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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 江文章(Wenchang Chiang) | |
| dc.contributor.author | Ching-Wen Chang | en |
| dc.contributor.author | 張瀞文 | zh_TW |
| dc.date.accessioned | 2021-06-15T16:14:30Z | - |
| dc.date.available | 2025-07-28 | |
| dc.date.copyright | 2015-08-19 | |
| dc.date.issued | 2015 | |
| dc.date.submitted | 2015-08-18 | |
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/52427 | - |
| dc.description.abstract | 糖尿病是一種因體內胰島素缺乏或功能不全而導致體內長期處於高血糖的慢性代謝疾病。臨床上雖已有許多口服降血糖藥物，但有其使用限制且伴隨副作用的疑慮，因此從傳統食材尋找更多延緩糖尿病之標的是目前的研究趨勢。薏仁(Coix lacryma-jobi L.var. ma-yuen Stapf.)，自古即被認為是藥食兼用的材料，具有抗發炎、降血脂、降血糖等生理功能，是藥性溫和的保健食材。薏仁麩皮(adlay bran, AB)占糙薏仁的7%，是加工過程重要的副產物，AB富含蛋白質、脂質、膳食纖維及生物活性物質，如酚類化合物和植物固醇，本研究目的是以體內與體外研究方法探討薏仁油(Oil)及脫脂薏仁麩皮水萃物(DABW)抗糖尿病的效用及其調節血糖的機制。本研究第一部分體內試驗-預防模式，探討不同薏仁麩皮萃取物是否能預防糖尿病之病徵。實驗結果顯示，高劑量薏仁油(Oil-H)能透過影響肝臟葡萄糖代謝，有效降低高血糖的情況。第二部分則以體內試驗-治療模式，探討高劑量薏仁油 (Oil-H)及脫脂薏仁麩皮水萃物(DABW-H)抗糖尿病之效用。結果顯示，DABW能有效降低發炎相關因子，進而達到調節血糖之功效。我們同時利用肌肉細胞(L6)胰島素阻抗模式進一步探討薏仁麩皮水萃物是否能刺激肌肉細胞之葡萄糖攝取，結果發現在胰島素阻抗模式下，脫脂薏仁麩皮水萃物與胰島素共同處理，有促進肌肉細胞葡萄糖攝取之趨勢，推測其可能提高胰島素敏感性而達此效果。綜上所述，在不同時間點介入薏仁麩皮萃取物，對於調降血糖之潛力與機制有不同程度之正面影響。本篇研究期望能透過提升薏仁麩皮的機能性及應用性，達到廢棄物再利用之目的。 | zh_TW |
| dc.description.abstract | Diabetes is a chronic metabolic disease caused by long-term hyperglycemia as a result of insulin insufficiency or dysfunction. Many oral hypoglycemic drugs are available currently, but not without limitations and side effects. Thus, finding potential therapeutics for diabetes from traditional foods has become the main trend. Adlay (Coix lachryma-jobi L.var. ma-yuen Stapf.) has been used as both food and medicine, and has proven to exhibit anti-inflammatory, hypolipidemic, and hypoglycemic effects. A significant by-product during adlay processing, adlay bran (AB) constitutes 7% of dehulled adlay and is rich in proteins, lipids, dietary fiber, and bioactive compounds such as phenolics and phytosterols. The present study involves in vivo and in vitro investigations of ameliorating effects on diabetes of adlay bran oil (Oil) and defatted adlay bran water extract (DABW) and the underlying mechanisms. The first part of this thesis investigates the in vivo preventive effects of adlay bran extracts on diabetes. The results show that high-dose Oil can lower high blood glucose by affecting hepatic glucose metabolism. The second part investigates the in vivo attenuating effects of the defatted adlay bran extracts on diabetes. The results indicate DABW can regulate blood glucose by reducing inflammatory factors. Furthermore, in an insulin-resistant L6 myoblast cell model, DABW is found to potently increase muscle glucose uptake, possibly increasing insulin sensitivity. In summary, different time-course dietary interventions of adlay bran extracts result in differing effects on diabetic symptoms through varying mechanisms. This study hopes to explore more functions and applications of adlay bran to achieve by-product recycling. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T16:14:30Z (GMT). No. of bitstreams: 1 ntu-104-R02641011-1.pdf: 1738874 bytes, checksum: e3bd98672f12edc87f26c6d535197f8f (MD5) Previous issue date: 2015 | en |
| dc.description.tableofcontents | 摘要 I
謝誌 III 圖目錄 IX 表目錄 XI 縮寫對照表 XII 第一章 前言 1 第二章 文獻回顧 2 一、糖尿病簡介 2 1. 糖尿病定義、診斷標準及其分類 2 2. 第二型糖尿病病理機轉 4 二、胰島素與血糖恆定 6 1. 胰島素與醣類代謝 6 2. 肝臟中葡萄糖代謝途徑 7 3. 糖解作用與糖質新生 7 4. 周邊組織與血糖調控 8 5. 胰島素訊息傳遞 9 6. 葡萄糖轉運蛋白 10 7. AMP-activated protein kinase (AMPK) 11 三、第二型糖尿病動物誘導模式 12 1. 單純藥物誘導模式 12 2. 合併藥物及高脂飲食誘導模式 13 四、細胞模式探討胰島素阻抗 13 1. 肌肉組織胰島素抗性 13 五、膳食中膳食纖維、油脂對於糖尿病的影響 14 1. 膳食纖維 14 2. 油脂 14 六、薏苡 15 1. 薏苡簡介 15 2. 薏苡改善血糖之研究 17 第三章 研究動機與實驗架構 20 一、研究動機 20 二、實驗架構 21 1. 體內試驗-預防模式 21 2. 體內試驗-治療模式 22 3. 體外試驗-肌肉細胞模式 23 第四章 材料與方法 24 一、薏仁麩皮萃取物製備 24 1. 萃取方法和步驟 24 (1) 薏仁油(Oil)的製備 24 (2) 脫脂薏仁麩皮水萃物(DABW)的製備 24 二、實驗動物 25 1. 體內試驗-預防模式： 25 2. 體內試驗-治療模式： 27 3. 樣品分析 28 (1) 血液分析 28 (2) 即時定量聚合酶連鎖反應 29 三、體外試驗-肌肉細胞胰島素阻抗模式 30 1. 細胞株 30 2. 細胞培養與分化 30 3. 胰島素阻抗誘發與葡萄糖攝取試驗 31 四、統計分析 32 第五章 結果 33 一、薏仁油製備 33 二、體內試驗-預防模式 33 1. 實驗期間大白鼠體重、攝食量及組織臟器重量變化 33 2. 大白鼠血液相關生化值之影響 33 3. 不同實驗飼料對糖尿病大鼠肝臟組織mRNA基因表現量 34 三、體內試驗-治療模式 43 1. 實驗期間大白鼠體重、攝食量及組織臟器重量變化 43 2. 大白鼠血液相關生化值之影響 43 (3) 脂質濃度變化 44 (4) 腫瘤壞死因子α濃度含量 44 3. 不同實驗飼料對糖尿病大鼠肝臟mRNA基因表現量 44 四、體外試驗-肌肉細胞模式 57 1. 細胞胰島素阻抗模式建立 57 2. 胰島素阻抗模式下脫脂薏仁麩皮水萃物(DABW)對已分化L6細胞葡萄糖攝取之影響 57 第六章 綜合討論 60 一、薏仁油製備 60 二、體內試驗-預防模式 60 1. 薏仁油對動物生長、攝食量以及組織臟器之影響 60 2. 薏仁油對動物醣類代謝之影響 60 3. 薏仁油對動物脂質代謝之影響 61 4. 薏仁油對肝臟mRNA基因表現量 62 二、體內試驗-治療模式 63 1. 薏仁麩皮萃取物對動物生長、攝食量以及組織臟器之影響 63 2. 薏仁麩皮萃取物對動物醣類代謝之影響 63 3. 薏仁麩皮萃取物對動物脂質代謝之影響 64 4. 薏仁麩皮萃取物對TNF-α濃度之變化 64 5. 薏仁麩皮萃取物對肝臟mRNA基因表現量 65 三、體外試驗-薏仁麩皮水萃物對肌肉細胞葡萄糖攝取之影響 65 1. 細胞胰島素阻抗模式 65 2. 胰島素阻抗模式下脫脂薏仁麩皮水萃物對已分化L6細胞葡萄糖攝取之影響 65 第七章 結論 66 一、體內試驗-預防模式 66 二、體內試驗-延緩模式 66 三、體外試驗-細胞胰島素阻抗模式 66 第八章 參考資料 67 | |
| dc.language.iso | zh-TW | |
| dc.title | 以體外及體內模式探討薏仁麩皮萃取物減緩第二型糖尿病的效用及其作用機制 | zh_TW |
| dc.title | In vitro and in vivo evaluation of the possible echanisms of adlay bran extract in preventing and attenuating type 2 diabetes | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 103-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.coadvisor | 謝淑貞 | |
| dc.contributor.oralexamcommittee | 龔瑞林,江孟燦,李信昌,陳宏彰 | |
| dc.subject.keyword | 糖尿病,薏仁麩皮,薏仁油,血糖,肌肉細胞, | zh_TW |
| dc.subject.keyword | diabetes,adlay bran,oil,blood glucose,myoblast cell, | en |
| dc.relation.page | 77 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2015-08-18 | |
| dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
| dc.contributor.author-dept | 食品科技研究所 | zh_TW |
| 顯示於系所單位： | 食品科技研究所 | |
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