台灣地區馬匹無汗症之研究

Abstract

本研究依據臨床症狀判定可能為無汗症的實驗組馬匹 (n=9) 進行下列探討，包括完整的血液學檢查、血清生化學檢查、血漿腎上腺素濃度、血漿總甲狀腺素濃度、皮內注射試驗、組織病理學檢查汗腺細胞型態，以及免疫組織化學染色評估汗腺細胞的運水能力等診斷方式來判定無汗症。並藉由皮內注射試驗來評估臨床上給予維生素E配合甲狀腺素，以及新香薷散配合麥門冬之療效。 結果可得數據如下：血液學檢查 (0%, 0/9)、血清生化學檢查 (0%, 0/9)、血漿腎上腺素濃度 (0%, 0/5)、血漿總甲狀腺素濃度 (11.1%, 1/9)、皮內注射試驗 (100%, 9/9)、組織病理學檢查 (33.3%-88.9%, 3/9-8/9)，以及免疫組織化學染色(66.7%, 6/9)。結果得知維生素E配合甲狀腺素療效為較佳(40%, 2/5)，而新香薷散配合麥門冬之療效則不顯著(0%, 0/4)。由此研究的得知，馬匹可藉由臨床症狀並配合實驗診斷，確診為無汗症。並以維生素E配合甲狀腺素治療，可得治療效果。

In this research, suspected affected horses (n=9) were performed complete blood count (C.B.C), serum biochemistry, plasma epinephrine concentration examination, plasma total T4 concentration, intradermal injecting test (IDT), the histopathology of the skin sample to examine the sweat gland conformation, and evaluate the water transportation of the sweat gland cells by immunohistochemistry (IHC) staining. Base on the IDT, the effects of vitamin E with levothyroxine and New Xiang Ru San with Mai Men Tong were evaluated. Results as follow: complete blood count (0%, 0 of 9), serum biochemistry (0%, 0 of 9), plasma epinephrine concentration examination (0%, 0 of 5), plasma total T4 concentration (11.1%, 1 of 9), intradermal injecting test (100%, 9 of 9), the histopathology of the skin sample to examine the sweat gland conformation (33.3% to 88.9%, 3 of 9 to 8 of 9), and evaluate the water transportation of the sweat gland cells by immunohistochemistry staining (66.7%, 6 of 9). The effects of treatment by vitamin E with levothyroxine (40%, 2 of 5) was better than by New Xiang Ru San with Mai Men Tong (0%, 0 of 4)