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DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 詹長權(Chang-Chuan Chan) | |
dc.contributor.author | Yi-Ting Chen | en |
dc.contributor.author | 陳禕婷 | zh_TW |
dc.date.accessioned | 2021-06-16T10:21:19Z | - |
dc.date.available | 2023-12-31 | |
dc.date.copyright | 2013-09-24 | |
dc.date.issued | 2013 | |
dc.date.submitted | 2013-08-16 | |
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F J Jongeneelen, F.E.v.L., S Oosterink, R B Anzion, F van der Loop, R P Bos, and H G van Veen, Ambient and biological monitoring of cokeoven workers: determinants of the internal dose of polycyclic aromatic hydrocarbons. British Journal of Industrial Medicine, 1990. 47: p. 454-461. 28. Gündel J, M.C., Büttner K, Ewers U, Angerer J., Urinary levels of 1-hydroxypyrene, 1-, 2-, 3-, and 4-hydroxyphenanthrene in females living in an industrial area of Germany. Arch Environ Contam Toxicol., 1996. 31(4): p. 585-90. 29. Mucha, A.P., et al., Urinary 1-Hydroxypyrene as a Biomarker of PAH Exposure in 3-Year-Old Ukrainian Children. Environ Health Perspect, 2006. 114(4): p. 603-609. 30. Lee, M.S., et al., Seasonal and regional contributors of 1-hydroxypyrene among children near a steel mill. Cancer Epidemiol Biomarkers Prev, 2009. 18(1): p. 96-101. 31. Hu, S.W., et al., Urinary levels of 1-hydroxypyrene in children residing near a coal-fired power plant. 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Zdenek Fiala, A.V., Vladimir Krajak,Claude Viau,Eva Ettlerova,Josef Bukac,Dana Fialova,Stanislav Emminger Environmental exposure of small children to polycyclic aromatic hydrocarbons. International Archives of Occupational and Environmental Health, 2001. 74(6): p. 411-420. 43. Ruchirawat, M., et al., Measurement of genotoxic air pollutant exposures in street vendors and school children in and near Bangkok. Toxicol Appl Pharmacol, 2005. 206(2): p. 207-14. | |
dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/60549 | - |
dc.description.abstract | 背景:
蒙古首都烏蘭巴托過去十幾年來工業化及都市化發展快速,二氧化硫(SO2)和二氧化氮(NO2)空氣汙染日益嚴重,尤其在冬季期間,蒙古包地區居民會燃燒木材及煤炭取暖煮食。然而暴露於空氣汙染物多環芳香烴對於居民的影響至今尚未有評估,因此本研究目的為利用多環芳香烴的代謝物尿中1-羥基芘,探討住在烏蘭巴托不同地區的學童尿中1-羥基芘濃度情況。 方法: 本研究於研究地區烏蘭巴托的六間學校,選取320位學童作為研究對象,年齡介於11至15歲之間,並於2011年9月(溫暖季節)和12月(寒冷季節)以及2012年3月(溫和季節)分三次季節進行尿液採樣與問卷調查。之後使用高效能液相層析儀及螢光偵測器(HPLC/FLD)進行實驗分析,並做廣義估計方程式(GEE)分析,校正個人和環境因子,評估季節影響蒙古學童尿中1-羥基芘濃度情況,且依學童住址使用土地利用回歸模式預測可能暴露之二氧化硫和二氧化氮濃度,藉以了解蒙古烏蘭巴托地區學童尿中1-羥基芘濃度情形。 結果: 蒙古學童尿中1-羥基芘濃度在寒冷季節為0.30±0.57 μmol/mol creatinine,溫和季節為0.14±0.12 μmol/mol creatinine,溫暖季節為0.14±0.21 μmol/mol creatinine。寒冷季節與溫和季節的尿液1-羥基芘濃度分別高於溫暖季節2.13倍和1.37倍;而蒙古包區的尿液1-羥基芘濃度高於非蒙古包區1.27倍;在房屋形式則是蒙古包與磚造屋的尿液1-羥基芘濃度分別高於公寓大廈1.58和1.34倍。 結論: 蒙古學童的尿液1-羥基芘濃度於寒冷季節、蒙古包區以及居住在蒙古包或磚造屋時顯著增加,顯示在烏蘭巴托地區尿液1-羥基芘濃度和燃燒燃料產生的空氣汙染物相關。 | zh_TW |
dc.description.abstract | Background:
Urbanization and industrialization has rapidly increased air pollution of SO2 and NO2 in Ulaanbaatar, Mongolia in the past few decades, especially in the ger areas in the winter when wood or coal-burning stoves for heating and cooking were needed. The exposure to air pollutants, such as polycyclic aromatic hydrocarbons (PAHs) among residents remains unknown. The purpose of this study is to study urinary 1-hydroxypyrene (1-OHP) levels, a metabolite of PAHs, among students living in different parts of Ulaanbaatar. Methods: Our study subjects were 320 students aged from 11 to 15 years old in 6 schools in Ulaanbaatar. Spot urine samples and questionnaires were collected three times for each subject in three seasons, i.e. September (warm) and December (cold) in 2011and March (moderate) in 2012. Urinary 1-OHP was analyzed by high-performance liquid chromatography with fluorescent detection (HPLC/FLD). Generalized Estimating Equation (GEE) models were applied to estimate seasonal effects on 1-OHP levels, adjusting for demographic and environmental factors. SO2 and NO2 concentrations at subjects’ addresses predicted by land use regression models were used to regress against students’ urinary 1-OHP levels. Results: Students’ urinary 1-OHP levels were 0.30±0.57 μmol/mol creatinine in cold season, 0.14±0.12 μmol/mol creatinine in moderate season, and 0.14±0.21 μmol/mol creatinine in warm season. Urinary 1-OHP levels in cold and moderate seasons were respectively 2.13 and 1.37 higher than the warm season. Urine 1-OHP levels for students living in ger areas were 1.27 higher than those living in non-ger areas. Students who lived in either gers or brick houses had respectively 1.58 and 1.34 higher 1-OHP levels compared with those living in apartments. 1-ppb increase in SO2 at student’s address was associated with 0.01 μmol/mol creatinine increase in urinary 1-OHP. 1-ppb increase in NO2 at student’s address was associated with 0.02 μmol/mol creatinine increase in urinary 1-OHP. Conclusion: Mongolian children’s urinary 1-OHP levels were significantly elevated during cold seasons, and for those living in ger areas or in ger or brick houses in Ulaanbaatar. Urinary 1-OHP levels were associated with air pollutants from fuel use in Ulaanbaatar. | en |
dc.description.provenance | Made available in DSpace on 2021-06-16T10:21:19Z (GMT). No. of bitstreams: 1 ntu-102-R00841009-1.pdf: 6555373 bytes, checksum: 0c9a7b3f628d39bdf5ed73d670a3b5d7 (MD5) Previous issue date: 2013 | en |
dc.description.tableofcontents | 摘要………………………………………………………………………………………I
Abstract ……………………………… …………………………………………………II 表目錄…… …………………………………………………………………………… VI 圖目錄………………………………………………………………………………… VII 第一章、 前言………………………………………………………………………… 1 1.1研究背景…………………………………………………………………1 1.2研究目的…………………………………………………………………5 第二章、 文獻探討 ……………………………………………………………………6 2.1取暖與煮食之空氣汙染研究 …………………………………………6 2.2多環芳香族碳氫化合物(Polycyclic Aromatic Hydrocarbons, PAHs) …8 2.3尿液中1-羥基芘(1-hydroxypyrene ,1-OHP) ………………………… 11 第三章、 材料與方法………………………………………………………………… 13 3.1研究設計 ………………………………………………………………13 3.2研究架構 ………………………………………………………………15 3.3尿液採樣收集 …………………………………………………………21 3.4學童問卷資料收集 ……………………………………………………23 3.5尿中1-OHP分析方法…………………………………………………24 3.5.1 1-OHP前處理之藥品與設備……………………………………26 3.5.2緩衝液製備 …………………………………………………… 27 3.5.3 1-OHP前處理方法………………………………………………27 3.5.4 1-OHP上機分析方法……………………………………………28 3.5.5 1-OHP分析之品質管制…………………………………………29 3.6統計分析方法 …………………………………………………………33 第四章、 研究結果……………………………………………………………………35 4.1 320位蒙古學童基本資料描述 ……………………………………… 35 4.2 320位學童重複測量尿液1-OHP濃度分季節比較 …………………37 4.3 320位學童重複測量尿液1-OHP濃度分析 …………………………39 4.4 320位學童尿液1-OHP與預測之SO2、NO2濃度皮爾森相關係數分 析……………………………………………………………………… 41 4.5 320位學童重複測量尿液1-OHP與預測之SO2、NO2濃度分析……43 4.6 162位蒙古學童基本資料描述 ……………………………………… 45 4.7 162位學童重複測量尿液1-OHP濃度分季節比較 …………………47 4.8 162位學童重複測量尿液1-OHP濃度分析 …………………………49 4.9 162位學童尿液1-OHP與預測之SO2、NO2濃度皮爾森相關係數分 析……………………………………………………………………… 51 4.10 162位學童重複測量尿液1-OHP與預測之SO2、NO2濃度分析…53 第五章、 討論………………………………………………………………………… 55 第六章、 結論與建議…………………………………………………………………61 參考文獻 … …………………………………………………………………………64 附錄… …………………………………………………………………………………67 附錄A─照片說明 ………………………………………………………………67 附錄B─問卷 ……………………………………………………………………88 附錄C─問卷(蒙古文版) … …………………………………………………… 94 | |
dc.language.iso | zh-TW | |
dc.title | 蒙古國烏蘭巴托學童尿中1-羥基芘濃度之研究 | zh_TW |
dc.title | Study on urinary1-hydroxypyrene levels of students in Ulaanbaatar, Mongolia | en |
dc.type | Thesis | |
dc.date.schoolyear | 101-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 黃嵩立,陳家揚,胡素婉 | |
dc.subject.keyword | 蒙古,烏蘭巴托,蒙古包,1-羥基芘,多環芳香烴, | zh_TW |
dc.subject.keyword | Mongolia,Ulaanbaatar,Ger,1-hydroxypyrene,Polycyclic aromatic hydrocarbons, | en |
dc.relation.page | 99 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2013-08-16 | |
dc.contributor.author-college | 公共衛生學院 | zh_TW |
dc.contributor.author-dept | 職業醫學與工業衛生研究所 | zh_TW |
顯示於系所單位: | 職業醫學與工業衛生研究所 |
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