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http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/49521完整後設資料紀錄
| DC 欄位 | 值 | 語言 |
|---|---|---|
| dc.contributor.advisor | 陳青周(Ching-Chow Chen) | |
| dc.contributor.author | An-Chieh Chiu | en |
| dc.contributor.author | 邱安婕 | zh_TW |
| dc.date.accessioned | 2021-06-15T11:32:46Z | - |
| dc.date.available | 2021-08-26 | |
| dc.date.copyright | 2016-08-26 | |
| dc.date.issued | 2016 | |
| dc.date.submitted | 2016-08-17 | |
| dc.identifier.citation | Siegel RL, Miller KD, & Jemal A (2016) Cancer statistics, 2016. CA Cancer J Clin 66(1):7-30.
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| dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/49521 | - |
| dc.description.abstract | 第一代EGFR-TKI為activating mutation非小細胞肺癌病人之第一線用藥，治療約一年後會產生acquired resistance，因此發展第二及第三代藥物，然而抗藥性依舊會產生，因此探討EGFR-TKI抗藥性之機轉以克服抗藥性為重要之課題。
我們發現，HCC287/IR與H1975/AR皆具有mesenchymal form，伴隨E-cadherin之downregulation和Vimentin之upregulation，且H1975/AR細胞有Zeb1之upregulation；HCC287/IR與H1975/AR皆具較易形成spheroids，因此，EMT及癌幹細胞可能為EGFR-TKI抗藥性之主要原因。新穎HDAC抑制劑JMF3086在H1975/AR可抑制Zeb1之表現，增加E-cadherin及降低Vimentin之表現，對spheroids亦有相同之抑制作用。因此，JMF3086具潛力對抗EGFR-TKI之抗藥性。我們於RNA sequencing發現，HCC287/IR與H1975/AR皆有FoxC1之upregulation，可能亦與抗藥性和癌幹細胞之形成有關；JMF3086可抑制HCC287/IR與H1975/AR及spheroids之FoxC1表現，FoxC1可能可作為對抗非小細胞肺癌抗藥性之標的。 發炎性腸道疾病包括克隆氏症及潰瘍性結腸炎，目前未有治癒之藥物；TNBS誘導之急性大腸炎比擬人類之克隆氏症，本實驗中，新穎HDAC抑制劑JMF3086之salt form TWJ101，可預防TNBS造成之急性大腸炎，具開發為抗發炎藥物之潛力。 | zh_TW |
| dc.description.provenance | Made available in DSpace on 2021-06-15T11:32:46Z (GMT). No. of bitstreams: 1 ntu-105-R03443018-1.pdf: 3644868 bytes, checksum: 4c15f304cc187ffad81e85738eb1d35d (MD5) Previous issue date: 2016 | en |
| dc.description.tableofcontents | 縮寫表…………………………………………………………2
中文摘要………………………………………………………7 英文摘要………………………………………………………8 第一章 緒論…………………………………………………9 第一節 肺癌…………………………………………………10 第二節 非小細胞肺癌之標靶治療…………………………18 第三節 HDAC抑制劑和HMGR抑制劑…………………………23 第四節 癌幹細胞……………………………………………32 第五節 上皮間質轉換作用(EMT) …………………………40 第六節 發炎性腸道疾病(IBD) ……………………………47 研究動機 ……………………………………………………58 第二章 實驗材料與方法……………………………………59 第三章 實驗結果……………………………………………66 第一節 非小細胞肺癌………………………………………67 第二節 發炎性腸道疾病……………………………………78 第四章 討論………………………………………………….87 結論……………………………………………………………92 參考文獻………………………………………………………93 | |
| dc.language.iso | zh-TW | |
| dc.subject | non-small cell lung cancer | zh_TW |
| dc.subject | TNBS | zh_TW |
| dc.subject | IBD | zh_TW |
| dc.subject | TKI resistance | zh_TW |
| dc.title | 新穎HDAC抑制劑在非小細胞肺癌之研究及建立TNBS誘導發炎性腸道疾病之動物模式 | zh_TW |
| dc.title | Effects of Novel HDAC Inhibitor on Non-Small Cell Lung Cancer and establishment of TNBS-induced acute colitis animal model | en |
| dc.type | Thesis | |
| dc.date.schoolyear | 104-2 | |
| dc.description.degree | 碩士 | |
| dc.contributor.oralexamcommittee | 吳明賢(Ming-Shiang Wu),黃偉謙(Wei-Chien Huang) | |
| dc.subject.keyword | TNBS,IBD,TKI resistance,non-small cell lung cancer, | zh_TW |
| dc.relation.page | 100 | |
| dc.identifier.doi | 10.6342/NTU201602872 | |
| dc.rights.note | 有償授權 | |
| dc.date.accepted | 2016-08-17 | |
| dc.contributor.author-college | 醫學院 | zh_TW |
| dc.contributor.author-dept | 藥理學研究所 | zh_TW |
| 顯示於系所單位： | 藥理學科所 | |
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