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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 林郁真(Yu-Chen Lin) | |
dc.contributor.author | Chau-Shuen Kang | en |
dc.contributor.author | 康朝舜 | zh_TW |
dc.date.accessioned | 2021-06-16T16:41:33Z | - |
dc.date.available | 2014-09-13 | |
dc.date.copyright | 2012-09-13 | |
dc.date.issued | 2012 | |
dc.date.submitted | 2012-08-29 | |
dc.identifier.citation | Berkenboom, G., Unger, P., Goldman, M., Fang, Z.-Y., & Fontaine, J. (1991). Prevention of Cyclosporine A-Induced Vascular Toxicity by Pentoxifylline. Journal of Cardiovascular Pharmacology, 18(5), 761-768.
Beshay, E., Croze, F., & Prud'homme, G. J. (2001). The Phosphodiesterase Inhibitors Pentoxifylline and Rolipram Suppress Macrophage Activation and Nitric Oxide Production in Vitro and in Vivo. Clinical Immunology, 98(2), 272-279. doi: 10.1006/clim.2000.4964 Black, F. J., Poulin, B. A., & Flegal, A. R. (2012). Factors controlling the abiotic photo-degradation of monomethylmercury in surface waters. Geochimica et Cosmochimica Acta, 84(0), 492-507. doi: 10.1016/j.gca.2012.01.019 Chen, Y., Hu, C., Hu, X., & Qu, J. (2009). Indirect Photodegradation of Amine Drugs in Aqueous Solution under Simulated Sunlight. Environmental Science & Technology, 43(8), 2760-2765. doi: 10.1021/es803325j Chowdhury, R. R., Charpentier, P. A., & Ray, M. B. (2011). Photodegradation of 17β-estradiol in aquatic solution under solar irradiation: Kinetics and influencing water parameters. Journal of Photochemistry and Photobiology A: Chemistry, 219(1), 67-75. doi: 10.1016/j.jphotochem.2011.01.019 Cooper William, J., Zika Rod, G., Petasne Robert, G., & Fischer Anne, M. (1988). Sunlight-Induced Photochemistry of Humic Substances in Natural Waters: Major Reactive Species Aquatic Humic Substances (Vol. 219, pp. 333-362): American Chemical Society. Ge, L., Chen, J., Qiao, X., Lin, J., & Cai, X. (2009). Light-Source-Dependent Effects of Main Water Constituents on Photodegradation of Phenicol Antibiotics: Mechanism and Kinetics. Environmental Science & Technology, 43(9), 3101-3107. doi: 10.1021/es8031727 Grebel, J. E., Pignatello, J. J., & Mitch, W. A. (2012). Impact of Halide Ions on Natural Organic Matter-Sensitized Photolysis of 17β-Estradiol in Saline Waters. Environmental Science & Technology, 46(13), 7128-7134. doi: 10.1021/es3013613 Hua, W. Y., Bennett, E. R., Maio, X.-S., Metcalfe, C. D., & Letcher, R. J. (2006). Seasonality effects on pharmaceuticals and s-triazine herbicides in wastewater effluent and surface water from the Canadian side of the upper Detroit River. Environmental Toxicology and Chemistry, 25(9), 2356-2365. doi: 10.1897/05-571r.1 Jurgens, M. D., Holthaus, K. I. E., Johnson, A. C., Smith, J. J. L., Hetheridge, M., & Williams, R. J. (2002). The potential for estradiol and ethinylestradiol degradation in english rivers. Environmental Toxicology and Chemistry, 21(3), 480-488. doi: 10.1002/etc.5620210302 Ji, Y., Zeng, C., Ferronato, C., Chovelon, J.-M., & Yang, X. (2012). Nitrate-induced photodegradation of atenolol in aqueous solution: Kinetics, toxicity and degradation pathways. Chemosphere, 88(5), 644-649. doi: 10.1016/j.chemosphere.2012.03.050 Kim, I., & Tanaka, H. (2009). Photodegradation characteristics of PPCPs in water with UV treatment. Environment International, 35(5), 793-802. doi: 10.1016/j.envint.2009.01.003 Lam, M. W., & Mabury, S. A. (2005). Photodegradation of the pharmaceuticals atorvastatin, carbamazepine, levofloxacin, and sulfamethoxazole in natural waters. [Article]. Aquatic Sciences, 67(2), 177-188. doi: 10.1007/s00027-004-0768-8 Lam, M. W., Tantuco, K., & Mabury, S. A. (2003). PhotoFate: A New Approach in Accounting for the Contribution of Indirect Photolysis of Pesticides and Pharmaceuticals in Surface Waters. Environmental Science & Technology, 37(5), 899-907. doi: 10.1021/es025902+ Li, W. Z., Lu, S. G., Chen, N., Gu, X. G., Qiu, Z. F., Fan, J., & Lin, K. F. (2009). Photo-degradation of clofibric acid by ultraviolet light irradiation at 185 nm. [Article]. Water Science and Technology, 60(11), 2983-2989. doi: 10.2166/wst.2009.690 Lin, A. Y.-C., Yu, T.-H., & Lin, C.-F. (2008). Pharmaceutical contamination in residential, industrial, and agricultural waste streams: Risk to aqueous environments in Taiwan. Chemosphere, 74(1), 131-141. doi: 10.1016/j.chemosphere.2008.08.027 Lin, A. Y. C., Yu, T. H., & Lin, C. F. (2008). Pharmaceutical contamination in residential, industrial, and agricultural waste streams: Risk to aqueous environments in Taiwan. [Article]. Chemosphere, 74(1), 131-141. doi: 10.1016/j.chemosphere.2008.08.027 Mack, J., & Bolton, J. R. (1999). Photochemistry of nitrite and nitrate in aqueous solution: a review. Journal of Photochemistry and Photobiology A: Chemistry, 128(1–3), 1-13. doi: 10.1016/s1010-6030(99)00155-0 Maeng, S. K., Sharma, S. K., Abel, C. D. T., Magic-Knezev, A., & Amy, G. L. (2011). Role of biodegradation in the removal of pharmaceutically active compounds with different bulk organic matter characteristics through managed aquifer recharge: Batch and column studies. Water Research, 45(16), 4722-4736. doi: 10.1016/j.watres.2011.05.043 Magureanu, M., Piroi, D., Mandache, N. B., David, V., Medvedovici, A., & Parvulescu, V. I. (2010). Degradation of pharmaceutical compound pentoxifylline in water by non-thermal plasma treatment. Water Research, 44(11), 3445-3453. doi: 10.1016/j.watres.2010.03.020 Moldovan, Z., Chira, R., & Alder, A. C. (2009). Environmental exposure of pharmaceuticals and musk fragrances in the Somes River before and after upgrading the municipal wastewater treatment plant Cluj-Napoca, Romania. [Article]. Environmental Science and Pollution Research, 16, 46-54. doi: 10.1007/s11356-008-0047-7 Mone, M. K., & Chandrasekhar, K. B. (2010). Degradation studies of pentoxifylline: Isolation and characterization of a novel gem-dihydroperoxide derivative as major oxidative degradation product. Journal of Pharmaceutical and Biomedical Analysis, 53(3), 335-342. doi: 10.1016/j.jpba.2010.04.006 Ouannes, C., & Wilson, T. (1968). Quenching of singlet oxygen by tertiary aliphatic amines. Effect of DABCO (1,4-diazabicyclo[2.2.2]octane). Journal of the American Chemical Society, 90(23), 6527-6528. doi: 10.1021/ja01025a059 Packer, J. L., Werner, J. J., Latch, D. E., McNeill, K., & Arnold, W. A. (2003). Photochemical fate of pharmaceuticals in the environment: Naproxen, diclofenac, clofibric acid, and ibuprofen. Aquatic Sciences - Research Across Boundaries, 65(4), 342-351. doi: 10.1007/s00027-003-0671-8 Peuravuori, J. (2012). Aquatic photochemistry of paracetamol in the presence of dissolved organic chromophoric material and nitrate. Environmental Science and Pollution Research, 19(6), 2259-2270. doi: 10.1007/s11356-011-0730-y Ruddock, M. W., & Hirst, D. G. (2005). Pentoxifylline inhibits agonist-induced vasoconstriction in vascular smooth muscle and spontaneous peristalsis in isolated ileum. [Article]. Oncology Research, 15(2), 81-86. Sacher, F., Ehmann, M., Gabriel, S., Graf, C., & Brauch, H. J. (2008). Pharmaceutical residues in the river Rhine - results of a one-decade monitoring programme. [Article]. Journal of Environmental Monitoring, 10(5), 664-670. doi: 10.1039/b800701b Standley, L. J., Rudel, R. A., Swartz, C. H., Attfield, K. R., Christian, J., Erickson, M., & Brody, J. G. (2008). Wastewater-contaminated groundwater as a source of endogenous hormones and pharmaceuticals to surface water ecosystems. Environmental Toxicology and Chemistry, 27(12), 2457-2468. doi: 10.1897/07-604.1 Walse, S. S., Morgan, S. L., Kong, L., & Ferry, J. L. (2004). Role of Dissolved Organic Matter, Nitrate, and Bicarbonate in the Photolysis of Aqueous Fipronil. Environmental Science & Technology, 38(14), 3908-3915. doi: 10.1021/es0349047 Ward, A., & Clissold, S. P. (1987). Pentoxifylline. A review of its pharmacodynamic and pharmacokinetic properties, and its therapeutic efficacy. Drugs, 34(1), 50-97. Wenk, J., von Gunten, U., & Canonica, S. (2011). Effect of Dissolved Organic Matter on the Transformation of Contaminants Induced by Excited Triplet States and the Hydroxyl Radical. Environmental Science & Technology, 45(4), 1334-1340. doi: 10.1021/es102212t Werner, J. J., Arnold, W. A., & McNeill, K. (2006). Water Hardness as a Photochemical Parameter: Tetracycline Photolysis as a Function of Calcium Concentration, Magnesium Concentration, and pH†. Environmental Science & Technology, 40(23), 7236-7241. doi: 10.1021/es060337m Wetzel, R. G. (1992). GRADIENT-DOMINATED ECOSYSTEMS - SOURCES AND REGULATORY FUNCTIONS OF DISSOLVED ORGANIC-MATTER IN FRESH-WATER ECOSYSTEMS. [Article; Proceedings Paper]. Hydrobiologia, 229, 181-198. doi: 10.1007/bf00007000 Zepp, R. G. (1988). Factors affecting the photochemical treatment of hazardous waste. Environmental Science & Technology, 22(3), 256-257. doi: 10.1021/es00168a003 Zepp, R. G., & Cline, D. M. (1977). Rates of direct photolysis in aquatic environment. Environmental Science & Technology, 11(4), 359-366. doi: 10.1021/es60127a013 Zhou, D., Huang, W., Wu, F., Han, C., & Chen, Y. (2010). Photodegradation of chloromycetin in aqueous solutions: kinetics and influencing factors. Reaction Kinetics, Mechanisms and Catalysis, 100(1), 45-53. doi: 10.1007/s11144-010-0149-3 | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/63435 | - |
dc.description.abstract | 近來個人用藥對於環境污染的議題逐漸受到重視,且國人普遍對於藥物使用與回收觀念並不正確,以至於有濫用或任意拋棄藥物的情況,進而對環境與人類健康產生潛在性的風險。本研究的目的為探討一種普遍使用的血管擴張劑(vasodilator)pentoxifylline在環境裡的宿命,並以日光模擬器的模擬光源探討目標化合物的直接、間接與以環境水體為基質的光降解情形。間接光降解以環境水體中常見到的光敏感前驅物質為研究方向,其中包含硝酸鹽(nitrate)、碳酸氫鹽(bicarbonate)與溶解性有機物質(dissolced organic matter,DOM),而環境水體則以台灣北部兩個表面水體做為環境水體光降解的基質。研究結果顯示pentoxifylline無法經由模擬光源進行直接光降解,而在間接光解之部分單獨添加硝酸鹽與溶解性有機物質皆有降解能力,而組合添加硝酸鹽與碳酸氫鹽也具有光降解能力。由間接光降解之試驗可得知目標化合物能經由前述光敏感覺區物質所產生之氫氧自由基(hydroxyl radical)、三重激發溶解性有機物質(triplet excited states of dissolved organic matter)與碳酸自由基(carbonate radical)產生反應進行降解。而以環境水樣為基質的光降解試驗與實驗是合成水質所做之結果幾乎一致,故可以說在自然水體中pentoxifylline在水體中主要影響光降解之物質是前述三種光敏感前驅物質。本次實驗結果證實pentoxifylline在自然水體中不易受到光降解的影響,所以可將pentoxifylline歸類為在環境水體中較具持久性的藥物。其由實驗結果所分析之降解機制亦可應用於廢水處理的環節,以降低個人用藥物對自然環境所造成之衝擊。 | zh_TW |
dc.description.abstract | Recently, the issue of environmental pollution by pharmaceuticals and personal care products is taken more seriously. The correct concept of drugs use and recycle is not widely spread in Taiwan. This causes drug overuse and dispose without awareness, which has been a potential risk either for the environment or for the human beings. The study investigated the photodegradation of widely used vasodilator drug, pentoxifylline. Direct, indirect and surface water photolysis experiment were processed by sunlight simulator. Three precursors which generate photoreactive species including nitrate, bicarbonate and dissolved organic matter (DOM) were studied individually and in combination in the indirect photolysis batch experiments. Two surface water samples were collected from the metropolitan area in northern Taiwan and were used to study the effect of different water matrices. Results show that pentoxifylline does not undergo direct photolysis. Nitrate, DOM and bicarbonate demonstrated to be important factors for pentoxifylline photodegradation. And pentoxifylline could be reacted by three Reactive oxygen species by three precursors, the hydroxyl radical, triplet excited states of dissolved organic matter and carbonate radical. Although the matrices were quite complex in the two surface water samples, their overall photodegradation rate were consistent with the conclusion of the indirect photolysis batch experiment, it indicates that the selected three precursors are major materials affecting the photodegradation in aquatic environment. The result also explains its high occurrence in the nature aquatic environments. The mechanism of photodegradation may also apply to the part of wastewater treatment to reduce the impact of drugs on the natural aquatic environment. | en |
dc.description.provenance | Made available in DSpace on 2021-06-16T16:41:33Z (GMT). No. of bitstreams: 1 ntu-101-R97541138-1.pdf: 3861217 bytes, checksum: d7faa7622a97d74c61ae338615e98cdf (MD5) Previous issue date: 2012 | en |
dc.description.tableofcontents | 摘要 i
Abstract ii 圖目錄 vi 表目錄 viii 第一章 緒論 1 1.1 研究緣起 1 1.2 研究目的 1 1.3 研究內容 2 第二章 文獻回顧 3 2.1 Pentoxifylline 3 2.1.1物化性質 3 2.1.2 來源與使用 3 2.1.3 藥理機制 4 2.1.4 生物毒性 4 2.1.5 環境流佈 4 2.1.6 工程處理方法 5 2.1.7 自然淨化(natural attenuation) 6 2.2 光降解反應原理與機制 7 2.2.1 直接光降解 7 2.2.2 間接光降解 7 2.3 PPCPs在環境中的光降解宿命 9 第三章 實驗方法與材料 12 3.1 研究架構 12 3.2 實驗流程與方法 12 3.3實驗藥品與儀器設備 14 3.3.1 藥品明細 14 3.3.2 儀器設備 14 3.4 光降解實驗儀器架設 15 3.5 光降解實驗方式 15 3.5.1 照光實驗 15 3.5.2 未光照實驗 15 3.5.2實驗取樣間隔 15 3.5 實驗步驟 15 3.5.2 光降解初始濃度配製 16 3.5.3 UV-Vis吸收光譜 16 3.5.4 直接光降解 16 3.5.5 間接光降解(合成水質) 16 3.5.6環境水體光降解 17 3.5.7 生物毒性分析 18 3.6 定量分析方法 19 3.6.1 目標化合物濃度定量分析 19 3.6.2環境水體水質分析 19 第四章 結果與討論 20 4.1 UV-Vis 吸收光譜 20 4.2 直接光降解 20 4.3 間接光降解 21 4.3.1單獨添加nitrate 22 4.3.2添加nitrate與bicarbonate 23 4.3.3單獨添加DOM 25 4.3.4 組合添加nitrate、DOM、bicarbonate 27 4.4 環境水體光降解 30 4.4.1 華江橋(hua jiang bridge) 32 4.4.2 寶橋(bau bridge) 34 4.5 副產物的分析 35 4.5.1 使用Nitrate: 30ppm 35 4.5.2 使用Nitrate: 30ppm加上Bicarbonate: 2mM 進行光解 36 4.6 毒性分析 43 第五章 結論與建議 44 5.1 結論 44 5.1.1 pentoxifylline 在水體環境中的光降解宿命 44 5.2 建議 45 Reference 46 | |
dc.language.iso | zh-TW | |
dc.title | 血管擴張劑Pentoxifylline在水體環境中的光降解 | zh_TW |
dc.title | Photodegradation of Pentoxifylline in Aquatic Environments | en |
dc.type | Thesis | |
dc.date.schoolyear | 100-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 林正芳(Cheng-Fang Lin),康佩群(Pui-Kwa Hong) | |
dc.subject.keyword | Pentoxifylline,光降解,硝酸鹽,碳酸氫鹽,溶解性有機物質,急毒性,環境水體, | zh_TW |
dc.subject.keyword | photodegradation,pentoxifylline,nitrate,dissolved organic,bicarbonate,aquatic environment,toxicity, | en |
dc.relation.page | 48 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2012-08-30 | |
dc.contributor.author-college | 工學院 | zh_TW |
dc.contributor.author-dept | 環境工程學研究所 | zh_TW |
顯示於系所單位: | 環境工程學研究所 |
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