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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 沈立言 | |
| dc.contributor.author | YING-YU CHOU | en |
| dc.contributor.author | 周映妤 | zh_TW |
| dc.date.accessioned | 2021-06-16T03:40:30Z | - |
| dc.date.available | 2020-03-16 | |
| dc.date.copyright | 2015-03-16 | |
| dc.date.issued | 2015 | |
| dc.date.submitted | 2015-02-13 | |
| dc.identifier.citation | 唐德才。中藥學英漢對照新編實用中醫文庫。2003。上海中醫藥大學出版社。
林世航。以蛋白質體學探討天麻水萃物抗憂鬱之功效。2012。國立台灣大學生物資源暨農學院食品科技研究所碩士論文。 柯慧貞。憂鬱症的心理因素。2002。學生輔導，80期，68-75 頁。 郝承偉。檸檬精油對於小鼠抗憂鬱之效果。2013。國立台灣大學生物資源暨農學院食品科技研究所博士論文。 洪怡婷。慢性溫和壓力發展及停止階段對大鼠的生理、行為與神經反應之時間效果。2012。天主教輔仁大學臨床心理學系碩士班碩士論文。 行政院衛生福利部。2011台灣十大死因統計資料。2011。 行政院衛生福利部。2012台灣十大死因統計資料。2012。 行政院衛生福利部。台灣版世界衛生組織生活品質問卷之發展與應用。2002。 行政院衛生福利部。台灣中藥典（第二版）。2013。 周美伶。香蜂草可能經由調節單胺類神經傳導物質而具有抗憂鬱之功效。 2013。國立台灣大學生物資源暨農學院食品科技研究所碩士論文。 陳珮茹。天麻水萃物的抗憂鬱效果。2008。國立台灣大學生物資源暨農 學院食品科技研究所博士論文。 成大附屬醫院。憂鬱症千人認知大調查。2001。 孫亞男。天麻保健功能研究進展。2009。中國老年學雜誌第29期。 Alesci, S., Martinez, P. E., Kelkar, S., Ilias, I., Ronsaville, D. S., Listwak, S. J., Ayala, A. R., Licinio, J., Gold, H. K., Kling, M. A., Chrousos, G. P., Gold, P. W. Major depression is associated with significant diurnal elevations in plasma interleukin-6 levels, a shift of its circadian rhythm, and loss of physiological complexity in its secretion: clinical implications. J Clin Endocrinol Metab 2005, 90, 2522-2530. Beattie, D. T., Armstrong, S. R., Vickery, R. G., Tsuruda, P. R., Campbell, C. B., Richardson, C., McCullough, J. L., Daniels, O., Kersey, K., Li, Y. P., Kim, K. H. The Pharmacology of TD-8954, a Potent and Selective 5-HT(4) Receptor Agonist with Gastrointestinal Prokinetic Properties. Front Pharmacol 2011, 2, 25. Bekris, S., Antoniou, K., Daskas, S., Papadopoulou-Daifoti, Z. Behavioural and neurochemical effects induced by chronic mild stress applied to two different rat strains. Behav Brain Res 2005, 161, 45-59. Brown, J. P., Couillard-Despres, S., Cooper-Kuhn, C. M., Winkler, J., Aigner, L., Kuhn, H. G. Transient expression of doublecortin during adult neurogenesis. J Comp Neurol 2003, 467, 1-10. Buzsaki, G. Large-scale recording of neuronal ensembles. Nat Neurosci 2004, 7, 446-451. Camp, N. J., Lowry, M. R., Richards, R. L., Plenk, A. M., Carter, C., Hensel, C. H., Abkevich, V., Skolnick, M. H., Shattuck, D., Rowe, K. G., Hughes, D. C., Cannon-Albright, L. A. Genome-wide linkage analyses of extended Utah pedigrees identifies loci that influence recurrent, early-onset major depression and anxiety disorders. Am J Med Genet B Neuropsychiatr Genet 2005, 135B, 85-93. Cao, Y., Zhang, X., Fang, Y., Ye, J. Determination of the active ingredients in Gastrodia rhizoma by capillary electrophoresis with electrochemical detection. Analyst 2001, 126, 1524-1528. Capuron, L., Raison, C. L., Musselman, D. L., Lawson, D. H., Nemeroff, C. B., Miller, A. H. Association of exaggerated HPA axis response to the initial injection of interferon-alpha with development of depression during interferon-alpha therapy. Am J Psychiatry 2003, 160, 1342-1345. Castren, E. Is mood chemistry? Nature Reviews: Neuroscience 2005, 6, 241-246. Castren, E., Voikar, V., Rantamaki, T. Role of neurotrophic factors in depression. Current Opinion in Pharmacology 2007, 7, 18-21. Cavanagh, J. T., Carson, A. J., Sharpe, M., Lawrie, S. M. Psychological autopsy studies of suicide: a systematic review. Psychol Med 2003, 33, 395-405. Cereghino, J. J., Dow, R. S. Effects of cobalt applied to the cerebellum on cobalt experimental epilepsy in the cat. Epilepsia 1970, 11, 413-421. Charles, J., Knox, S., Britt, H. Postnatal depression in Australian general practice. Aust Fam Physician 2006, 35, 668-669. Chen, P. J., Hsieh, C. L., Su, K. P., Hou, Y. C., Chiang, H. M., Sheen, L. Y. Rhizomes of Gastrodia elata Bl. possess antidepressant-like effect via monoamine modulation in subchronic animal model. Am J Chin Med 2009, 37, 1113-1124. Chen, P. J., Hsieh, C. L., Su, K. P., Hou, Y. C., Chiang, H. M., Lin, I. H., Sheen, L. Y. The antidepressant effect of Gastrodia elata Bl. on the forced-swimming test in rats. Am J Chin Med 2008, 36, 95-106. Choleris, E., Thomas, A. W., Kavaliers, M., Prato, F. S. A detailed ethological analysis of the mouse open field test: effects of diazepam, chlordiazepoxide and an extremely low frequency pulsed magnetic field. Neurosci Biobehav Rev 2001, 25, 235-260. Conwell, Y., Duberstein, P. R., Cox, C., Herrmann, J. H., Forbes, N. T., Caine, E. D. Relationships of age and axis I diagnoses in victims of completed suicide: a psychological autopsy study. Am J Psychiatry 1996, 153, 1001-1008. Cooke, R. G. Repetitive transcranial magnetic stimulation for depression. J Psychiatry Neurosci 2003, 28, 400. Coppen, A., Shaw, D. M., Herzberg, B., Maggs, R. Tryptophan in the treatment of depression. Lancet 1967, 2, 1178-1180. Couillard-Despres, S., Winkler, J., Uyanik, G., Aigner, L. Molecular mechanisms of neuronal migration disorders, quo vadis? Curr Mol Med 2001, 1, 677-688. Cryan, J. F., Holmes, A. The ascent of mouse: advances in modelling human depression and anxiety. Nat Rev Drug Discov 2005, 4, 775-790. Curzon, G., Gibson, E. L., Oluyomi, A. O. Appetite suppression by commonly used drugs depends on 5-HT receptors but not on 5-HT availability. Trends Pharmacol Sci 1997, 18, 21-25. Danzer, M., Samberger, C., Schicho, R., Lippe, I. T., Holzer, P. Immunocytochemical characterization of rat brainstem neurons with vagal afferent input from the stomach challenged by acid or ammonia. Eur J Neurosci 2004, 19, 85-92. de Andrade, J. S., Cespedes, I. C., Abrao, R. O., Dos Santos, T. B., Diniz, L., Britto, L. R., Spadari-Bratfisch, R. C., Ortolani, D., Melo-Thomas, L., da Silva, R. C., Viana, M. B. Chronic unpredictable mild stress alters an anxiety-related defensive response, Fos immunoreactivity and hippocampal adult neurogenesis. Behav Brain Res 2013, 250, 81-90. De Raedt, R., Schacht, R., Franck, E., De Houwer, J. Self-esteem and depression revisited: implicit positive self-esteem in depressed patients? Behav Res Ther 2006, 44, 1017-1028. des Portes, V., Francis, F., Pinard, J. M., Desguerre, I., Moutard, M. L., Snoeck, I., Meiners, L. C., Capron, F., Cusmai, R., Ricci, S., Motte, J., Echenne, B., Ponsot, G., Dulac, O., Chelly, J., Beldjord, C. doublecortin is the major gene causing X-linked subcortical laminar heterotopia (SCLH). Hum Mol Genet 1998, 7, 1063-1070. Detke, M. J., Lucki, I. Detection of serotonergic and noradrenergic antidepressants in the rat forced swimming test: the effects of water depth. Behav Brain Res 1996, 73, 43-46. Dickson, B. J., Gilestro, G. F. Regulation of commissural axon pathfinding by slit and its Robo receptors. Annu Rev Cell Dev Biol 2006, 22, 651-75. Dietrich, A. J., Oxman, T. E., Williams, J. W., Jr. Treatment of depression by mental health specialists and primary care physicians. JAMA 2003, 290, 1991; author reply 1992-1993. Dumais, A., Lesage, A. D., Alda, M., Rouleau, G., Dumont, M., Chawky, N., Roy, M., Mann, J. J., Benkelfat, C., Turecki, G. Risk factors for suicide completion in major depression: a case-control study of impulsive and aggressive behaviors in men. Am J Psychiatry 2005, 162, 2116-2124. Duman, C. H. Models of depression. Vitam Horm 2010, 82, 1-21. Duman, R. S., Monteggia, L. M. A neurotrophic model for stress-related mood disorders. Biol Psychiatry 2006, 59, 1116-1127. Dunn, D. W., Austin, J. K., Huster, G. A. Symptoms of depression in adolescents with epilepsy. J Am Acad Child Adolesc Psychiatry 1999, 38, 1132-1138. Dwivedi, Y. Brain-derived neurotrophic factor: role in depression and suicide. Neuropsychiatr Dis Treat 2009, 5, 433-449. Edgar, V. A., Cremaschi, G. A., Sterin-Borda, L., Genaro, A. M. Altered expression of autonomic neurotransmitter receptors and proliferative responses in lymphocytes from a chronic mild stress model of depression: effects of fluoxetine. Brain Behav Immun 2002, 16, 333-350. Elhwuegi, A. S. Central monoamines and their role in major depression. Prog Neuropsychopharmacol Biol Psychiatry 2004, 28, 435-451. Emanuele, E., Arra, M., Bertona, M. 7-Hydroxystaurosporine may have a therapeutic role in treatment-resistant depression by inhibition of calcium/calmodulin-dependent protein kinase II. Med Hypotheses 2007, 68, 236-237. Faivre-Sarrailh, C., Lena, J. Y., Had, L., Vignes, M., Lindberg, U. Location of profilin at presynaptic sites in the cerebellar cortex; implication for the regulation of the actin-polymerization state during axonal elongation and synaptogenesis. J Neurocytol 1993, 22, 1060-1072. Fanous, A. H., Neale, M. C., Aggen, S. H., Kendler, K. S. A longitudinal study of personality and major depression in a population-based sample of male twins. Psychological Medicine 2007, 37, 1163-1172. Forbes, N. F., Stewart, C. A., Matthews, K., Reid, I. C. Chronic mild stress and sucrose consumption: validity as a model of depression. Physiol Behav 1996, 60, 1481-1484. Freitas, A. E., Machado, D. G., Budni, J., Neis, V. B., Balen, G. O., Lopes, M. W., de Souza, L. F., Dafre, A. L., Leal, R. B., Rodrigues, A. L. Fluoxetine modulates hippocampal cell signaling pathways implicated in neuroplasticity in olfactory bulbectomized mice. Behav Brain Res 2013, 237, 176-184. Gao, X. F., Wang, X. Q., He, C., Lu, C. L. [Progress of monoaminergic receptor investigation on depression]. Sheng Li Ke Xue Jin Zhan 2002, 33, 17-20. Garza, J. C., Guo, M., Zhang, W., Lu, X. Y. Leptin restores adult hippocampal neurogenesis in a chronic unpredictable stress model of depression and reverses glucocorticoid-induced inhibition of GSK-3beta/beta-catenin signaling. Mol Psychiatry 2012, 17, 790-808. Gorman, J. M., Kent, J. M., Sullivan, G. M., Coplan, J. D. Neuroanatomical hypothesis of panic disorder, revised. Am J Psychiatry 2000, 157, 493-505. Gourley, P. L., Hendricks, J. K., McDonald, A. E., Copeland, R. G., Yaffe, M. P., Naviaux, R. K. Reactive biomolecular divergence in genetically altered yeast cells and isolated mitochondria as measured by biocavity laser spectroscopy: rapid diagnostic method for studying cellular responses to stress and disease. J Biomed Opt 2007, 12. Gratzner, H. G. Monoclonal antibody to 5-bromo and 5-iododeoxyuridine: A new reagent for detection of DNA replication. Science 1982, 218, 474-475. Ha, J. H., Lee, D. U., Lee, J. T., Kim, J. S., Yong, C. S., Kim, J. A., Ha, J. S., Huh, K. 4-Hydroxybenzaldehyde from Gastrodia elata B1. is active in the antioxidation and GABAergic neuromodulation of the rat brain. J Ethnopharmacol 2000, 73, 329-333. Henriksson, M. M., Aro, H. M., Marttunen, M. J., Heikkinen, M. E., Isometsa, E. T., Kuoppasalmi, K. I., Lonnqvist, J. K. Mental disorders and comorbidity in suicide. Am J Psychiatry 1993, 150, 935-940. Hohenester, E. Structural insight into Slit-Robo signalling. Biochem Soc Trans 2008, 36, 251-256. Homberg, J. R., Olivier, J. D., Blom, T., Arentsen, T., van Brunschot, C., Schipper, P., Korte-Bouws, G., van Luijtelaar, G., Reneman, L. Fluoxetine exerts age-dependent effects on behavior and amygdala neuroplasticity in the rat. PLoS One,2011, 6. Hsieh, C. L., Chang, C. H., Chiang, S. Y., Li, T. C., Tang, N. Y., Pon, C. Z., Hsieh, C. T., Lin, J. G. Anticonvulsive and free radical scavenging activities of vanillyl alcohol in ferric chloride-induced epileptic seizures in Sprague-Dawley rats. Life Sci 2000, 67, 1185-1195. Hu, H., Su, L., Xu, Y. Q., Zhang, H., Wang, L. W. Behavioral and [F-18] fluorodeoxyglucose micro positron emission tomography imaging study in a rat chronic mild stress model of depression. Neuroscience 2010, 169, 171-181. Hu, X. H., Bull, S. A., Hunkeler, E. M., Ming, E., Lee, J. Y., Fireman, B., Markson, L. E. Incidence and duration of side effects and those rated as bothersome with selective serotonin reuptake inhibitor treatment for depression: patient report versus physician estimate. J Clin Psychiatry 2004, 65, 959-965. Hua, J. Y., Smith, S. J. Neural activity and the dynamics of central nervous system development. Nat Neurosci 2004, 7, 327-332. Huminiecki, L., Gorn, M., Suchting, S., Poulsom, R., Bicknell, R. Magic roundabout is a new member of the roundabout receptor family that is endothelial specific and expressed at sites of active angiogenesis. Genomics 2002, 79, 547-52. Hwang, S. M., Lee, Y. J., Kang, D. G., Lee, H. S. Anti-inflammatory effect of Gastrodia elata rhizome in human umbilical vein endothelial cells. Am J Chin Med 2009, 37, 395-406. Jylha, P., Isometsa, E. Temperament, character and symptoms of anxiety and depression in the general population. Eur Psychiatry 2006, 21, 389-395. Kapur, S., Mann, J. J. Role of the dopaminergic system in depression. Biol Psychiatry 1992, 32, 1-17. Ketz, R. J., Roth, K. A., Carroll, B. J. Acute and chronic stress effects on open field activity in the rat: implications for a model of depression. Neurosci Biobehav Rev 1981, 5, 247-251. Katzenstein, A., Kriegel, E., Gaefke, I. Sociopsychophysiological stress and hypertension. Act Nerv Super (Praha) 1982, Suppl 3, 453-456. Kessler, R. Depression screening. J Fam Pract 2003, 52, 466; author reply 467. Kho, M. C., Lee, Y. J., Cha, J. D., Choi, K. M., Kang, D. G., Lee, H. S. Gastrodia elata Ameliorates High-Fructose Diet-Induced Lipid Metabolism and Endothelial Dysfunction. Evid Based Complement Alternat Med 2014, 2014. Kihara, M., Kubo, T. Cardiovascular effects of GABA system activating drugs injected into the caudal ventrolateral medulla of the rat. Arch Int Pharmacodyn Ther 1988, 295, 67-79. Kim, D. S., Kim, J. Y., Han, Y. S. Alzheimer's disease drug discovery from herbs: neuroprotectivity from beta-amyloid (1-42) insult. J Altern Complement Med 2007, 13, 333-340. Kim, I. S., Choi, D. K., Jung, H. J. Neuroprotective effects of vanillyl alcohol in Gastrodia elata Blume through suppression of oxidative stress and anti-apoptotic activity in toxin-induced dopaminergic MN9D cells. Molecules 2011, 16, 5349-5361. Kiuru, N., Burk, W. J., Laursen, B., Nurmi, J. E., Salmela-Aro, K. Is depression contagious? A test of alternative peer socialization mechanisms of depressive symptoms in adolescent peer networks. J Adolesc Health 2012, 50, 250-255. Klimek, V., Stockmeier, C., Overholser, J., Meltzer, H. Y., Kalka, S., Dilley, G., Ordway, G. A. Reduced levels of norepinephrine transporters in the locus coeruleus in major depression. J Neurosci 1997, 17, 8451-8458. Knol, M. J., Twisk, J. W., Beekman, A. T., Heine, R. J., Snoek, F. J., Pouwer, F. Depression as a risk factor for the onset of type 2 diabetes mellitus. A meta-analysis. Diabetologia 2006, 49, 837-845. Lee, B. H., Kim, Y. K. Reduced platelet BDNF level in patients with major depression. Prog Neuropsychopharmacol Biol Psychiatry 2009, 33, 849-853. Lee, O. H., Kim, K. I., Han, C. K., Kim, Y. C., Hong, H. D. Effects of acidic polysaccharides from gastrodia rhizome on systolic blood pressure and serum lipid concentrations in spontaneously hypertensive rats fed a high-fat diet. Int J Mol Sci 2012, 13, 698-709. Lee, Y. S., Ha, J. H., Yong, C. S., Lee, D. U., Huh, K., Kang, Y. S., Lee, S. H., Jung, M. W., Kim, J. A. Inhibitory effects of constituents of Gastrodia elata Bl. on glutamate-induced apoptosis in IMR-32 human neuroblastoma cells. Arch Pharm Res 1999, 22, 404-409. Lin, L., Rao, Y., Isacson, O. Netrin-1 and slit-2 regulate and direct neurite growth of ventral midbrain dopaminergic neurons. Mol Cell Neurosci 2005, 28, 547-555. Liu, J., Mori, A. Antioxidant and free radical scavenging activities of Gastrodia elata Bl. and Uncaria rhynchophylla (Miq.) Jacks. Neuropharmacology 1992, 31, 1287-1298. Liu, Q. R., Lu, L., Zhu, X. G., Gong, J. P., Shaham, Y., Uhl, G. R. Rodent BDNF genes, novel promoters, novel splice variants, and regulation by cocaine. Brain Res 2006, 1067, 1-12. Liu, X. J., Zhou, Y. Z., Li, Z. F., Cui, J., Li, Z. Y., Gao, X. X., Sun, H. F., Zhang, L. Z., Du, G. H., Qin, X. M. Anti-depressant effects of Xiaoyaosan on rat model of chronic unpredictable mild stress: a plasma metabonomics study based on NMR spectroscopy. J Pharm Pharmacol 2012, 64, 578-588. Liu, Y. L. The role of perceived social support and dysfunctional attitudes in predicting Taiwanese adolescents' depressive tendency. Adolescence 2002, 37, 823-834. Malison, R. T., Price, L. H., Berman, R., van Dyck, C. H., Pelton, G. H., Carpenter, L., Sanacora, G., Owens, M. J., Nemeroff, C. B., Rajeevan, N., Baldwin, R. M., Seibyl, J. P., Innis, R. B., Charney, D. S. Reduced brain serotonin transporter availability in major depression as measured by [123I]-2 beta-carbomethoxy-3 beta-(4-iodophenyl) tropane and single photon emission computed tomography. Biol Psychiatry 1998, 44, 1090-1098. McKinney, W. T., Jr., Bunney, W. E., Jr. Animal model of depression. I. Review of evidence: implications for research. Arch Gen Psychiatry 1969, 21, 240-248. Miller, M. N., Miller, B. E., Chinouth, R., Coyle, B. R., Brown, G. R. Increased premenstrual dosing of nefazodone relieves premenstrual magnification of depression. Depress Anxiety 2002, 15, 48-51. Miller, W. R., Seligman, M. E., Kurlander, H. M. Learned helplessness, depression, and anxiety. J Nerv Ment Dis 1975, 161, 347-357. Nacher, J., Crespo, C., McEwen, B. S. Doublecortin expression in the adult rat telencephalon. Eur J Neurosci, 2001, 14, 629-644. Nalepa, I., Manier, D. H., Gillespie, D. D., Rossby, S. P., Schmidt, D. E., Sulser, F. Lack of beta adrenoceptor desensitization in brain following the dual noradrenaline and serotonin reuptake inhibitor venlafaxine. Eur Neuropsychopharmacol 1998, 8, 227-232. Naranjo, C. A., Tremblay, L. K., Busto, U. E. The role of the brain reward system in depression. Prog Neuropsychopharmacol Biol Psychiatry 2001, 25, 781-823. Nomura, S., Okada, H., Naruse, R., Yamaoka, K. The tail suspension test for screening antidepressant drugs: comparison of movement in ICR and NMRI mice. Jpn J Psychiatry Neurol 1991, 45, 113-114. Nutt, D. J., Kessler, R. C., Alonso, J., Benbow, A., Lecrubier, Y., Lepine, J. P., Mechanic, D., Tylee, A. Consensus statement on the benefit to the community of ESEMeD (European Study of the Epidemiology of Mental Disorders) survey data on depression and anxiety. J Clin Psychiatry 2007, 68 Suppl 2, 42-48. Ojemann, L. M., Nelson, W. L., Shin, D. S., Rowe, A. O., Buchanan, R. A. Tian ma, an ancient Chinese herb, offers new options for the treatment of epilepsy and other conditions. Epilepsy Behav 2006, 8, 376-383. Owens, M. J., Nemeroff, C. B. Role of serotonin in the pathophysiology of depression: focus on the serotonin transporter. Clin Chem 1994, 40, 288-295. Papakostas, G. I. Dopaminergic-based pharmacotherapies for depression. Eur Neuropsychopharmacol 2006, 16, 391-402. Papp, M., Lappas, S., Muscat, R., Willner, P. Attenuation of place preference conditioning but not place aversion conditioning by chronic mild stress. J Psychopharmacol 1992, 6, 352-356. Parihar, V. K., Hattiangady, B., Kuruba, R., Shuai, B., Shetty, A. K. Predictable chronic mild stress improves mood, hippocampal neurogenesis and memory. Mol Psychiatry 2011, 16, 171-183. Park, S., Kim da, S., Kang, S. Gastrodia elata Blume water extracts improve insulin resistance by decreasing body fat in diet-induced obese rats: vanillin and 4-hydroxybenzaldehyde are the bioactive candidates. Eur J Nutr 2011, 50, 107-118. Parker, K. J., Schatzberg, A. F., Lyons, D. M. Neuroendocrine aspects of hypercortisolism in major depression. Horm Behav 2003, 43, 60-66. Patelis-Siotis, I., Young, L. T., Robb, J. C., Marriott, M., Bieling, P. J., Cox, L. C., Joffe, R. T. Group cognitive behavioral therapy for bipolar disorder: a feasibility and effectiveness study. J Affect Disord 2001, 65, 145-153. Pelloux, Y., Hagues, G., Costentin, J., Duterte-Boucher, D. Helplessness in the tail suspension test is associated with an increase in ethanol intake and its rewarding effect in female mice. Alcohol Clin Exp Res 2005, 29, 378-388. Pittenger, C., Duman, R. S. Stress, depression, and neuroplasticity: a convergence of mechanisms. Neuropsychopharmacology 2008, 33, 88-109. Porsolt, R. D., Le Pichon, M., Jalfre, M. Depression: a new animal model sensitive to antidepressant treatments. Nature 1977, 266, 730-732. Praschak-Rieder, N., Willeit, M., Zill, P., Winkler, D., Thierry, N., Konstantinidis, A., Masellis, M., Basile, V. S., Bondy, B., Ackenheil, M., Neumeister, A., Kaplan, A. S., Kennedy, J. L., Kasper, S., Levitan, R. A Cys 23-Ser 23 substitution in the 5-HT (2C) receptor gene influences body weight regulation in females with seasonal affective disorder: an Austrian-Canadian collaborative study. J Psychiatr Res 2005, 39, 561-567. Raison, C. L., Capuron, L., Miller, A. H. Cytokines sing the blues: inflammation and the pathogenesis of depression. Trends in Immunology 2006, 27, 24-31. Roberts, R. E., Vernon, S. W. Depression in the community: prevalence and treatment. Arch Gen Psychiatry 1982, 39, 1407-1409. Rothberg, J. M., Hartley, D. A., Walther, Z., Artavanis-Tsakonas, S. Slit: an EGF-homologous locus of D. melanogaster involved in the development of the embryonic central nervous system. Cell 1988, 55, 1047-59. Scheel, A. K., Hermann, K. G., Kahler, E., Pasewaldt, D., Fritz, J., Hamm, B., Brunner, E., Muller, G. A., Burmester, G. R., Backhaus, M. A novel ultrasonographic synovitis scoring system suitable for analyzing finger joint inflammation in rheumatoid arthritis. Arthritis & Rheumatism 2005, 52, 733-743. Schenkel, L. C., Segal, J., Becker, J. A., Manfro, G. G., Bianchin, M. M., Leistner-Segal, S. The BDNF Val66Met polymorphism is an independent risk factor for high lethality in suicide attempts of depressed patients. Prog Neuropsychopharmacol Biol Psychiatry 2010, 34, 940-944. Schlatter, J., Ortuno, F., Cervera-Enguix, S. Monocytic parameters in patients with dysthymia versus major depression. J Affect Disord 2004, 78, 243-247. Schmidt, H. D., Duman, R. S. The role of neurotrophic factors in adult hippocampal neurogenesis, antidepressant treatments and animal models of depressive-like behavior. Behav Pharmacol 2007, 18, 391-418. Scocco, P., Toffol, E. [Group interpersonal psychotherapy: a review]. Sante Ment Que, 2008 33, 105-131. Sherman, A. D., Sacquitne, J. L., Petty, F. Specificity of the learned helplessness model of depression. Pharmacol Biochem Behav 1982, 16, 449-454. Stefanini, M., Dalpra, L., Zei, G., Giorgi, R., Falaschi, A., Nuzzo, F. Incorporation of (3H)thymidine stimulated by ultraviolet radiation into human fibroblast cultures. Mutat Res 1976, 34, 313-326. Steru, L., Chermat, R., Thierry, B., Simon, P. The tail suspension test: a new method for screening antidepressants in mice. Psychopharmacology （Berl）, 1985, 85（3）, 367-370. Stewart, K. T., Gaddy, J. R., Benson, D. M., Byrne, B., Doghramji, K., Brainard, G. C. Treatment of winter depression with a portable, head-mounted phototherapy device. Prog Neuropsychopharmacol Biol Psychiatry 1990, 14, 569-578. Stockmeier, C. A., Mahajan, G. J., Konick, L. C., Overholser, J. C., Jurjus, G. J., Meltzer, H. Y., Uylings, H. B., Friedman, L., Rajkowska, G. Cellular changes in the postmortem hippocampus in major depression. Biol Psychiatry 2004, 56, 640-650. Storksen, I., Roysamb, E., Holmen, T. L., Tambs, K. Adolescent adjustment and well-being: effects of parental divorce and distress. Scand J Psychol 2006, 47, 75-84. Sullivan, P. F., Neale, M. C., Kendler, K. S. Genetic epidemiology of major depression: review and meta-analysis. Am J Psychiatry 2000, 157, 1552-1562. Thomas, A. J., Davis, S., Morris, C., Jackson, E., Harrison, R., O'Brien, J. T. Increase in interleukin-1beta in late-life depression. Am J Psychiatry 2005, 162, 175-177. Treiman, D. M. GABAergic mechanisms in epilepsy. Epilepsia, 2001, 42 Suppl 3, 8-12. Tsai, C. F., Huang, C. L., Lin, Y. L., Lee, Y. C., Yang, Y. C., Huang, N. K. The neuroprotective effects of an extract of Gastrodia elata. J Ethnopharmacol 2011, 138, 119-125. Tsigos, C., Chrousos, G. P. Hypothalamic-pituitary-adrenal axis, neuroendocrine factors and stress. J Psychosom Res 2002, 53, 865-871. van Riezen, H., Schnieden, H., Wren, A. F. Olfactory bulb ablation in the rat: behavioural changes and their reversal by antidepressant drugs. Br J Pharmacol 1977, 60, 521-528. Vinkers, C. H., Breuer, M. E., Westphal, K. G., Korte, S. M., Oosting, R. S., Olivier, B., Groenink, L. Olfactory bulbectomy induces rapid and stable changes in basal and stress-induced locomotor activity, heart rate and body temperature responses in the home cage. Neuroscience 2009, 159, 39-46. Wang, B., Feng, G., Tang, C., Wang, L., Cheng, H., Zhang, Y., Ma, J., Shi, M., Zhao, G. Ginsenoside Rd maintains adult neural stem cell proliferation during lead-impaired neurogenesis. Neurol Sci 2013, 34, 1181-1188. Wang, Q., Chen, G., Zeng, S. Distribution and metabolism of gastrodin in rat brain. J Pharm Biomed Anal 2008, 46, 399-404. Wang, X., Sun, X., Liu, X., Ma, W., Xie, W., Wang, C., Wang, D. [Determination of kinds of monoamine neurotransmitters in Alzheimer's blood plasma by high performance liquid chromatography]. Wei Sheng Yan Jiu 2012, 41, 963-965, 970. Weissman, M. M., Bland, R. C., Canino, G. J., Faravelli, C., Greenwald, S., Hwu, H. G., Joyce, P. R., Karam, E. G., Lee, C. K., Lellouch, J., Lepine, J. P., Newman, S. C., Rubio-Stipec, M., Wells, J. E., Wickramaratne, P. J., Wittchen, H., Yeh, E. K. Cross-national epidemiology of major depression and bipolar disorder. JAMA 1996, 276, 293-299. Whitford, K. L., Marillat, V., Stein, E., Goodman, C. S., Tessier-Lavigne, M., Chedotal, A., Ghosh, A. Regulation of cortical dendrite development by Slit-Robo interactions. Neuron 2002, 33, 47-61. Willner, P., Towell, A., Sampson, D., Sophokleous, S., Muscat, R. Reduction of sucrose preference by chronic unpredictable mild stress, and its restoration by a tricyclic antidepressant. Psychopharmacology (Berl) 1987, 93, 358-364. Xu, Y., Ku, B., Cui, L., Li, X., Barish, P. A., Foster, T. C., Ogle, W. O. Curcumin reverses impaired hippocampal neurogenesis and increases serotonin receptor 1A mRNA and brain-derived neurotrophic factor expression in chronically stressed rats. Brain Res 2007, 1162, 9-18. Zeng, X., Zhang, S., Zhang, L., Zhang, K., Zheng, X. A study of the neuroprotective effect of the phenolic glucoside gastrodin during cerebral ischemia in vivo and in vitro. Planta Med 2006, 72, 1359-1365. Zhang, R., Peng, Z., Wang, H., Xue, F., Chen, Y., Wang, Y., Wang, H., Tan, Q. Gastrodin ameliorates depressive-like behaviors and up-regulates the expression of BDNF in the hippocampus and hippocampal-derived astrocyte of rats. Neurochem Res 2014, 39, 172-179. Zhou, B. H., Li, X. J., Liu, M., Wu, Z., Ming Hu, X. Antidepressant-like activity of the Gastrodia elata ethanol extract in mice. Fitoterapia 2006, 77, 592-594. Zhu, M. Y., Klimek, V., Dilley, G. E., Haycock, J. W., Stockmeier, C., Overholser, J. C., Meltzer, H. Y., Ordway, G. A. Elevated levels of tyrosine hydroxylase in the locus coeruleus in major depression. Biol Psychiatry 1999, 46, 1275-1286. Zueger, M., Urani, A., Chourbaji, S., Zacher, C., Roche, M., Harkin, A., Gass, P. Olfactory bulbectomy in mice induces alterations in exploratory behavior. Neurosci Lett 2005, 374, 142-146. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/54877 | - |
| dc.description.abstract | 憂鬱症是一種盛行率高，會造成嚴重失能的精神疾病，世界衛生組織（World Health Organization, WHO）預估憂鬱症將在2030年時成為世界第一的高負擔疾病。此外，憂鬱症患者有比未患病者人高出30倍的自殺風險，WHO在2001年已將其與癌症、愛滋病並列而21世紀三大重要疾病。而台灣的憂鬱症患病率約為9%，並造成約350億台幣的經濟損失，可見憂鬱症的預防與治療是目前迫切需要關注的議題。現行抗憂鬱藥物伴隨許多副作用，進而造成病患順應性減低，加上目前尚未有很好的預防措施，因此替代性中草藥療法或食療預防性方法等，可能可以做為憂鬱症防治策略。本實驗室先前研究發現，天麻水萃物（WGE）在強迫游泳試驗中，可能透過調節神經傳導物質與提升神經可塑性，降低大鼠類憂鬱行為。因此，本研究以慢性壓力模式（CMS），模擬人類長期處於壓力下所造成的神經可塑性下降，使大鼠產生類憂鬱情況來評估WGE之抗憂鬱效果，並進一步以免疫組織染色與西方墨點染色法，探討神經可塑性的表現與相關路徑。行為試驗的結果顯示，慢性壓力組的糖水攝取在第四周較正常組顯著減少，推測此週已誘導類憂鬱行為，而中劑量與低劑量天麻水萃物組分別於第五週和第六週顯著較慢性壓力組增加，推測WGE已有抗憂鬱效果。開放空間試驗（open filed test）中，穿越與站立探索次數是在第四週壓力組顯著低於正常組，WGE中劑量與低劑量組分別於第五、第六週顯著高於與慢性壓力組。免疫組織染色結果顯示在海馬迴部位BrdU細胞存活的表現量中，正常組與天麻水萃物中劑量組均顯著高於慢性壓力組，但在神經細胞增生部分，正常組顯著高於慢性壓力，但天麻水萃物中劑量組與慢性壓力組並沒有顯著差異。另外一個神經可塑性相關蛋白doublecortin（DCX），正常組與中劑量組均顯著多於慢性壓力組，顯示慢性壓力確實可能使神經可塑性下降，給予天麻水萃物中劑量組能夠回復或增加神經可塑性來達到抗憂鬱之效果。由西方墨點驗證海馬迴Slit-1，慢性壓力組顯著高於天麻中劑量組與正常組、額葉皮質則是慢性壓力組顯著高於天麻中劑量組，Slit-2各部位皆沒差異。綜合以上，天麻水萃物可能透過回復神經可塑性來達到抗憂鬱功效，機制可能與抑制Slit-Robo路徑的Slit-1有關。 | zh_TW |
| dc.description.abstract | According to the World Health Organization（WHO） statistics in 2002, major depressive disorder was defined as one of the three major diseases in 21th century and over 87% suicide victims has mood disorder. In Taiwan, there is over 8.9% population has the depression. Therefore, it is necessary for investigative the pathophysiology of depression and the antidepressant therapeutics. However, depression pathology is multifactorial, which includes monoamine dysregulation, HPA（Hypothalamic–pituitary–adrenal）dysfunction, chronic inflammation and neuroplasticity reduction. The antidepressant used in clinics now brings a lot of side effects. Thus, looking for the alternative therapy and prevention strategy for depression are very important issues. One of animal models used to study depression is the chronic mild stress model .It is a well-known animal model which has high-validity, mimics the real human stressed environment. Recently, Gastrodia elata Blume has shown anxiolytic, mood and memory enhancing effects. In previous study, the water extract of Gastrodia elata Blume (WGE) has antidepressant-like effects in the forced swimming model. Therefore, the aim of this project is to investigate the antidepressant effects of Gastrodia elata Blume in the chronic mild stress model. The results of behavior showed that CMS group markedly decreased in sucrose intake in week 4 comparing to normal group. The group of WGE medium dose and low dose had significantly different with CMS group separately in week 5 and week 6. In the open field test, CMS showed significantly lower than normal and WGE treatment group in crossing in week 4 and week 5. In the rearing part, CMS also had significantly different with normal in week 4 to week 6, even with fluoxetine and L-WGE in week 6. The result of IHC (immunohistochemistry)showed that CMS group was lower number of cell survival and proliferation than normal group. M-WGE showed significantly higher than CMS group in cell survival. In the WGE related antidepressive pathway: Slit-robo, Slit-1 showed that chronic mild stress truly had higher level than normal and WGE treatment in hippocampus. In conclusion, WGE may had antidepressive effect though reverse neuroplasticity in chronic mild stress model. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-16T03:40:30Z (GMT). No. of bitstreams: 1 ntu-104-R01641031-1.pdf: 19172064 bytes, checksum: 0c0f3aff7f3f355aad7fc3b0edf7befd (MD5) Previous issue date: 2015 | en |
| dc.description.tableofcontents | 中文摘要 I
英文摘要 II 目錄 III 圖次 V 表次 VII 縮寫表 VIII 第一章 前言 1 第二章 文獻回顧 2 第一節、憂鬱症 2 一、憂鬱症簡介 2 二、診斷 3 三、流行病學研究 4 四、憂鬱症病理成因 6 五、治療 18 第二節、憂鬱症研究模式 20 一、憂鬱症與動物模式 20 二、慢性壓力動物模式 22 第三節、天麻 23 一、簡介 23 二、生理活性 24 第三章 研究目的與假說 27 第四章 實驗架構 28 第五章 材料與方法 30 第一節、實驗材料 30 一、天麻水萃物 30 二、實驗動物 30 三、實驗藥品 30 第二節、實驗方法 32 一、天麻水萃物抗憂鬱功效之動物行為實驗 32 二、天麻水萃物抗憂鬱功效之蛋白質分析實驗 36 三、統計分析 39 第六章 實驗結果 40 第一節、動物試驗 40 一、糖水試驗 40 二、體重與攝食攝水量變化 41 三、開放空間試驗 42 第二節、免疫組織染色 43 一、BrdU（Bromodeoxyuridine）─細胞存活 43 二、BrdU（Bromodeoxyuridine）─細胞增生 43 三、DCX（doublecortin）─神經細胞發展 43 第三節、西方墨點染色法 44 第七章 討論 70 第一節、動物飼養與類憂鬱行為誘發結果之探討 70 一、慢性壓力模式與糖水攝取 70 二、攝食攝水量與體重變化 71 三、開放空間試驗 72 第二節、慢性壓力、天麻與神經可塑性 73 一、慢性壓力與神經可塑性 73 二、天麻水萃物抗憂鬱與神經可塑性 75 第八章 結論與未來研究方向 79 參考文獻 80 | |
| dc.language.iso | zh-TW | |
| dc.subject | 神經可塑性 | zh_TW |
| dc.subject | 慢性壓力模式 | zh_TW |
| dc.subject | 憂鬱症 | zh_TW |
| dc.subject | 天麻水萃物 | zh_TW |
| dc.subject | depression | en |
| dc.subject | neuroplasticity | en |
| dc.subject | chronic mild stress (CMS) | en |
| dc.subject | water extract of Gastrodia elata Blume (WGE) | en |
| dc.title | 探討天麻水萃物對於慢性誘導類憂鬱大鼠透過促進神經分化生長而具有抗憂鬱效果 | zh_TW |
| dc.title | Water Extract of Gastrodia elata Bl. May Have Antidepressant Effect via Enhancing Neuroplasticity in Chronic Mild Stress Model | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 103-1 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 何其儻,藍祚鴻,賴文崧,陳志成 | |
| dc.subject.keyword | 憂鬱症,慢性壓力模式,神經可塑性,天麻水萃物, | zh_TW |
| dc.subject.keyword | depression,water extract of Gastrodia elata Blume (WGE),chronic mild stress (CMS),neuroplasticity, | en |
| dc.relation.page | 93 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2015-02-13 | |
| dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
| dc.contributor.author-dept | 食品科技研究所 | zh_TW |
| 顯示於系所單位： | 食品科技研究所 | |
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