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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 游若? | |
dc.contributor.author | Sue-Xia Low | en |
dc.contributor.author | 劉素霞 | zh_TW |
dc.date.accessioned | 2021-06-16T23:48:43Z | - |
dc.date.available | 2017-08-01 | |
dc.date.copyright | 2012-08-01 | |
dc.date.issued | 2012 | |
dc.date.submitted | 2012-07-23 | |
dc.identifier.citation | 王姿以。2009。攝食菊糖改善人體腸胃道菌相並降低糞便萃取液對 HT-29 及 Caco-2 毒性之研究。國立臺灣大學食品科技研究所碩士學位論文。台北。台 灣。
朱芳瑢。2008。數株益生菌及其發酵乳抑制大腸癌細胞增生及 4NQO 誘導 Int-407 基因毒性之研究。國立臺灣大學食品科技研究所碩士學位論文。台北。台灣。 行政院衛生署。2012。100 年國人主要死因統計。行政院衛生署。台北。台灣。 陳智強。2004。培養條件對乳酸菌胞外多醣生產及抗氧化性之影響。國立臺灣大 學食品科技研究所碩士學位論文。台北。台灣。 陳惠英、顏國欽。1996。膳食中之抗致突變物及其作用機制。中華民國營養學會 雜誌。21(3):323-338。 廖啟成。1994。多重面貌的乳酸菌產品。健康世界。206:62-70。 廖啟成。1998。乳酸菌之分類及應用。食品工業。30(2):1-10。 廖啟成。2011。台灣保健食品學會 2011 年會員大會暨保健食品與代謝症候群研 討會-乳酸菌與代謝症候群。 劉曲婷。2010。餵食 Lactobacillus casei 01 及其胞外多醣對 1,2-二甲基聯胺誘導 F344 大鼠結腸癌前病變之影響。國立臺灣大學食品科技研究所博士論文。台 北。台灣。 賴永裕。2000。乳酸菌的深度應用。食品資訊。178:49-52。 Abbad-Andaloussi, S.; Talbaoui, H.; Marczak, R.; Bonaly, R. Isolation and characterization of exocellular polysaccharides produced by Bifidobacterium longum. Appl. Microbiol. Biotechnol. 1995, 43, 995-1000. Albert, M. J.; Bhat, P.; Rajan, D.; Maiya, P. P.; Pereira, S. M.; Baker, S. J. Faecal flora of South Indian infants and young children in health and with acute gastroenteritis. J. Med. Microbiol. 1978, 11, 37-43. Anderson, D.; Yu, T. W.; Philips, B. J.; Schmezer, P. The effect of various antioxidants and other modifying agents on oxygen-radical-generated DNA damage in human lymphocytes in the comet assay. Mutat. Res. 1994, 307, 261-271. Arima, Y.; Nishigori, C.; Takeuchi, T.; Oka, S.; Morimoto, K.; Utani, A.; Miyachi, Y. 4-Nitroquinoline 1-oxide forms 8-hydroxydeoxyguanosine in human fibroblasts through reactive oxygen species. Toxicol. Sci. 2006, 91, 382-392. Axelsson, L. Lactic acid bacteria: Classification and physiology. Marcel Dekker Inc., New York. 2004. Ayrton, A. D.; Lewis, D. F. V.; Walker, R. Antimutagenicity of ellagic acid towards the food mutagen IQ-investigation into possible mechanisms of action. Food Chem. Toxicol. 1992, 30, 289-295. Baricault, L.; Denariaz, G.; Houri, J. J.; Bouley, C.; Sapin, C.; Trugnan, G. Use of HT-29, a cultured human colon cancer cell, to study the effect of fermented milks on colon cancer cell growth and differentiation. Carcinogenesis. 1995, 16, 245-252. Bello, F. D.; Walter, J.; Hertel, C.; Hammes, W. P. In vitro study of prebiotic properties of levan-type exopolysaccharides from lactobacilli and non-digestible carbohydrates using denaturing gradient gel electrophoresis. Syst. Appl. Microbiol. 2001, 24, 232-237. Bhattacharyya, S.; Borthakur, A.; Dudeja, P. K.; Tobacman, J. K. Carrageenan induces cell cycle arrest in human intestinal epithelial cells in vitro. J. Nutri. 2008, 138, 469-475. Blumenkrantz, N.; Asboe, H. G. New method for quantitative determination of uronic acid. Anal. Biochem. 1973, 54, 484-489. Brady, L.; Gallaher, D.; Busta, F. The role of probiotic cultures in the prevention of colon cancer. J. Nutr. 2000, 130, 410-414. Bradford, M. M. Rapid and sensitive method for quantitation of microgram quantities of protein utilizing principle of protein-Dye binding. Anal. Biochem. 1976, 72, 248-254. Bronzetti, G. Antimutagens in foods. Trends. Food Sci. Technol. 1994, 5, 390-395. Brown, G. D. Dectin-1: A signalling non-TLR pattern-recognition receptor. Nat. Rev. Immunol. 2006, 6, 33-43. Burlinson, B.; Tice, R. R.; Speit, G.; Agurell, E.; Brendler-Schwaab, S. Y.; Collins, A. R.; Escobar, P.; Honma, M.; Kumaravel, T. S.; Nakajima, M.; Sasaki, Y. F.; Thybaud, V.; Uno, Y.; Vasquez, M.; Hartmann, A. Fourth international workgroup on genotoxicity testing: Results of the in vivo comet assay workgroup. Mutat. Res. 2007, 627, 31-35. Campling, B. G.; Pym, J.; Galbraith, P. R.; Cole, S. P. C. Use of the MTT assay for rapid determination of chemosensitivity of human leukemic blast cell. Leuk. res. 1988, 12, 823-831. Cerning, J. Exocellular exopolysaccharides by lactic acid bacteria. Fems Microbiol. Rev. 1990, 87, 113-130. Cerning, J.; Bouillanne, C.; Landon, M.; Desmazeaud, M. J. Isolation and characterization of exopolysaccharides from slime-forming mesophilic lactic acid bacteria. J. Dairy Sci. 1992, 75, 692-699. Cerning, J.; Renard, C. M. G. C.; Thibault, J. F.; Bouillanne, C.; Landon, M.; Desmazeaud, M.; Topisirovic, L. Carbon source requirements for exopolysaccharide produced by Lactobacillus casei CG11 and partial structure analysis of the polymer. Appl. Environ. Microbiol. 1994, 60, 3914-3919. Chen, H. Y.; Yen, G. C. Possible mechanisms of antimutagens by various teas as judged by their effects on mutagenesis by 2-amino-3-methylimidazo [4,5-f] quinoline and benzo[a]pyrene. Mutat. Res. 1997, 393, 115-122. Choi, S. S.; Kim, Y.; Han, K. S.; You, S.; Oh, S.; Kim, S. H. Effects of Lactobacillus strains on cancer cell proliferation and oxidative stress in vitro. Lett. Appl. Microbiol. 2006, 42, 452-458. Comalada, M.; Bailon, E.; De Haro, O.; Lara-Villoslada, F.; Xaus, J.; Zarzuelo, A.; Galvez, J. The effects of short-chain fatty acids on colon epithelial proliferation and survival depend on the cellular phenotype. J. Cancer Res. Clin. Oncol. 2006, 132, 487-497. Crociani, F.; Alessandrini, A.; Mucci, M. M.; Biavati, B. Degradation of complex carbohydrates by Bifidobacterium spp. Int. J. Food Microbiol. 1994, 24, 199-210. Daeschel, M. A. Antimicrobial substances from lactic acid bacteria for use as food preservatives. Food Technol. 1989, 43, 164-166. De Vuyst, L.; Degeest, B. Heteropolysaccharides from lactic acid bacteria. FEMS Microbiol. Rev. 1999, 23, 153-177. De Vuyst, L.; De Vin, F.; Vaningelgem, F.; Degeest, B. Recent developments in the biosynthesis and applications of heteropolysaccharides from lactic acid bacteria. Int. Dairy J. 2001, 11, 687-708. De Vuyst, L.; Zamfir, M.; Mozzi, F.; Adriany, T.; Marshall, V.; Degeest, B.; Vaningelgem, F. Exopolysaccharide-producing Streptococcus thermophilus strains as functional starter cultures in the production of fermented milks. Int. Dairy J. 2003, 13, 707-717. Denholm, J.; Horne, K.; McMahon, J.; Grayson, M.; Johnson, P. Yoghurt consumption and damaged colonic mucosa: A case of Lactococcus lactis liver abscess in an immunocompetent patient. Scand. J. Infect. Dis. 2006, 38, 739-741. Dubois, M.; Gilles, K. A.; Hamilton, J. K.; Rebers, P. A.; Smith, F. Colorimetric method for determination of sugars and related substances. Anal. Chem. 1956, 28, 350-356. Dunne, C. Adaptation of bacteria to the intestinal niche: Probiotics and gut disorder. Inflamm. Bowel. Dis. 2001, 7, 136-145. Dunne, C.; Murphy, L.; Flynn, S.; O’Mahony, L.; O’Halloran, S.; Freeney, M.; Morrisey, D.; Thornton, G.; Fitzgerald, G.; Daly, C.; Kiely, B.; Quigley, E.M.M.; O’Sullivan, G.C.; Shanahan, F.; Collins, J.K. Probiotics: from myth to reality. Demonstration of functionality in animal models of disease and in human clinical trials. Antonie van Leeuwenhoek. 1999, 76, 279-292. Fassler, C.; Gill, C. I. R.; Arrigoni, E.; Rowland, I.; Amado, R. Fermentation of resistant starches: influence of in vitro models on colon carcinogenesis. Nutri. Cancer. 2007, 58, 85-92. Faure, J. C.; Schellenberg, D. A.; Bexter, A.; Wuerzner, H. P. Barrier effect of Bifidobacterium longum on a pathogenic Escherichia coli strain by gut colonization in the germ-free rat. Z. Ernahrungswiss. 1984, 23, 41-51. Favier, C.; Neut, C.; Mizon, C.; Cortot, A.; Colombel, J. F.; Mizon, J. Fecal beta-D-galactosidase production and bifidobacteria are decreased in Crohn’s disease. Dig. Dis. Sci. 1997, 42, 817-822. Fuller, R. Probiotics in man and animals. J. Appl. Bacteriol. 1989, 66, 365-378. Gamer, L.; Blondeau, K.; Simonet, J. Physilogical approach to extracellular polysaccharide production by Lactobacillus rhamnosus strain C83. J. Appl. Microbiol. 1997, 83, 281-287. Gancel, F.; Novel, G. Exopolysaccharide production by Streptococcus salivarius ssp. thermophilus cultures. 2. Distinct modes of polymer production and degradation among clonal variants. J. Dairy Sci. 1994, 77, 689-695. Gantner, B. N.; Simmons, R. M.; Canavera, S. J.; Akira, S.; Underhill, D. M. Collaborative induction of inflammatory responses by dectin-1 and toll-like receptor 2. J. Exp. Med. 2003, 197, 1107-1117. Gardiner, G.E.; O’Sullivan, E.; Kelly, J.; Auty, M.A.E.; Fitzgerald, G.F.; Collins, J.K.; Ross, R.P.; Stanton, C. Comparative survival rates of human-derived probiotic Lactobacillus paracasei and L. salivarium strains during heat treatment and spray drying. Appl. Environ. Microbiol. 2000, 66, 2605-2612. Gibson, G. R.; Beatty, E. R.; Wang, X.; Cummings, J. H. Selective stimulation of bifidobacteria in the human colon by oligofructose and inulin. Gastroenterology. 1995, 108, 975-982. Gibson, G. R.; Wang, X. Enrichment of bifidobacteria from human gut contents by oligofructose using continuous culture. FEMS Microbiol. Lett. 1994, 118, 121-127. Gilliland, S. E.; Nelson, C. R.; Maxwell, C. Assimilation of cholesterol by Lactobacillus acidophilus. Appl. Environ. Microbiol. 1985, 49, 377-381. Glei, M.; Hofmann, T.; Kuster, K.; Hollmann, J.; Lindhauer, M.G.; Pool-Zobel, B. Both Wheat (Triticum aestivum) bran arabinoxylans and gut flora-mediated fermentation products protect human colon cells from genotoxic activities of 4-hydroxynonenal and hydrogen peroxide. J. Agric. Food Chem. 2006, 54, 2088-2095. Glei, M.; Liegibel, U. M.; Ebert, M. N.; Bohm, V.; Pool-Zobel, B. L. Beta-carotene reduces bleomycin-induced genetic damage in human lymphocytes. Toxicol. Appl. Pharmacol. 2002, 179, 65-73. Grobben, G. J.; Chin-Joe, I.; Kitzen, V. A.; Boels, I. C.; Boer, F.; Sikkema, J.; Smith, M. R.; De Bont, J. A. Enhancement of exopolysaccharide production by Lactobacillus delbrueckii subsp. bulgaricus NCFB2772 with a simplified defined medium. Appl. Environ. Microbiol. 1998, 64, 1333-1337. Grobben, G. J.; Smith, M. R.; Sikkema, J.; de Bont, J. A. M. Influence of fructose and glucose on the production of exopolysaccharides and the activities of enzymes involved in the sugar metabolism and the synthesis of sugar necleotides in Lactobacillus delbrueckii subsp. bulgaricus NCFB 2772. Appl. Microbiol. Biotechnol. 1996, 46, 279-284. Guarner, F.; Schaafsma, G.J. Probiotics. Int. J. Food Microbiol. 1998, 39, 237-238. Hartwell, L. H.; Weinert, T. A. Checkpoints: controls that ensure the order of cell cycle events. Science. 1989, 246, 629-634. Havenaar, R.; Huis in’t Veld, J.H.J. Probiotics: A general view. In Wood, B.J.B. (Ed.): The Lactic Acid Bacteria, Vol. 1: The Lactic Acid Bacteria in Health and Disease. Elsevier Applied Sciences, London, UK. 1992, 151-170. He, L.; Li, X.; Luo, H. S.; Rong, H.; Cai, J. Possible mechanism for the regulation of glucose on proliferation, inhibition and apoptosis of colon cancer cells induced by sodium butyrate. World J. Gastroenterol. 2007, 13, 4015-4018. Herre, J.; Gordon, S.; Brown, G. D. Dectin-1 and its role in the recognition of b-glucans by macrophages. Mol. Immunol. 2004, 40, 869-876. Hopkins, M. J.; Cummings, J. H.; Macfarlane, G. T. Inter-species difference in maximum specific growth rates and cell yields of bifidobacteria cultured on oligosaccharides and other simple carbohydrate sources. J. Appl. Microbiol. 1998, 85, 381-386. Hose, H.; Sozzi, T. Biotechnology group meeting probiotics - factor fiction. J. Chem. Technol. Biotechnol. 1991, 51, 540-544. Hosono, A.; Lee, J.; Ametani, A.; Natsume, M.; Hirayama, M.; Adachi, T.; Kaminogawa, S. Characterization of a water-soluble polysaccharide fraction with immunopotentiating activity from Bifidobacterium adolescentis M101-4. Biosci. Biotechnol. Biochem. 1997, 61, 312-316. Hsieh, M. H.; Fang, S. W.; Yu, R. C.; Chou, C. C. Possible mechanisms of antimutagenicity in fermented soymilk prepared with a coculture of Streptococcus infantis and Bifidobacterium infantis. J. Food Prot. 2007, 70, 1025-1028. Huebner, J.; Wehling, R. L.; Hutkins, R. W. Functional activity of commercial prebiotics. Int. Dairy J. 2007, 17, 770-775. Jagerstad, M.; Skog, K. Genotoxicity of heat processed foods. Mutat. Res. 2005, 574, 156-172. Kada, T.; Kaneko, K.; Matsuzaki, S.; Matsuzaki, T. Detection and chemical identification of natural bio-antimutagens. A case of the green tea factor. Mutat. Res. 1985, 150, 127-132. Kada, T.; Morita, K.; Inoue, T. Anti-mutagenic action of vegetable factor(s) on the mutagenic principle of tryptophan pyrolysate. Mutat. Res. 1978, 53, 351-353. Kandler, O. Carbohydate metabolism in lactic acid bacteria. Antonie van Leeuwenhoek. 1983, 49, 209-224. Kanojia, D.; Vaidya, M. M. 4-Nitroquinoline-1-oxide induced experimental oral carcinogenesis. Oral Oncol. 2006, 42, 655-667. Kaplan, H.; Hutkins, R. W. Metabolism of fructooligosaccharides by Lactobacillus paracasei 1195. Appl. Environ. Microbiol. 2003, 69, 2217-2222. Kaur, I. P.; Chopra, K.; Saini, A. Probiotics: potential pharmaceutical applications. Eur. J. Pharm. Sci. 2002, 15, 1-9. Kim, Y.; Oh, S.; Yun, H. S.; Oh, S.; Kim, S. H. Cell-bound exopolysaccharide from probiotic bacteria induces autophagic cell death of tumour cells. Lett. Appl. Microbiol. 2010, 51, 123-130. Kimmel, S. A.; Roberts, R. F.; Ziegler, G. R. Optimization of exopolysaccharide production by Lactobacillus delbrueckii subsp. bulgaricus RR grown in a semidefined medium. Appl. Environ. Microbiol. 1998, 64, 659-664. Kitazawa, H.; Nomura, M.; Itoh, T.; Yamaguchi, T. Functional alteration of macrophages by a slime-forming encapsulated Lactococcus lactis spp. cremosis. J. Dairy. Sci. 1991a, 74, 2082-2088. Kitazawa, H.; Toba, T.; Itoh, T.; Kumano, N.; Adachi, S.; Yamaguchi, T. Antitumoral activity of slime-forming encapsulated Lactococcus lactis subsp. cremoris isolated from Scandinavian ropy sour milk, ‘villi’. Animal Sci. Technol. 1991b, 62, 277-283. Klaenhammer, T.R. Probiotic bacteria: today and tomorrow. J. Nutr. 2000, 130, 415s-416s. Kleessen, B.; Hartmann, L.; Blaut, M. Oligofructose and long-chain inulin: Influence on the gut microbial ecology of rats associated with a human faecal flora. Br. J. Nutr. 2001, 86, 291-300. Klenow, S.; Glei, M.; Haber, B.; Owen, R.; Pool-Zobel, B. L. Carob fibre compounds modulate parameters of cell growth differently in human HT29 colon adenocarcinoma cells than in LT97 colon adenoma cells. Food Chem. Toxicol. 2008, 46, 1389-1397. Knoshaug, E. P.; Ahlgren, J. A.; Trempy, J. E. Growth associated exopolysaccharide expression in Lactococcus lactis subspecies cremoris ropy 352. J. Dairy Sci. 2000, 83, 633-640. Kojima, H.; Miwa, N.; Mori, M.; Osaki, M.; Konishi, H. Desmutagenic effect of oolong tea. J. Food Hyg. Soc. Jpn. 1989, 30, 233-239. Koller, V. J.; Marian, B.; Stidl, R.; Nersesyan, A.; Winter, H.; Simic, T.; Sontag, G.; Knasmuller, S. Impact of lactic acid bacteria on oxidative DNA damage in human derived colon cells. Food Chem. Toxicol. 2008, 46, 1221-1229. Korakli, M.; Ganzle, M. G.; Vogel, R. F. Metabolism by bifidobacteria and lactic acid bacteria of polysaccharides from wheat and rye and exopolysaccharides produced by Lactobacillus sanfranciscensis. J. Appl. Microbiol. 2002, 92, 958-965. Krishan, A. Rapid flow cytofluorometric analysis of mammalian cell cycle by propidium iodide staining. J. Cell Biol. 1975, 66, 188-193. Laws, A. P.; Marshall, V. M. The relevance of exopolysaccharides to the rheological properties in milk fermented with ropy strains of lactic acid bacteria. Int. Dairy J. 2001, 11, 709-722. Liebler-Tenario, E. M.; Pohlenz, J. F. Experimental mucosal disease of cattle: Changes in cell proliferation in lymphoid tissues and intestinal epithelium. J. Comp. Pathol. 1997, 117, 339-350. Lilly, D. M.; Stillwell, R. H. Probiotics: Growth promoting factors produced by microorganisms. Science. 1965, 147, 747-748. Lin, M. Y.; Yen, C. L. Antioxidative ability of lactic acid bacteria. J. Agric. Food Chem. 1999, 47, 1460-1466. Liu, C.; Lu, J.; Lu, L.; Liu, Y.; Wang, F.; Xiao, M. Isolation, structural characterization and immunological activity of an exopolysaccharide produced by Bacillus licheniformis 8-37-0-1. Bioresour. Technol. 2010, 101, 5528-5533. Liu, C. T.; Chu, F. J.; Chou, C. C.; Yu, R. C. Antiproliferative and anticytotoxic effects of cell fractions and exopolysaccharides from Lactobacillus casei 01. Mutat. Res. 2011, 721, 157-162. Lo, P. R.; Yu, R. C.; Chou, C. C.; Tsai, Y. H. Antimutagenic activity of several probiotic bifidobacteria against Benzo[a]pyrene. J. Biosci. Bioeng. 2002, 94, 148-153. Looijesteijn, P. J.; Trapet, L.; de Vries, E.; Abee, T.; Hugenholtz, J. Physiological function of exopolysaccharides produced by Lactococcus lactis. Int. J. Food Microbiol. 2001, 64, 71-80. Looijesteijn, P. J.; van Casteren, W. H. M.; Tuinier, R.; Dosewijk-Vorage, C. H. L.; Hugenholtz, J. Influence of different substrate limitations on the yield, composition and molecular mass of exopolysaccharides produced by Lactococcus lactis subsp. cremoris in continuous cultures. J. Appl. Microbiol. 2000, 89, 116-122. Low, D.; Ahlgren, J. A.; Horne, D.; McMahon, D. J.; Oberg, C. J.; Broadbent, J. R. Role of Streptococcus thermophilus MR.1C capsular exopolysaccharide in cheese moisture retention. Appl. Environ. Microbiol. 1998, 64, 2147-2151. Luo, Q.; Li, Z. N.; Huang, X. L.; Yan, J.; Zhang, S. H.; Cai, Y. Z. Lycium barbarum polysaccharides: Protective effects against heat-induced damage of rat testes and H2O2-induced DNA damage in mouse testicular cells and beneficial effect on sexual behavior and reproductive function of hemicastrated rats. Life Sciences. 2006, 79, 613-621. Ma, S. S.; Wang, S. P.; Lian, Z. X.; Han, H. B.; Liu, H. Study on growth inhibiting effect of Streptococcus thermophilus exopolysaccharide from Tibetan kefir on human colon cancer cells. Food Sci. 2008, 29, 405-408. MacLaughlin, F. C.; Mumper, R. J.; Wang, J. J. Chitosan and depolymerized chitosan oligomers as condensing carriers for in vivo plasmid delivery. J. Controlled Release. 1998, 56, 259-272. Macura, D.; Townsley, P. M. Scandinavian ropy milk-identification and characterization of endogenous ropy lactic streptococci and their extracellular excretion. J. Dairy Sci. 1984, 67, 735-744. Madigan, M. T.; Martinko, J. M.; Parker, J. Brock biology of microorganisms. Prentice Hall Int. Ltd., London, UK. 8th ed. 1997. Maity, A.; Mckenna, W. G.; Muschel, R. J. The molecular basis for cell cycle delays following ionizing radiation: a review. Radiotherapy Oncol. 1994, 319, 1-2. Mancuso Nichols, C. A.; Garon, S.; Bowman, J. P.; Raguenes, G.; Guezennec, J. Production of exopolysaccharides by Antarctic marine baterial isolates. J. Appl. Microbiol. 2004, 96, 1057-1066. Miao, Z. H.; Rao, V. A.; Agama K.; Antony, S.; Kohn, K. W.; Pommier, Y. 4-Nitroquinoline-1-oxide induces the formation of cellular topoisomerase I-DNA cleavage complexes. Cancer Res. 2006, 66, 6540-6545. Miyamae, Y.; Yamamoto, M.; Sasaki, Y. I.; Kobayashi, H.; Igarashi-Soga, M.; Shimoi, K.; Hayashi, M. Evaluation of a tissue homogenization technique hat isolated nuclei for the in vivo single cell electrophoresis (comet) assay: A collaborative study by five laboratories. Mutat. Res. 1998, 418, 131-140. Monsan, P.; Bozonnet, S.; Albenne, C.; Joucla, G.; Willemot, R. M.; Remaud-Sime’on, M. Homopolysaccharides from lactic acid bacteria. Int. Dairy J. 2001, 11, 675-686. Mosmann, T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods. 1983, 65, 55-63. Mozzi, F.; Savoy de Giori, G.; Oliver, G.; de Valdez, G. F. Exopolysaccharide production by Lactobacillus casei. II. Influence of the carbon source. Milchwissenchaft. 1995, 50, 307-309. Mozzi, F.; Savoy de Giori, G.; Oliver, G.; de Valdez, G. F. Exopolysaccharide production by Lactobacillus casei under controlled pH. Biotechnol. Lett. 1996, 18, 435-439. Murray, A. W. Recycling the cell cycle: Cyclins revisited. Cell. 2004, 116, 221-234. Naidu, A.S.; Bidlack, W.R.; Clemens, R.A. Probiotic spectra of lactic acid bacteria (LAB). Crit. Rev. Food Sci. Nutr. 1999, 39, 113-126. Nakajima, H.; Suzuki, Y.; Kaizu, H.; Hirota, T. Cholesterol-lowering activity of ropy fermented milk. J. Food Sci. 1992, 57, 1327-1329. Oda, M.; Haegawa, H.; Komatsu, S.; Kambe, M.; Tsuchiya, F. Antitumor polysaccharide from Lactobacillus sp. Agric. Biol. Chem. 1983, 47, 1623-1625. Oliveira, R. J.; Ribeiro, L. R.; da Silva, A. F.; Matuo, R.; Mantovani, M. S. Evaluation of antimutagenic activity and mechanisms of action of b-glucan from barley, in CHO-k1 and HTC cell lines using the micronucleus test. Toxicol. in Vitro. 2006, 20, 1225-1233. Osman, M. E. A.; El-Shouny, W.; Talat, R.; El-Za haby, H. Polysaccharides production from some Pseudomonas syringae pathovars as affected by different types of culture media. J. Microbiol. Biotechnol. Food Sci. 2012, 1, 1305-1318. Ou, C. C.; Ko, J. L.; Lin, M. Y. Antioxidative effects of intracellular extracts of yogurt bacteria on lipid peroxidation and intestine 407 cells. Journal of Food and Drug Analysis. 2006, 14, 304-310. Ouwehand, A.; Salminen, S.; Isolauri, E. Probiotics: An overview of beneficial effects. Antonie van Leeuwenhoek. 2002, 82, 279-289. Pang, Q. S.; Guo, B. J.; Ruan, J. H. Enhancement of endonuclease activity and repair DNA synthesis by polysaccharide of Spirulina platensis. I Chuan Hsuch Pao. 1998, 15, 374-381. Perdigon, G.; Valdez, J.; Rachid, M. Antitumour activity of yogurt: Study of possible immune mechanisms. J. Dairy Res. 1998, 65, 129-138 Pillai, T. G.; Nair, C. K. K.; Janardhanan, K. K. Polysaccharides isolated from Ganoderma lucidum occurring in Southern parts of India, protects radiation induced damages both in vitro and in vivo. Environ. Toxicol. Pharmacol. 2008, 26, 80-85. Ricciardi, A.; Clementi, F. Exopolysaccharides from lactic acid bacteria: Structure, production and technological applications. Italian J. Food Sci. 2000, 1, 23-45. Roberfroid, M. B. Introducing inulin-type fructans. Br. J. Nutr. 2005, 93, S13-S15. Roberts, C. M.; Fett, W. F.; Osman, S. F.; Wijey, C.; O’Oonnor, J. V.; Hoover, D. G. Exopolysaccharide production by Bifidobacterium longum BB-79. J. Appl. Bacteriol. 1995, 78, 463-468. Robyt, J. F. Essentials of carbohydrate chemistry. Springer. 1998, 366. Ruas-Madiedo, P.; de los Reyes-Gavilan, C. G. Invited review: Methods for the screening, isolation, and characterization of exopolysaccharides produced by lactic acid bacteria. J. Dairy Sci. 2005, 88, 843-856. Ruas-Madiedo, P.; Hugenholtz, J.; Zoon, P. An overview of the funtionality of exopolysaccharides produced by lactic acid bacteria. Int. Dairy J. 2002a, 12, 163-171. Ruas-Madiedo, P.; Tuinier, R.; Kanning, M.; Zoon, P. Role of exopolysaccharides produced by Lactococcus lactis subsp. cremoris on the viscosity of fermented milks. Int. Dairy J. 2002b, 12, 689-695. Saarela, M.; Lahteenmaki, L.; Crittenden, R.; Salminen, S.; Mattila-Sandholm, T. Gut bacteria and health foods – the European perspective. Int. J. Food Microbiol. 2002, 78, 99-117. Saavedra, J. M.; Bauman, N. A.; Oung, I.; Perman, J. A.; Yolken, R. H. Feeding of Bifidobacterium bifidum and Streptococcus thermophilus to infants in hospital for prevention of diarrhea and shedding of rotavirus. Lancet. 1994, 344, 1046-1049. Sanders, M.E.; Huis in’t Veld, J. Bringing a probiotic-containing functional food to the market: microbiological, product, regulatory and labeling issues. Antonie van Leeuwenhoek. 1999, 76, 293-315. Scharlau, D.; Borowicki, A.; Habermann, N.; Hofmann, T.; Klenow, S.; Miene, C.; Munjal, U.; Stein, K.; Glei, M. Review: Mechanisms of primary cancer prevention by butyrate and other products formed during gut flora-mediated fermentation of dietary fibre. Muta. Res. 2009, 682, 39-53. Schwartz, G. K.; Shah, M. A. Targeting the cell cycle: a new approach to cancer therapy. J. Clin. Oncol. 2005, 23, 9408-9421. Semjonovs, P.; Jasko, J.; Auzina, L.; Zikmanis, P. The use of exopolysaccharide-producing cultures of lactic acid bacteria to improve the functional value of fermented foods. J. Food Technol. 2008, 6 (2), 101-109. Shiff, S. J.; Qiao, L.; Tsai, L. L.; Rigas, B. Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells. J. Clin. Invest. 1995, 96, 491-503. Sikkema, J.; Oba, T. Extracellular polysaccharides of lactic acid bacteria. Snow Brand R&D Reports. 1998, 107, 1-31. Singh, N. P.; McCoy, M. T.; Tice, R. R.; Schneider, E. L. A simple technology for quantitation of low levels of DNA damage in individual cells. Exp. Cell Res. 1988, 175, 184-191. Sioga, A.; Economou, L.; Kaklamanos, E. G.; Antonia, V.; Keramidas, G.; Manthos, A. Ultrastructural changes of the palatal mucosa following application of 4-nitroquinoline-1-oxide (4NQO) in rats subjected to major salivary gland excision. Oral Surg. Oral Med. Oral Pathol. Oral Radiol. Endod. 2006, 101, 487-498. Smitinont, T.; Tansakul, C.; Tanasupawat, S.; Keeratipibul, S.; Navarini, L.; Bosco, M.; Cescutti, P. Exopolysaccharide-producing lactic acid bacteria strains from traditional thai fermented foods: isolation, identification and exopolysaccharide characterization. Int. J. Food Microbiol. 1999, 51, 105-111. Speit, G.; Hartmann, A. The contribution of excision repair to the DNA effects seen in the alkaline single cell gel test (comet assay). Mutagenesis. 1995, 10, 555-560. Sperti, G.S. Probiotics. AVI Publishing Co., Roslyn, NY, USA. 1971. Sreekumar, O.; Hosono, A. The antimutagenic properties of a polysaccharide produced by Bifidobacterium longum and its cultured milk against some heterocyclic amines. Can. J. Microbiol. 1998, 44, 1029-1036. Stoler, D. L.; Chen, N.; Basik, M.; Kahlenberg, M. S.; Rodiguez-Bigas, M. A.; Petrelli, N. J.; Anderson, G. R. The onset and extent of genomic instability in sporadic colorectal tumor progression. Proc. Natl. Acad. Sci. USA. 1999, 96, 15121-15126. Sutherland, I. W. Xanthan lyases – novel enzymes found in various bacterial species. J. Gen. Microbiol. 1987, 133, 3129-3134. Tannock, G. W. Probiotic properties of lactic acid bacteria: Plenty of scope for fundamental R and D. Trends Biotechnol. 1997, 15, 270-274. Teitelbaum, J. E.; Walker, W. A. Nutritional impact of pre- and probiotics as protective gastrointestinal organisms. Annu. Rev. Nutr. 2002, 22, 107-138. Tsuda, H.; Hara, K.; Miyamoto, T. Binding of mutagens to exopolysaccharide produced by Lactobacillus plantarum mutant strain 301102S. J. Dairy Sci. 2008, 91, 2960-2966. Tsuda, H.; Miyamoto, T. Production of exopolysaccharide by Lactobacillus plantarum and the prebiotic activity of the exopolysaccharide. Food Sci. Technol. Res. 2010, 16, 87-92. Tuinier, R.; van Casteren, W. H. M.; Looijesteijn, P. J.; Schols, H. A.; Voragen, A. G. J.; Zoon, P. Effects of structural modifications on some physical characteristics of exo-polysaccharides from Lactococcus lactis. Biopolymers. 2001, 59, 160-166. Twentyman, P. R.; Luscombe, M. A study of some variables in a tetrazolium dye (MTT) based assay for cell growth and chemosensitivity. Br. J. Cancer. 1987, 56, 275-279. van Geel-Schutten, G. H.; Flesch, F.; ten Brink, B.; Smith, M. R.; Dijkhuizen, L. Screening and characterization of Lactobacillus strains producing large amounts of exopolysaccharides. Appl. Microbiol. Biotechnol. 1998, 50, 697-703. van Kranenburg, R.; van Swam, II; Marugg, J. D.; Kleerebezem, M.; de Vos, W. M. Exopolysaccharide biosynthesis in Lactococcus lactis NIZO B40: Functional analysis of the glycosyltransferase genes involved in synthesis of the polysaccharide backbone. J. Bacteriol. 1999, 181, 338-340. Vesa, T. H.; Marteau, P. R.; Breat, F. B.; Boutron-Ruault, M. C.; Rambaud, J. C. Raising milk energy content retards gastric emptying of lactose in lactose-intolerant humans with little effect on lactose digestion. J. Nutr. 1997, 127, 2316-2320. Vijayendra, S. V. N.; Palanivel, G.; Mahadevamma, S.; Tharanathan, R. N. Physico-chemical characterization of an exopolysaccharide produced by a non-ropy strain of Leuconostoc sp. CFR 2181 isolated from dahi, an Indian traditional lactic fermented milk product. Carbohydrate Polymers. 2008, 72, 300-307. Weerasooriya, V.; Rennie, M. J.; Anant, S.; Alpers, D. H.; Patterson B. W.; Klein, S. Dietary fiber decreases colonic epithelial cell proliferation and protein synthetic rates in human subjects. Am. J. Physiol: Endocrinol. Metab. 2006, 290, E1104-E1108. Welman, A. D.; Maddox, I. S. Exopolysaccharides from lactic acid bacteria: perspectives and challenges. Trends Biotech. 2003, 21, 269-274. Willment, J. A.; Marshall, A. S.; Reid, D. M.; Williams, D. L.; Wong, S. Y.; Gordon, S.; Brown, B. D. The human beta-glucan receptor is widely expressed and functionally equivalent to murine dectine-1 on primary cells. Eur. J. Immunol. 2005, 35, 1539-1547. Yen, G. C.; Chiang, H. C.; Wu, C. H.; Yeh, C. T. The protective effects of Aspergillus candidus metabolites against hydrogen peroxide-induced oxidative damage to Int 407 cells. Food Chem. Toxicol. 2003, 41, 1561-1567. You, J. H.; Oh, D. K.; Ji, G. E. Anticancerogenic effect of a novel chiroinositol-containing polysaccharide from Bifidobacterium bifidum BGN4. FEMS Microbiol. 2004, 240, 131-136. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/65530 | - |
dc.description.abstract | 結腸直腸癌 (colorectal cancer, CRC) 是目前常見的癌症,約 70% 結腸直腸 癌與飲食習慣相關。益生菌及益生質具有維持人體腸道內正常微生物菌相、減緩乳糖不耐症、降低膽固醇、調節免疫系統、抗腫瘤及抗致突變等諸多生理功能,有研究指出部分原因可能與其所產之胞外多醣 (exopolysaccharides, EPS) 有關。 本研究以五株乳酸桿菌胞外多醣為為材料進行試驗,首先探討其對雙叉桿菌的助生性效果,接著利用致突變劑 4-nitroquinoline-1-oxide (4NQO) 誘導人類腸道上 皮細胞 Int-407 產生細胞及基因毒性,評估降低細胞及基因毒性的能力,並探討抗細胞毒性的機制。最後以 MTT assay 及流式細胞儀分析其抑制人類結腸癌細 胞 HT-29 增生及細胞週期阻滯的能力。結果顯示,乳酸桿菌胞外多醣對雙叉桿菌皆有助生性效果,以 L. acidophilus BCRC 14079 胞外多醣效果最佳。在抗細胞毒性方面,五株乳酸桿菌胞外多醣皆可顯著提高經誘導損傷後 Int-407 的細胞存活率,但在不同濃度下有最佳的效果。利用分段式預反應探討其抗細胞毒性機制,結果顯示主要為阻斷效應 (blocking effects) 及生物抗細胞毒性效應 (bioanticytotoxic effects)。由彗星電泳結果顯示,乳酸桿菌胞外多醣處理組 DNA 拖尾程度顯著小於 4NQO 組。在抑制人類結腸癌細胞 HT-29 增生方面,隨作用時間增加,細胞存活率越低,且在 48 小時作用下呈現濃度效應,以 200 ug/mL 之 L. casei 01 胞外多醣效果最佳,抑制率為 31.2%。流式細胞儀分析結果顯示,乳酸桿菌胞外多醣能使 HT-29 細胞週期停滯於 G0/G1 phase,並顯著增加 sub-G1 phase,誘導細胞走向凋亡。本研究結果顯示,乳酸桿菌胞外多醣具有助生效果,也能有效的保護腸道細胞降低損傷,抑制癌細胞的增生。 | zh_TW |
dc.description.abstract | Colorectal cancer commonly known as bowel cancer, is one of the leading causes of cancer. About 70% of colorectal cancer is related to dietary habits. Probiotics and prebiotics have received an increasing amount of attention in recent years mainly because of their positive health effects such as maintenance of human intestinal microflora, reduction of lactose intolerance, cholesterol-lowering activities, immunomodulating, antitumor and antimutagenic activity. Studies had shown that the beneficial effects could be attributable to positive physiological effect of exopolysaccharides (EPS). In this study, we employed EPS produced by five Lactobacillus spp. as materials. At first, we investigated the prebiotic effects of EPS on the growth of bifidobacteria. Then EPS were studied for their anticytotoxicity and antigenotoxicity activities against 4-nitroquinoline-1-oxide (4NQO) induced human intestine cell line Int 407. In addition, MTT assay and flow cytometry were used to explore the antiproliferation and cell cycle arrest of human colon cancer cell, HT-29. The results showed that EPS had the prebiotic effects on the growth of bifidobacteria, especially EPS produced by L. acidophilus BCRC 14079. Besides that, EPS could reduce cytotoxicity of Int-407 induced by 4NQO. The possible anticytotoxic mechanisms of EPS were blocking effects and bioanticytotoxic effects. From the results of comet assay, we observed that the DNA tails significantly reduced in the EPS groups, showed the antigenotoxicity effects of EPS. Furthermore, MTT assay showed that the proliferation of HT-29 cells was inhibited after treatment with EPS, and in a time- and dose-dependent manner. At 200 ug/mL, EPS produced by L. casei 01 strongly inhibited the proliferation of HT-29 cells, with a sustained diminution of the number of viable cells throughout the 48 h treatment period. The results of flow cytometry analysis showed that EPS treatment enabled the HT-29 cell cycle arrest at G0/G1 phase, and a significant increase in the sub-G1 phase which induced cell apoptosis. Conclusively, all of EPS produced by Lactobacillus spp. in this study had the prebiotic effects, and protect the intestinal cells from damage effect, antiproliferation of cancer cells and reducing the possibility of suffering from colorectal cancer. | en |
dc.description.provenance | Made available in DSpace on 2021-06-16T23:48:43Z (GMT). No. of bitstreams: 1 ntu-101-R99641040-1.pdf: 2453754 bytes, checksum: 35c967dcaeaa3ba8dd3bd35f1d631db2 (MD5) Previous issue date: 2012 | en |
dc.description.tableofcontents | 謝誌.....i
中文摘要.....iii 英文摘要.....iv 目錄.....vi 圖目錄.....ix 表目錄......x 壹、前言.....1 貳、文獻整理.....2 一、益生菌.....2 (一) 益生菌的定義.....2 (二) 益生菌之特性與應用.....2 二、乳酸菌.....4 (一) 乳酸菌之特性.....6 (二) 乳酸菌的分類.....6 (三) 乳酸菌對人體健康的功效.....7 三、乳酸菌胞外多醣.....9 (一) 乳酸菌胞外多醣的組成與分子大小.....10 (二) 乳酸菌胞外多醣的生產.....13 (三) 乳酸菌胞外多醣之功效.....14 參、材料與方法.....16 一、實驗架構.....16 二、實驗材料.....18 (一) 試驗菌株.....18 (二) 試驗細胞株.....18 (三) 培養基.....18 (四) 藥品.....19 (五) 器材設備.....20 三、實驗方法.....22 (一) 菌種的活化與保存.....22 (二) 乳酸桿菌胞外多醣製備.....23 (三) 總醣含量測定 - Phenol-sulfuric acid method.....24 (四) 醣醛酸 (uronic acid) 含量測定 - m-hydroxydiphenyl method.....25 (五) 蛋白質含量測定 - Bradford method.....27 (六) 乳酸桿菌胞外多醣之助生性試驗.....27 (七) 細胞株的活化、繼代培養、保存與計數.....30 (八) 細胞存活率分析 (Cell viability analysis) – MTT assay.....32 (九) 乳酸桿菌胞外多醣對人類腸道上皮細胞 Int-407 存活率影響試驗.....33 (十) 乳酸桿菌胞外多醣抑制 4NQO 誘導 Int-407 之細胞毒性試驗.....34 (十一) 利用倒立式顯微鏡觀察 Int-407 之細胞形態.....35 (十二) 乳酸桿菌胞外多醣抑制 4NQO 誘導 Int-407 細胞毒性之機制探討.....35 (十三) 以彗星電泳法 (Comet assay) 評估基因毒性.....37 (十四) 乳酸桿菌胞外多醣抑制人類結腸癌細胞 HT-29 增生試驗.....39 (十五) 利用倒立式顯微鏡觀察 HT-29 之細胞形態.....39 (十六) 乳酸桿菌胞外多醣抑制 HT-29 細胞週期分析.....40 四、統計分析.....41 肆、結果與討論.....42 一、乳酸桿菌胞外多醣產量與組成分析.....42 二、乳酸桿菌胞外多醣之助生性效果.....45 三、乳酸桿菌胞外多醣對人類腸道上皮細胞 Int-407 存活率之影響.....55 四、乳酸桿菌胞外多醣抑制 4NQO 誘導 Int-407 細胞毒性.....57 五、乳酸桿菌胞外多醣對 4NQO 誘導 Int-407 細胞形態的影響.....59 六、乳酸桿菌胞外多醣抑制 4NQO 誘導 Int-407 細胞毒性之機制探討.....61 七、乳酸桿菌胞外多醣抑制 4NQO 誘導 Int-407 基因毒性.....67 八、乳酸桿菌胞外多醣對人類結腸癌細胞 HT-29 之抑制效果.....73 九、乳酸桿菌胞外多醣對 HT-29 細胞形態的影響.....76 十、乳酸桿菌胞外多醣對 HT-29 細胞週期之影響.....78 伍、結論.....82 陸、參考文獻.....83 | |
dc.language.iso | zh-TW | |
dc.title | 數株乳酸桿菌胞外多醣抑制 4NQO 誘導人類腸道上皮細胞 Int-407 細胞毒性及人類結腸癌細胞 HT-29 增生之研究 | zh_TW |
dc.title | Effects of Lactobacillus spp. Exopolysaccharides on the Anticytotoxicity of Human Intestine Cell Line Int-407 and Inhibition of Colon Cancer Cell Line HT-29 Proliferation | en |
dc.type | Thesis | |
dc.date.schoolyear | 100-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 丘志威,蔡國珍,潘崇良,周正俊,顏聰榮 | |
dc.subject.keyword | 乳酸桿菌胞外多醣,結腸直腸癌,助生性,抗細胞基因毒性,抑制癌細胞增生, | zh_TW |
dc.subject.keyword | exopolysaccharides (EPS),colorectal cancer,prebiotic,anticytotoxicity,antigenotoxicity,antiproliferation, | en |
dc.relation.page | 96 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2012-07-23 | |
dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
dc.contributor.author-dept | 食品科技研究所 | zh_TW |
顯示於系所單位: | 食品科技研究所 |
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