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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 薛景中 | |
dc.contributor.author | Szu-Hsian Lee | en |
dc.contributor.author | 李思賢 | zh_TW |
dc.date.accessioned | 2021-06-15T04:56:04Z | - |
dc.date.available | 2012-08-06 | |
dc.date.copyright | 2010-08-06 | |
dc.date.issued | 2010 | |
dc.date.submitted | 2010-07-30 | |
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/46159 | - |
dc.description.abstract | 在金基材上沉積具有硫醇 (thiol)及長碳鏈自組裝單層分子 (Self-Assembled Monolayers, SAMs),已經被廣泛的利用在固定及偵測各類型生醫分子,包括DNA和蛋白質等。然而這些分子通常都藉由共價鍵鍵結於金基材上,所以硫醇自組裝單層分子可以穩固的貼附在金基板表面。利用不同尾端官能基分子,可以選擇特定的表面電荷;因此在給定的情況下,自組裝單層分子可藉由靜電力的交互作用應用於固定及選擇性吸脫附各種分子材料。而以現今的材料來說,胺基自組裝單層分子已經普遍的被應用在固定及偵測各式分子上。根據本團隊之前的研究,利用混合不同比例之特定官能基,自組裝單層分子可以控制固體基材表面電荷,並成功調配一系列等電位點 (Isoelectric points, IEP)。於金基板上,利用帶有-COOH和-NH2官能基的自組裝單層分子,可調配出範圍由3.5到6.5的IEP值。除了IEP,由帶有不同官能基的自組裝單層分子亦可以微調金屬電極的功函數值 (work function),受表面官能基與另一端分子形成偶極 (dipole)所影響,亦可在金基板上調配出一系列的功函數值從3.3eV到3.9eV。然而,對這種自組裝單層分子材料的穩定度並不完全了解,在本論文中,由界面電位的測量得知胺基自組裝單層分子在大氣下會隨著存放時間長短使得等電位點有衰退的現象發生;此一現象顯示表面之胺官能基,並不能穩定的存放在大氣下 (常態溫度與壓力下)。本論文透過兩種保存方法去抑制胺官能基之衰退;將胺基自組裝單層分子與光或氧氣隔離,可抑制住尾端胺基的氧化反應,且保留原來的表面特性。換句話說即是延長在金基板上的胺官能基之壽命。 | zh_TW |
dc.description.abstract | Alkanethiol anchored self-assembled monolayers (SAMs) on gold are widely used to immobilize and detect molecules including DNA and proteins. Most of these molecules are covalently bonded with the SAM on the Au surface and cannot be released easily. Amine-terminated self-assembled monolayers (SAMs) on Au surfaces are commonly used to immobilize and detect various types of molecules. By using different functional groups, the interfacial charge of SAMs can be selected, and thus, they can be considered as adaptors for immobilizing and releasing materials selectively through electrostatic interaction under given conditions. In previous work, as an additional factor to control the surface charge, SAMs with mixed functional groups are presented, and it is demonstrated that the isoelectric point (IEP) can be tailored by the ratio of functional groups. Using carboxylic acid- and amine-SAM on gold substrates as an example, isoelectric points (IEPs) from 3.5 to 6.5 can be obtained arbitrarily. Furthermore, using different functional groups can make series of suface functional groups and head groups forming dipoles, it can modify work function from 3.3 eV to 3.9eV on metal electrode. However, little is known about the stability of these types of surfaces. In this work, it was observed that the surface potential (as well as the isoelectric point) of amine-bearing SAMs on flat gold substrates changed significantly with time, indicating that the surface functional group is not stable to storage under ambient conditions (standard temperature and pressure). Two methods for retarding the oxidation of the amine functional group are presented in this work. By isolating the SAM from either light or oxygen, the oxidation is suppressed and the surface properties are preserved. In other words, the shelf life of the amine-modified gold substrates is prolonged. | en |
dc.description.provenance | Made available in DSpace on 2021-06-15T04:56:04Z (GMT). No. of bitstreams: 1 ntu-99-R97527042-1.pdf: 3627191 bytes, checksum: 2539be880ff103a88433c512dcecc294 (MD5) Previous issue date: 2010 | en |
dc.description.tableofcontents | 中文摘要 III
Abstrate V 圖目錄 IX 表目錄 XI 第一章 緒論 1 第二章 文獻回顧 4 2-1-1 自組裝單層分子 (SAMs)結構 6 2-1-2 胺基(amine)自組裝單層分子膜 7 2-2 奈米金粒子在生醫檢測的應用[34] 8 2-2-1 奈米分離/純化 (nano-separation/nano-purification) 9 2-2-2 奈米放大 (nano-amplification) 方法 10 2-2-3 奈米偵測 (Nano-detection) 13 2-3 藥物傳輸 14 2-3-1 高分子材料藥物傳輸 15 2-3-2 微脂粒藥物傳輸 16 2-3-3 以-COOH及-NH2官能基混合沉積在金基板上[14] 17 2-3-4 以-COOH及-NH2的官能基混合沉積在奈米金粒子[15] 20 2-4 自組裝單層分子應用於有機光電元件 24 2-4-1 自組裝單層分子影響ITO或金屬其功函數 24 2-5 硫醇自組裝單層分子在金基板之穩定度 26 2-5-1 硫醇自組裝單層分子沉積在金表面上的品質 26 2-5-2 硫醇自組裝單層分子在大氣環境下的穩定度 28 2-6 研究動機及目的 35 第三章 實驗部份 37 3-1 實驗基材&藥品 37 3-2 實驗儀器 38 3-3 實驗步驟 39 3-3-1 自組裝單層分子沉積於金試片上之製備. 39 3-3-2 試片存放條件 (Sample Handling) 40 3-4 實驗原理 41 3-4-1 動態接觸角 (Contact Angle Measurements) 41 3-4-2 界面電位實驗 (Zeta potential Measurments) 43 3-4-3 原子力顯微鏡(Atomic Force Microscopy ,AFM) 45 3-4-4 X射線光電子光譜儀(X-ray Photoelectron Spectroscopy, XPS) 47 3-4-5 二次離子質譜分析儀 (Time of Flight Secondary Ion Mass Spectrometry, ToF-SIMS) 49 第四章 結果與討論 52 4-1 添加HCl對胺基 (-NH2)自組裝單層分子溶液的影響 52 4-1-1 用XPS分析添加HCl於沉積溶液中的金基板表面元素 54 4-1-2 X光電子光譜之角度分析胺基自組裝單分子之表面結構 56 4-2 界面電位實驗研究(Zeta Potential) 60 4-2-1 胺基自組裝單層分子在金基板之衰退現象 60 4-2-2 接觸角實驗研究胺基自組裝單層分子在金表面之表面能 61 4-3 胺基自組裝單層分子在金基板上之衰退機制 63 4-3-1 XPS研究胺基自組裝單層分子之光氧化行為 63 4-4 ToF-SIMS 研究胺基自組裝單層分子之光催化氧化 66 4-5 保存胺基自組裝單層分子的等電位點 69 4-5-1胺基自組裝單層分子保存在酒精中之界面電位 69 4-5-2胺基自組裝單層分子保存在黑暗中之界面電位 70 4-6 其他討論 72 4-6-1 保存環境的含氧量對等電位點影響 72 4-6-2 添加硫脲分子(thiourea)反應後的界面電位 72 4-6-3 金基板上混合-COOH及-NH2官能基微調功函數值 74 第五章 結論. 79 參考文獻 79 附錄一 86 | |
dc.language.iso | zh-TW | |
dc.title | 研究在金基板上沉積胺基自組裝單層分子的光氧化作用 | zh_TW |
dc.title | Photo-Oxidation of Amine-Terminated Self-Assembled Monolayers on Gold | en |
dc.type | Thesis | |
dc.date.schoolyear | 98-2 | |
dc.description.degree | 碩士 | |
dc.contributor.oralexamcommittee | 虞邦英,康佳正 | |
dc.subject.keyword | 自組裝單層分子,衰退,光氧化作用,等電位點,藥物傳遞, | zh_TW |
dc.subject.keyword | SAMs,degradation,photooxidation,isoelectric point,drug delivery, | en |
dc.relation.page | 86 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2010-07-30 | |
dc.contributor.author-college | 工學院 | zh_TW |
dc.contributor.author-dept | 材料科學與工程學研究所 | zh_TW |
顯示於系所單位: | 材料科學與工程學系 |
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