y., Chen, X., Zhang, X., Zhou, Q., Xue, Z., Pang, X., Zhao, L., Tong, X. (2015). Structural modulation of gut microbiota during alleviation of type 2 diabetes with a Chinese herbal formula. ISME J, 9(3), 552-562. Xu, X. Y., Meng, X., Li, S., Gan, R. Y., Li, Y., Li, H. B. (2018). Bioactivity, Health Benefits, and Related Molecular Mechanisms of Curcumin: Current Progress, Challenges, and Perspectives. Nutrients, 10(10). Yin, H., Fang, J., Liao, L., Maeda, H., Su, Q. (2014). Upregulation of heme oxygenase-1 in colorectal cancer patients with increased circulation carbon monoxide levels, potentially affects chemotherapeutic sensitivity. BMC Cancer, 14, 436. Yin, J., Wang, L., Wang, Y., Shen, H., Wang, X., Wu, L. (2019). Curcumin reverses oxaliplatin resistance in human colorectal cancer via regulation of TGF-beta/Smad2/3 signaling pathway. Onco Targets Ther, 12, 3893-3903. You, W., Henneberg, M. (2018). Cancer incidence increasing globally: The role of relaxed natural selection. Evol Appl, 11(2), 140-152. Zaki, M. H., Lamkanfi, M., Kanneganti, T. D. (2011). The Nlrp3 inflammasome: contributions to intestinal homeostasis. Trends Immunol, 32(4), 171-179. Zhang, Y. J., Gan, R. Y., Li, S., Zhou, Y., Li, A. N., Xu, D. P., Li, H. B. (2015). Antioxidant Phytochemicals for the Prevention and Treatment of Chronic Diseases. Molecules, 20(12), 21138-21156. Zhang, Z., Cao, H., Song, N., Zhang, L., Cao, Y., Tai, J. (2020). Long-term hexavalent chromium exposure facilitates colorectal cancer in mice associated with changes in gut microbiota composition. Food Chem Toxicol, 138, 111237. Zhao, P., Zhang, Z. (2018). TNF-alpha promotes colon cancer cell migration and invasion by upregulating TROP-2. Oncol Lett, 15(3), 3820-3827. Zheng, A., Li, H., Wang, X., Feng, Z., Xu, J., Cao, K., Zhou, B., Wu, J., Liu, J. (2014). Anticancer effect of a curcumin derivative B63: ROS production and mitochondrial dysfunction. Curr Cancer Drug Tar, 14(2), 156-166. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/71405 | - |
| dc.description.abstract | 流行病學報告指出，大腸直腸癌為全世界發生率及死亡率前三名的癌症，如何預防或治療大腸直腸癌成為現今關注的議題。天然物中富含多種具有抗發炎、抗氧化活性之植化素，如:白藜蘆醇 (resveratrol)。薑黃素 (curcumin, CUR) 為薑黃中主要的活性成分，研究證實其具抗氧化、抗發炎與抗癌作用。然而，CUR 屬於親脂性且結構不穩定物質，在生物體中生物利用度偏低。為了增進 CUR 生物利用率，許多 CUR 衍生物因而被開發與研究。Aminated-curcumin (AC) 是從天然薑黃素結構合成的胺化衍生物。本研究第一部分透過體外實驗，以小鼠巨噬細胞 RAW264.7 與 HT-29 腸癌細胞，初步探討 AC 於抗發炎及抑制腸癌細胞增生之表現；第二部分實驗以 azoxymethane (AOM)/dextran sulfate sodium (DSS) 誘導 BALB/c 小鼠腸癌模式，觀察與分析小鼠腸道外觀、組織及蛋白表現之變化，探討 AC 對於潰瘍性腸癌之影響。細胞實驗結果顯示，相較於 CUR，AC 可顯著降低 RAW264.7 細胞一氧化氮生成量與發炎相關蛋白表現，並且能抑制腸癌細胞存活。在動物實驗結果中，餵食 0.005% AC 明顯減少 AOM/DSS 誘導腸道腫瘤生成數量、改善潰瘍造成的腸道縮短現象、降低血清與腸道組織蛋白中促發炎細胞激素 TNF-α 和 IL-6 之含量，並透過 PI3K/AKT/NFκB 傳訊路徑與誘發 HO-1 活化，降低 iNOS 與 COX-2 表現；此外，餵食 0.005% AC 可透過抑制 NF-κB/IL-6/STAT3 路徑，調節上皮間質轉化蛋白 E-cadherin 和 N-cadherin 表現並抑制腫瘤轉移。此外，由腸道菌相分析結果得知，AC 可調節腸道中產生短鏈脂肪酸與抑制腸炎之益菌與癌症相關壞菌之比例，改善 AOM/DSS 誘導造成的菌相失衡。綜合上述，本研究為首篇在動物模式中探討 AC 於化學預防方面之功效，對於有罹患大腸直腸癌較高風險的潰瘍性腸炎患者可能具有益處，唯需特別注意劑量的使用。 | zh_TW |
| dc.description.abstract | Colorectal cancer (CRC) ranks third among the cancer related deaths in Taiwan. Curcumin (CUR), a major active component of turmeric, which is known to have anti-inflammatory and anti-cancer properties. However, low oral bioavailability of CUR attributed to the poor absorption and rapid systemic elimination from body hinders its clinical application. Discovery of curcumin derivatives is one of the feasible ways to improve its bioavailability. Aminated-curcumin (AC), a novel CUR derivative which is synthesized by modifying the structure of naturally CUR. This study was dedicated to investigating the chemopreventive effects of AC in colon carcinogenesis. First, we carried out cell experiments for preliminary understanding the bioactivities of AC. Second, we conducted the animal experiment to figure out the impact of AC on colitis-associated colon carcinogenesis by AOM (azomethane)/DSS (dextran sodium sulfate) model. In vitro study demonstrated that AC not only significantly decreased the nitrite production and protein expression of iNOS and COX-2 in LPS-activated RAW264.7 macrophages, but also inhibited HT29 cell viability. In vivo, the results showed that AC markedly reduced numbers of tumor in colorectum and ameliorated colon length shortening. Additionally, AC apparently decreased the expression levels of pro-inflammatory factors (IL-6, TNF-α, iNOS, and COX-2), and epithelial-mesenchymal transition (EMT)-related proteins expression (E-cadherin, N-cadherin, and p-STAT3) in plasma or colonic tissue. Furthermore, gut microbiota analysis revealed that AC could exhibit modulative effect on the growth of short-chain fatty acids (SCFA)-producing bacteria, which may in connection with the preventive effect of AC. In summary, AC could prevent AOM/DSS induced colon carcinogenesis by inhibiting inflammation, epithelial-mesenchymal transition, and modulating gut microbiota. This is the first study that demonstrates chemopreventive effects of AC in animal model, suggesting AC might have benefit to patients with ulcerative colitis who are at an increased risk of developing CRC. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-17T06:00:10Z (GMT). No. of bitstreams: 1 U0001-2611202015372200.pdf: 5032273 bytes, checksum: d1d0102e54ad42a5708b5e99c1b259f0 (MD5) Previous issue date: 2020 | en |
| dc.description.tableofcontents | 誌謝 I 摘要 II Abstract III 目錄 V 附圖目錄 IX 附表目錄 X 表目錄 XI 圖目錄 XII 縮寫表 XIII 第一章、緒論 1 第二章、文獻回顧 2 第一節、大腸直腸癌 (colorectal cancer) 2 (一)、大腸直腸癌流行病學 2 (二)、大腸直腸癌形成過程 4 (三)、大腸直腸癌常見動物模式 6 第二節、發炎反應與大腸直腸癌 9 (一)、發炎反應 9 (二)、發炎反應與大腸直腸癌形成 9 (三)、參與發炎反應與腫瘤形成因子 10 第三節、上皮間質轉換 (EMT) 對大腸直腸癌形成之影響 12 (一)、上皮間質轉換 (EMT) 12 (二)、上皮間質轉換與腸癌形成相關分子機制 13 第四節、腸道菌對大腸直腸癌形成過程之影響 14 (一)、腸道細菌在腸癌形成過程中扮演之角色 14 (二)、異生素 (xenobiotics) 17 第五節、Aminated-curcumin (AC) 18 (一)、薑黃素 (curcumin) 簡介 18 (二)、薑黃素生物利用度 19 (三)、薑黃素衍生物 (curcumin derivatives) 20 (四)、Aminated-curcumin (AC) 22 第三章、實驗目的與架構 23 第一節、實驗目的 23 第二節、實驗架構 23 第四章、材料與方法 25 第一節、實驗材料 25 (一)、儀器設備 25 (二)、藥品與試劑 26 (三)、抗體 27 (四)、樣品來源 27 第二節、實驗方法 28 第一部分、細胞實驗 28 (一)、細胞株 28 (二)、樣品配製 28 (三)、細胞存活率試驗 (MTT assay) 29 (四)、RAW264.7 細胞發炎模式誘導與 Nitrite 測定 30 (五)、西方墨點法 (western blot) 31 第二部分、動物實驗 34 (一)、實驗設計 34 (二)、飼料配製 34 (三)、疾病活動指數 (disease activity index, DAI) 35 (四)、動物犧牲 36 (五)、組織包埋與切片 36 (六)、蘇木精—伊紅染色 (hematoxylin and eosin stain, H E stain) 36 (七)、組織均質與蛋白質萃取 38 (八)、蛋白質定量 38 (九)、細胞激素 (cytokines) 測定 39 (十)、西方墨點法 (western blot) 40 (十一)、微生物體 16S rDNA 定序分析 40 (十二)、統計分析 42 第五章、結果與討論 44 第一節、Aminated-curcumin (AC) 減少細胞發炎並抑制腸癌細胞增生 44 (一)、Aminated-curcumin (AC) 抑制小鼠巨噬細胞 RAW264.7 發炎 44 (二)、AC 可抑制人類腸癌細胞 HT29 存活率 44 第二節、餵食 aminated-curcumin (AC) 對 AOM/DSS 誘導的小鼠之影響 45 (一)、餵食 AC 對 AOM/DSS 誘導的小鼠臟器重量之影響 45 (二)、餵食 AC 對 AOM/DSS 誘導的小鼠飲水量及攝食量之影響 45 (三)、AOM/DSS 誘導期間小鼠之疾病活動指數 (DAI) 變化 46 (四)、餵食 AC 對 AOM/DSS 誘導的小鼠腸道長度與組織型態之影響 46 (五)、餵食 AC 減少 AOM/DSS 誘導的小鼠之腫瘤生成 47 (六)、餵食 AC 減少 AOM/DSS 誘導小鼠之腸道組織及血中促發炎細胞激素生成 48 (七)、餵食 AC 抑制 AOM/DSS 誘導小鼠腸道組織發炎相關蛋白表現 49 (八)、AC 透過調節發炎之上游訊號預防 AOM/DSS 誘導小鼠之腸道發炎反應 50 (九)、AC 透過抑制癌細胞上皮間質轉換預防 AOM/DSS 誘導小鼠之腸道腫瘤發展 51 (十)、AC 調節 AOM/DSS 誘導腸癌之小鼠腸道菌相組成 52 (十一)、餵食 AC 對 AOM/DSS 誘導腸癌之小鼠腸道菌中特定菌屬之影響 53 (十二)、餵食 AC 改變 AOM/DSS 誘導腸癌之小鼠腸道菌相及環境因子對菌相之影響 54 第三節、討論 56 第六章、結論 57 第七章、圖表 58 表一、AC 減少 AOM/DSS 誘導小鼠之腫瘤生成 58 圖一、AC對小鼠巨噬細胞 RAW264.7 之影響 59 圖二、AC 抑制人類腸癌細胞 HT29 存活率 60 圖三、AC 於 AOM/DSS 誘導腸癌模式對臟器重量之影響 61 圖四、飼養期間小鼠之平均攝食量與飲水量 62 圖五、AC 對於DSS誘導之 BALB/c 小鼠的疾病活動指數影響 63 圖六、AC 改善 AOM/DSS 誘導小鼠之腸道長度縮短情況 64 圖七、AC 對 AOM/DSS 誘導小鼠腸癌之組織型態影響 65 圖八、AC 減少 AOM/DSS 誘導小鼠之腫瘤生成 65 圖九、AC 減少 AOM/DSS 誘導小鼠之腸道組織及血中促發炎細胞激素生成 66 圖十、AC 抑制 AOM/DSS 誘導小鼠之腸道組織發炎相關蛋白表現 67 圖十一、AC 透過調節發炎之上游訊號預防 AOM/DSS 誘導小鼠之腸道腫瘤發展 68 圖十二、AC 對於腸道組織中 Nrf-2/HO-1 傳訊路徑中蛋白表現量之影響 69 圖十三、AC 對於腸道組織中 EMT 傳訊路徑蛋白表現量之影響 70 圖十四、以主座標分析 (PCoA) 分析 AC 對 AOM/DSS 誘導腸癌小鼠腸道菌相組成之改變 71 圖十五、AC 調節 AOM/DSS 誘導腸癌小鼠腸道菌相之組成 72 圖十六、AC 調節 AOM/DSS 誘導腸癌小鼠腸道中特定菌種之豐度 74 圖十七、AC 與 AOM/DSS 誘導對各組間小鼠腸道菌種與環境因子之影響 75 圖十八、AC 於 AOM/DSS 誘導小鼠潰瘍性大腸直腸癌之作用 76 參考文獻 77 附錄 90 | |
| dc.language.iso | zh-TW | |
| dc.subject | aminated-curcumin | zh_TW |
| dc.subject | 大腸直腸癌 | zh_TW |
| dc.subject | 薑黃素 | zh_TW |
| dc.subject | 生物利用度 | zh_TW |
| dc.subject | AOM/DSS | zh_TW |
| dc.subject | microbiota | en |
| dc.subject | colorectal cancer | en |
| dc.subject | curcumin derivative | en |
| dc.subject | aminated-curcumin | en |
| dc.subject | inflammation | en |
| dc.subject | epithelial-mesenchymal transition | en |
| dc.title | 胺化薑黃素抑制氧化偶氮甲烷與葡聚糖硫酸鈉誘導大腸直腸癌之功效及腸道菌在其中扮演之角色 | zh_TW |
| dc.title | Efficacy of aminated-curcumin on suppressing AOM/DSS-induced colon carcinogenesis and modulating the composition of gut microbiota | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 109-1 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 何元順(Yuan-Soon Ho),黃步敏(Bu-Miin Huang),王應然(Ying-Jan Wang),郭靜娟 | |
| dc.subject.keyword | 薑黃素,大腸直腸癌,生物利用度,aminated-curcumin,AOM/DSS, | zh_TW |
| dc.subject.keyword | colorectal cancer,curcumin derivative,aminated-curcumin,inflammation,epithelial-mesenchymal transition,microbiota, | en |
| dc.relation.page | 90 | |
| dc.identifier.doi | 10.6342/NTU202004365 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2020-11-27 | |
| dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
| dc.contributor.author-dept | 食品科技研究所 | zh_TW |
| 顯示於系所單位： | 食品科技研究所 | |
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