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完整後設資料紀錄
DC 欄位 | 值 | 語言 |
---|---|---|
dc.contributor.advisor | 陳炳煇(Ping-Hei Chen) | |
dc.contributor.author | Dar-Sun Liou | en |
dc.contributor.author | 劉達生 | zh_TW |
dc.date.accessioned | 2021-06-15T01:35:08Z | - |
dc.date.available | 2014-07-17 | |
dc.date.copyright | 2009-07-17 | |
dc.date.issued | 2009 | |
dc.date.submitted | 2009-07-17 | |
dc.identifier.citation | Abate, A. R., Romanowsky, M. B., Agresti, J. J. and Weitz, D. A. (2009) Valve-based flow focusing for drop formation. Applied Physics Letters, 94, 023053.
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dc.identifier.uri | http://tdr.lib.ntu.edu.tw/jspui/handle/123456789/43063 | - |
dc.description.abstract | 請參閱英文摘要 | zh_TW |
dc.description.abstract | A new modular design concept for microfluidic devices is proposed and demonstrated in this work. I design three key modular microfluidic components: membrane pumps, unidirectional membrane valves and guiding-fluid reservoirs, and demonstrate that a microfluidic device with specific functions can be easily assembled with those key modular components. Since all components are combination maneuverable similar to the concept of Lego, this design is named Lego-Type Modular Components or LTMC. My pumps run on man-power so that the assembled microfluidic devices require no other power sources like expensive syringe pumps or air compressors. This feature makes the assembled microfluidic devices completely portable. I also successfully combine my assembled device with other existing mixing microchannels, to serve as the mixing and loading system in PCR experiment to amplify DNA. Besides, I design a simple microchannel to separate particles in fluids by size. With integration of particles sieving chip and LTMC unit to have the control in switching channels, it is successfully found that the size distribution of the head part is different from that of the tail part. This result shows that these modular components can be integrated into other microchannels, implying great potential applications of the modular design. | en |
dc.description.provenance | Made available in DSpace on 2021-06-15T01:35:08Z (GMT). No. of bitstreams: 1 ntu-98-D94522006-1.pdf: 8020637 bytes, checksum: 062e69cd84ced324f8138d86ed1e2f9e (MD5) Previous issue date: 2009 | en |
dc.description.tableofcontents | 口試委員會審定書 I
致謝 II Abstract III Nomenclature IV Table of Contents VI List of Figures X List of Tables XVIII List of Tables XVIII Chapter 1 Introduction 1 1.1 General Remarks 1 1.2 Literature Survey 4 1.2.1 Microfluidic pump and valve 4 1.2.2 Particles sieving chip 26 1.3 Motivation and purpose of research 34 1.4 Chapter outline 36 Chapter 2 Fabrication of Major Lego-Type Modular Components and a Microfluidic chip for sieving particles 38 2.1 Fabrication of LTMC 38 2.1.1 Fabrication of MP 39 2.1.2 Fabrication of unidirectional membrane valve 47 2.1.3 Fabrication of GFR 55 2.2 Fabrication of microfluidic chip 59 2.2.1 Design of unit and production of mask 59 2.2.2 Production of microfluidic chip base mold with Photolithography processing 61 2.2.3 Remolding of PDMS microchannel to combine with substrate 71 Chapter 3 Function and verification of Lego-Type Modular Components 76 3.1 Function and character of the components 77 3.1.1 Function and verification of UMV 77 3.1.2 Function and verification of MP 81 3.1.3 Function and character of GFR 88 3.2 LTMC combination and application 91 Chapter 4 Constructing LTMC unit with particles sieving chip to progress 98 4.1 Design and function of particles sieving chip 99 4.1.1 Four sections of the particles sieving chip 101 4.1.2 Function of initial segmentation (section A) 102 4.1.3 Function of differentiation (section B) 103 4.1.4 Function of finer segmentation (section C) 104 4.1.5 Function of classification (section D) 105 4.2 Integrating particles sieving chip with LTMC unit 107 4.3 Particles sieving experiment 108 4.3.1 Testing particles 108 4.3.2 Experiment equipments 114 4.3.3 Experiment procedure 116 4.4 Conclusion and Discussion 119 4.5 Summary of the chapter 124 Chapter 5 Integrating Lego-Type Modular Components with current chip into a system 125 5.1 First experiment – Assemble microfluidic chip as a driver of one droplet 126 5.1.1 Introduction of the first experiment 126 5.1.2 Conclusion and discussion of first experiment 128 5.2 Second experiment – GFR unit guiding mode and transmission of DNA mixture reagent 130 5.2.1 Introduction of the second experiment 131 5.2.2 Conclusion and discussion of second experiment 136 5.3 Summary of the chapter 139 Chapter 6 Conclusions and Prospects 140 Reference 144 | |
dc.language.iso | en | |
dc.title | 樂高模組化微流元件應用於微流晶片之研究 | zh_TW |
dc.title | Development and Research on Lego-Type Modular Components for the Application of Microfluidic Chips | en |
dc.type | Thesis | |
dc.date.schoolyear | 97-2 | |
dc.description.degree | 博士 | |
dc.contributor.oralexamcommittee | 楊鏡堂,曾繁根,苗志銘,楊進丁,李達生,楊天祥,蘇裕軒 | |
dc.subject.keyword | 微幫普,微閥門,微流裝置,模組化設計,顆粒分離, | zh_TW |
dc.subject.keyword | micropump,microvalve,microfluidic device,modular design,particles sieving, | en |
dc.relation.page | 147 | |
dc.rights.note | 有償授權 | |
dc.date.accepted | 2009-07-17 | |
dc.contributor.author-college | 工學院 | zh_TW |
dc.contributor.author-dept | 機械工程學研究所 | zh_TW |
顯示於系所單位: | 機械工程學系 |
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