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| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 江文章(Wenchang Chiang) | |
| dc.contributor.author | Kun-Hsuan Wu | en |
| dc.contributor.author | 吳冠萱 | zh_TW |
| dc.date.accessioned | 2021-06-15T14:08:30Z | - |
| dc.date.available | 2020-08-25 | |
| dc.date.copyright | 2015-08-25 | |
| dc.date.issued | 2015 | |
| dc.date.submitted | 2015-08-19 | |
| dc.identifier.citation | 吳雅婷。2011。薏苡殼萃取物在體外及體內試驗對於雄烯二酮分泌的影響。國立臺灣大學食品科技研究所碩士論文。臺北。
夏詩閔。2001。薏苡籽實萃取物對大鼠卵巢性類固醇激素、腦下腺黃體促素 和濾泡刺激素分泌之效應。國立臺灣大學食品科技研究所碩士論文。臺北。 夏詩閔。2006。薏苡麩皮及薏苡殼甲醇萃取物對大鼠卵巢顆粒細胞分泌孕酮之效 應。國立臺灣大學食品科技研究所博士論文。臺北。 陳彥霖。2005。黑木耳方在多囊性卵巢症候群的臨床應用評估。南台科技大學生 物科技研究所。台南。 蔡志忠。2002。生物體內梅納反應的化學與其抑制。國立中正大學化學研究所碩士論文。台北 姜佩均。2010。糖化蛋白對內皮前驅細胞功能異常之影響及丹參在治療上可能扮演之角色。國立陽明大學傳統醫藥研究所碩士論文。 Alison-Goldin, B.A., Joshua, A., Beckman, M.D, Ann Marie Schmidt, M.D., Mark, A., Creager, M.D. Advanced glycation end products (sparking the development of diabetic vascular injury). Circulation. 2006, 114, 597-605 Allmen, E. U., Koch, M., Fritz, G., Legler, D. F., V domain of RAGE interacts with AGEs on prostate carcinoma cells. Prostate. 2008, 68, 748-58. Amer, SA. K., Banu, Z., Li, T. C., Cooke, I. D. Long-term follow-up of patients with polycystic ovary syndrome after laparoscopic ovarian drilling: endocrine and ultrasonographic outcomes. Hum. Reprod. 2002, 11, 2851-2857. Azziz, R., Carmina, E., Dewailly, D., Diamanti-Kandarakis, E., Escobar-Morreale, H. F., Futterweit, W., Janssen, O. E., Legro, R. S., Norman, R. J., Taylor, A. E., Witchel, S. F. Positions statement:criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an androgen excess society guideline. J. Clin. Endocrinol. Metab. 2006, 91,4237-4245. Balen, A., Michelmore, K. What is polycystic ovary syndrome? Are national views important? Hum. Reprod. 2002, 17, 2219-2227. Balen, A.H., Laven, J.S., Tan, S.L., Dewailly, D. Ultrasound assessment of the polycystic ovary: international consensus definitions. Hum. Reprod. Update. 2003, 9, 505-514. Barbieri, R. L., Hyperandrogenism, insulin resistance and acanthosis nigricans. 10 years of progress. J. Reprod. Med. 1994, 39, 327-36. Beers, W. H., Strickland, S., Reich, E., Ovarian plasminogen activator: relationship to ovulation and hormonal regulation. Cell. 1975, 6, 387-94. Bierhaus, A., Stern, D. M., Nawroth, P. P., RAGE in inflammation: a new therapeutic target? Curr Opin Investig Drugs. 2006, 7, 985-91. Brownlee, M. Biochemistry and molecular cell biology of diabetic complications. Nature. 2001, 414, 813-820. Cai, W., Ramdas, M., Zhu, L., Chen, X., Striker, G. E., Vlassara, H., Oral advanced glycation endproducts (AGEs) promote insulin resistance and diabetes by depleting the antioxidant defenses AGE receptor-1 and sirtuin 1. Proc. Natl. Acad. Sci. U. S. A. 2012, 109, 15888-15893. Cecconi, S., Rossi, G., De Felici, M., and Colonna, R. Mammalian oocyte growth in vitro is stimulated by soluble factor(s) produced by preantral granulosa cells and by Sertoli cells. Mol Reprod Dev.1996, 44, 540-546. Chan, C. C., Koo, M. W., Ng, E. H., Tang, O. S., Yeung, W. S., Ho, P. C. Effect of Chinese green tea on weight, ang hormonal and biochemical profiles in obese patients with polycystic ovary syndrome—a randomized placebo-controlled trial. Soc. Gynecol. Investig. 2006, 13, 63-68. Chellan, P., Nagaraj, R. H. Protein crosslinking by the Maillard reaction: dicarbonyl-derived imidazolium crosslinks in aging and diabetes. Arch. Biochem. Biophys. 1999, 368, 98-104 Chen, M. J., Chiu, H. M., Chen, C. L., Yang, W. S., Yang, Y. S., Ho, H. N., Hyperandrogenemia is independently associated with elevated alanine aminotransferase activity in young women with polycystic ovary syndrome. J. Clin. Endocrinol. Metab. 2010, 95, 3332-41 Clark, E., Orio, F., Palomba, S., Cascella, T., Longo, R. A., Colao, A. M. Evidence for altered adipocyte function in polycystic ovary syndrome. Eur. J. Endocrinol. 2005, 152, 389-394. Dewailly, D., Hieronimus, S., Mirakian, P., Hugues, J. N., Polycystic ovary syndrome (PCOS). Ann Endocrinol. (Paris). 2010, 71, 8-13. Diamanti-Kandarakis, E., Dunaif, A., Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications. Endocr. Rev. 2012, 33, 981-1030. Diamanti-Kandarakis, E., Katsikis, I., Piperi, C., Alexandraki, K., Panidis, D. Effect of long-term orlistat treatment on serum levels of advanced glycation end-products in women with polycystic ovary syndrome. Clin Endocrinol (Oxf). 2007, 66, 103 – 109. Diamanti-Kandarakis, E., Katsikis, I., Piperi, C., Kandaraki, E., Piouka, A., Papavassiliou, AG., Panidis, D. Increased serum advanced glycation endproducts is a distinct finding in lean women with polycystic ovary syndrome (PCOS). Clin Endocrinol (Oxf). 2008, 634–641. Diamanti-Kandarakis, E., Katsikis, I., Piperi, C., Kandaraki, E., Piouka, A., Papavassiliou, A. G., Panidis, D., Increased serum advanced glycation end-products is a distinct finding in lean women with polycystic ovary syndrome (PCOS). Clin Endocrinol (Oxf). 2008, 69, 634-641. Diamanti-Kandarakis, E., Kouli, C. R., Bergiele, A. T., Filandra, F. A., Tsianateli, T. C., Spina, G. G., Zapanti, E. D., Bartzis, M. I., A survey of the polycystic ovary syndrome in the Greek island of Lesbos: hormonal and metabolic profile. J. Clin. Endocrinol. Metab. 1999, 84, 4006-4011. Diamanti-Kandarakis, E., Economou, F., Palimeri, S., Christakou, C. Metformin in polycystic ovary syndrome. Ann. N. Y. Acad. Sci. 2010a, 1205, 192-198. Diamanti-Kandarakis, E., Christakou, C. D., Kandaraki, E., Economou, F. N. Metformin: an old medication of new fashion: evolving new molecular mechanisms and clinical implications in polycystic ovary syndrome. Eur. J. Endocrinol. 2010b, 162, 193-212. Doshi, S. B., Agarwal, A., The role of oxidative stress in menopause. J. Midlife Health. 2013, 4, 140-146. Dunaif, A., Insulin resistance and the polycystic ovary syndrome: mechanism and implications for pathogenesis. Endocr. Rev. 1997, 18, 774-800. Ehrmann, D. A. Polycystic ovary syndrome. N. Engl. J. Med. 2005, 352, 1223-1236. Elia, E., Vighi, S., Lombardi, E., Motta, A. B. Detrimental effects of hyperandrogenism on uterine function. Int. Immunopharmacol. 2009, 8, 1827-1834. Franko, B., Brault, J., Jouve, T., Beaumel, S., Benhamou, P. Y., Zaoui, P., Stasia, M. J., Differential impact of glucose levels and advanced glycation end-products on tubular cell viability and pro-inflammatory/profibrotic functions. Biochem. Biophys. Res. Commun. 2014, 451, 627-31. Franks, S., White, D.M. Prevalence of and etiological factors in polycystic ovarian syndrome. Ann N Y Acad. Sci. 1993, 28, 112-114. Fujii, E.Y., Nakayama, M., Nakagawa, A. Concentrations of receptor for advanced glycation end products, VEGF and CML in plasma, follicular fluid, and peritoneal fluid in women with and without endometriosis. Reprod. Sci. 2008, 15, 1066-1074. George, J. W., Dille, E. A., Heckert, L. L. Current Concepts of Follicle-Stimulating Hormone Receptor Gene Regulation .Biol. Reprod. 2011, 84, 7-17. Goh, S. Y., Cooper, M. E., Clinical review: The role of advanced glycation end products in progression and complications of diabetes. J. Clin. Endocrinol. Metab. 2008, 93, 1143-1152. Goh, S. Y., Cooper, M. E. Clinical review: The role of advanced glycation end products in progression and complications of diabetes. J Clin Endocrinol Metab 2008, 93, 1143-52. Goodwin, M., Herath, C., Jia, Z., Leung, C., Coughlan, M. T., Forbes, J., Angus, P. Advanced glycation end products augment experimental hepatic fibrosis. J. Gastroenterol. Hepatol. 2013, 28, 369-76. Grossin, N., Auger, F., Niquet-Leridon, C., Durieux, N., Montaigne, D., Schmidt, A. M., Susen, S., Jacolot, P., Beuscart, J. B., Tessier, F. J., Boulanger, E. Dietary CML-enriched protein induces functional arterial aging in a RAGE-dependent manner in mice. Mol. Nutr. Food Res. 2015, 59, 927-938. Hahn, S., Haselhorst, U., Tan, S., Quadbeck, B., Schmidt, M., Roesler, S., Kimmig, R., Mann, K., Janssen, O. E. Low serum 25- hydroxyvitamin D concentration are associated with insulin resistance and obesity in women with polycystic ovary syndrome. Exp. Clin. Endocrinol. Diabetes. 2006, 114, 577-583. Hannon, P. R., Flaws, J. A. The effects of phthalates on the ovary. Front Endocrinol. (Lausanne) 2015, 6, 8. Hao, L., Noguchi, S., Kamada, Y., Sasaki, A., Matsuda, M., Shimizu, K., Hiramatsu, Y., Nakatsuka, M. Adverse effects of advanced glycation end products on embryonal development. Acta. Med. Okayama. 2008, 62, 93-99. Hart, R., Doherty, DA. The potential implications of a PCOS diagnosis on a woman's long-term health using data linkage. J. Clin. Endocrinol. Metab. 2015, 100, 911-919. Hawley, S. A., Selbert, M. A., Goldstein, E. G., Edelman, A. M., Carling, D., Hardie, D. G. 5'-AMP activates the AMP-activated protein kinase cascade, and Ca2+/calmodulin activates the calmodulin-dependent protein kinase I cascade, via three independent mechanisms. J. Biol. Chem. 1995, 270, 27186-27191. He, C., Sabol, J., Mitsuhashi, T., Vlassara, H., Dietary glycotoxins: inhibition of reactive products by aminoguanidine facilitates renal clearance and reduces tissue sequestration. Diabetes. 1999, 48, 1308-1315. Henmi, H., Endo, T., Nagasawa, K., Hayashi, T., Chida, M., Akutagawa, N., Iwasaki, M., Kitajima, Y., Kiya, T., Nishikawa, A., Manase, K., Kudo, R., Lysyl oxidase and MMP-2 expression in dehydroepiandrosterone-induced polycystic ovary in rats. Biol. Reprod .2001, 64, 157-62. Henmi, H., Endo, T., Nagasawa, K., Hayashi, T., Chida, M., Akutagawa, N., Iwasaki, M., Kitajima, Y., Kiya, T., Nishikawa, A., Manase, K., Kudo, R., Lysyl oxidase and MMP-2 expression in dehydroepiandrosterone-induced polycystic ovary in rats. Biol. Reprod. 2001, 64, 157-162. Hsia, S. M., Yeh, C. L., Kuo, Y. H., Wang, P. S., Chiang, W. Effects of adlay (Coix lachryma-jobi L. var. ma-yuen Stapf.) hull extracts on the secretion of progesterone and estradiol in vivo and in vitro. Exp. Biol. Med. (Maywood) 2007, 232, 1181-94. Illien-Junger, S., Lu, Y., Qureshi, S. A., Hecht, A. C., Cai, W., Vlassara, H., Striker, G. E., Iatridis, J. C., Chronic ingestion of advanced glycation end products induces degenerative spinal changes and hypertrophy in aging pre-diabetic mice. PLoS One. 2015, 10, e0116625. Jahn, M. P., Gomes, L. F., Jacob, M. H., da Rocha Janner, D., Araujo, A. S., Bello-Klein, A., Ribeiro, M. F., Kucharski, L. C. The effect of dehydroepiandrosterone (DHEA) on renal function and metabolism in diabetic rats. Steroids. 2011, 76, 564-570. Jedel, E., Labrie, F., Oden, A., Holm, G., Nilsson, L., Janson, P., Lind, A. K., Ohlsson, C., Stener-Victorin, E. Impact of electroacupuncture and physical exercise on hyperandrogenism and oligo/ amenorrhoea in women with polycystic ovary syndrome: a randomized controlled trial. Am. J. Physiol. Endocrinol. Metab. 2010, 300, 37-45. Jinno, M., Takeuchi, M., Watanabe, A., Teruya, K., Hirohama, J., Eguchi, N., Miyazaki, A., Advanced glycation end-products accumulation compromises embryonic development and achievement of pregnancy by assisted reproductive technology. Hum. Reprod. 2011, 26, 604-610. Kalgaonkar, S., Almario, R. U., Gurusinghe, D., Garamendi, E. M., Buchan, W., Kim K., Karakas, S. E. Differential effects of walnuts v.s almonds on improving metabolic and endocrine parameters in PCOS. Eur. J. Clin. Nutr. 2011, 65, 386-393. Kaur, S., Archer, K. J., Devi, M. G., Kriplani, A., Strauss, J. F., 3rd, Singh, R., Differential gene expression in granulosa cells from polycystic ovary syndrome patients with and without insulin resistance: identification of susceptibility gene sets through network analysis. J Clin Endocrinol Metab. 2012, 97, E2016-21. Kelley, C. E., Brown, A. J., Diehl, A. M., Setji, T. L., Review of nonalcoholic fatty liver disease in women with polycystic ovary syndrome. World J. Gastroenterol. 2014, 20, 14172-84. Kellow, N. J., Savige, G. S., Dietary advanced glycation end-product restriction for the attenuation of insulin resistance, oxidative stress and endothelial dysfunction: a systematic review. Eur J Clin Nutr. 2013, 67, 239-48. Kew, M. C., Serum aminotransferase concentration as evidence of hepatocellular damage. Lancet 2000, 355, 591-592. Kimura, S., Matsumoto, T., Matsuyama, R., Shiina, H., Sato, T., Takeyama, K., Kato, S., Androgen receptor function in folliculogenesis and its clinical implication in premature ovarian failure. Trends Endocrinol. Metab. 2007, 18, 183-189. Kiuchi, K., Nejima, J., Takano, T., Ohta, M., Hashimoto, H., Increased serum concentrations of advanced glycation end products: a marker of coronary artery disease activity in type 2 diabetic patients. Heart. 2001, 85, 87-91. Kolodziejczyk, B., Duleba, A. J., Spaczynski, R. Z., Pawelczyk, L., Metformin therapy decreases hyperandrogenism and hyperinsulinemia in women with polycystic ovary syndrome. Fertil Steril. 2000, 73, 1149-54. Kopplow, K., Wayss, K., Enzmann, H., Mayer, D., Dehydroepiandrosterone causes hyperplasia and impairs regeneration in rat liver. Int. J. Oncol. 2005, 27, 1551-1558. Lambert, A., Harris, S. D., Knaggs, P., Robertson, W. R., Improved FSH sensitisation and aromatase assay in human granulosa-lutein cells. Mol. Hum. Reprod. 2000, 6, 677-680. Lan, K. C., Chiu, C. Y., Kao, C. W., Huang, K. H., Wang, C. C., Huang, K. T., Tsai, K. S., Sheu, M. L., Liu, S. H., Advanced glycation end-products induce apoptosis in pancreatic islet endothelial cells via NF-kappaB-activated cyclooxygenase-2/prostaglandin E2 up-regulation. PLoS One. 2015, 10, e0124418. Legro, R. S. Diabetes prevalence and risk factors in polycystic ovary syndrome. Obstet. Gynecol. Clin. North. Am. 2001, 28, 99-109. Li, R., Albertini, D. F., The road to maturation: somatic cell interaction and self-organization of the mammalian oocyte. Nat. Rev. Mol. Cell Biol. 2013, 14, 141-152. Lopes-Virella, M. F., Hunt, K. J., Baker, N. L., Lachin, J., Nathan, D. M., Virella, G. Levels of oxidized LDL and advanced glycation end products-modified LDL in circulating immune complexes are strongly associated with increased levels of carotid intima-media thickness and its progression in type 1 diabetes. Diabetes. 2011, 60, 582-9 Luevano-Contreras, C., Chapman-Novakofski, K., Dietary advanced glycation end products and aging. Nutrients. 2010, 2, 1247-65 Magoffin, D. A. Ovarian theca cell. Int. J. Biochem. Cell Biol. 2005, 37, 1344-1349. Mailankot, M., Padmanabha, S., Pasupuleti, N., Major, D., Howell, S., Nagaraj, R. H., Glyoxalase I activity and immunoreactivity in the aging human lens. Biogerontology. 2009, 10, 711-720. Maillard, L. C., Acad, C. R. des acides amines sur les sucres: formation des melanoidines par voie methodique. Sci. (Paris). 1912, 154, 66-68. Mallidis, C., Agbaje, I.M., Rogers, D.A., Glenn, J.V., Pringle, R., Atkinson, A.B., Steger, K., Stitt, A.W., McClure, N. Advanced glycation end products accumulate in the reproductive tract of men with diabetes. Int. J. Androl. 2009, 32, 295-305. Marcondes F., Bianchi F. and Tanno A. Determination of the estrous cycle phases of rats: some helpful considerations. Braz. J. Biol. 2002, 62, 609-614. Matthews, D. R., Hosker, J. P., Rudenski, A. S., Naylor, B. A., Treacher, D. F., Tumer R. C. Homeostasis model assessment: insulin resistance and β-cell function from fasting plasma glucose and insulin concertrations in man. Diabetologia. 1985, 28, 412-419. Meenakumari, K. J., Agarwal, S., Krishna, A., Pandey, L. K., Effects of metformin treatment on luteal phase progesterone concentration in polycystic ovary syndrome. Braz J Med Biol Res. 2004, 37, 1637-44. Merhi, Z., Advanced glycation end products and their relevance in female reproduction. Hum. Reprod. 2014, 29, 135-145. Merhi, Z., Irani, M., Doswell, A.D., Ambroggio, J. Follicular fluid soluble receptor for advanced glycation end-products (sRAGE): a potential indicator of ovarian reserve. J. Clin. Endocrinol. Metab. 2014, 99, E226-33. Messinis, I. E. Ovulation induction: a mini review. Hum. Reprod. 2005, 20, 2688-2697. Michael, B., Yano, B., Sellers, R. S., Perry, R., Morton, D., Roome, N., Johnson, J. K., Schafer, K., Pitsch, S., Evaluation of organ weights for rodent and non-rodent toxicity studies: a review of regulatory guidelines and a survey of current practices. Toxicol. Pathol. 2007, 35, 742-750. Mitkov, M., Pehlivanov, B., Terzieva, D. Combined use of metformin and ethinyl estradiol-cyproterone acetate in polycystic ovary syndrome. Eur. J. Obstet. Gynecol. Reprod. Biol. 2005, 118, 209-213. Moghetti, P., Castello, R., Negri, C., Tosi, F., Perrone, F., Caputo, M., Zanolin, E., Muggeo, M. Metformin effects on clinical features, endocrine and metabolic profiles, and insulin sensitivity in polycystic ovary syndrome: a randomized, double-blind, placebo-controlled 6-month trial, followed by open, long-term clinical evaluation. J. Clin. Endocrinol. Metab. 2000, 85,139-146. Monnier, V.M. Nonenzymatic glycosylation, the Maillard reaction and the aging process. J. Gerontol. 1990, 45, 105-111. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J. Immunol. Methods 1983, 65, 55-63. Nestler, J. E., Metformin for the treatment of the polycystic ovary syndrome. N. Engl. J. Med. 2008, 358, 47-54. Norman, R., Wu, R., Stankiewicz, M.T. Polycystic ovary syndrome. Med. J. 2004, 180, 132-137. Okon, M. A., Laird, S. M., Tuckerman, E. M., Li, T. C., Serum androgen levels in women who have recurrent miscarriages and their correlation with markers of endometrial function. Fertil Steril. 1998, 69, 682-690. Ott, C., Jacobs, K., Haucke, E., Navarrete Santos, A., Grune, T., Simm, A., Role of advanced glycation end products in cellular signaling. Redox Biol. 2014, 2, 411-429. Powell, J. M., Sonnenfeld, G., The effects of dehydroepiandrosterone (DHEA) on in vitro spleen cell proliferation and cytokine production. J. Interferon Cytokine Res. 2006, 26, 34-39. Qi, Y.W., Hu, C.Y., Chen, S.H., Liu, Y. Advanced glycation end products inhibit testosterone production in rat Leydig cells. Zhonghua Nan Ke Xue. 2014. 20, 410-413. Qiu, S., Wu, C., Lin, F., Chen, L., Huang, Z., Jiang, Z. Exercise training improved insulin sensitivity and ovarian morphology in rats with polycystic ovary syndrome. Horm. Metab. Res. 2009, 41, 880-885. Quinn, M.C., McGregor, S.B., Stanton, J.L., Hessian, P.A., Gillett, W.R., Green, D.P. Purification of granulosa cells from human ovarian follicular fluid using granulosa cell aggregates. Reprod. Fertil. Dev. 2006, 18, 501-508. Raja-Khan, N., Stener-Victorin, E., Wu, X., Legro, R. The Physiological Basis of Complementary and Alternative Medicine for Polycystic Ovary Syndrome. Am. J. Physiol. Endocrinol. Metab. 2011, Epub ahead of print. Ramasamy, R., Vannucci, S. J., Yan, S. S. D., Herold, K., Yan, S. F., Schmidt, A. M. Review: Advanced glycation end products and RAGE: a common thread in aging diabetes, neurodegeneration, and inflammation. Glycobio. 2005, 15, 16R-28R. Reddy, V. P., Beyaz, A. Inhibitors of the Maillard reaction and AGE breakers astherapeutics for multiple diseases. Drug Discov. Today. 2006, 11, 647-654. Roe, A. H., Dokras, A. The diagnosis of polycystic ovary syndrome in adolescents. Rev. Obstet. Gynecol. 2011, 4, 45-51. Roy, A., Matzuk, M. M., Reproductive tract function and dysfunction in women. Nat. Rev. Endocrinol. 2011, 7, 517-525. Roy, S., Mahesh, V. B., Greenblatt, R. B. Effect of dehydroepiandrosterone and delta4-androstenedione on the reproductive organs of female rats: production of cystic changes in the ovary. Nature. 1962, 196, 42-43. Selimoglu, H., Duran, C., Kiyici, S., Ersoy, C., Guclu, M., Ozkaya, G., Tuncel, E., Erturk E., Imamoglu, S. The effect of vitamin D replacement therapy on insulin resistance and androgen levels in women with polycystic ovary syndrome. J. Endocrinol. Invest. 2010, 33, 234-238. Semchyshyn, H. M., Reactive carbonyl species in vivo: generation and dual biological effects. Scientific World Journal. 2014, 2014, 417842. Simpson, E. R., Aromatase: biologic relevance of tissue-specific expression. Semin Reprod Med. 2004, 22, 11-23. Singh, V. P., Bali, A., Singh, N., Jaggi, A. S., Advanced glycation end products and diabetic complications. Korean J. Physiol. Pharmacol. 2014, 18, 1-14. Slowik, A., Merres, J., Elfgen, A., Jansen, S., Mohr, F., Wruck, C. J., Pufe, T., Brandenburg, L. O., Involvement of formyl peptide receptors in receptor for advanced glycation end products (RAGE)--and amyloid beta 1-42-induced signal transduction in glial cells. Mol Neurodegener. 2012, 7, 55. Soro-Paavonen, A., Watson, A. M., Li, J., Paavonen, K., Koitka, A., Calkin, A. C., Barit, D., Coughlan, M. T., Drew, B. G., Lancaster, G. I., Thomas, M., Forbes, J.M., Nawroth, P. P., Bierhaus, A., Cooper, M. E., Jandeleit-Dahm, K. A. RAGE deficiency attenuates the development of atherosclerosis in diabetes. Diabetes. 2008, Epub ahead of print. Sousa, S. M., Gomes, R. A., Ferreira, A. E., Ponces, F. A., Cordeiro, C. The glyoxalase pathway: the first hundred years… and beyond. Biochemical Journal. 2013, 453, 1-15. Stein, I. F., Leventhal, M. L. Amenorrhea associated with bilateral polycystic ovaries. Am. J. Obs. Gynecol. 1935. 29, 181–186. Stensen, M. H., Tanbo, T., Storeng, R., Fedorcsak, P., Advanced glycation end products and their receptor contribute to ovarian ageing. Hum. Reprod. 2014, 29, 125-134. STITT. A. Advanced glycation: an important pathological event in diabetic and age related ocular disease. Br. J. Ophthalmol. 2001, 85,746–753. Takeuchi, M., Makita, Z., Bucala, R., Suzuki, T., Koike, T., Kameda, Y., Immunological evidence that non-carboxymethyllysine advanced glycation end-products are produced from short chain sugars and dicarbonyl compounds in vivo. Mol. Med. 2000, 6, 114-125. Tanaka, Y. O., Tsunoda, H., Kitagawa, Y., Ueno, T., Yoshikawa, H., Saida, Y. Functioning ovarian tumors: direct and indirect findings at MR imaging. Radiographics. 2004, 1, 147-166. Tatone, C., Amicarelli, F. The aging ovary-the poor granulosa cells. Fertil Steril. 2013, 99, 12-17. The Rotterdam ESHRE/ASRM – Sponsored PCOS consensus workshop group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil. Steril. 2004, 81, 19–25. Thornalley, P.J., Langborg, A., Minhas, H. S. Formation of glyoxal, methylglyoxal and 3-deoxyglucosone in the glycation of proteins by glucose. Biochem. J. 1999, 344, 109–116. Tothova, L., Celec, P., Ostatnikova, D., Okuliarova, M., Zeman, M., Hodosy, J. Effect of exogenous testosterone on oxidative status of the testes in adult male rats. Andrologia. 2013, 45, 417-23. Uribarri, J., Woodruff, S., Goodman, S., Cai, W., Chen, X., Pyzik, R., Yong, A., Striker, G. E., Vlassara, H. Advanced glycation end products in foods and a practical guide to their reduction in the diet. J Am Diet Assoc. 2010, 110, 911–16.e12. Vlassara, H., Palace, M.R. Glycoxidation: the menace of diabetes and aging. Mt Sinai J. Med. 2003, 70, 232-241. Vlassara, H., Palace, M. R., Diabetes and advanced glycation endproducts. J. Intern. Med. 2002, 251, 87-101. Wang, C., Jackson, G., Jones, T. H., Matsumoto, A. M., Nehra, A., Perelman, M. A., Swerdloff, R. S., Traish, A., Zitzmann, M., Cunningham, G., Low testosterone associated with obesity and the metabolic syndrome contributes to sexual dysfunction and cardiovascular disease risk in men with type 2 diabetes. Diabetes Care. 2011, 34, 1669-1675. Wickenheisser, J. K., Nelson-DeGrave, V. L., McAllister, J. M. Human ovarian theca cells in culture. Trends Endocrinol. Metab. 2006, 17, 65-71 Wimalasena, J., Meehan, D., Cavallo, C., Human epithelial ovarian cancer cell steroid secretion and its control by gonadotropins. Gynecol. Oncol. 1991, 41, 56-63. Wu, C, H., Chen, M, J., Shieh, T, M., Wang, K, L., Wu, Y, T., Hsia, S. M., Chiang, W. Potential benefits of adlay on hyperandrogenism in human chorionic gonadotropin-treated theca cells and a rodent model of polycystic ovary syndrome. J. Funct. Foods. 2014, 11, 393–406. Wu, C. H., Yen, G. C. Inhibitory effect of naturally occurring flavonoids on the formation of advanced glycation endproducts. J. Agric. Food Chem. 2005, 53, 3167-3173. Wu, J., Zhao, M. Y., Zheng, H., Zhang, H., Jiang, Y., Pentoxifylline alleviates high-fat diet-induced non-alcoholic steatohepatitis and early atherosclerosis in rats by inhibiting AGE and RAGE expression. Acta. Pharmacol. Sin. 2010, 31, 1367-1375. Xiang, S. K., Hua, F., Tang, Y., Jiang, X. H., Zhuang, Q., Qian, F. J. Relationship between serum lipoprotein ratios and insulin resistance in polycystic ovary syndrome. Int. J. Endocrinol. 2012, 2012, 173281. Xie, J., Mendez, J. D., Mendez-Valenzuela, V., Aguilar-Hernandez, M. M., Cellular signalling of the receptor for advanced glycation end products (RAGE). Cell Signal. 2013, 25, 2185-2197. Yamagishi, S., Nakamura, K., Imaizumi, T. Advanced glycation end products (AGEs) and diabetic vascular complications. Curr. Diabetes Rev. 2005, 1, 93-106. Yu, J., Zhai, D., Hao, L., Zhang, D., Bai, L., Cai, Z., Yu, C. Cryptotanshinone reverses reproductive and metabolic disturbances in PCOS model rats via regulating the expression of CYP17 and AR. Evid. Based Complement Alternat. Med. 2014, 2014, 670743. Zawadzki, J. K., Dunaif, A. Diagnostic criteria for polycystic ovary syndrome: towards a rational approach. Blackwell Scientific Publications. 1992, 19, 377-384. Zenclussen, M. L., Casalis, P. A., Jensen, F., Woidacki, K., Zenclussen, A. C., Hormonal fluctuations during the estrous cycle modulate heme oxygenase-1 expression in the uterus. Front Endocrinol (Lausanne). 2014, 5, 32. Zhang, J., Sun, Y., Liu, Y., Sun, Y., Liao, D. J., Synergistic effects of androgen and estrogen on the mouse uterus and mammary gland. Oncol Rep. 2004, 12, 709-716. | |
| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/52098 | - |
| dc.description.abstract | 多囊性卵巢症候群(Polycystic Ovary Syndrome, PCOS)為生育年齡婦女常見的一種內分泌相關疾病，臨床表徵為月經週期紊亂、高雄性素血症及多囊性卵巢的狀況；其致病原因尚無定論，目前研究指出可能與體內荷爾蒙分泌異常及胰島素抵抗有關。顆粒細胞為卵巢中特有的內分泌細胞，可分泌助孕酮及轉換體內雄性素為雌激素，調控月經週期及濾泡發展。醣化終產物(Advanced Glycation End-product, AGEs)能引起發炎、糖尿病併發症等發展，臨床統計上顯示PCOS患者血清中含有較高醣化終產物含量，亦有研究證實攝取高醣化終產物的飲食會影響PCOS患者體內荷爾蒙及提升氧化壓力。本研究以卵巢顆粒細胞株(KGN)及初代卵巢顆粒細胞為平台，以甲基乙二醛(Methylglyoxal, MG)、甘油醛(Glyceraldehyde, GA)、乙二醛(Glyoxal, GO)、乙醇醛(Glycolaldehyde, GOA)及葡萄醣(Glucose, GLU)與牛血清白蛋白(Bovine serum albumin, BSA)合成之五種不同醣化終產物，從影響細胞生長及生殖內分泌的調節等方面探討醣化終產物於卵巢顆粒細胞的影響，並進一步以體內模式印證。結果顯示五種AGEs皆顯著抑制顆粒細胞株KGN及初代顆粒細胞生長，其中以GOA-BSA效果最為顯著。內分泌調節部分，MG-BSA、GA-BSA及GO-BSA於不同刺激物給予下皆能顯著抑制助孕酮分泌。在動物模式中，給予MG-BSA能顯著促使動物表現胰島素阻抗的狀況及提升肝臟指標酵素天門冬氨酸轉氨酶的表現，且顯著降低體內助孕酮濃度。綜合上述結果，醣化終產物可影響顆粒細胞生長、抑制助孕酮分泌及促胰島素阻抗表現上升等PCOS之相關因子。 | zh_TW |
| dc.description.abstract | Polycystic ovary syndrome (PCOS) is the most common endocrine disorder in women of reproductive age. PCOS is characterized by menstrual cycle disorders, hyperandrogenism and polycystic ovary morphology. No single etiologic factor fully accounts for the spectrum of abnormalities in the polycystic ovary syndrome. Hormonal abonormality and insulin resistance may be associated with the pathogenesis of PCOS in current study. Granulosa cells are specific endocrine cells in ovaries which regulate menstrual cycle and the development of follicles by secreting progesterone and conversion of androgen to estradiol. Advanced glycation end products (AGEs) are known that can spark the development of inflammation and diabetes complications. Research has shown that serum AGEs level was elevated in women with PCOS. Other studies have indicated that consumption of high-AGEs diet can affect hormone expression and enhance oxidative stress. In the present study, we prepared different AGEs by mixing methylglyoxal (MG), glyceraldehyde (GA), glyoxal (GO), glycolaldehyde (GOA) and glucose (GLU) with bovine serum albumin. Human granulosa cell lines (KGN) and human primary granulosa cells are used to investigate the effects of AGEs on hormonal secretion and the proliferation of ovarian cells. Further effect was confirmed by in vivo study. It was observed that five different AGEs treatments significantly inhibit the proliferation of granulosa cells and the dose-dependence was existed. GOA-BSA has the most significant inhibitory effect. The parts of hormonal secretion, MG-BSA, GA-BSA, GO-BSA significantly inhibit progesterone secretion by different stimulators. MG-BSA can significantly increase insulin resistance, serum aspartate transaminase level and inhibit progesterone release in vivo. In conclusion, AGEs can affect granulosa cells proliferation, progesterone secretion and insulin resistance which are risk factors of PCOS. | en |
| dc.description.provenance | Made available in DSpace on 2021-06-15T14:08:30Z (GMT). No. of bitstreams: 1 ntu-104-R02641036-1.pdf: 9482943 bytes, checksum: a1b981b1791414630fd0fab7cda813df (MD5) Previous issue date: 2015 | en |
| dc.description.tableofcontents | 摘要 I
Abstract II 縮寫對照表 IV 目錄 VI 圖目錄 IX 表目錄 XII 第一章、前言 1 第二章、文獻回顧 2 一、女性內分泌生殖系統 2 （一）卵巢之生理功能 2 （二）雌性性類固醇激素的分泌細胞 5 （三）卵巢激素合成路徑(Steroidogenesis) 7 （四）月經週期 8 二.多囊性卵巢症候群(Polycystic ovary syndrome, PCOS) 9 （一）診斷標準 9 （二）多囊性卵巢症候群臨床症狀 11 （三）病因病理學 13 （四）臨床處理 14 三、醣化終產物(Advanced glycation end-product, AGEs) 16 （一）醣化作用(glycation)介紹 16 （二）梅納反應機制 16 （三）醣化終產物之來源與代謝 19 （四）醣化終產物的結構分類 20 （五）醣化終產物對人體之負面影響 21 （六）醣化終產物對女性生殖系統之影響 24 第三章、研究動機、目的與架構 25 第四章、以不同醣化終產物對人類卵巢顆粒細胞株KGN及人類初代卵巢顆粒細胞於生長及分泌性類固醇激素的探討 28 一、材料與方法: 28 （一）醣化終產物的製備及定量 28 （二）人類卵巢顆粒細胞來源及製備 29 （三）細胞之培養、解凍、繼代及保存 30 （四）細胞計數及存活率之計算 31 （五）培養液激素之測定 34 （六）免疫螢光染色 (Immunofluorescence, IFC) 36 （七）統計分析 37 二、結果 37 （一）五種醣化終產物對卵巢顆粒細胞株KGN生長影響之效應 37 （二）不同劑量醣化終產物對KGN細胞株及初代卵巢顆粒細胞細胞存活率影響 37 （三）醣化終產物對卵巢顆粒細胞株KGN分泌助孕酮之效應 39 （四）醣化終產物對卵巢顆粒細胞株KGN分泌雌二醇之效應 41 （五）人類初代卵巢顆粒細胞中的FSH-receptor及DAPI的表現 41 第五章、體內試驗進行甲基乙二醛醣化終產物對於多囊性卵巢症候群內分泌及相關症狀的影響 57 一、 材料與方法 57 （一）實驗動物 57 （二）動物分組 57 （三）脫氫表固酮誘導多囊性卵巢症候群動物模式(DHEA-induced PCOS animal model) 57 （四）醣化終產物之介入 58 （五）動情週期判定 58 （六）組織樣本收集與分析方法 59 （七）統計分析 62 二、結果 62 （一）甲基乙二醛醣化終產物對動物生長、攝食量以及組織臟器之影響 62 （二）甲基乙二醛醣化終產物對血液相關生化值之影響 63 （三）卵巢切片之組織學觀察 64 第六章、綜合討論 80 一、醣化終產物對顆粒細胞生長影響之效應 80 二、醣化終產物對顆粒細胞性類固醇激素分泌影響之效應 80 三、甲基乙二醛醣化終產物合併脫氫睪固酮誘導多囊性卵巢症候群動物模式之探討 82 (一)甲基乙二醛醣化終產物對動物生長、攝食量以及組織臟器之影響 82 (二)甲基乙二醛醣化終產物對動物類固醇荷爾蒙之影響 84 (三)甲基乙二醛醣化終產物對動物血糖以及胰島素阻抗之影響 85 第七章、 結論 86 參考文獻 87 附錄 104 | |
| dc.language.iso | zh-TW | |
| dc.title | 以體內及體外試驗探討高度醣化終產物對性荷爾蒙分泌之影響 | zh_TW |
| dc.title | The effects of advanced glycation end products on sexual hormonal secretion in vivo and in vitro | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 103-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.coadvisor | 夏施閔(Shih-Min Hsia),陳宏彰(Hong-Jhang Chen) | |
| dc.contributor.oralexamcommittee | 吳啟豪,施純光 | |
| dc.subject.keyword | 多囊性卵巢症候群,顆粒細胞,醣化終產物, | zh_TW |
| dc.subject.keyword | Polycystic ovary syndrome (PCOS),granulosa cell,advanced glycation end product (AGEs), | en |
| dc.relation.page | 105 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2015-08-19 | |
| dc.contributor.author-college | 生物資源暨農學院 | zh_TW |
| dc.contributor.author-dept | 食品科技研究所 | zh_TW |
| 顯示於系所單位： | 食品科技研究所 | |
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