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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 沈立言(Lee-Yan Sheen) | |
| dc.contributor.author | Guan-Ling Ou | en |
| dc.contributor.author | 歐冠伶 | zh_TW |
| dc.date.accessioned | 2021-06-17T03:25:50Z | - |
| dc.date.available | 2021-05-31 | |
| dc.date.copyright | 2018-05-31 | |
| dc.date.issued | 2018 | |
| dc.date.submitted | 2018-05-16 | |
| dc.identifier.citation | 行政院衛生福利部。「健康食品安全性評估方法」衛署食字第 88037803 號公告。台北。1999。
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/69737 | - |
| dc.description.abstract | 天麻 (Gastrodia elata Blume) 為一種多年生蘭科草本植物 (Orchidaceae Family)，產地多分布於亞洲東部，尤其是中國、韓國、日本和印度山區，為一種常用於中醫以及民間食療的中草藥。天麻水萃物 (water extract of Gastrodia elata Blume, WGE) 在近年來受到廣泛地研究，目前已有文獻指出WGE具有抗憂鬱、改善空間學習及記憶，以及改善代謝相關疾病(例如:糖尿病)等多種功效，因此具有開發成為保健產品的高度潛力。過去研究中提及天麻粗萃取物及其活性成分於囓齒動物注射下的毒性是非常低的，但也有少部分於人體個案中提及天麻在不當使用下可能會造成皮疹、暈眩，甚至是嚴重的過敏性休克等，而目前尚缺乏完整的安全性資料來確立WGE 於保健食品開發以及大量食用上的風險。依據衛生福利部公告之健康食品安全性評估方法，WGE屬於第二類，須進行的毒性測試項目包含基因毒性試驗及 28天亞急毒性試驗。因此本研究利用微生物、細胞以及動物實驗的基因毒性檢測方法，並且利用WGE在抗憂鬱動物實驗之有效劑量估計人體相對應之建議攝取量，乘以30、60及100倍之安全邊際係數 (Margin of safety, MOS) 作為試驗劑量，進行WGE的28 天亞急毒性試驗作為安全性評估，以建立WGE在相關研究上所使用的安全劑量以及消費者安全食用量之依據。基因毒性試驗結果顯示，WGE在安姆氏細菌回復突變試驗中，在Salmonella typhimurium的TA98、TA100、TA102、TA1535及TA1537菌株測試下均未產生致突性，且並不會增加CHO-k1細胞染色體的變異率，小鼠周邊血液中之血球微核發生率也未發生顯著提高的情形。28天亞急毒性試驗的結果顯示，WGE在臨床觀察無不良反應產生，並且血清生化及血液學分析也落於正常範圍中，組織病理學的切片分析也未呈現不良反應之結果，因此於本研究中判讀WGE之無毒性顯示劑量(no-observed-adverse-effect level, NOAEL) 值為高於8065 mg/kg bw，乃人體建議攝取量87.65 mg/kg bw之乘以安全係數100之劑量，由此可提供給WGE相關功效研究及保健食品開發上之可應用之劑量參考。 | zh_TW |
| dc.description.abstract | Abstract
Gastrodia elata Blume (Tianma) is a kind of Orchidaceae Family plants, which is mainly distributed in the mountainous areas of eastern Asia, especially in China, South Korea, Japan and India. It’s also a kind of herbal medicine commonly used in Chinese medicine, folk remedy and dietary therapy. Water extract of Gastrodia elata Blume (WGE) has also been widely researched. Currently, many studies have shown that WGE has a variety of effects such as anti-depression, improvement of space learning and memory, and metabolic-related diseases such as diabetes. Therefore, WGE has the great potential for development of healthy food products. A previous study was mentioned that the toxicity of Tianma and its active compositions are very low under injection in animal experiment, but a clinical case showed that Tianma possibly caused rash, dizziness, and even severe anaphylactic shock. It is still lack of whole safety information of WGE in healthy food development or massive consumption. WGE belongs to the class 2 healthy food according to the regulations of Healthy Food Safety Assessment announced by the Ministry of Health and Welfare in Taiwan. The healthy food in class 2 have to perform toxicity tests includes genotoxicity test and 28-day subacute toxicity test. Therefore, in this study I used the microorganism and animal models to evaluate genotoxicity of WGE. Moreover, I performed the 28-day repeated-dose toxicity study in mice by referencing the effective dose in antidepressant animal experiments corresponding to the recommended daily intake of human which is multiplied by the Margin of Safety (MOS) in 30, 60 and 100 to establish safe dosage of WGE. The results of genotoxicity test showed that WGE not only had no potential of mutagenicity under testing Salmonella typhimurium strains (TA98, TA100, TA102, TA1535 and TA1537) , but also did not significantly raise the aberrations rate in CHO-k1 cells and incidence of micronucleus in red blood cells in peripheral blood of mice. Moreover, in the 28-day repeated-dose toxicity study revealed that no adverse reaction in clinical observation, blood biochemistry, hematology and histopathological examination. Therefore, the no-observed-adverse-effect level (NOAEL) in WGE is the dosage over 8065 mg/kg body weight in this study. It could provide the safety dosage of WGE to functional researches and healthy food development. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-17T03:25:50Z (GMT). No. of bitstreams: 1 ntu-107-R04641027-1.pdf: 3411738 bytes, checksum: 10e2e3577a534e2dc22d01a791519eb4 (MD5) Previous issue date: 2018 | en |
| dc.description.tableofcontents | 中文摘要 I
Abstract III 目錄 V 圖目錄 VIII 表目錄 IX 縮寫表 X 第一章、前言 1 第二章、文獻回顧 2 第一節、天麻 2 一、天麻簡介 2 二、天麻的活性成分 2 三、天麻的生理活性 3 四、天麻之安全性探討 4 第二節、安全性評估 5 一、安全性評估相關法規 5 二、基因毒性 6 三、細菌回復突變測試法 7 四、體外哺乳動物染色體變異試驗 13 五、囓齒動物周邊血液微核試驗 14 六、28天亞急毒性試驗 17 第三章、實驗假說與目的 19 第一節、實驗假說 19 第二節、實驗目的 19 第三節、實驗架構 20 第四章、材料與方法 21 第一節、實驗材料 21 一、天麻水萃物 21 二、實驗藥品 21 三、實驗儀器 23 第二節、實驗方法 24 一、安姆氏細菌回復突變測試法 24 二、體外哺乳動物染色體結構異常分析 28 三、囓齒動物體內周邊血液微核測試法 30 四、28天亞急毒性試驗 31 五、統計方法 33 第五章、結果 34 第一節、基因毒性試驗結果 34 一、安姆氏細菌回復突變測試法 34 二、體外哺乳動物細胞染色體變異試驗 35 三、囓齒動物周邊血液微核試驗 36 第二節、28天亞急毒性試驗結果 37 一、亞急毒性試驗期間體重、攝食及飲水變化 37 二、亞急毒性試驗小鼠臟器相對重量 38 三、亞急毒性試驗小鼠血清生化值 38 四、亞急毒性試驗小鼠血液常規檢測結果 39 五、亞急毒性試驗小鼠組織病理切片分析 39 第六章、討論 41 第一節、基因毒性試驗 41 一、天麻水萃物之微生物致突變潛力 41 二、天麻水萃物處理之體外哺乳動物細胞染色體變異之情形 43 三、天麻水萃物對囓齒動物周邊血液微核發生率之影響 44 第二節、天麻水萃物之亞急毒性探討 45 第七章、結論與未來研究 50 第八章、結果圖表 51 第九章、參考文獻 70 第十章、附錄 75 | |
| dc.language.iso | zh-TW | |
| dc.subject | 基因毒性 | zh_TW |
| dc.subject | 亞急毒性試驗 | zh_TW |
| dc.subject | 安全性評估 | zh_TW |
| dc.subject | 天麻水萃物 | zh_TW |
| dc.subject | water extract of Gastrodia elata Blume | en |
| dc.subject | subacute toxicity test | en |
| dc.subject | genotoxicity | en |
| dc.subject | safety evaluation | en |
| dc.title | 天麻水萃物之安全性評估 | zh_TW |
| dc.title | The safety evaluation of the water extract of Gastrodia elata Blume | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 106-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 劉興華(Shing-Hwa Liu),華國泰(Kuo-Tai Hua),潘敏雄(Min-Hsiung Pan) | |
| dc.subject.keyword | 天麻水萃物,安全性評估,基因毒性,亞急毒性試驗, | zh_TW |
| dc.subject.keyword | water extract of Gastrodia elata Blume,safety evaluation,genotoxicity,subacute toxicity test, | en |
| dc.relation.page | 75 | |
| dc.identifier.doi | 10.6342/NTU201800805 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2018-05-17 | |
| dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
| dc.contributor.author-dept | 食品科技研究所 | zh_TW |
| 顯示於系所單位： | 食品科技研究所 | |
文件中的檔案：
| 檔案 | 大小 | 格式 | |
|---|---|---|---|
| ntu-107-1.pdf 未授權公開取用 | 3.33 MB | Adobe PDF |
系統中的文件，除了特別指名其著作權條款之外，均受到著作權保護，並且保留所有的權利。