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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 潘敏雄 | |
dc.contributor.author | Rou-Fong Chou | en |
dc.contributor.author | 周柔夆 | zh_TW |
dc.date.accessioned | 2021-06-17T04:41:53Z | - |
dc.date.available | 2021-08-08 | |
dc.date.copyright | 2018-08-08 | |
dc.date.issued | 2018 | |
dc.date.submitted | 2018-08-06 | |
dc.identifier.citation | Ahn, J.; Lee, H.; Kim, S.; Park, J.; Ha, T., The anti-obesity effect of quercetin is mediated by the AMPK and MAPK signaling pathways. Biochemical and Biophysical Research Communications 2008, 373, 545-549.
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/70873 | - |
dc.description.abstract | 肥胖為現今相當重要的一項健康議題,近年研究指出在低溫或天然化合物刺激下會促使白色脂肪棕色化 (browning) 而具有產熱特性,此細胞稱之為米色脂肪細胞 (beige adipocyte),使白色脂肪可藉由促進能量消耗而減少脂質的堆積。研究指出3' Hydroxydaidzein (3'-OHD) 為大豆異黃酮 Daidzein (Dai) 的代謝物,並存在於大豆發酵製品如味噌和豆豉中。目前已有文獻指出 Dai 具有減少脂質堆積的功效,然而3'-OHD 對於減少脂肪之功效仍未知,因此本研究以細胞及動物實驗探討3'-OHD 減少脂肪堆積之功效及相關分子機制。研究結果顯示,細胞實驗中,3'-OHD 可顯著降低3T3-L1前脂肪細胞中累積的油脂且不具細胞毒性,並可促進脂解作用 (lipolysis),而在相同濃度之下,Dai 則無顯著減少脂肪堆積效果。在高脂飲食誘導 C57BL/6小鼠肥胖模式下,餵食0.1% 3'-OHD 及0.1% Dai 組別在不影響小鼠攝食量的情形下與單獨高脂飲食 (HFD) 組相比,可顯著降低小鼠體重、內臟脂肪及腹股溝皮下脂肪重量,血液中三酸甘油酯及總膽固醇亦顯著較低。另由組織切片觀察到,0.1% 3'-OHD 及0.1% Dai 組腹股溝脂肪之脂肪細胞體積明顯較 HFD 組小。因此進一步針對腹股溝脂肪進行分析,腹股溝脂肪屬小鼠米色脂肪,結果顯示3'-OHD 與 Dai 除了可提高與脂解作用相關的 ATGL 及 p-HSL之蛋白質表現量,並可以增加白色脂肪棕色化及能量消耗相關的 PRDM16、C/EBP β、p-p38、SIRT1、PGC1 α 和 UCP1之表現量。綜合以上結果顯示,3'-OHD 及 Dai 可藉由促進脂解作用及增加白色脂肪棕色化而促進能量消耗以減少脂質堆積,而有益減緩肥胖形成。 | zh_TW |
dc.description.provenance | Made available in DSpace on 2021-06-17T04:41:53Z (GMT). No. of bitstreams: 1 ntu-107-R05641032-1.pdf: 5035886 bytes, checksum: bc4c75073c3672dafc16fc696a9f1c15 (MD5) Previous issue date: 2018 | en |
dc.description.tableofcontents | 口試委員會審定書 #
謝誌 I 中文摘要 IV Abstract IV 目錄 VII 附圖目錄 X 附表目錄 XI 圖目錄 XIIII 表目錄 XIIIII 縮寫表 XIV 第一章、文獻回顧 1 第一節、肥胖 (Obesity) 1 (一) 盛行率及併發症 1 (二) 定義 2 (三) 成因及危害 3 (四) 預防及治療 5 第二節、脂肪組織 (Adipose tissue) 7 (一) 簡介 7 (二) 分類 7 第三節、白色脂肪組織 (White adipose tissue, WAT) 7 (一) 簡介 7 (二) 脂質生成及脂解作用 (Lipogenesis and Lipolysis) 8 (三) 脂肪細胞新生作用 (Adipogenesis) 11 第四節、棕色脂肪組織 (Brown adipose tissue, BAT) 14 (一) 簡介 14 (二) 生熱作用 (Thermogenesis) 14 (三) 棕色脂肪細胞新生 16 第五節、米色脂肪組織 (Beige adipose tissue) 17 (一) 簡介 17 (二) 來源 18 (三) 特性 19 第六節、3'-Hydroxydaidzein (7, 3', 4'-Trihydroxyisoflavone) 20 (一) 大豆異黃酮 (Soy isoflavones) 20 (二) 3'-Hydroxydaidzein 20 第二章、實驗目的與架構 23 第一節、研究目的 23 第二節、實驗架構 23 第三章、材料與方法 25 第一節、實驗材料 25 (一) 儀器設備 25 (二) 藥品試劑 26 第二節、細胞實驗 (in vitro) 方法 29 (一) 樣品配製 (Sample preparation) 29 (二) 細胞培養 (Cell culture) 29 (三) 細胞分化 (Preadipocyte differentiation) 31 (四) 油紅染色 (Oil red O stain) 32 (五) 細胞存活率試驗 (Trypan blue assay) 32 (六) 脂解作用試驗 (Glycerol assay) 33 第三節、動物實驗 (in vivo) 方法 35 (一) 動物品系 35 (二) 飼養環境 35 (三) 飼料配製 35 (四) 動物犧牲 37 (五) H&E染色 (Hematoxylin and Eosin stain) 38 (六) RNA 萃取 41 (七) cDNA 合成 42 (八) 即時聚合酶鏈鎖反應 (qPCR) 43 (九) 組織均質及蛋白質萃取 44 (十) 蛋白質定量 45 (十一) 西方墨點法 (Western blot) 46 (十二) 統計分析 49 第四章、結果與討論 50 第一節、細胞實驗 (in vitro) 50 (一) 3'-OHD 抑制3T3-L1前脂肪細胞內脂質堆積之情形 50 (二) 3'-OHD 對3T3-L1前脂肪細胞存活率之影響 51 (三) 3'-OHD 對成熟脂肪細胞脂解作用 (Lipolysis) 之影響 51 第二節、動物實驗 (in vivo) 54 (一) 3'-OHD 對餵食高脂飲食 C57BL/6小鼠體重之影響 54 (二) 3'-OHD 對餵食高脂飲食 C57BL/6小鼠攝食量之影響 55 (三) 3'-OHD 對餵食高脂飲食 C57BL/6小鼠臟器重量之影響 56 (四) 3'-OHD 對餵食高脂飲食 C57BL/6小鼠肝臟組織之影響 57 (五) 3'-OHD 對餵食高脂飲食 C57BL/6小鼠脂肪重量之影響 58 (六) 3'-OHD 對餵食高脂飲食 C57BL/6小鼠脂肪細胞大小之影響 59 (七) 3'-OHD 對餵食高脂飲食 C57BL/6小鼠血清生化數值之影響 60 (八) 3'-OHD 對餵食高脂飲食 C57BL/6小鼠腹股溝脂肪脂解作用蛋白之影響 62 (九) 3'-OHD 對餵食高脂飲食 C57BL/6小鼠腹股溝脂肪能量消耗相關蛋白之影響 63 (十) 3'-OHD 對餵食高脂飲食 C57BL/6小鼠腹股溝脂肪棕色化相關指標影響 64 (十一) 3'-OHD 對餵食高脂飲食 C57BL/6小鼠棕色脂肪中產熱相關蛋白影響 65 第五章、結論 66 第六章、圖表 68 參考文獻 86 附錄 100 | |
dc.language.iso | zh-TW | |
dc.title | 3'-Hydroxydaidzein 減緩高脂飲食誘導小鼠肥胖之功效及其相關分子機制 | zh_TW |
dc.title | The anti-obesity efficacy of 3'-Hydroxydaidzein in high-fat diet fed mice and its molecular mechanisms | en |
dc.type | Thesis | |
dc.date.schoolyear | 106-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 王朝鐘,何元順,黃步敏,陳億承 | |
dc.subject.keyword | 肥胖,白色脂肪棕色化,米色脂肪細胞,脂解作用, | zh_TW |
dc.subject.keyword | obesity,browning,beige adipocytes,lipolysis, | en |
dc.relation.page | 100 | |
dc.identifier.doi | 10.6342/NTU201802414 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2018-08-06 | |
dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
dc.contributor.author-dept | 食品科技研究所 | zh_TW |
顯示於系所單位: | 食品科技研究所 |
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